• Asian Pacific Journal of Cancer Prevention
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• 제17권10호
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• pp.4719-4722
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• 2016

Background: Glutathione S-transferase M1 (GSTM1) is involved in the detoxification of carcinogenic agents. DNA copy number variants of GSTM1 may be associated with cancer progression and may result in reduced survival time of various cancers. Determination of DNA copy number variants was here used to assess the association between GSTM1 copy number variant and pathological status and survival time of colorectal-cancer patients treated with 5-fluorouracil-based chemotherapy. Methods: One hundred thirteen Thai colorectal-cancer patients were investigated for GSTM1 copy number variant by real-time PCR. Relationships between gene copy number variants and clinico-pathological parameters were determined. Result: Associations were evident between GSTM1 copy number and stage of tumor (P = 0.026) and metastasis at diagnosis (P = 0.049), with odds ratio values of 0.2 and 0.3 respectively. Conclusions: GSTM1 copy number variant was here not related with reduced overall survival for the colorectal-cancer patients receiving 5-FU-based chemotherapy.

• 대한수학회지
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• 제35권4호
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• pp.903-931
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• 1998

Since the modular curves X(N) = $\Gamma$(N)\(equation omitted)＊ (N =1,2,3) have genus 0, we have field isomorphisms K(X(l))(equation omitted)C(J), K(X(2))(equation omitted)(λ) and K(X(3))(equation omitted)( $j_3$) where J, λ are the classical modular functions of level 1 and 2, and $j_3$ can be represented as the quotient of reduced Eisenstein series. When N = 4, we see from the genus formula that the curve X(4) is of genus 0 too. Thus the field K(X(4)) is a rational function field over C. We find such a field generator $j_4$(z) = x(z)/y(z) (x(z) = $\theta$$_3$((equation omitted)), y(z) = $\theta$$_4$((equation omitted)) Jacobi theta functions). We also investigate the structures of the spaces $M_{k}$($\Gamma$(4)), $S_{k}$($\Gamma$(4)), M(equation omitted)((equation omitted)(4)) and S(equation omitted)((equation omitted)(4)) in terms of x(z) and y(z). As its application, we apply the above results to quadratic forms.rms.

• 동아시아식생활학회지
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• 제18권6호
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• pp.1014-1021
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• 2008

The principal objective of this study was to assess the quality characteristics of cookies prepared with oddi powder (0, 1, 3, 5, 7%). The highest dough density value was 1.49, which was also observed in the 7% added group. The pH of the cookie dough was significantly reduced in at all oddi powder groups as compared to the controls. The spread factor of the cookies evidenced an inverse relationship with the concentration of oddi powder as compared to the controls (7.52). Hunter's color L, a, and b values in the cookies were reduced with increases in the level of added oddi powder. Hardness decreased, but chewiness increased, with increasing oddi concentrations as compared to the controls. In the sensory evaluation, the color of the cookies increased in a dose-dependent fashion with increasing concentrations of oddi powder. The taste scores were higher with a 3% addition of oddi powder. The cookies with $3{\sim}5%$ of the flour substituted for oddi powder scored highest on scores in appearance, flavor, taste, texture, and overall acceptability.

• 한국재난정보학회 논문집
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• 제11권4호
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• pp.634-638
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• 2015

해마다 반복적으로 인적 물적 피해를 유발하여 사회 안전에 큰 영향을 미치는 산업재해, 교통사고, 화재, 범죄 등의 항목을 4대 사회안전지표로 선정하여 2003년 이후 시계열에 따른 변화 추이를 분석하였다. 2003년을 기준으로 산업재해가 27.8% 감소하여 가장 두드러지게 개선된 것으로 확인되었으며, 교통사고와 범죄자표는 12% 정도 저감된 것으로 나타났다. 그러나 화재의 경우 2006년 이후 국가화재분류체계가 바뀌면서 경미한 생활 화재도 발생건수에 포함되도록 변경되어 기준년도 대비 40% 화재안전지수가 증가한 것으로 나타났다.

• Clinical and Experimental Reproductive Medicine
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• 제48권2호
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• pp.150-155
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• 2021

Objective: Oxidative stress (OS) plays a key role in the etiology of unexplained male infertility. Coenzyme Q10 (CoQ10) is a potent antioxidant that may improve semen quality and OS in infertile men with idiopathic oligoasthenoteratospermia (OAT), but the underlying mechanism is unknown. Therefore, the present study was undertaken to investigate the effect of CoQ10 on OS markers and sperm DNA damage in infertile patients with idiopathic OAT. Methods: This prospective controlled study included 50 patients with idiopathic OAT and 50 fertile men who served as controls. All patients underwent a comprehensive medical assessment. Patients and controls received 200 mg of oral CoQ10 once daily for 3 months. Semen and blood were collected and analyzed for sperm parameters, seminal CoQ10 levels, reactive oxygen species (ROS) levels, total antioxidant capacity, catalase, sperm DNA fragmentation (SDF), and serum hormonal profile. Results: The administration of CoQ10 to patients with idiopathic OAT significantly improved sperm quality and seminal antioxidant status and significantly reduced total ROS and SDF levels compared to pretreatment values. Conclusion: CoQ10, at a dose of 200 mg/day for 3 months, may be a potential therapy for infertile patients with idiopathic OAT, as it improved sperm parameters and reduced OS and SDF in these patients.

• Korean Journal of Radiology
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• 제21권4호
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• pp.462-470
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• 2020

Objective: To demonstrate that human visual illusion can contribute to sub-endocardial dark rim artifact in contrast-enhanced myocardial perfusion magnetic resonance images. Materials and Methods: Numerical phantoms were generated to simulate the first-passage of contrast agent in the heart, and rendered in conventional gray scale as well as in color scale with reduced luminance variation. Cardiac perfusion images were acquired from two healthy volunteers, and were displayed by the same gray and color scales used in the numerical study. Before and after k-space windowing, the left ventricle (LV)-myocardium boarders were analyzed visually and quantitatively through intensity profiles perpendicular the boarders. Results: k-space windowing yielded monotonically decreasing signal intensity near the LV-myocardium boarder in the phantom images, as confirmed by negative finite difference values near the board ranging -1.07 to -0.14. However, the dark band still appears, which is perceived by visual illusion. Dark rim is perceived in the in-vivo images after k-space windowing that removed the quantitative signal dip, suggesting that the perceived dark rim is a visual illusion. The perceived dark rim is stronger at peak LV enhancement than the peak myocardial enhancement, due to the larger intensity difference between LV and myocardium. In both numerical phantom and in-vivo images, the illusory dark band is not visible in the color map due to reduced luminance variation. Conclusion: Visual illusion is another potential cause of dark rim artifact in contrast-enhanced myocardial perfusion MRI as demonstrated by illusory rim perceived in the absence of quantitative intensity undershoot.

• Carbon letters
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• 제15권3호
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• pp.171-179
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• 2014

An attempt was made to investigate the effect of the preparation temperature on the electrocapacitive performance of polypyrrole (PPY)/graphene oxide (GO) nanocomposites (PNCs). For this purpose, a series of PNCs were prepared at various temperatures by the cetyltrimethylammonium bromide-assisted dilute-solution polymerization of pyrrole in presence of GO (wt%) ranging from 1.0 to 4.0 with ferric chloride as an oxidant. The formation of the PNCs was ascertained through Fourier-transform infrared spectrometry, X-ray diffraction spectra, scanning electron microscopy and simultaneous thermogravimetric-differential scanning calorimetry. The electrocapacitive performance of the electrodes derived from sulphonated polysulphone-bound PNCs was evaluated through cyclic voltammetry with reference to Ag/AgCl at a scan rate (V/s) ranging from 0.2 and 0.001 in potassium hydroxide (1.0 M). The incorporation of GO into the PPY matrix at a reduced temperature has a pronounced effect on the electrocapacitive performance of PNCs. Under identical scan rates (0.001 V/s), PNCs prepared at $10{\pm}1^{\circ}C$ render improved specific conductivity (526.33 F/g) and power density (731.19 W/Kg) values compared to those prepared at $30{\pm}1^{\circ}C$ (217.69 F/g, 279.43 W/Kg). PNCs prepared at $10{\pm}1^{\circ}C$ rendered a capacitive retention rate of ~96% during the first 500 cycles. This indicates the excellent cyclic stability of the PNCs prepared at reduced temperatures for supercapacitor applications.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.2393-2398
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• 2003

In this paper, we proposes a new fuzzy inference system for modeling nonlinear systems given input and output data. In the suggested fuzzy inference system, the number of fuzzy rules and parameter values of membership functions are automatically decided by using the kernel-based method. The kernel-based method individually performs linear transformation and kernel mapping. Linear transformation projects input space into linearly transformed input space. Kernel mapping projects linearly transformed input space into high dimensional feature space. The structure of the proposed fuzzy inference system is equal to a Takagi-Sugeno fuzzy model whose input variables are weighted linear combinations of input variables. In addition, the number of fuzzy rules can be reduced under the condition of optimizing a given criterion by adjusting linear transformation matrix and parameter values of kernel functions using the gradient descent method. Once a structure is selected, coefficients in consequent part are determined by the least square method. Simulated result illustrates the effectiveness of the proposed technique.

• Journal of Mechanical Science and Technology
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• 제17권10호
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• pp.1520-1532
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• 2003

An experiment was performed to obtain the local heat transfer coefficient and Nusselt number in a circular duct with a 180$^{\circ}$ bend for Re=6 x 10$^4$, 8 x 10$^4$ and 1 x 10$\^$5/ under swirling flow and non-swirling flow conditions. The test tube with a circular section was made from stainless steel having a curvature ration of 9.4. Current heat flux of 5.11 kW/㎡ was applied to the test tube by electrical power and the swirling motion of air was produced by a tangential inlet to the pipe axis at 180$^{\circ}$. Measurements of local wall temperatures and the bulk mean temperatures of air were made at four circumferential positions at 16 stations. The wall temperatures showed a reduced distribution curve at the bend for the non-swirling flow, but this effect did not appear for the swirling flow. The Nusselt number distributions for the swirling flow, which was calculated from the measured wall and the bulk temperatures, were higher than that of the non-swirling flow. The average Nusselt number of the swirling flow increased by about 90-100%, compared to that of the non-swirling flow. The Nu/Nu$\_$DB/ values at the 90$^{\circ}$ station for non-swirling flow and swirling flow were approximately 2.5 and 4.8 at Re=6x10$^4$ respectively. The values agree well with Said's results for non-swirling flow.

• Journal of Microbiology and Biotechnology
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• 제13권1호
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• pp.134-138
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• 2003

The secondary and tertiary structures of ${\beta}$-galactosidase from L. lactis ssp. lactis 7962 were designed using Nnpredict and Sybyl version 6.3. By using site-directed mutagenesis, the mutated enzymes, Tyr-475-phe and Glu-506-Asp, were generated based on the structural modeling of L. lactis ssp. lactis 7962. The enzymes Tyr.-475-Phe and Glu-506-Asp had <$1\%$ of the activity of the native enzyme with ONPG as substrate. The $V_{max}$ values of the mutated enzymes were greatly reduced (1,800~40,000-1314) compared with the value for the native ${\beta}$-galactosidase. However, the $K_m$ values of Tyr-475-Phe and Glu-506-Asp with ONPG, PNPG, PNPF, and PNPA were not significantly different from those of the native enzyme. The results obtained support the suggestion that Tyr-475 and Glu-506 constitute very important parts of the catalytic machinery of the ${\beta}$-galactosidase.