• Molecules and Cells
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• 제37권2호
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• pp.161-171
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• 2014

In several lysosomal storage disorders, including Niemann-Pick disease Type C (NP-C), sphingolipids, including glycosphingolipids, particularly gangliosides, are the predominant storage materials in the brain, raising the possibility that accumulation of these lipids may be involved in the NP-C neurodegenerative process. However, correlation of these accumulations and NP-C neuropathology has not been fully characterized. Here we derived NP-C mice with complete and partial deletion of the Siat9 (encoding GM3 synthase) gene in order to investigate the role of ganglioside in NP-C pathogenesis. According to our results, NP-C mice with homozygotic deletion of GM3 synthase exhibited an enhanced neuropathological phenotype and died significantly earlier than NP-C mice. Notably, in contrast to complete depletion, NP-C mice with partial deletion of the GM3 synthase gene showed ameliorated NP-C neuropathology, including motor disability, demyelination, and abnormal accumulation of cholesterol and sphingolipids. These findings indicate the crucial role of GM3 synthesis in the NP-C phenotype and progression of CNS pathologic abnormality, suggesting that well-controlled inhibition of GM3 synthesis could be used as a therapeutic strategy.

• 한국화재소방학회논문지
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• 제25권5호
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• pp.1-7
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• 2011

본 연구에서는 한옥의 주요 부재에 대한 난연기술 개발 및 성능향상을 위한 기초단계로 미국, 일본, 유럽 및 국내의 건축물 마감재의 난연성능 관련 법규 및 시험기준 등을 비교 분석하여 각 부재의 난연성능 평가기준을 제시하고자 하였다. 미국의 경우 최근 통합되어 사용 중인 IBC(International Building Code) 및 NFPA(National Fire Protection Association) Code가 적용되고 있으며, 평가항목으로는 바닥재에 대해서는 임계열유속을, 천장 및 벽체에 대해서는 화염확산지수 및 연기발생량을 적용하고 있다. 유럽의 경우 통합된 Euroclass가 적용되고 있는데 바닥재와 비바닥재를 구분하여 난연성능 등급별로 불연성시험, 화염 전파성시험, 소규모실물화재시험, 발열량시험 등을 평가항목으로 두고 있다. 일본의 경우는 우리나라의 체계와 유사하였는데, 이들 각국의 기준을 비교분석하여 목조물인 한옥 부재에 적용할 수 있는 정량적인 난연성능 평가방법에 대해 고찰해 보았다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1739-1743
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• 2014

MicroRNAs are a class of small noncoding RNA which play important regulatory roles in a variety of cancers. MiRNA-specific expression profiles have been reported for several pathological conditions. In this study, we combined large scale parallel Solexa sequencing to identify 11 up-regulated miRNAs and 19 down-regulated miRNAs with computational techniques in the sera of ovarian cancer patients while using healthy serum as the control. Among the above, four miRNAs (miR-22, miR-93, miR-106b, miR-451) were validated by quantitative RT-PCR and found to be significantly aberrantly expressed in the serum of ovarian cancer patients (P<0.05). There were no significant differences between samples from cancer stage I/II and III/IV. However, the levels of miR-106b (p=0.003) and miR-451 (p=0.007) were significantly different in those patients under and over 51 yearsof age. MiR-451 and miR-93 were also specific when analyzed with reference to different levels of CA125. This study shows that Solexa sequencing provides a promising method for cancer-related miRNA profiling, and selectively expressed miRNAs could be used as potential serum-based biomarkers for ovarian cancer diagnosis.

• 한국정밀공학회지
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• 제29권11호
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• pp.1236-1244
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• 2012

A equivalent stiffness modeling has been performed for extracting the equivalent stiffness properties which are orthotropic elastic model from a large scale wind turbine rotor blade so that structure model can be constructed more simply for the three dimensional static aeroelastic analysis. In order to present the procedure of equivalent stiffness modeling, NREL 5MW class wind turbine rotor having the three stiffness information which are flapewise, edgewise and torsional stiffness was chosen. This method is based on applying unit moment at the tip of the blade as well as fixing all degree of freedom at the blade root and calculating the displacement from the load analysis to obtain the elastic modulus corresponding to equivalent stiffness referred to the NREL reports on blade divided into 5 sections respectively. In addition, one section was divided into 3 parts and the trend functions were used to make the equivalent stiffness model more correctly and quickly. Through the comparison of stiffness between the reference values and calculated values from equivalent stiffness model, the investigation of the accuracy on the stiffness values and the efficiency for constructing the model was conducted.

• 건축역사연구
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• 제1권2호
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• pp.52-67
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• 1992

In Cho-Sun Dynasty, since Czhu-Ja Ga Rae be introduced in late Korea dynasty, many kinds of $Y\^{a}e\;Se\^{o}$ by a personal or national edition had been published, based on supports of the political ideology. Especially, in the age of governing by $'Y^{a}e'$ in 16 17c, after completion of publishing $'Oh\;R^{a}e\;Yi(1474),'$ 'Geong Guk Dae Jeon (1469)' in late 15c, norm of $'Ga\;R^{a}e'$ has prevailing and the quantity of publishment of it is more growing. Generally, the contents of these kinds of $Y^{a}e\;Se^{o}$ is intended to interprete the czhu-Ja $'Ga\;R^{a}e'$. and furthermore, some kinds of it, descripted directly architectural institutions as a part of $Y^{a}e\;J^{a}e$ through architectural drawings, with quatating chinese scholar's theory. It can be said that architectural institution on $Y^{a}e\;S^{e}o$ may be a kind of political institution as a tool for execution of a ideal ideology in Confucianism. In this Context, it can be concluded that the governing-class in Cho-Sun Dynasty refered to the architectural institution on $Y^{a}e Se^{o}$ as a ideal norm and, in constructing or organizing buildings, it was taken in account as a 'frame of reference'. The Locus of this study is on architectural drawings on $Y^{a}e\;Se^{o}$, for certifying interrelationship the institution which is executed in the drawings and the architectural characteristics of construction and organization in Cho-Sun Dynasty.

• 컴퓨터교육학회논문지
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• 제16권6호
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• pp.33-43
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• 2013

컴파일러와 언어구현 교과목은 컴퓨터과학 교과과정에서 오랫동안 중요한 주제로 인식되어 왔다. 그것은 컴파일러에 관한 지식이 프로그래밍 언어와 시스템을 이해하는 데에 중요한 역할을 할 뿐 아니라, 컴파일러 기술이 많은 응용 영역에서 활용될 수 있기 때문이다. 그러나 제한된 자원과 시간적 제약 때문에 컴파일러 기술을 효과적으로 전달하기 위해서는 많은 노력이 필요하다. 본 논문에서는 교육용 컴파일러 개발환경인 Edu-IDEC을 이용한 컴파일러 수업모형을 제시한다. Edu-IDEC는 로봇 플랫폼에서의 컴파일러 개발환경으로서, 컴파일러 제작도구, 레퍼런스 컴파일러, 구문트리 시각화도구, 목적언어 시각화 도구, 로봇제어기, 그리고 로봇시뮬레이터 등의 기능이 있으며, 이클립스 플러그인 기반으로 동작한다. 그리고 제시된 모형을 실제 수업에 적용하여 그 평가결과를 제시한다.

• Journal of Periodontal and Implant Science
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• 제26권1호
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• pp.80-88
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• 1996

The aim of the present investigation was to see the effect of combined use of PDGF BB and IGF -1 on the guided tissue regeneration(GTR) using barrier membrane in the treatment of human furcation involvement. Twelve patients with initially diagnosed as having moderate to advanced adult periodontitis with mandibular class II buccal furcation defects have been wer selected. Initial scaling and root planing has been performed and baseline data consisting of probing depths and attachment levels have been recorded prior to surgical procedures. The GTR procedures using either barrier membrane(control : ePTFE) alone or together with the application of PDGF - BB and IGF -l(experimental : ePTFE+PDGF/IGF) have been done under the routine guidelines. During the surgery, the distance from CEJ either to the bottom of the bone defects(CEJ - BD) or to the bone crest(CEJ-BC) were measured. Horizontal distance to the deepest area in the furcal defects were measured from the reference line connection the most prominent bony walls of the two buccal roots. 6 months following the GTR therapy, all the measurements were made repeatedly. The probing attachment gain of the experimental and the control grous were 2.14mm and l.07mm, respectively with no statically significnant difference. Amont of vertical bone fill in the experimental and the control groups were 2.43mm and 2.29mm, rexpectively. Amonut of horizontal bone fill were 2.86mm in the experimental group and 2.17mm in the control group, respectively. However, there were no significant differences in the amount of bone fill(both vertical and horizontal)between the two groups.

• 복식
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• 제63권4호
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• pp.158-167
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• 2013

The cotton fabric armour for lower class soldiers can be found from the historical records of the mid-Joseon Korea. And the records show that the form and the structure of the armour was modified in the late 19th century in order to provide better protection from gunshots for the soldiers in the midst of the invasions from the West. This is a survey and research of the only artifact of the cotton fabric armour remaining in Korea - for its form, dimensions, and design. Using the historical records as reference, we can confirm the structure and characteristics of the cotton fabric armour of the Joseon period. This cotton fabric armour, preserved in National Museum of Korea, is a vest-type armour made of 30 layers of cotton. On the right shoulder, there is a button for tying knots and strings were tied under both armpits. On the surface of the cotton fabric armour there were some characters and patterns stamped in black. Presently, this artifact in Korea is the only specimen relic of its sort, but there are some other related relics in foreign countries including helmets and belts. Continuous researches would help extend the scope of armour study beyond the traditional researches that only focuses on the armours of the officials, thus helping us to understand the military costumes in traditional Korea.

• 대한토목학회논문집
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• 제36권2호
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• pp.317-324
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• 2016

본 연구는 현수교 분야 기술수준의 정량적인 평가와 기술개발, 국토교통 R&D의 전략적 방향 모색 및 기술정책 수립 등 수요에 대응할 수 있는 기초자료 제공을 목적으로 수행하였다. 이를 위해 현수교 분야의 기술 분류체계를 구축하고 기술별 핵심 키워드를 도출하여 한국, 미국, 일본, 독일, 영국의 기술수준 조사를 실시하였다. 기술수준 평가결과 미국과 일본이 모든 기술분야에서 상위의 특허 및 논문기술경쟁력을 보유한 것으로 나타났다. 한국의 경우 전반적으로 중위권의 기술경쟁력을 보유한 것으로 나타났으나, 기술별 편차가 있는 것으로 나타났다. 본 연구결과는 향후 현수교 분야 기술개발 및 계획수립 시 기초자료로 활용될 수 있다. 그리고 기술 경쟁국간의 기술 수준 비교 방법론의 표준화를 위한 연구에 활용 될 수 있다.

• Journal of Oral Medicine and Pain
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• 제17권2호
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• pp.27-35
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• 1992

The purpose of this study was to evaluate the size of the temporomandibular joint space by the increase of the occlusal force on the working side and the non-working side during unilateral biting. For the study, 22 normal adults, age from 23 to 25, who had normal or class I molar relationship and had no symptoms on TMJ area and masticatory muscles were selected. Transcranial TMJ radiograph was taken during unilateral biting with the sensor of occlusal load measuring device (MPM-3000 ; Nihon Kohden Kogyo Co. Ltd., Japan) on 1st molar teeth of right and left side given to force of 0kg, 10kg, 20kg and 30kg respectively with Accurad-200(Denar Corperation's product). The radiographs were traced on the screen, with enlaged as 5 times. The size of temporomandibular joint space at anterior, superior and posterior compartment were measured with Dumas's method (reference line between squamotympanic fissure and the lowest point of articular eminence). The following results were obtained by this study. 1. The size of anterior TMJ space showed a tendency to decrease on the working side and increase on the non-working side by the increase of the occlusal force, but had no statistical significancy (P>0.05). 2. The size of superior TMJ space showed a tendency to increase on the working side and decrease on the non-working side by the increase of the occlusal force (P<0.05). 3. The size of posterior TMJ space showed a tendency to decrease on both working and nonworking side, but had no statistical significancy (P>0.05)