• Fisheries and Aquatic Sciences
• /
• v.24 no.1
• /
• pp.1-9
• /
• 2021

Human prostate cancer is the second most frequently diagnosed cancer worldwide, and its incidence rate continues to increase. Advanced prostate cancer is more difficult to treat than early forms due to its chemotherapy resistance. There is need for more effective agents that can inhibit the progression of advanced prostate cancer. Demethoxyfumitremorgin C (DMFTC) was isolated from the fermentation extract of the marine fungus Aspergillus fumigatus. Antiproliferative activity of DMFTC against human prostate cancer PC3 cells was examined through cell cycle analysis by flow cytometry, the fluorescent nuclear imaging analysis with propidium iodide (PI), and proteins expression related to cell cycle arrest and apoptosis were investigated via Western blotting. DMFTC inhibited PC3 cells growth through G1 phase cell cycle arrest and apoptosis induction. It activated the tumor suppressor p53 and the Cdk inhibitor p21, which regulate the cell progression into the G1 phase. Additionally, PI-positive late apoptotic non-viable cells were increased and the expression levels of the G1-positive downstream regulators cyclin D, cyclin E, Cdk2, and Cdk4 were decreased by DMFTC treatment. These results suggest that DMFTC induces G1 arrest and apoptosis induction through regulation of p53/p21-dependent cyclin-Cdk complexes, and it may be a useful therapeutic agent for the treatment of human advanced prostate cancer.

• Journal of Ceramic Processing Research
• /
• v.20 no.4
• /
• pp.411-417
• /
• 2019

Graphene doped zinc oxide nanoparticles (G-ZnO) were prepared using modified hummer's technique together with the ultrasonic method and characterized by field emission scanning electron microscopy (FESEM), X-ray powder diffraction (XRD), fourier-transform infrared spectroscopy (FTIR) and high-resolution transmission electron microscopy (HRTEM). Different samples of epoxy resin nanocomposites reinforced with G-ZnO nanoparticles were prepared and were marked as F1 (without adding nanoparticles), F2 (1% w/w G-ZnO), and F3 (2% w/w G-ZnO) in combination of ≈ 56:18:18:8w/w% with epoxy resin/hardener, ammonium polyphosphate, boric acid, and Chitosan. The peak heat release rate (PHRR) of the epoxy nanocomposites was observed to decrease dramatically with the increasing G-ZnO nanoparticles. However, the LOI values increased significantly with the increase in wt % of G-ZnO nanoparticles. From the UL-94V data, it was confirmed that the F2 and F3 samples passed the flame test and were rated as V-0. The results obtained in the present work clearly revealed that the synthesized samples can be used as efficient materials in fire-retardant coating technology.

• Korean Chemical Engineering Research
• /
• v.62 no.2
• /
• pp.191-199
• /
• 2024

A study was conducted on a tubular heat exchanger to improve its heat transfer rate by using a novel baffle plate design with discontinuous swirling patterns. The design consisted of perforated baffle plates with rectangular air deflectors positioned at varying angles. The tubes in the heat exchanger were arranged in a consistent alignment with the airflow direction and exposed to a uniform heat flux on their surfaces. Each baffle plate included sixteen deflectors inclined at the same angle and arranged in a clockwise pattern. This arrangement induced a swirling motion of the air inside a circular duct where the heated tubes were located, leading to increased turbulence and improved heat transfer on the tube surfaces. The spacing between the baffle plates was adjusted at different pitch ratios, and the Reynolds number was controlled within a range of 16,000 to 29,000. The effects of pitch ratios and inclination angles on the heat exchanger's performance were analyzed. The results indicated that using a baffle plate with rectangular deflectors inclined at 30° and a pitch ratio of 1.2 resulted in an average increase of 1.29 in the thermal enhancement factor.

• Tribology and Lubricants
• /
• v.27 no.1
• /
• pp.7-12
• /
• 2011

Interest in advanced machining process such as AJM(abrasive jet machining) and CMP(chemical-mechanical polishing) using micro/nano-sized abrasives has been on the increasing demand due to wide use of super alloys, composites, semiconductor and ceramics, which are difficult to or cannot be processed by traditional machining methods. In this paper, the effects of pressure, wafer moving velocity and fluid viscosity were investigated by 2-dimensional finite element analysis method considering slurry fluid flow. From the investigation, it could be found that the simulation results quite corresponded well to the Preston's equation that describes pressure/velocity dependency on material removal. The result also revealed that the stress and corresponding material removal induced by the collision of particle may decrease under relatively high wafer moving speed due to the slurry flow resistance. In addition, the increase in slurry fluid viscosity causes the reduction of material removal rate. It should be noted that the viscosity effect can vary with the shape of abrasive particle.

• Tribology and Lubricants
• /
• v.33 no.1
• /
• pp.31-35
• /
• 2017

Recently, international attention has been focused on the development of non-traditional energy resources such as shale gas and oil sands, due to the steep increase in the demand for natural resources. The materials incorporated in an oil gas plant module experience extreme environments, and are prone to various problem such as fracture, corrosion and abrasion due to low-temperature brittleness. In order to improve the plant life, it is necessary to perform characteristics study and performance evaluation of the materials. In particular, this paper explains the main set of materials which are most frequently used in oil sands plant project. In order to investigate wear characteristics, the authors carried out abrasive wear tests of TP 316, stainless steel and SS 400, structural rolled steel. For the analysis of the abrasive wear resistance of an oil sands plant, the authors carried out the test according to ASTM G 105 "Standard Test Method for Conducting Wet Sand/Rubber Wheel Abrasion Test" standard guidelines. The authors have derived the results from the data associated with the loss of mass with respect to wear rate. During the test, for a given wear length for 10,000 revolutions, the rotational speed and applied force of the rubber wheel were varied.

• Rapid Communication in Photoscience
• /
• v.4 no.1
• /
• pp.25-28
• /
• 2015

The time-resolved photoexcitation dynamics of electrical conductivity of the magnetic organic superconductor ${\lambda}-(BETS)_2Fe_{0.45}Ga_{0.55}Cl_4$ has been studied with a nanosecond visible laser pulse at its three different phases, i. e., metallic phase, superconducting phase and insulating phase. A transient increase of the resistance is induced by photoirradiation at all the temperatures measured for all three phases, but the decay profile shows a significant temperature dependence. The relaxation rate in the metallic and insulating phase are different from each other, and the decay time is relatively faster and almost constant in the metallic phase. However, a prolongation of the relaxation time is observed at temperature just around the narrow superconducting phase. Nonbolometric (nonthermal) origin of the observed photoresponse of the electrical conductivity is confirmed in the superconducting phase.

• Membrane Journal
• /
• v.21 no.1
• /
• pp.13-21
• /
• 2011

This study investigated the fouling behavior of $Al_2O_3$ colloids on polyethylene microfiltration membrane. To examine the effect of operation variation on fouling, operating pressure was increased from 0.49 to 1.96 bar along with time elapses and then was reduced to 0.49 bar reversely. A hysteresis behavior was observed in the membrane permeate flux over pressure, revealing different fluxes at the same pressure according to the pressure control type, increasing and decreasing. Permeate resistance and its rate of increase was higher in the decreasing pressure cycle than in the increasing pressure cycle. At the initial period of filtration, fouling mechanism for the both cycles was governed by the cake filtration. The degree of fouling was higher in the decreasing pressure cycle compared with in the increasing pressure cycle.

• Journal of the Korean Society for Precision Engineering
• /
• v.18 no.12
• /
• pp.192-199
• /
• 2001

Chemical mechanical planarization (CMP) has emerged as the planarization technique of choice in both front-end and back-end integrated circuit manufacturing. Conventional CMP process utilize a polyurethane polishing pad and liquid chemical slurry containing abrasive particles. There hale been serious problems in CMP in terms of repeatability and deflects in patterned wafers. Especial1y, dishing and erosion defects increase the resistance because they decrease the interconnection section area, and ultimately reduce the lifetime of the semiconductor. Methods to reduce dishing & erosion have recently been interface hardness of the pad, optimization of the pattern structure as dummy patterns. Dishing & erosion are initially generated an uneven pressure distribution in the materials. These defects are accelerated by free abrasives and chemical etching. Therefore, it is known that dishing & erosion can be reduced by minimizing the abrasive concentration. Minimizing the abrasive concentration by using CeO$_2$is the best solution for reducing dishing & erosion and for removal rate. This paper introduce dishing & erosion generating mechanism and a method fur developing a semi-rigid abrasive pad to minimize dishing & erosion during CMP.

• Journal of the Korean Society of Manufacturing Process Engineers
• /
• v.14 no.6
• /
• pp.41-48
• /
• 2015

Stainless steel mesh has been used as a filter in various fields, including domestic, medical, etc. However, the surface before machining may have an adverse effect the product quality and performance because it is not smooth. Especially, adsorbed impurities in the surface result in difficulty in cleaning. Therefore, in this paper, we propose an improved surface quality through electrochemical polishing (ECP). Two electrodes, composed of STS304 (anode) and copper (cathode) underwent machining with two conditions according to polishing time and current density. As the polishing time and current density increase, the surface of curvature decreases, and roughness and material removal rate (MRR) improves. The machined surface roughness and image were obtained through the atomic force microscope (AFM) and stereoscopic microscope. The study also analyzed hydrophilic effect through contact angles. This obtains corrosion resistance, smoothness, hydrophilic property, etc.

• Elastomers and Composites
• /
• v.33 no.3
• /
• pp.149-158
• /
• 1998

SBR latex, polyurethane latex and epoxy latex were separately mixed with polyvinyl acetate emulsion. The various physical properties were examined for the mixtures. Epoxy mixtures gave a transparent film. Both polyurethane and SBR mixtures showed opaque film with high viscosity. In SBR and polyurethane increase in hardness was dependent on the evaporation rate of water, but in epoxy it was dependent on the degrees of crosslink. Epoxy's showed excellent water-resistance. SBR showed a good flexural strength and impact strength. When vinyl acetate emulsion was mixed with less than 10% latex paper tube showed the ductile fracture, but over latex content 20%, it showed the brittle fracture.