• Journal of the Korean Physical Society
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• v.73 no.11
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• pp.1774-1786
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• 2018

Phenotypic variation among clones (individuals with identical genes, i.e. isogenic individuals) has been recognized both theoretically and experimentally. We investigate the effects of phenotypic variation on evolutionary dynamics of a population. In a population, the individuals are assumed to be haploid with two genotypes : one genotype shows phenotypic variation and the other does not. We use an individual-based Moran model in which the individuals reproduce according to their fitness values and die at random. The evolutionary dynamics of an individual-based model is formulated in terms of a master equation and is approximated as the Fokker-Planck equation (FPE) and the coupled non-linear stochastic differential equations (SDEs) with multiplicative noise. We first analyze the deterministic part of the SDEs to obtain the fixed points and determine the stability of each fixed point. We find that there is a discrete phase transition in the population distribution when the probability of reproducing the fitter individual is equal to the critical value determined by the stability of the fixed points. Next, we take demographic stochasticity into account and analyze the FPE by eliminating the fast variable to reduce the coupled two-variable FPE to the single-variable FPE. We derive a quasi-stationary distribution of the reduced FPE and predict the fixation probabilities and the mean fixation times to absorbing states. We also carry out numerical simulations in the form of the Gillespie algorithm and find that the results of simulations are consistent with the analytic predictions.

• Nuclear Medicine and Molecular Imaging
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• v.43 no.4
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• pp.323-329
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• 2009

Purpose: Radioimmunoassay (RIA) was usually performed by the batch assay. To improve the efficiency of RIA without increase of the cost and time, random assay could be a choice. We investigated the possibility of the random assay using automatic dispenser by assessing the agreement between batch assay and random assay. Materials and Methods: The experiments were performed with four items; Triiodothyronine (T3), free thyroxine (fT4), Prostate specific antigen (PSA), Carcinoembryonic antigen (CEA). In each item, the sera of twenty patients, the standard, and the control samples were used. The measurements were done 4 times with 3 hour time intervals by random assay and batch assay. The coefficient of variation (CV) of the standard samples and patients' data in T3, fT4, PSA, and CEA were assessed. ICC (Intraclass correlation coefficient) and coefficient of correlation were measured to assessing the agreement between two methods. Results: The CVs (%) of T3, fT4, PSA, and CEA measured by batch assay were 3.2$\pm$1.7%, 3.9$\pm$2.1%, 7.1$\pm$6.2%, 11.2$\pm$7.2%. The CVs by random assay were 2.1$\pm$1.7%, 4.8$\pm$3.1%, 3.6$\pm$4.8%, and 7.4$\pm$6.2%. The ICC between the batch assay and random assay were 0.9968 (T3), 0.9973 (fT4), 0.9996 (PSA), and 0.9901 (CEA). The coefficient of correlation between the batch assay and random assay were 0.9924(T3), 0.9974 (fT4), 0.9994 (PSA), and 0.9989 (CEA) (p<0.05). Conclusion: The results of random assay showed strong agreement with the batch assay in a day. These results suggest that random assay using automatic dispenser could be used in radioimmunoassay.

• Computers and Concrete
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• v.22 no.1
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• pp.53-62
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• 2018

Cracking of concrete cover induced by reinforcement corrosion is a critical issue for life-cycle design and maintenance of reinforced concrete structures. However, the critical degree of corrosion, based on when the concrete surface cracks, is usually hard to predict accurately due to the heterogeneity inherent in concrete. To investigate the influence of concrete heterogeneity, a modified rigid-body-spring model, which could generate concrete sections with randomly distributed coarse aggregates, has been developed to study the corrosion-induced cracking process of the concrete cover and the corresponding critical degree of corrosion. In this model, concrete is assumed to be a three-phase composite composed of coarse aggregate, mortar and an interfacial transition zone (ITZ), and the uniform corrosion of a steel bar is simulated by applying uniform radial displacement. Once the relationship between radial displacement and degree of corrosion is derived, the critical degree of corrosion can be obtained. The mesoscale model demonstrated its validity as it predicted the critical degree of corrosion and cracking patterns in good agreement with analytical solutions and experimental results. The model demonstrates how the random distribution of coarse aggregate results in a variation of critical degrees of corrosion, which follows a normal distribution. A parametric study was conducted, which indicates that both the mean and variation of critical degree of corrosion increased with the increase of concrete cover thickness, coarse aggregates volume fraction and decrease of coarse aggregate size. In addition, as tensile strength of concrete increased, the average critical degree of corrosion increased while its variation almost remained unchanged.

• Journal of Life Science
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• v.24 no.6
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• pp.612-617
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• 2014

The phenetic relationships among six natural populations of Equisetum pratense in Korea were investigated at the population level by constructing a tree based on Random Amplified Polymorphic DNA (RAPD) markers. RAPD analysis was also conducted to estimate genetic diversity and the population structure of E. pratense. A mean of 26.7% at the six population levels indicated polymorphism. E. pratense was found to have fewer alleles per locus (1.267) and fewer effective alleles per locus (1.176). Genetic diversity (0.102) in E. pratense is lower than the average for species with similar life history traits. Total genetic diversity values (HT) varied between 0.112 (OPD-07) and 0.445 (OPD-16), for an average overall polymorphic locus of 0.141. Inter-locus variation in the within-population genetic diversity ($H_S$) was low (0.102). Asexual reproduction, small population size, and the colonization process are proposed as possible factors contributing to the observed low genetic diversity in E. pratense. On a per-locus basis, the proportion of total genetic variation due to differences among populations ($G_{ST}$) ranged from 0.129 for OPD-07 to 0.455 for OPD-09, with a mean of 0.277. This indicated that about 27.7% of the total variation was among populations. Thus, genetic variation (72.3%) resided within populations. This study contributes new information for research on the taxonomy and population genetics of E. pratense.

• Animal cells and systems
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• v.5 no.4
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• pp.333-339
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• 2001

Common carp (Cyprinus carpio) and its aquaculture breed Israeli carp samples were obtained from two separate aquaculture facilities under the similar raising conditions during two years in the Kunsan National University, Korea. Genomic DNA was isolated from the common carp and Israeli carp for identification of genetic characteristics and genomic polymorphisms by polymerase chain reaction amplification of DNA using arbitrary primers. The arbitrary primer No.21 (ACTTCGCCAC) yielded the highest number of fragments with the average of 15.0 among the primers used in Israeli carp. A tota1 of 294 polymorphic products in common carp and 336 in Israeli carp were observed by random primers. The average number of polymorphic products generated by random RAPD primer No. 2 (GTAGAC-CCGT) showed 8.0 in Israeli carp. On average, each random RAPD primer produced 5.4 amplified polymorphic products in common carp and 6.2 in Israeli carp. An average genetic similarity (BS value) was 0.44$\pm$0.05 within the common carp and 0.32$\pm$0.04 within the Israeli carp. The degree of similarity frequency (BS) between two carps was 0.67 as generated by the primer No. 19 (GACGGATCAG). The average level of bandsharing was 0.57$\pm$0.03 between the two carps. Accordingly, the two carp populations were genetically a little distant. The electrophoretic analysis of PCR-RAPD products showed middle levels of variation between the two carp populations. This result implies that the genetic diversity among intra-population may be higher when compared with that between the two carps. The RAPD polymorphism generated by these random primers might be used as a genetic marker for populations or lines identification in important aquacultural carp.

• Journal of the Korea Institute of Military Science and Technology
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• v.2 no.1
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• pp.139-149
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• 1999

In this paper, we estimate the scale factor error and random walk characteristics of the ring laser gyro which has the body dither for Lock-in compensation. And then, we compared those results with the static test results for 28cm square ring laser gyro which has about 0.5 deg/sec static Lock-in. In the case of sinusoidal body dither, dynamic Lock-in occurs periodically at the points where the gyro output pulse becomes the integer multiples of body dither frequency. The width of dynamic Lock-in is changed by variation of dither amplitude, and, between the width of dynamic Lock-in which occurs at the even multiple points of body dither frequency and that at the odd muliple points of body dither frequency, it has 180o phase difference. Generally random body dither is adopted to compensate for dynamic Lock-in. Then if the irregularity is not large enough, the scale factor error by dynamic Lock-in is not vanished. And if the irregularity is large enough, the scale factor error decreases, but random walk becomes larger relatively. And we confirmed that the larger body dither amplitude, the smaller random walk.

• Geotechnical Engineering
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• v.6 no.2
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• pp.5-20
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• 1990

In the seismic analysis of structures, where the dynamic soil-structure interaction (DSSI) is considred, earthquake input motions as well as dynamic soil properties are random in nature. To take into account the random nature of both the input motions and the dynamic soil properties systematically, a probabilistic analysis of the DSSI subjected to seismic loading is proposed in this paper, The complex response method formulized by the elastic half space theory, the random vibration theory, and the Rosenblueth's two-point estimate method are combined for the proposed probabilistic analysis. The conclusions drawn from this study are as follows ' 1) The uncertainty bands of the earthquake input motions proposed by Kanai-Tajimi as well as those of the dynamic properties are large the coefecients of variation of those parameters tinge from 0.4 to 0.6. 2) The uncertainties of the dynamic soil properties are more sensitive to the structural responses than those of the input motion parameters. 3) The effect of correlations between the input motion parameters and the dynamic soil properties is negligible.

• The Transactions of the Korean Institute of Power Electronics
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• v.15 no.1
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• pp.69-74
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• 2010

In a grid connected variable speed wind turbine, the PCC voltage and the wind power fluctuate as the wind velocity changed. And this voltage variation is changed due to location of PCC. This paper calculate the value of PCC voltage variation which is proportional to the product of the line impedance from the ideal generator to the PCC and the wind turbine output current. And to reduce this PCC voltage variation, this paper calculate the required reactive power analytically using the vector diagram method. Output reactive current is changed, if the reactive current is limited by inverter capacity or grid code have the margin of voltage variation. If the grid connected inverter is controlled by proposed algorithm, the PCC voltage variation is minimized though the wind turbine output change at random. To verify calculated voltage variation and required reactive power, this paper utilized Matlab and PSCAD/EMTDC simulation and real small wind turbine and power system in Sapsido, island in the Yellow Sea.

• Journal of Plant Biotechnology
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• v.47 no.4
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• pp.289-297
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• 2020

The genetic diversity of two subpopulations of Corynandra chelidonii, one of terrestrial and the other of aquatic environments, was measured with molecular markers, such as start codon targeted (SCoT), inter simple sequence repeats (ISSR), and random amplification of polymorphic DNA (RAPD). The traditional morphological traits such as habitat, habit, leaf morphology, the colour of the sepals and petals, number of stamens, and seed morphology formed the base for their realization as two varieties, C. chelidonii var. pallae and C. chelidonii var. chelidonii. The polymorphism between the two variants was 100% with the primers SCoT-2 and OPA-1 and 4, while maximum polymorphism was detected with ISSR-2, SCoT-3, and OPA-3. The study used, for the first time, more than one molecular marker to assess the genetic variation underscoring the morphological variation in Corynandra chelidonii (L.f.) Cochrane & Iltis. The study justifies the recognition of the two subpopulations of Corynandra chelidonii from aquatic and terrestrial environments as two distinct varieties, C. chelidonii var. pallae (Reddy & Raju) V.S.Raju and C. chelidonii var. chelidonii, respectively, based on the traditional taxonomic evidence.

• The Journal of Asian Finance, Economics and Business
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• v.9 no.3
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• pp.53-63
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• 2022

Despite the relationship between cash flow, financial management, and project performance, no study examined the mediating role of financial management on the relationship between cash flow and construction project performance, especially in Kuwait. The goal of this study was to examine the impact of cash flow fluctuations on construction project performance, as well as the role of financial management in mediating this relationship. To accomplish these goals, the researcher employed a descriptive-analytical method to create a questionnaire of 31 items. The study's sample was chosen at random and includes (181) project managers and firm owners from contractors' companies in Kuwait. The study found a statistically positive and significant effect of cash flow variation on project performance from the perspective of Kuwaiti contractors at the significance level (0.05), as well as a mediated role of financial management in the relationship between cash flow variation and project performance. The research came up with a number of recommendations based on the findings, including the need for contractors to have a better understanding of cash flow to arrange project activities correctly and efficiently. Further studies may be included into the effect of cash flow forecasting (planning) and financial management (control) on various construction activities.