• 제목/요약/키워드: rearrangement

검색결과 813건 처리시간 0.023초

카바프로스타싸이클린의 중간체로 이용가능한 히드록시싸이클로펜탄의 합성 (Synthesis of Hydroxycyclopentane as a Synthetic Intermediate for Carbaprostacyclin)

  • 서영거;구본암;정재경;조윤상;나운용
    • 약학회지
    • /
    • 제37권3호
    • /
    • pp.290-294
    • /
    • 1993
  • An efficient synthetic route to the trisubstituted cyclopentane as an useful synthetic intrermediate for carbaprostacyclin is described. Ireland Claisen rearrangement of a hydroxylactone has been employed as a key reaction.

  • PDF

Synthesis of 1, 1-Diheteroaryl Ethylenes by a Tandem Appel's Dehydration/Thermal Rearrangement Methodology

  • 이기정;허 열;전종갑
    • Bulletin of the Korean Chemical Society
    • /
    • 제20권3호
    • /
    • pp.341-344
    • /
    • 1999
  • The hydrazones of 2-acetylfuran, 2-acetylthiophene, and 2-acetylpyrrole, were allowed to react with S-methylthioacetimidate hydroiodide (8) to give azinoureas 10, and the reaction of 10 with Appel's dehydration conditions (triphenylphosphine/carbon tetrachloride/triethylamine) led to the corresponding azinocarbodiimides 11, which underwent thermal rearrangement under the reaction conditions to give 1,1-diheteroaryl ethylenes 13.