• Title/Summary/Keyword: recurrent

Search Result 3,538, Processing Time 0.031 seconds

Platelet-rich plasma treatment in patients with refractory thin endometrium and recurrent implantation failure: A comprehensive review

  • Kim, Min Kyoung;Song, Haengseok;Lyu, Sang Woo;Lee, Woo Sik
    • Clinical and Experimental Reproductive Medicine
    • /
    • v.49 no.3
    • /
    • pp.168-174
    • /
    • 2022
  • Refractory thin endometrium and recurrent implantation failure are among the most challenging infertility-related factors hindering successful pregnancy. Several adjuvant therapies have been investigated to increase endometrial thickness and the pregnancy rate, but the treatment effect is still minimal, and for many patients, these treatment methods can be quite costly and difficult to approach. Platelet-rich plasma (PRP) is an autologous concentration of platelets in plasma and has recently been elucidated as a better treatment option for these patients. PRP is rich in cytokines and growth factors, which are suggested to exert a regenerative effect at the level of the injured tissue. Another advantage of PRP is that it is easily obtained from the patient's own blood. We aimed to review the recent findings of PRP therapy used for patients with refractory thin endometrium and recurrent implantation failure.

Forecasting realized volatility using data normalization and recurrent neural network

  • Yoonjoo Lee;Dong Wan Shin;Ji Eun Choi
    • Communications for Statistical Applications and Methods
    • /
    • v.31 no.1
    • /
    • pp.105-127
    • /
    • 2024
  • We propose recurrent neural network (RNN) methods for forecasting realized volatility (RV). The data are RVs of ten major stock price indices, four from the US, and six from the EU. Forecasts are made for relative ratio of adjacent RVs instead of the RV itself in order to avoid the out-of-scale issue. Forecasts of RV ratios distribution are first constructed from which those of RVs are computed which are shown to be better than forecasts constructed directly from RV. The apparent asymmetry of RV ratio is addressed by the Piecewise Min-max (PM) normalization. The serial dependence of the ratio data renders us to consider two architectures, long short-term memory (LSTM) and gated recurrent unit (GRU). The hyperparameters of LSTM and GRU are tuned by the nested cross validation. The RNN forecast with the PM normalization and ratio transformation is shown to outperform other forecasts by other RNN models and by benchmarking models of the AR model, the support vector machine (SVM), the deep neural network (DNN), and the convolutional neural network (CNN).

Minimally Invasive Distal Transverse Metatarsal Osteotomy - Akin Osteotomy (MITA) for Recurrent Hallux Valgus: A Report of Four Cases (최소 침습적 원위 중족골 횡절골술 및 Akin 절골술을 통한 재발한 무지외반증 교정 수술(MITA): 4예 보고)

  • Taebyeong Kang;Dongoh Lee;Tae Wook Yoo;Sang Gyo Seo
    • Journal of Korean Foot and Ankle Society
    • /
    • v.28 no.3
    • /
    • pp.114-118
    • /
    • 2024
  • Recurrent deformity following hallux valgus surgery can be technically challenging to treat. In cases of revision surgery, a surgical technique with greater corrective power is often chosen compared to the primary surgery. Therefore, minimally invasive surgery is not commonly performed. On the other hand, minimally invasive surgery minimizes soft tissue damage and allows for greater correction of deformity compared to traditional open approaches. This paper reports four cases of recurrent hallux valgus treated with a minimally invasive distal transverse metatarsal osteotomy - Akin osteotomy (MITA), resulting in significant improvements in the clinical and radiographic outcomes.

Retreatment of a recurrent giant aneurysm of the internal carotid artery after treatment with a flow-diverting stent

  • Ginam Kim;Junhyung Kim;Sang Kyu Park;Joonho Chung
    • Journal of Cerebrovascular and Endovascular Neurosurgery
    • /
    • v.25 no.2
    • /
    • pp.208-213
    • /
    • 2023
  • Flow-diverting stents (FDSs) have proven advantageous for the treatment of large, fusiform, and dissecting aneurysms that are otherwise difficult to treat. Retreatment strategies for recurrent large or giant aneurysms after FDSs are limited to overlapping implantation of an additional FDS or definitive occlusion of the parent vessel. We report a recurrent giant aneurysm that was initially treated with an FDS with coils and was successfully treated with an additional FDS. Visual symptoms due to the mass effect of the recurrent aneurysm were completely resolved, and follow-up digital subtraction angiography revealed complete obliteration of the aneurysm. Additional FDS implantation for the retreatment of incompletely occluded aneurysms after the initial FDS treatment may be feasible and safe. Further studies are required to validate these results.

Recurrent Discrete Flows on Totally Disconnected Spaces

  • Hong, Seung-Heui;Koo, Ki-Shik
    • Journal of the Chungcheong Mathematical Society
    • /
    • v.1 no.1
    • /
    • pp.65-69
    • /
    • 1988
  • In this paper dynamical properties of recurrent discrete flows are stated. The pointwise periodic discrete flows on totally disconnected spaces are of characteristic 0.

  • PDF

The Analysis of Methylenetetrahydrofolate Reductase Mutation in Recurrent Spontaneous Abortion (반복자연유산에서 Methylenetetrahydrofolate Reductase 돌연변이에 대한 분석)

  • Nam, Yoon-Sung;Cha, Kwang-Yul;Kim, Nam-Keun;Kim, Sun-Hee;Lim, Jin-Woo;Kang, Geum-Duk;Kang, Myung-Seo;Kim, Se-Hyun;Oh, Do-Yeun
    • Clinical and Experimental Reproductive Medicine
    • /
    • v.28 no.3
    • /
    • pp.247-253
    • /
    • 2001
  • Objective: To analyze the methylenetetrahydrofolate reductase (MTHFR) mutation in patients with recurrent spontaneous abortion. Material and Method: The blood samples of patients with recurrent spontaneous abortion were tested by PCR-RFLP method. Results: Of 51 cases of study group, 14 (27.5%) were normal, 25 (49.0%) were heterozygosity, and 12 (23.5%) were homozygosity. Of 58 cases of control group, 20 (34.5%) were normal, 30 (51.7%) were heterozygosity, and 8 (13.8%) were homozygosity. But the difference between two groups was not significant (p=0.190). Conclusion: Hyperhomocysteinemia due to MTHFR mutation is a cause of recurrent spontaneous abortion. Therefore, the study for MTHFR mutation should be included in the workup of recurrent spontaneous abortion.

  • PDF