• Biomolecules & Therapeutics
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• v.31 no.1
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• pp.40-47
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• 2023

Activation of the NLRP3 inflammasome is a necessary process to induce fibrosis in nonalcoholic fatty liver disease (NAFLD). Nonalcoholic steatohepatitis (NASH) is a kind of NAFLD that encompasses the spectrum of liver disease. It is characterized by inflammation and ballooning of hepatocytes during steatosis. We tested whether inhibiting the NLRP3 inflammasome could prevent the development and pathology of NASH. We identified loganin as an inhibitor of the NLRP3 inflammasome and investigated whether in vivo administration of loganin prevented NASH symptoms using a methionine-choline deficient (MCD) diet model in mice. We found that loganin inhibited the NLRP3 inflammasome activation triggered by ATP or nigericin, as shown by suppression of the production of interleukin (IL)-1β and caspase-1 (p10) in mouse primary macrophages. The speck formation of apoptosisassociated speck-like protein containing a caspase recruitment domain (ASC) was blocked by loganin, showing that the assembly of the NLRP3 inflammasome complex was impaired by loganin. Administration of loganin reduced the clinical signs of NASH in mice fed the MCD diet, including hepatic inflammation, fat accumulation, and fibrosis. In addition, loganin reduced the expression of NLRP3 inflammasome components in the liver. Our findings indicate that loganin alleviates the inflammatory symptoms associated with NASH, presumably by inhibiting NLRP3 inflammasome activation. In summary, these findings imply that loganin may be a novel nutritional and therapeutic treatment for NASH-related inflammation.

• 한국정보교육학회:학술대회논문집
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• 2021.08a
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• pp.425-431
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• 2021

In this study, in order to develop a manual for the AI convergence education competency strengthening project, project personnel were interviewed and an overall analysis of the business process was made. As a result of analysis, the manual includes methods to solve problems currently being raised in the field such as recruitment of graduate students, education program management, academic registration management, and budget management. In order to increase the continuity and efficiency of the project, it is necessary to build an administrative management site that provides information on the overall project, to strengthen publicity for general teachers about AI convergence education, and meet the educational needs and level of enrolled students.

• International Journal of Stem Cells
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• v.16 no.2
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• pp.202-214
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• 2023

Background and Objectives: To investigate the role of exosomes from periodontal ligament cells (PDLCs) in bone marrow mesenchymal stem cell (BMSC) migration. Methods and Results: Human PDLCs were applied cyclic tension stretching. Exosomes were extracted from cultured PDLCs by ultracentrifugation, then characterized for their size, morphology and protein markers by NTA, TEM and western blotting. The process that PKH26-labeled exosomes taken up by BMSCs was assessed by confocal microscope. BMSC migration was examined by Transwell assay. Exosomes derived from PDLCs were identified. Cyclic tension stretch application on PDLCs can enhance the migration ability of BMSCs through exosomes. The exosomal miRNA expression profiles of unstretched and stretched PDLCs were tested by miRNA microarray. Four miRNAs (miR-4633-5p, miR-30c-5p, miR-371a-3p and let-7b-3p) were upregulated and six (miR-4689, miR-8485, miR-4655-3p, miR-4672, miR-3180-5p and miR-4476) were downregulated in the exosomes after stretching. Sixteen hub proteins were found in the miRNA-mRNA network. Gene Ontology and KEGG pathway analyses demonstrated that the target genes of differentially expressed exosomal miRNAs closely related to the PI3K pathway and vesicle transmission. Conclusions: The exosomes derived from cyclic tension-stretched PDLCs can promote the migration of BMSCs. Alternation of microRNA profiles provides a basis for further research on the regulatory function of the exosomal miRNAs of PDLCs during orthodontic tooth movement.

• Journal of The Korean Association For Science Education
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• v.28 no.5
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• pp.395-408
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• 2008

The purpose of this study was to analyze Korean Women's U.S. Ph.D. Degree-seeking Process and career development in the field of science and engineering in the United States. We conducted the analysis on the basis of SED (Survey of Earned Doctorates) data of the National Science Foundation. Since 2001, the number of Korean Ph.D. degree recipients from United States universities has been increasing and about 25% of them were women. Their median age was 33.3 years old, and one third of them were the recipients of research and teaching assistantships while pursuing a Ph.D. degree. At the time of receiving the degree, 51.8% reported having definite commitments for employment or postdoctoral study or research. Over 70% of the degree holders were presumed to stay and work in the United States. The study finally addressed policy implications regarding their recruitment to Korea and a need for a longitudinal survey.

• Korean journal of communication and information
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• v.17
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• pp.61-84
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• 2001

Discussions and debates over media education abound in Korra as the number of both institutions that provide media related education and students enrollment for these programs increases rapidly in recent years. In spite of this rather impressive expansion, however, many have raised serious questions about media education of Korea for its not being able to meet the need of the Industry and students, and, moreover, inability to face the challenges brought by new communication related technologies. Who teaches What for what purposes are some of the fundamental questions underlying these heated debates and discussions. To understand these rather complex and interrelated issues more clearly, it is attempted to delineate the nature of these debates by exploring the evolutionary process of media education. The issues related to debates over purposes of media education, curriculum, and faculty qualification have changed through the history of media education, but the nature of the debates, that is the struggle between professionalism and academism, or the tension between practice and theory, has not. Upon this understanding, some argue that what distinguishes opposing sets of dichotomies, such as skills vs. knowledge, training vs. education, now-how vs. know-why. professional vs. academic, practice vs. theory, is more a reflection of social class division and group interests which have privileged theory over practice than a rational scholastic distinction. In addition, it has been often pointed out that the media studies have failed to establish ties with specific industries, and furthermore academic studies seriously lack solid theoretical and practical bases. In the case of the United States, leaders of the industry had contributed much for the Initiation of journalism education in a college setting. However, once inaugurated,, the process of its evolution has depended heavily on academicians. In a country like Korea, where academic and theoretical orientation is much stronger, these problems of media studies and education are even more acute. In this study, it is suggested that academicians and educators be more open-hearted to the realities of changing world, practices of the industries, and recruitment of professionals and practitioners to fill the gap between practice and theory, for the sake of the future of media studies and education.

• Journal of the Korean Society of Clothing and Textiles
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• v.32 no.12
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• pp.1857-1865
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• 2008

The purpose of this study was to examine the importance of personal attributes as they related to developing first impressions and managing group acceptance in the context of sorority recruitment process. Specifically, we examined how certain personal characteristics of a sorority member were related to her use of a potential member's clothing and appearance as non-verbal cues during the member selection process. The characteristics identified through the literature review were materialism, fashion clothing involvement, and proximity of clothing to self. A questionnaire was distributed to members of two sorority houses at a southeastern university in the United States. A total of 140 US sorority members participated in the study. The results showed that a member's satisfaction with her chapter, her level of participation, and her length of membership in the chapter had no relation with her tendency to base her member selection on clothing and appearance. However, members' use of clothing and appearance as guiding their member selection decisions was related to other individual characteristics selected for the study(materialism, fashion clothing involvement, and proximity of clothing to self). Fashion clothing involvement and proximity of clothing to self(clothing for acceptance) were most significantly related to clothing-based member selection. Partial correlations were also produced to examine the mediating role of clothing-based impression formation.

• Journal of Information Technology Services
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• v.13 no.2
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• pp.219-250
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• 2014

Corporations look for their competitiveness in many different areas, and one of them is customer call center, which provides professional, special service to the customers. The importance and the value of realization of customer satisfaction at each call center have become significant as it plays a leading role and is responsible for customer recreation and follow-up services. This study held in-depth interviews with 3 groups of professional call representatives (categorized by experience) from popular property and life insurance companies in Korea who operate in and outbound calls. Three variables, emotional quotient, organizational citizenship behavior (OCB), and IT utilization skill, were selected and it was observed how these variables affect the job performance of in and outbound call center representatives. The importance of the relationship between the variables and the key factors in the future direction of improvement of the call center representative organization was analyzed. Emotional quotient refers to the ability to recognize and use the emotion of oneself and others. It was considered it would be effective in enhancing the counseling ability of call center representatives, This study identifies the effect of emotional quotient on job performance and organizational citizenship behavior, which is defined as actions outside of normative roles in the organization. Also, the study aims to prove the effect of emotional quotient on the rapidly developing IT utilization ability in relation to job performance. As a result, it was found that service career (3 months, 3 years, 10 years) had a significant effect on the key factors that affect the organization-emotional quotient, IT utilization skill, and OCB. Especially for OCB, it was considered relatively less important to the new employees, while it greatly affected the job performance, rate of settlement, and sustainment of the working life for those with longer experience. Also, the result of the interview for each variable differed by the service career. Emotional quotient, IT utilization skill, and OCB were close connection for the representatives with longer experience than for those with shorter experience. And the level of intimacy of their relationship with job performance was in proportion to the years of service. Thus, to secure stability for the call center representatives and enhance their job performance continually, the importance of emotional quotient and IT utilization skill shall be reflected in the operation process actively. In particular, in order to lead a organization with outstanding culture, a management system shall apply OCB from the recruitment process.

• Management & Information Systems Review
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• v.34 no.2
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• pp.97-111
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• 2015

A preliminary study on the existing attraction effect and compromise effect was started on the experiment studies about product or service and conducted on the empirical studies on things, research trips, staff recruitment process in the research and the actual US presidential election. However most studies have been limited in the theories of the frequency range and no research about combining compromise effect and attraction effect with the types of promotion. The purpose of this study verifies that how attraction effect and compromise effect in the choice option of the choice process for brand varies according to the types of promotion. This study compares the difference of choice of brand between the influence of the attraction effect and compromise effect. The independent variables among the manipulated variables are as follows : (1) Brand choice (attraction effect and compromise effect), (2) Promotion Type (price promotion/non-price promotion). This study was manipulated in between-subjects design and within-subjects design. The results of this study will be able to see the implications for the positioning strategy of offering several new products such as practical dimensions of promotion strategy because the entry of new brands rather increases market share of similar existing brands.

• Korean Journal of Comparative Education
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• v.27 no.1
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• pp.29-49
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• 2017

The purpose of this study is to analyze the characteristics and implications of the quality management policy through teachers' entire life in Japan case study. This article composed of four chapters; Implication and problem situation, Backgrounds and streams of the japanese teacher reform policy, Characteristics of the main policies about managing the teacher's quality through their life, and Conclusion(Japanese characteristics and the suggestion for Korea). The main quality management policy means the various teacher recruitment and selection system, Merit system of personnel management, Effective management of a system for teachers performing unsatisfactorily, Professional development for teachers with new and 10 years' experience, and Teacher Certificate Renewal System every ten years. The method of study composed of the literature search and interview. The System Analysis[input-process-output-feedback] is used as a model of the analyze the policy process[backgrounds & T.O-quality management system-japanese teacher's reaction & implications to korea] The Central Council for Education(CCE;2012.8.28) has released "An Outline of Measures for Comprehensively Improving the Quality and Ability of Teachers throughout their career". This report can be regarded as a blueprint for the teacher reform policy in japan. As a conclusion, Ten lessons is proposed for the Korea policy improving the quality and ability of teachers(training, employment, and development).

• Korean Journal of Comparative Education
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• v.28 no.3
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• pp.103-133
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• 2018

The modern world stands on the cusp of massive change in connection with the 4th industrial revolution. Following developed countries, developing countries also try to grow and keep up with the flow. Among them, trough the international cooperation government of Kazakhstan decided to include the International Baccalaureate Diploma Programme(IBDP) into the Nazarbayev Intellectual School(NIS) in April 2013. The goal of this study is to analyze the efficiency of introduction and implementation of the IBDP in the NIS and to consider the possibility of implementing this program in regular schools. To achieve the research goal, was applied the CIPP evaluation model(context - input - process - product) to assess IBDP program systematically. The analysis of empirical data collected due to the results of the international school system implementation, also in this study were used the results of questionnaires and interviews with the students and teachers who took part in the IBDP educational program. The results of the analysis showed that the average satisfaction of teachers and students who participated in IBDP was 3.64 points, however they pointed out the problems with management and organizations of the program, the establishment of a variety of subjects, recruitment of IBDP teachers etc. These measures would help to raise the status of school to the internationalization.