• Asian Pacific Journal of Cancer Prevention
• /
• 제14권5호
• /
• pp.2753-2758
• /
• 2013

Various studies examining the relationship between Ezrin overexpression and response to chemotherapy and clinical outcome in patients with osteosarcoma have yielded inconclusive results. We accordingly conducted a meta-analysis of 7 studies (n = 318 patients) that evaluated the correlation between Ezrin and histologic response to chemotherapy and clinical prognosis (death). Data were synthesized in receiver operating characteristic curves and with fixed-effects and random-effects likelihood ratios and risk ratios. Quantitative synthesis showed that Ezrin is not a prognostic factor for the response to chemotherapy. The positive likelihood ratio was 0.538 (95% confidence interval [95% CI], 0.296- 0.979; random-effects calculation), and the negative likelihood ratio was 2.151 (95% CI, 0.905- 5.114; random-effects calculations). There was some between-study heterogeneity, but no study showed strong discriminating ability. Conversely, Ezrin positive status tended to be associated with a lower 2-year survival (risk ratio, 2.45; 95% CI, 1.26-4.76; random-effects calculation) with some between-study heterogeneity that disappeared when only studies that employed immunohistochemistry were considered (risk ratio, 2.97; 95% CI, 2.01- 4.40; fixed-effects calculation). To conclude, Ezrin is not associated with the histologic response to chemotherapy in patients with osteosarcoma, whereas Ezrin positivity was associated with a lower 2-year survival rate regarding risk of death at 2 years. Expression change of Ezrin is an independent prognostic factor in patients with osteosarcoma.

• Communications for Statistical Applications and Methods
• /
• 제30권1호
• /
• pp.65-73
• /
• 2023

Contemporary biomedical data often involve an ill-posed problem owing to small sample size and large number of multi-collinear variables. Partial least squares (PLS) method could be a plausible alternative to an ill-conditioned ordinary least squares. However, in the case of a PLS model that includes a random-effect, how to deal with a random-effect or mixed effects remains a widely open question worth further investigation. In the present study, we propose a modified multivariate PLS method implementing mixed-effect model (PLSM). The advantage of PLSM is its versatility in handling serial longitudinal data or its ability for taking a randomeffect into account. We conduct simulations to investigate statistical properties of PLSM, and showcase its real clinical application to predict treatment outcome of esthetic surgical procedures of human faces. The proposed PLSM seemed to be particularly beneficial 1) when random-effect is conspicuous; 2) the number of predictors is relatively large compared to the sample size; 3) the multicollinearity is weak or moderate; and/or 4) the random error is considerable.

• Structural Engineering and Mechanics
• /
• 제90권1호
• /
• pp.41-49
• /
• 2024

In recent years, China's high-speed railway (HSR) line continues to expand into seismically active regions. Analyzing the features of earthquake rail irregularity is crucial in this situation. This study first established and experimentally validated a finite element (FE) model of bridge-track. The FE model was then combined with earthquake record database to generate the earthquake rail irregularity library. The sample library was used to construct a model of desired earthquake rail irregularity based on signal processing (SFT) and hypothesis principle. Finally, the effects of random pier height and random span number on desired irregularity were analyzed. Herein, an equivalent method of calculating earthquake rail irregularities for random structures was proposed. The results of this study show that the amplitude of desired irregularity is found to increase with increasing pier height. When calculating the desired irregularity of a structure with unequal pier heights, the structure can be regarded as that with equal pier heights (taking the largest pier height). For a structure with the span number large than 9, its desired irregularity can be considered equal to that of a 9-span structure. For the structures with both random pier heights and random span number, their desired irregularities are obtained by equivalent calculations for pier height and span number, respectively.

• Journal of the Korean Data and Information Science Society
• /
• 제13권2호
• /
• pp.329-340
• /
• 2002

Two methods are proposed for constructing a confidence interval on the among group variance component in a unbalanced one-way random effects model. Computer simulation is used to compare these methods with alternative procedures. The results indicate that the method1 and methods2 perform well over small group size and large sample size respectively.

• Journal of the Korean Data and Information Science Society
• /
• 제13권2호
• /
• pp.227-234
• /
• 2002

In this paper, we consider hierarchical Bayes generalized linear models for the analysis of longitudinal count data. Specifically we introduce the hierarchical Bayes random effects models. We discuss implementation of the Bayes procedures via Markov chain Monte Carlo (MCMC) integration techniques. The hierarchical Baye method is illustrated with a real dataset and is compared with other statistical methods.

• 한국통계학회:학술대회논문집
• /
• 한국통계학회 2002년도 추계 학술발표회 논문집
• /
• pp.79-83
• /
• 2002

A phase III clinical trial of a new drug for neutropenia induced by chemotherapy is presented and consider adding random effects in crossover design which was used in the clinical study. The diagnostics for its heteroscedasticity based on score statistic is derived for detecting homoscedasticity of errors in crossover design. A small simulation study is peformed to investigate the finite sample behaviour of the test statistic which is known to have an asymptotic chi-square distribution under the null hypothesis.

• Communications for Statistical Applications and Methods
• /
• 제7권1호
• /
• pp.141-150
• /
• 2000

In this paper we propose a method of computing Bayes factor to detect an outlier in a random effects model. When no information is available and hence improper noninformative priors should be used Bayes factor includes the unspecified constants and has complicated computational burden. To solve this problem we use the fractional Bayes factor (FBF) of O-Hagan(1995) and the generalized Savage0-Dickey density ratio of Verdinelli and Wasserman (1995) The proposed method is applied to outlier deterction problem We perform a simulation of the proposed approach with a simulated data set including an outlier and also analyze a real data set.

• 전자공학회논문지
• /
• 제49권12호
• /
• pp.179-183
• /
• 2012

3차원 시뮬레이션을 이용하여 터널링 전계효과 트랜지스터(TFET)의 불순물 분포 변동(RDF) 효과에 대해 살펴보았다. TFET의 RDF 효과는 매우 낮은 바디 도핑 농도 때문에 많이 논의되지 않았다. 하지만 본 논문에서는 임의로 생성되고 분포되는 소스 불순물이 TFET의 문턱전압 ($V_{th}$)과 드레인 유기 전류 증가 (DICE), 문턱전압이하 기울기 (SS)의 변화를 증가시킴을 발견하였다. 또한, TFET의 RDF 효과를 감소시킬 수 있는 몇 가지 방법을 제시하였다.

• 응용통계연구
• /
• 제29권2호
• /
• pp.291-299
• /
• 2016

본 논문은 고정요인과 확률요인의 혼합모형에서 추정가능함수를 논의하고 있다. 고정효과모형에서 정의된 추정가능 함수가 혼합효과모형에서 어떻게 정의되어야 하는 가를 규정하고 추정가능함수의 분산추정치를 구하는 방법을 제시하고 있다. 또한 혼합모형에서 분산성분의 추정을 위한 제곱합의 계산에 상수적합법을 이용하고 추론을 위한 자유도의 계산에 Satterthwaite의 근사화를 다루고 있으며 분산성분을 구하기 위한 모형의 적합방식으로 단계별 방법을 적용하고 있다. 모형의 단계별 적합에서 주어지는 모형행렬의 사영을 이용한 제1종 제곱합의 계산방식이 제공되며 사영을 이용한 변동요인별 제1종 제곱합의 기댓값 계산에 Hartley의 합성법이 논의된다.

• 한국지진공학회논문집
• /
• 제26권6호
• /
• pp.237-246
• /
• 2022

Based on the random-vibration-theory methodology, dynamic responses of nuclear facilities subjected to obliquely incidental and incoherent earthquake ground motions are calculated. The spectral power density functions of the 6-degree-of-freedom motions of a rigid foundation due to the incoherent ground motions are obtained with the local wave scattering and wave passage effects taken into consideration. The spectral power density function for the pseudo-acceleration of equipment installed on a structural floor is derived. The spectral acceleration of the equipment or the in-structure response spectrum is then estimated using the peak factors of random vibration. The approach is applied to nuclear power plant structures installed on half-spaces, and the reduction of high-frequency earthquake responses due to obliquely incident incoherent earthquake ground motions is examined. The influences of local wave scattering and wave passage effects are investigated for three half-spaces with different shear-wave velocities. When the shear-wave velocity is sufficiently large like hard rock, the local wave scattering significantly affects the reduction of the earthquake responses. In the cases of rock or soft rock, the earthquake responses of structures are further affected by the incident angles of seismic waves or the wave passage effects.