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The Efficiency Analysis of National R&D Programs for Drug Development Using Range Adjusted Measure (영역조절모형(RAM)을 활용한 신약개발 국가연구개발사업의 효율성 분석)

  • Um, Ik-Cheon;Baek, Chulwoo;Hong, Seho
    • Journal of Korea Technology Innovation Society
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    • v.19 no.4
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    • pp.711-735
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    • 2016
  • Drug Development is very important for promoting public health and pharmaceutical industry. There has been many studies on the efficiency of drug development, but there are few studies on the drug development R&D performed by government. Since CCR model assumes unidirectional influence of input and output, it is not appropriate to analyze the efficiency of R&D due to the time-lag and spill-over effect. Also, BBC model which assumes variable returns to scale has difficulty in deriving priorities between decision making units. Recently, Range Adjusted Measure (RAM) model has been suggested in R&D efficiency analysis. RAM model measures the efficincy by eliminating inefficiencies under variable returns to scale assumption, and its strong monotonicity enables to provide clear priorities between decision making units. In this study, we analyzed the efficiency of national R&D programs for drug development using the two-step approach, including RAM model and Tobit regression analysis, and discussed major policy implications.

Measures for Improvement of RAM Target Value Setting Methods for Submarine Weapon Systems (잠수함 무기체계 RAM 목표 값 설정 방식의 개선방안)

  • Jung, Sun-uk;Shim, Hang-geun;Choi, Myoung-jin
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.4
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    • pp.419-427
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    • 2020
  • In the case of large combined weapon systems, such as submarines, the application, and verification of methods of setting the reliability, availability, and maintainability (RAM) target values for conventional weapon systems are limited. Submarines are complex weapon systems with the characteristics of the diversity of operation mode summary and mission profiles (OMS/MP) as well as equipment complexity because they are composed of multiple weapon systems, such as sonar systems and armed systems. Therefore, this study analyzed the development cases of existing weapon systems, i.e., the RAM target value-setting cases, and derived the problems and limitations of the cases to present measures to improve the setting and verification of the ram target values of submarines. In addition, submarines operate around the world and have different operating and maintenance conditions. Therefore, a submarine's ram target values should be set and verified centering on the mission essential equipment and mission critical equipment, instead of all components that constitute weapon systems. This study examined a method to verify the required performance RAM target-value setting, considering the characteristics of submarines as well as the physical performance requirements for the systems and equipment of submarines that must be considered when implementing national defense acquisition projects for submarines.

The impact of substrate bias on the Z-RAM characteristics in n-channel junctionless MuGFETs (기판 전압이 n-채널 무접합 MuGFET 의 Z-RAM 특성에 미치는 영향)

  • Lee, Seung-Min;Park, Jong-Tae
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.18 no.7
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    • pp.1657-1662
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    • 2014
  • In this paper, the impact of substrate bias($V_{BS}$) on the zero capacitor RAM(Z-RAM) in n-channel junctionless multiple gate MOSFET(MuGFET) has been analyzed experimentally. Junctionless transistors with fin width of 50nm and 1 fin exhibits a memory window of 0.34V and a sensing margin of $1.8{\times}10^4$ at $V_{DS}=3.5V$ and $V_{BS}=0V$. As the positive $V_{BS}$ is applied, the memory window and sensing margin were improved due to an increase of impact ionization. When $V_{BS}$ is increased from 0V to 10V, not only the memory window is increased from 0.34V to 0.96V but also sensing margin is increased slightly. The sensitivity of memory window with different $V_{BS}$ in junctionless transistor was larger than that of inversion-mode transistor. A retention time of junctionless transistor is better than that of inversion-mode transistor due to low Gate Induced Drain Leakage(GIDL) current. To evaluate the device reliability of Z-RAM, the shifts in the Set/Reset voltages and current were measured.

A Study on the Assessment for the Functions of Inland Wetlands Using RAM(Rapid Assessment Method) (RAM(일반기능평가기법)을 이용한 내륙 습지 기능 평가)

  • Koo, Bon-Hak;Kim, Kwi-Gon
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.4 no.3
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    • pp.38-48
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    • 2001
  • A wetland is an ecosystem which is the most useful and highly-energetic transition area. This study has been carried out to develop the wetland function assessment methods and apply on the natural wetlands (Mul-young-ari wetland in Jeju-island and Bangdong wetland in Taejon Metropolitan city) using RAM (Rapid Assessment Method). The RAM is useful method for assessing the wetland functions in terms of general functions acquired by once or twice onsite surveying. Eight functions of 2-12 variables each are analyzed for assessing the wetland functions. The results are as follows : 1) The conservation values of two wetlands are "High". 2) In Mul-young-ari wetland, such functions as groundwater discharge, floral diversity and wildlife habitat, shoreline/stream bank protection are relatively high, but some functions such as flood/storm water storage, aesthetics and recreation are "Moderate" - "High". 3) In Bangdong wetland, such functions as floral diversity and wildlife habitat, groundwater discharge, flood/storm water storage, aesthetics and recreation are high, and another functions are "Moderate" - "High". The taxonomy of this study stems from assessing functions of inland wetlands using indices of RAM. So It is needed that consequent studies are to be performed with verifying the variables and indices.

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The Formation of Detonation Wave and Acceleration Characteristics with the Ram Accelerator Projectile Shapes (램 가속기 탄체 형상에 따른 데토네이션파와 가속 특성에 관한 연구)

  • 전용희;이재우
    • Journal of the Korean Society of Propulsion Engineers
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    • v.3 no.2
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    • pp.82-91
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    • 1999
  • Projectile shapes of the superdetonative ram accelerator have great effects on shock structures, detonation wave formation, and ram acceleration characteristics. In this study, cone-cylinder-cone, a baseline projectile configuration of the superdetonative combustion mode, double-cone configurations and power-law shape, have been numerically investigated to analyze the effect of the front/rear configuration changes, on the flow field around the projectile, detonation wave formation process, and projectile acceleration characteristics. Hence, a ram projectile configuration with conspicuously improved acceleration characteristics has been proposed by adjusting the double cone angle and height. The results provide useful information for the ram accelerator design optimization study.

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A Study on Non-acoustic Stealth Techniques of Submarine (잠수함의 비음향 스텔스 기법에 관한 연구)

  • Choi, Chang-Mook
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.16 no.6
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    • pp.1330-1334
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    • 2012
  • The submarines reach their weakest point when they sail on the surface to operate snorkel and periscope. At this period, however, there lies a high possibility that the submarines are detected by non-acoustic sensors such as radars, IR signatures, and human observations. In this paper, the non-acoustic stealth was adopted on the mast and periscope of submarines so as to overcome their vulnerability of being easily detected in this given situation. First of all, the non-acoustic detection sensors were investigated and the stealth methods were analyzed. And multi-layered structures consisting of RAM layer, IR layer, and Camouflage layer were proposed on the surface of the submarine. As a results, multi-layered structure was suggested with 3~5 mm of a magnetic material such as ferrite for RAM layer, 1~2 mm of ceramic or nickel for IR layer, and sea-blue paint for Camouflage layer.

A Study on the Electrical Properties of MIM Structures Based on Ge2Sb2Te5 and Ge8Sb2Te11 Thin Films for ReRAM (ReRAM응용을 위한 Ge2Sb2Te5와 Ge8Sb2Te11 기반 MIM구조 박막의 전기적 특성 연구)

  • Jang, Hwi-Jong;Kong, Heon;Yeo, Jong-Bin;Lee, Hyun-Yong
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.30 no.3
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    • pp.144-147
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    • 2017
  • In this study, $Ge_2Sb_2Te_5$ and $Ge_8Sb_2Te_{11}$ were used as an insulator layer to fabricate ReRAM devices. The resistance change is correlated to the appearance or disappearance of a conductivity filament at the surface of the GeSbTe layer. Changes in the electrical properties of ITO/GeSbTe/Ag devices were measured using a I-V-L measurement system. As a result, compared to the $ITO/Ge_8Sb_2Te_{11}/Ag$ device, this $ITO/Ge_2Sb_2Te_5/Ag$ ReRAM device exhibits highly uniform bipolar resistive switching characteristics, such as the operating voltages, and the resistance values.

자료포락분석을 활용한 신약개발 분야 국가연구개발사업의 효율성 분석

  • Eom, Ik-Cheon;Baek, Cheol-U;Hong, Se-Ho
    • Proceedings of the Korea Technology Innovation Society Conference
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    • 2015.11a
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    • pp.430-443
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    • 2015
  • 신약개발은 국민의 건강권과 직결되며 국가 차원의 제약산업 육성을 위해 매우 중요하다. 그동안 신약개발 분야와 관련하여 다양한 연구가 수행되었지만, 신약개발 분야의 국가연구개발사업에 대한 효율성 분석은 매우 부족한 실정이다. 특히 R&D 분야는 연구개발시차, 일출효과(spill-over effect) 등으로 인해 투입과 산출의 일정한 방향성과 등비율적인 증감을 가정하는 CCR 모형이 적합하지 않다. 또한 가변규모수익을 가정하는 BCC 모형도 여유분(slack)으로 인해 의사결정단위간의 명확한 우선순위 도출이 어려운 한계점이 있다. 최근에는 R&D 분야의 특수성을 고려해서 자료포락분석 모형 중 RAM(Range Adjusted Measure) 모형을 활용한 분석방법이 제시되고 있다. RAM 모형은 가변규모수익 가정 하에 투입지향이나 산출지향처럼 방향성에 대한 사전적인 가정 없이 비효율성을 최대한 제거하는 방향으로 효율성을 측정하므로 R&D 분야의 효율성 분석에 적합하다. 특히 RAM 모형은 매우 강건한 단조성을 인해 의사결정단위 간 명확한 순위 구분도 용이하다. 따라서 본 연구에서는 자료포락분석 모형 중 RAM 모형과 토빗 회귀분석이 결합된 2단계 접근법을 활용해서 범부처전기신약개발사업을 중심으로 신약개발 분야의 국가연구개발사업들에 대한 효율성을 분석하고 주요 시사점들을 논의하였다.

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Spray and Combustion Characteristics of a Dump-type Ramjet Combustor

  • Lee, Choong-Won;Moon, Su-Yeon;Sohn, Chang-Hyun;Youn, Hyun-Jin
    • Journal of Mechanical Science and Technology
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    • v.17 no.12
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    • pp.2019-2026
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    • 2003
  • Spray and combustion characteristics of a dump-type ram-combustor equipped with a V-gutter flame holder were experimentally investigated. Spray penetrations with a change in airstream velocity, air stream temperature, and dynamic pressure ratio were measured to clarify the spray characteristics of a liquid jet injected into the subsonic vitiated airstream, which maintains a highly uniform velocity and temperature. An empirical equation was modified from Inamura's equation to compensate for experimental conditions. In the case of insufficient penetration, the flame in the ram-combustor was unstable, and vice versus in the case of sufficient penetration. When the flame holder was not equipped, the temperature at the center of the ram-combustor had a tendency to decrease due to the low penetration and insufficient mixing. Therefore, the temperature distribution was slanted to the low wall of the ram-combustor. These trends gradually disappeared as the length of the combustor became longer and the flame holder was equipped. Combustion efficiency increased when the length of the combustor was long and the flame holder was equipped. Especially, the effect of the flame holder was more dominant than that of the combustor length in light of combustion efficiency.