Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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The Analysis of Methylenetetrahydrofolate Reductase Mutation in Recurrent Spontaneous Abortion

반복자연유산에서 Methylenetetrahydrofolate Reductase 돌연변이에 대한 분석

  • Nam, Yoon-Sung (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University) ;
  • Cha, Kwang-Yul (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University) ;
  • Kim, Nam-Keun (Institute for Clinical Research, College of Medicine, Pocheon CHA University) ;
  • Kim, Sun-Hee (Institute for Clinical Research, College of Medicine, Pocheon CHA University) ;
  • Lim, Jin-Woo (Institute for Clinical Research, College of Medicine, Pocheon CHA University) ;
  • Kang, Geum-Duk (Department of Biological Science, Ajou University) ;
  • Kang, Myung-Seo (Institute for Clinical Research, College of Medicine, Pocheon CHA University) ;
  • Kim, Se-Hyun (Institute for Clinical Research, College of Medicine, Pocheon CHA University) ;
  • Oh, Do-Yeun (Institute for Clinical Research, College of Medicine, Pocheon CHA University)
  • 남윤성 (포천중문의과대학 산부인과학교실) ;
  • 차광렬 (포천중문의과대학 산부인과학교실) ;
  • 김남근 (포천중문의과대학 임상의학연구소) ;
  • 김선희 (포천중문의과대학 임상의학연구소) ;
  • 임진우 (포천중문의과대학 임상의학연구소) ;
  • 강금덕 (아주대학교 생명과학부) ;
  • 강명서 (포천중문의과대학 임상의학연구소) ;
  • 김세현 (포천중문의과대학 임상의학연구소) ;
  • 오도연 (포천중문의과대학 임상의학연구소)
  • Published : 2001.09.30
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Abstract

Objective: To analyze the methylenetetrahydrofolate reductase (MTHFR) mutation in patients with recurrent spontaneous abortion. Material and Method: The blood samples of patients with recurrent spontaneous abortion were tested by PCR-RFLP method. Results: Of 51 cases of study group, 14 (27.5%) were normal, 25 (49.0%) were heterozygosity, and 12 (23.5%) were homozygosity. Of 58 cases of control group, 20 (34.5%) were normal, 30 (51.7%) were heterozygosity, and 8 (13.8%) were homozygosity. But the difference between two groups was not significant (p=0.190). Conclusion: Hyperhomocysteinemia due to MTHFR mutation is a cause of recurrent spontaneous abortion. Therefore, the study for MTHFR mutation should be included in the workup of recurrent spontaneous abortion.

Keywords