• Mass Spectrometry Letters
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• 제13권4호
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• pp.146-151
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• 2022

Rotigotine (RTG) is a non-ergot dopamine agonist used to manage the early stage of Parkinson's disease (PD) as transdermal patch. However, the poor medication compliance of PD patients and skin issues related with repeated applications of RTG patches lead to the search for alternative formulations and it also requires appropriate analytical methods for their in vivo evaluation. Thus, here, a sensitive, efficient, and cost-effective method to determine RTG in rat plasma using liquid-liquid extraction (LLE) and multiple reaction monitoring was developed. The use of 20 µL of rat plasma for sample treatment, 8-OH-DPAT as the internal standard, and methyl tert-butyl ether as the LLE solvent in the present method gives it advantages over previous methods for the analysis of RTG in biological samples. The good analytical performance of the developed method was confirmed in specificity, linearity (the coefficient of determination ≥0.999 within 0.1-100 ng/mL), sensitivity (the lower limit of quantitation at 0.1 ng/mL), accuracy (81.00-115.05%), precision (≤10.75%), and recovery (81.00-104.48%) by following the FDA guidelines. Finally, the applicability test of the validated method to the in vivo evaluation of a RTG formulation showed that the present method is the only method which can be accurately applied to that longer than 24 hours, critical for the development of formulations with reduced dosing frequencies. Therefore, the present method could contribute to the development of new RTG formulations helpful to people suffering from PD.

• Animal Bioscience
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• 제37권4_spc호
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• pp.755-774
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• 2024

The main objective of this study was to present data on the current situation and future trends of pig meat production in the European Union-27 (EU). Pig production has played an important social and economic role for centuries in many states of the EU. In 2022, pig meat production in the EU reached 23 M tons, which represented 21% of total production worldwide. The two key reasons that justify such amount of pork produced, are the acceptance and high consumption of the meat by the local population and the high quality of the meat produced which facilitated pork export. However, current data show a reduction in pork production for the last three years, as a consequence of a series of events that include i) problems with the chain of ingredients supply, ii) uncontrolled increase in African Swine Fever (ASF) outbreaks, iii) fast recovery of pig production in China, iv) increasing concerns by the rural population on the high cost to meet future requirements of the EU legislation on farm management, environmental sustainability and animal welfare, v) increased cost of all inputs involved in pig production and vi) limited interest of the new farmer generation to work on the pig sector. Consequently, pork production is expected to decrease in the EU for the next years, although sales will be maintained at a relative high level because pork is the meat preferred by local consumers in most EU countries. In order to maintain the favourable position of the pork industry in the near future, strategies to implement include: i) maintain the quality of the meat destinated to export markets, ii) improve the control of outbreaks of ASF and other swine diseases, iii) implementation of technological innovations to improve working conditions making more attractive to work in the pork sector of the food chain to the new generation of farmers and workers.

• 한국토양비료학회지
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• 제45권3호
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• pp.410-420
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• 2012

The heavy reliance on fossil fuels, especially oil and gas has triggered the global energy crisis. Continued use of petroleum fuels is now widely recognized as unsustainable because of their depleting supplies and degradation to the environment. To become less dependent on fossil fuels, current world is shifting paradigm in energy by developing alternative energy sources mainly through the utilization of renewable energy sources. In particular, bioenergy recovery from wastes with the help of microorganism is viewed as one of the promising ways to mitigate the current global warming crisis as well as to supply global energy. It has been proved that microorganism can generate power by converting organic matter into electricity using microbial fuel cells (MFCs). MFC is a bioelectrochemical device that employs microbes to generate electricity from bio-convertible substrate such as wastewaters including municipal solid waste, industrial, agriculture wastes, and sewage. Sustainability, carbon neutral and generation of renewable energy are some of the major features of MFCs. However, the MFC technology is confronted with a number of issues and challenges such as low power production, high electrode material cost and so on. This paper reviews the recent developments in MFC technology with due consideration of electrode materials used in MFCs. In addition, application of biocathodes in MFCs has been discussed.

• 한국지리정보학회지
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• 제15권2호
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• pp.1-11
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• 2012

지구 환경 변화에 따른 폭우로 절토 사면 붕괴가 해마다 발생하고 인명과 경제적 손실이 증가하고 있다. 이는 절토 사면의 붕괴의 평가를 요구한다. 경사면이 절토 시행 전에 시뮬레이션 된다면, 절토 사면의 붕괴를 예측 할 수 있고, 붕괴 사고 시 복구 비용을 최소화 할 수 있다. 본 논문은 절토 사면에서 중요한 경사도의 시뮬레이션 방법을 나타낸다. 이것은 패트리넷을 이용하여 모델링되며 디자인되고, ArcGIS를 이용하여 윈도우 XP 환경에서 구현하고자 한다. 그래서 본 논문은 GIS를 이용한 절토와 간척을 시뮬레이션 함으로써 시간과 돈을 절약하는데 기여할 것이다.

• 한국환경복원기술학회지
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• 제13권3호
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• pp.152-162
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• 2010

This study provides preliminary data to support the need for appropriate and thorough restoration of quarries through investigating both domestic and overseas cases of sites that were restored in environment-friendly ways to make them re-usable after extraction. In cases of areas where it is difficult to restore the cut slope, putting it to other uses such as engraving buddhist images would be helpful to reduce the restoration cost and enhance the utilization of the slope. Phased land use conversion after exploitation needs to be considered in advance; for example, the location and size of the quarry should be determined according to the pre-planned use or development of the site. Considering the circumstances in the country, serious consideration should be given to methods that allow the restoration or recovery of the damaged sites to be completed in short periods of time. Quarry restoration needs to be approached from the view of ecological restoration and if a site is deemed to be usable for another purpose, land use conversion should be considered to enhance the utilization.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2010년도 추계학술대회 초록집
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• pp.64.1-64.1
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• 2010

In this study, the energy and economic analysis of KIER Zero Energy Solar House (KIER ZeSH) was carried out. KIER ZeSH was designed and constructed in the end of 2009 for the purpose of more than 70% energy self-sufficiency in total load as well as less than 20% of additional construction cost. The several building energy conservation technologies like as super insulation, high performance window, wast heat recovery system, etc and renewable energy system. The renewable heating and cooling system is a kind of solar thermal system combined with geo-source heat pump as a back-up device. The capacity of 3.15kW solar BIPV system was also installed on the roof. The measurement by monitering system of ZeSH was conducted for one year from November 2009 to October 2010. The energy self-sufficiency and economic analysis were conducted based on the this monitering result. As a result, the energy self sufficiency is about 83% which is higher than that of the target and the payback period is 11 years.

• 대한의용생체공학회:의공학회지
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• 제16권2호
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• pp.239-248
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• 1995

The method of increasing signal to noise ratio (SNR) in a Hadamard transform spectrometer (HTS) is multiplexing. The multiplexing is executed by a mask. Conventional masks are mechanical or electro-optical. A mechanical mask has disadvantages of jamming and misalignment. A stationary electro-optical mask has a disadvantage of information losses caused by spacers which partition mask elements. In this paper, a mixed-concept electro-optical mask (MCEOM) is developed by expanding the length of a spacer to that of lon-off mask element. An MCEOM is operated by stepping a movable mask. 2N measurements are required for N spectrum estimates. The average mean square error (AMSE) using MCEQM is equal to that using a stationary electro-optical mask without spacers for large N. The cost of manufacturing an MCEOM is lower than that of producing a conventional electro-optical mask because an MCEOM needs only (N + 1)/2 on-off mask elements whereas the con¬ventional electro-optical mask needs N on-off mask elements. There are no information losses in the spectrometers having an MCEOM.

• 한국융합학회논문지
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• 제4권4호
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• pp.1-5
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• 2013

본 연구는 회수물류의 실행의 중요성이 강조되고 있는 가운데, 기업이 보유한 회수물류역량이 공급사슬상의 협력기업들 간의 관계에서 기업의 수익을 향상시키며, 나아가 협력기업들 간의 협력만족도에도 긍정적인 영향을 미칠 수 있음을 보이고자 한다. 회수물류역량에 관한 선행연구들에서는 주로 최종조립자와 소비자간의 관계에서만 회수물류의 중요성을 다루고 있을 뿐 공급사슬 상의 협력 기업들 간의 관계에서 회수물류역량의 역할에 대한 연구는 거의 이루어지지 않은 실정이다. 회수물류의 실행은 자산가치를 복구하는 효과와, 재활용을 통한 비용감소 효과 및 이를 통한 이윤의 극대화의 성과와 관계가 있다. 이러한 회수물류역량은 협력기업들 간의 수익에도 영향을 미칠 뿐 아니라 협력 기업들 간의 협력 만족도에도 긍정적인 영향을 미칠 것으로 기대된다.

• 한국유체기계학회 논문집
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• 제19권3호
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• pp.19-24
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• 2016

Oil sands are a mixture of sand, clay, and a high-viscosity petroleum called bitumen. Steam-Assisted Gravity Drainage (SAGD) is the most viable and environmentally safe recovery technology for extracting bitumen. It extracts the viscosity-lowered bitumen by high pressure, high temperature steam injected into the bitumen reservoir. The steam is produced at the Central Processing Facility (CPF). Typically, more than 90% of the energy consumed in producing bitumen are used to generate the steam. Fuels are employed in the process, which cause economic and environmental problems. This paper explores the retrofit of heat exchanger network to reduce the usage of hot and cold utilities. The hot and cold utilities are reduced respectively 6% and 37.3% which in turn resulted in 5.3% saving of total annual cost by improving the existing heat exchanger network of the CPF.

• 한국유체기계학회 논문집
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• 제19권6호
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• pp.68-74
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• 2016

Hydraulic fracturing of wells during oil and gas (O&G) exploration consumes large volumes of fresh water and generates larger volumes of contaminated wastewater with high salinity. It is critical to treat and reuse the O&G wastewater in a cost-effective and environmentally sound manner for sustainable industrial development and for meeting stringent regulations. Recently, forward osmosis (FO) has been examined if it is a promising solution for treatment and desalination of complex industrial streams and especially fracturing flowback and produced waters. In the present study, the performances of a plate-and-frame FO membrane element and a module (6 elements combined in series) were investigated for concentrating high TDS wastewater. An FO module has achieved up to 64 % water recovery (i.e., concentration factor of 2.76) from 10,000 ppm wastewaters and can concentrate feed streams salinities to greater than 30,500 ppm.