• The Journal of Internal Korean Medicine
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• v.33 no.2
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• pp.231-242
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• 2012

Objectives : This study was designed to investigate the Efficacy of Gamiyukmijihwang-tang on Recurrent Aphthous Stomatitis. Methods : We surveyed 10 recurrent aphthous stomatitis patients visited the oral diseases clinic in the Kyung Hee University Oriental Medicine Hospital from September, 2011 to March, 2012. Before and 2 weeks after taking Gamiyukmijihwang-tang, the subjects were evaluated on clinical characteristics of recurrent aphthous stomatitis, severity of pain using visual analogue scale (VAS), quality of life about oral health (based on the 14-item Oral Health Impact Profile-14) and yin-deficiency condition (based on the 10-item Yin-deficiency Questionnaire). Then, 5 patients who had already finished treatment were assessed about recurrence of recurrent aphthous stomatitis by telephone survey 6 weeks later. Results : After 2 weeks taking Gamiyukmijihwang-tang, clinical characteristics of 10 patients of recurrent aphthous stomatitis improved; their severity of pain, quality of life about oral health and yin-deficiency condition improved significantly. After 6 weeks, 3 of 5 patients who had already finished treatment didn't experience recurrence of recurrent aphthous stomatitis. The other 2 patients experienced a recurrence, but their clinical characteristics of recurrent aphthous stomatitis improved significantly. Conclusions : Gamiyukmijihwang-tang is effective on recurrent aphthous stomatitis. Studies with a larger number of cases and longer follow-up will be needed in the future.

• Journal of Oral Medicine and Pain
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• v.33 no.2
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• pp.187-194
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• 2008

Recurrent aphthous stomatitis is common oral disease in the world. It is characterized by multiple, recurrent, painful ulcer with circumscribed margins, erythematous haloes and yellow or grey floors. Patients with recurrent aphthous stomatitis suffer from its painful ulcer. But unfortunately, its etiology and pathogenesis is not clear and still unknown. So we review etiology and pathogenesis of recurrent aphthous ulcer and wish to propose direction of the future study.

• Korean Journal of Bronchoesophagology
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• v.2 no.2
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• pp.227-231
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• 1996

Recurrent aphthous stomatitis is one of the most common diseases of ulcerative oral mucosal lesions and its cause remains elusive. The purpose of this study is to evaluate the therapeutic effect of topical steroids for the treatment of recurrent aphthous stomatitis. We performed the study with 50 cases who had visited to our office for the treatment of recurrent aphthous stomatitis during the recent five years. We devided 50 cases into five groups. Group 1 is that triamcinolone of 0.1-0.2mg was injected into the submucosal lesions of ulcerations. Group 2 is that the gargling of 5ml with triamcinolone tablet of 2mg was used three times per day for seven days. Group 3 is that the gargling of 5ml with betamethasone tablet 0.5mg was used three times per day for seven days. Group 4 is that tetracycline gargling was used six times per day for seven days. Group 5 is that normal saline gargling was used six times per day for seven days. The retrospective analysis of results were as follows : Betamethasone gargling was effective in the treatment of minor aphthous stomatitis and the submucosal injection of triamcinolone was effective in the treatment of major aphthous stomatitis, but none of the different therapeutic methods was effective for herpetiform stomatitis. In the evaluation of mean recurrence periods, the triamcinolone gargling and betamethasone gargling showed longer asymptomatic periods than other methods. We concluded that some kinds of topical steroids can be used for the treatment of recurrent aphthous stomatitis but the proper selection of agents according to the type of the disease is important for the treatment.

• The Journal of Korean Medicine
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• v.33 no.2
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• pp.73-77
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• 2012

Objectives: This report reports a clinical case of a patient with recurrent aphthous stomatitis (RAS) for 10 years who was completely cured using Korean medicine. Methods: A male patient with terribly severe RAS was hospitalized, and then treated with Jibaekpalmi-hwon, indirect moxibustion (KI 1 and CV 4) and acupuncture. The clinical outcome was observed by self-reported VAS measurement and macroscopy. Results: The severity of stomatitis became improved gradually and completely recovered during 17 hospital days, and RAS has not recurred for three months as an outpatient. The blood test including complement activity was in the normal range. Conclusions: This case report provides information about a therapeutic effect of Jibaekpalmi-hwon and Korean medicine on RAS.

• Journal of Sasang Constitutional Medicine
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• v.32 no.2
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• pp.80-95
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• 2020

Introduction This study is the first case report to observe a significant improvement of clinical symptoms of both Recurrent Aphthous Stomatitis(RAS) and pompholyx treating with modified Palmulgunja-tang for Soeum-type. Case presentation A 37-year-old female patient complained of pain by ulcers on her mouth and tongue, and of itching caused by vesicles on her palms and soles was diagnosed with RAS, pompholyx, and, especially moderate pattern of 'Congestive Hyperpsychotic symptomatology' according to the theory of Sasang Constitutional Medicine(SCM). During inpatient and outpatient treatment, she took modified Palmulgunja-tang, and was treated with acupuncture, moxibustion, and cupping therapy. The effectiveness of these therapies was assessed with subjective Neumeral Rating Scale(NRS) and Dyshidotic Eczema Area and Severity Index(DASI). Conclusion After the treatment according to the theory of SCM, NRS, and DASI score about RAS and pompoholyx was decreased, and the general condition of the patient also has improved.

• International Journal of Oral Biology
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• v.42 no.3
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• pp.123-128
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• 2017

Recurrent aphthous stomatitis (RAS) is a common oral mucosal disorder for which no curative treatment is available. We previously reported that decreased Streptococcus salivarius and increased Acinetobacter johnsonii on the oral mucosa are associated with RAS risk. The purpose of this study was to identify antibiotics that selectively inhibit A. johnsonii but minimally inhibit oral mucosal commensals. S. salivarius KCTC 5512, S. salivarius KCTC 3960, A. johnsonii KCTC 12405, Rothia mucilaginosa KCTC 19862, and Veillonella dispar KCOM 1864 were subjected to antibiotic susceptibility test using amoxicillin, cefotaxime, gentamicin, clindamycin, and metronidazole in liquid culture. The minimal inhibitory concentration (MIC) was defined as the concentration that inhibits 90% of growth. Only gentamicin presented a higher MIC for A. johnsonii than MICs for S. salivarius and several oral mucosal commensals. Interestingly, the growth of S. salivarius increased 10~200% in the presence of sub-MIC concentrations of gentamicin, which was independent of development of resistance to gentamicin. In conclusion, gentamicin may be useful to restore RAS-associated imbalance in oral microbiota by selectively inhibiting the growth of A. johnsonii but enhancing the growth of S. salivarius.

• The Journal of Internal Korean Medicine
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• v.24 no.4_2
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• pp.967-974
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• 2003

Recurrent Aphthous Stomatitis(RAS) is inflammatory ulcerative condition of the oral mucosa. The lesions of RAS are self-limited and persist for 1 to 2 weeks, resolved with or without scarring and recurred after periods of remission. It is known that nicotine may protect oral mucosa from aphthous ulcers by keratinization of the oral mucosa. After quitting smoking, a stroke patient who suffered from RAS, used to relapse into RAS unless he didn't gargle with nicotine extract water. We diagnosed his case as heat in the stomach and treated with Chungwie-San(Qingwei-San). After medication with Chungwie-San, RAS was subsided and he stopped smoking during admission period.

• RED RIBBON
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• s.66
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• pp.16-17
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• 2005

에이즈 환자에게서 흔히 나타나는 구강 내 병변은 충치, 구강칸디다증, 구강 모상 백반증(oral hairy leukoplakia),재발성 아프타성 구내염(recurrent aphthous stomatitis),재발성 포진성 구내염(recurrent herpetic stomatitis),치주염, 카포시 육종, 비호치킨성 림프종 등이다. 이 중 에이즈 환자에게 비교적 특징적인 병변은 구강 칸디다증, 입안털백색판증, 카포시 육종 등이지만 일반인들에서 흔히 관찰되는 충치라고 하더라도 치주염이나 농양으로 빠르게 진행한다면 에이즈를 의심해 보아야 하며, 반복적인 아프타성 궤양이나 포진성 궤양이 유달리 크고 오래 지속된다면 역시 에이즈의 가능성을 생각해 봐야 한다. 구강 병소는 에이즈 환자에게서 흔히 발견되며 이 질환의 초기 상태를 제시할 수 있다는데 의의가 있다.

• The Journal of the Korean dental association
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• v.21 no.6 s.169
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• pp.449-452
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• 1983

구강내에서 발생하는 연조직 질환중 궤양을 수반하여 환자로 하여금 통증을 호소하게 하는 질환으로는 급성 괴사성 궤양성 치간염 (Acute Necrotizing Ulcerative Gingivitis), 급성 수포성 구내염(Acute Herpetic Gingivo Stomatitis), 재발성 구순포진(Recurrent Herpes Labialis), 재발성 아프타성 구내염(Recurrent Aphthous Stomatitis), 대상성 포진(Herpes Zoster) 등이 있으며, 다른 질환보다도 그 발생빈도가 높아 임상에서 접하게 되며 그 치유속도가 늦어 가끔 당혹감을 느끼는 수가 있다. 이들 질환의 임상적 소견과 그 질환에 대한 치료법의 예를 간략하게 생각해 보고져 한다.

• The Journal of Internal Korean Medicine
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• v.38 no.5
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• pp.812-819
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• 2017

Objectives: The purpose of this study was to report the long-term efficacy of herbal medicine for treatment of patients with recurrent aphthous stomatitis (RAS). Methods: We reviewed the clinical records of 17 patients with RAS who visited the Oral Diseases Clinic of Kyung Hee University Korean Medicine Hospital from September 1st, 2014 to August 29th, 2017. The patients were treated with herbal medicine for more than 3 consecutive weeks, followed by a telephone survey. We evaluated the clinical characteristics of RAS, and compared the short-term and long-term efficacy of herbal medicine treatment. Results: After treatment with herbal medicine, the clinical characteristics improved in the 17 patients with RAS, especially in terms of the duration and interval of recurrence. Prolonged effects were reported upon the follow-up telephone survey. Conclusion: Herbal medicine treatment may have a long-term effect in patients with RAS.