• KSCE Journal of Civil and Environmental Engineering Research
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• v.34 no.4
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• pp.1269-1278
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• 2014

The urban highway, which is a motorway constructed to solve traffic issues, has the characteristic of extremely high damage to life during traffic accidents because the speed of vehicles is higher than typical roadways. In particular, because traffic accidents involving serious injuries hold a very important place among overall traffic accidents, analysis on factors affecting the occurrence of traffic accidents involving serious injuries must be considered with priority when establishing a reduction measure. Therefore, the study built a model that was capable of distinguishing the degree of the factors as part of microscopic analysis for investigating the complex effect of many elements concerning the occurrence of traffic accidents involving serious injuries in urban highways. The results are as follows. First, discriminant model showed a comparatively high level in overall accuracy rates, and, considering the correlation ratio, the models were determined to be valid, as all characteristics of the factors were clearly distinguished. Second, the problems of traffic accidents involving serious injuries on urban highways according to each factor, were clearly drawn out through the discriminant model. Third, the improvement measure for the problems drawn out from the discriminant models were clearly proposed.

• Journal of Oral Medicine and Pain
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• v.37 no.1
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• pp.47-59
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• 2012

A retrospective study was conducted to determine the patterns of Temporomandibular Disorder(TMD) among adolescents (12-19 years) over last ten years. 174 patients who had visited the Oral medicine of Pusan National University Dental Hospital in 2000 and 491 patients in 2008 were found on chart review. The results obtained were as follows : 1. The number of adolescent patients was significantly increased in 2008 than in 2000, especially in male. 2. Bruxing, clenching, holding habits and bad sleep hygiene were highly increased more in 2008 than in 2000. 3. Osteoarthritis was significantly increased in 2008 than in 2000 and anterior disc dislocation without reduction was slightly increased. 4. The ratio of male to female adolescent patients with osteoarthritis was remarkably increased. Among the patients who had holding, bruxing, clenching habits, significantly increased osteoarthritis found to be common. This could imply holding, bruxing, clenching habits are prominently associated with increasing risk of developing osteoarthritis.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.26 no.6
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• pp.628-635
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• 2000

The purpose of this study was to evaluate the result after 2-phase surgical-orthodontic treatment without preoperative orthodontic treatment for the skeletal Cl III malocclusion patient and to obtain an adequate protocol on the bases of this result. This retrospective study of ten patients who underwent 2-phase treatment were done to evaluate 1) the surgical stability and relapse pattern 2) the facial esthetics 3) the TMJ problem 4) the total time of the treatment. Results were followed : 1) The horizontal relapse of the mandible was 26.8% and didn't show significant differences compared to the conventional 3-phase treatment. But, it was considered that this amount of relapse was the sum of true relapse and autoratation of mandible due to decreased vertical dimension during orthodontic treatment. 2) It was estimated that there's no difference on the ratio of anterior facial height between the subjects and the normal patients. On the horizontal analysis, the mandible of the subjects was located more anteriorly than that of the normal patients. This result showed that there was a need for the accurate preoperative esthetic evaluation and the additional methods for reducing the relapse due to the occlusal interference. 3) Wide variation was noted on the TMJ symptoms of the subjects, however, it was estimated that there's no significant differencees of symptoms compared to that of the conventional 3-phase treatment on literatures. 4) The average of the overall period of treatment was 20.8 months and we obtained reduction of the treatment time compaired to 3-phase treatment on many literatures. Most of the results of this study were similar to the findings of the 3-phase treatment(preoperative orthodontic-orthognathic surgery-postoperative orthodontic), but total time of the treatment was shorter in patients with 2-phase treatment than in those with the conventional 3-phase treatment. With 2-phase treatment, we experienced many advantages compared to the conventional method considering that it was favarable conditions for the teeth, it had the flexibility for the treatment, and it could be the adequate treatment approach for the stomatognathic system. Although this retrospective pilot study had some limitations, due to small samples, the authors would hope that it could serve as a guide for the future researches, and the clinical applications.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.2
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• pp.741-746
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• 2015

Purpose: To investigate the influence of exogenous p53 upregulated modulator of apoptosis (PUMA) expression on cell proliferation and apoptosis in human non-small cell lung cancer A549 cells and transplanted tumor cell growth in nude mice. Materials and Methods: A549 cells were divided into the following groups: control, non-carrier (NC), PUMA (transfected with pCEP4-(HA) 2-PUMA plasmid), DDP ($10{\mu}g/mL$ cisplatin treatment) and PUMA+DDP (transfected with pCEP4-(HA)2-PUMA plasmid and $10{\mu}g/mL$ cisplatin treatment). The MTT method was used to detect the cell survival rate. Cell apoptosis rates were measured by flow cytometry, and PUMA, Bax and Bcl-2 protein expression levels were measured by Western blotting. Results: Compared to the control group, the PUMA, DDP and PUMA+DDP groups all had significantly decreased A549 cell proliferation (p<0.01), with the largest reduction in the PUMA+DDP group. Conversely, the apoptosis rates of the three groups were significantly increased (P<0.01), and the PUMA and DDP treatments were synergistic. Moreover, Bax protein levels significantly increased (p<0.01), while Bcl-2 protein levels significantly decreased (p<0.01). Finally, both the volume and the weights of transplanted tumors were significantly reduced (p<0.01), and the inhibition ratio of the PUMA+DDP group was significantly higher than in the single DDP or PUMA groups. Conclusions: Exogenous PUMA effectively inhibited lung cancer A549 cell proliferation and transplanted tumor growth by increasing Bax protein levels and reducing Bcl-2 protein levels.

• The Korean Journal of Malacology
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• v.27 no.3
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• pp.181-190
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• 2011

This study was investigated to find out the change of reproductive and histological biomarkers of Ruditapes philippinarum exposed to nonylphenol (NP). Experimental period was 16 weeks. Experimental groups were composed of one control condition and three NP exposure conditions (0.05, 0.1, $0.2 mg\;NP\;L^{-1}$). Gonad index was higher in exposure group than control in female and higher in control than exposure group in male. Intersexuality in the NP exposure group was 14.56% with male exhibiting higher ratio than female. Histological analysis of organ system illustrated expansion of hemolymph sinus, loss of striated border of inner epidermis and degeneration of mucous cell in the mantle. In the gill partially disappearance of frontal and lateral cilia, degeneration of mucous cell were observed. Also, hyperplasia of epithelium and disappearance of striated border were observed in the foot. As the concentration of NP increased, the accumulation of lipofuscin increased in the digestive gland. The results of this study suggest that NP induces reduction of survival rate, histopathology and intersex of R. philippinarum. Furthermore, it is indentified that NP functions as an estrogenic effector on the reproduction of R. philippinarum.

• Journal of the Earthquake Engineering Society of Korea
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• v.3 no.3
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• pp.9-20
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• 1999

A method is proposed to estimate the joint damages of a steel structure from modal data using the neural networks technique. The beam-to-column connection in a steel frame structure is represented by a zero-length rotational spring of the end of the beam element, and the connection fixity factor is defined based on the rotational stiffness so that the factor may be in the range 0~1.0. Then, the severity of joint damage is defined as the reduction ratio of the connection fixity factor. Several advanced techniques are employed to develop the robust damage identification technique using neural networks. The concept of the substructural indentification is used for the localized damage assessment in the large structure. The noise-injection learning algorithm is used to reduce the effects of the noise in the modal data. The data perturbation scheme is also employed to assess the confidence in the estimated damages based on a few sets of actual measurement data. The feasibility of the proposed method is examined through a numerical simulation study on a 2-bay 10-story structure and an experimental study on a 2-story structure. It has been found that the joint damages can be reasonably estimated even for the case where the measured modal vectors are limited to a localized substructure and the data are severely corrupted with noise.

• Clean Technology
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• v.17 no.2
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• pp.166-174
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• 2011

The xAl-yCe oxide catalysts with different mol ratios of Al/(Al+Ce) were prepared by a co-precipitation method and Pt supported on xAl-yCe oxide catalysts were synthesized by an incipient wetness impregnation method. The catalysts were characterized by X-ray Diffraction (XRD), $N_2$ sorption, and $H_2$/CO-temperature programmed reduction ($H_2$/CO-TPR) to correlate with catalytic activities in co oxidation. Among the catalysts studied here, Pt/1Al-9Ce oxide catalyst showed the highest activity in dry and wet reaction conditions and the catalytic activity showed a typical volcano-shape curve with respect to Al/(Al+Ce) mol ratio. When the presence of 5% water vapor in the feed, the temperature of $T_{50%}$ was shifted ca. $30^{\circ}C$ to lower temperature region than that in dry condition. From CO-TPR, the desorption peak of $CO_2$ on Pt/1Al-9Ce oxide catalyst showed the highest value and well correlated the catalytic performance. It indicates that the Pt/1Al-9Ce oxide catalyst has a large amount of active sites which can be adsorbed by co and easy to supplies the needed oxygen. In addition, the amount of pentacoordinated $Al^{3+}$ sites obtained through $^{27}Al$ NMR analysis is well correlated the catalytic performance.

• Korea-Australia Rheology Journal
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• v.21 no.1
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• pp.59-69
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• 2009

The prediction of pressure drop for a droplet flow in a confined micro channel is presented using FE-FTM (Finite Element - Front Tracking Method). A single droplet is passing through 5:1:5 contraction - straight narrow channel - expansion flow domain. The pressure drop is investigated especially when the droplet flows in the straight narrow channel. We explore the effects of droplet size, capillary number (Ca), viscosity ratio ($\chi$) between droplet and medium, and fluid elasticity represented by the Oldroyd-B constitutive model on the excess pressure drop (${\Delta}p^+$) against single phase flow. The tightly fitted droplets in the narrow channel are mainly considered in the range of $0.001{\leq}Ca{\leq}1$ and $0.01{\leq}{\chi}{\leq}100$. In Newtonian droplet/Newtonian medium, two characteristic features are observed. First, an approximate relation ${\Delta}p^+{\sim}{\chi}$ observed for ${\chi}{\geq}1$. The excess pressure drop necessary for droplet flow is roughly proportional to $\chi$. Second, ${\Delta}p^+$ seems inversely proportional to Ca, which is represented as ${\Delta}p^+{\sim}Ca^m$ with negative m irrespective of $\chi$. In addition, we observe that the film thickness (${\delta}_f$) between droplet interface and channel wall decreases with decreasing Ca, showing ${\delta}_f{\sim}Ca^n$ Can with positive n independent of $\chi$. Consequently, the excess pressure drop (${\Delta}p^+$) is strongly dependent on the film thickness (${\delta}_f$). The droplets larger than the channel width show enhancement of ${\Delta}p^+$, whereas the smaller droplets show no significant change in ${\Delta}p^+$. Also, the droplet deformation in the narrow channel is affected by the flow history of the contraction flow at the entrance region, but rather surprisingly ${\Delta}p^+$ is not affected by this flow history. Instead, ${\Delta}p^+$ is more dependent on ${\delta}_f$ irrespective of the droplet shape. As for the effect of fluid elasticity, an increase in ${\delta}_f$ induced by the normal stress difference in viscoelastic medium results in a drastic reduction of ${\Delta}p^+$.

• Journal of Korean Society of Steel Construction
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• v.30 no.2
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• pp.115-126
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• 2018

Internationally representative steel design standards have forbidden or limited the application of high-strength steels to tubular joints, partly because of concerns about their unique material characteristics such as high yield ratio. Most of design standards stipulate that for steels whose yield strengths exceed 355 or 360 MPa, the strength equations cannot be utilized or strength reduction factor below 1.0 should be multiplied. However, the mechanical background behind these limitations is not clear. Experimental testing of high-strength steel CHS (circular hollow section) X-joints recently conducted by the authors also clearly indicated that the current limitations might be unduly conservative. As a continuing work, extensive, test-validated numerical analyses were made to investigate the behavior of high-strength steel CHS X-joint under axial compression. Three steel grades covering ordinary to very high strength steels were considered in the analysis. Again it was found that the high strength penalty to the joint strength in current standards is too severe and needs to be relaxed. The high-strength steel joints under the effects of chord stress generally showed higher strength than the ordinary steel joints and their strengths were conservatively predicted by current standards. It is also emphasized that current format of the CHS X-joint strength equation does not reflect observed behavior and needs to be recast.

• Korean Journal of Food Science and Technology
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• v.31 no.5
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• pp.1337-1344
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• 1999

Lactic acid bacteria fermented foods were prepared from egg white powder, casein and growth stimulating agent. pH change and growth of Lactbacillus acidophilus(KCTC 2182) during freeze drying were studied. The effects of freeze drying on sensory evaluation. hardness and volatile aroma compounds in freeze dried sample or reconstituted sample were also studied. Freezing and freeze drying did not affect pH of fermented samples. Number of viable cells in original fermented samples was markedly reduced during freezing or freeze drying. When number of viable cells in original fermented sampler was considered at 100%. survival ratio of viable cells after freezing was $72.0{\sim}82.4%$ and that after freeze dying $10.0{\sim}20.4%$. When sensory properties of original fermented samples were compared with those of freeze dried/reconstituted samples, sensory properties of original samples were generally better than those of freeze dried/reconstitute samples. However, the reconstitution property and the acceptability of freeze dried samples were good. Volatile aroma compounds in original fermented samples were reduced during freeze drying. The reduction degree of volatile aroma compounds varied with sample.