• Journal of Environmental Health Sciences
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• v.40 no.5
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• pp.385-396
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• 2014

Objectives: By conducting a meta-analysis of cohort studies reporting standardized mortality ratios (SMRs) for workers exposed to trichloroethylene, we attempted to adjust for healthy hired effect by applying the same methods as described in a recent report from the Agricultural Health Study. Methods: Among all cohort studies that evaluated the association between all cancer, non-Hodgkin's lymphoma (NHL), kidney cancer, liver cancer and occupational exposure to trichloroethylene, a total of 10 studies reporting SMR values were selected. A random-effects model was used to estimate the summary SMRs or rSMRs and 95% confidence intervals. Relative SMR ($rSMR=SMR_x/SMR_{not\;x}$) was calculated comparing observed and expected counts for all cancer, NHL, kidney cancer, and liver cancer with an independent referent set of values consisting of the observed and expected counts for other causes. Results: The SMR values for all causes ranged from 0.68 to 1.03, suggesting moderate to weak healthy worker effect for the selected studies. When the healthy worker hire effect was taken into account, the summarized risk became statistically significant; the summary SMR of all cancer was 0.95 (0.91-1.00) and the summary rSMR of all cancer was 1.10 (1.04-1.15). The summary SMR of NHL was 1.04 (0.93-1.14) and the summary rSMR of NHL was 1.23 (1.04-1.46). The summary SMR of kidney cancer was 1.08 (0.88-1.33) and the summary rSMR of kidney cancer was 1.23 (1.02-1.49). The summary SMR of liver cancer was 0.88 (0.78-0.99), and the summary rSMR of liver cancer was 0.95 (0.84-1.07). Conclusion: The rSMR method is useful to determine summary risk adjusted for healthy worker effect through meta-analysis.

• Proceedings of the Korea Information Processing Society Conference
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• 2004.11a
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• pp.129-132
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• 2004

공간 색인구조는 공간 데이터를 효율적으로 관리하기 위한 도구로써, GIS와 같은 공간 데이터베이스의 성능을 결정하는 중요한 요소라 하겠다. 대부분의 응용분야에서 공간 데이터베이스는 보조기억장치에 저장된 방대한 양의 공간데이터 처리를 요구하므로 디스크 접근의 수를 줄이는 것이 전체 데이터베이스의 성능을 향상시키는데 중요한 요소이다. 이 논문에서는 SMR-tree라는 공간색인구조의 여러 응용분야에서 활용 가능성을 기존의 색인구조들과의 비교를 통해 확인한다. SMR-tree는 R-tree 계열의 구조로써 기존의 R-tree계열의 구조들과 동일한 노드의 형태를 가지고 있으나, 여러 개의 data space를 사용하여 data object를 배분함으로써 $R^{+}-tree$의 말단노드 내에 존재하는 잉여공간을 제거하면서 R-tree의 단점인 색인노드들 사이에 중첩을 허용치 않는다. SMR-tree의 성능은 여러 종류의 테스트 데이터(VLSI layout data, Tiger/Line file data)를 사용하여 R-tree, $R^{+}-tree,\;R^{\ast}-tree$와 비교된다. SMR-tree는 높은 공간 활용도와 다른 색인구조에 비해 빠른 질의 성능을 보임으로써 GIS와 같은 공간 데이터베이스를 위한 효율적인 색인구조로 사용이 될 것으로 기대된다.

• Journal of the Korea Institute of Military Science and Technology
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• v.12 no.1
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• pp.70-79
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• 2009

Currently, the investment on Research and Development(R&D) for defense core technology is continuously increasing to maintain advanced country's R&D level. In accordance with this trend, the national defense R&D investment management system is being more strengthening, and importance of performance evaluation is being emphasized more and more. However, the existing indicators of performance evaluation for defense core technology R&D is limited in efficient management because of the qualitative evaluation items and subjective allocation of points. In this paper, we developed a novel indicator for defense core technology R&D performance evaluation through domestic and foreign related literature and inquiry, brainstorming, and analysis techniques by Stepwise Multiple linear Regression(SMR) and Analytic Hierarchy Process(AHP). And we verified effectiveness of proposed indicators of performance evaluation by comparing with the existing evaluation indicators. Our proposed indicators for performance evaluation will create superiority performance on defense R&D fields.

• Journal of fish pathology
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• v.36 no.2
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• pp.379-388
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• 2023

Experiments were performed to investigate hypoxia tolerance with body size of red seabream (Pagrus major) at 24℃. The rate of oxygen consumption was measured at an interval of 10 min using automated intermittent-flow respirometry. The weight-specific standard metabolic rate (SMR, mg O₂ kg^-1hr^-1) and critical oxygen saturation (S_crit, % air saturation) of the fish were measured under normoxic condition and progressive hypoxia with 0.6-786 g of fish weight (W), respectively. SMR typically decreased with increasing body weight based on SMR=351.59·W^-0.195 (r²=0.934). S_crit was higher in larger fish than those of smaller fish in the range of 17.3-24.4%. The result of this study suggests that the smaller seabream can withstand in hypoxic waters better than the larger ones.

• The Korea Journal of Herbology
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• v.25 no.2
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• pp.71-79
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• 2010

Objectives : In this study, the neuroprotective effects of modified Boyanghwano-Tang (mBHT) and the major medicinal plants, Astragali Radix(AR) and Salviae Miltiorrhizae Radix(SMR) were investigated in transient middle cerebral artery occlusion (tMCAO)-induced ischemic stroke of rats. Methods : mBHT(400 mg/kg) and AR(154 mg/kg) or SMR(62 mg/kg) water extract orally injected in rats after 90 min occlusion of MCA and then allow reperfusion to 24 h. Brain infarction was measured by TTC staining and the expressions of NOS isoforms and apoptotic molecules were determined in ischemic brain by Western blot. Results : The results showed that mBHT has stronger neuropreotective property through inhibitions of the PARP cleaved and caspase-3 activation in ischemic rats, and could reduced infarction volumes comparison of those of AR or SMR, respectively. While, AR extract has an angiogenic property through increasing the expressions of eNOS and VEGF, and SMR extract has a strong anti-inflammatory effects through inhibition of iNOS expression in ischemic brains. Conclusions : These results suggest that mBHT has multifactorial therapeutic advantages through anti-apoptosis, anti-inflammation and angiogenesis for ischemic stroke based on a synergistic combination of ingradients rather than monotherapy.

• Transactions of the Korean hydrogen and new energy society
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• v.33 no.5
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• pp.499-506
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• 2022

This study proposes kinetic parameters of Ru catalyst for steam methane reforming (SMR). First, extensive experiments are performed under different SMR conditions to evaluate performance of the catalyst in SMR. Second, a kinetic model is designed and developed for parameter estimation and validation using gPROMS. Finally, estimated parameters are fitted to the kinetic model and then, the model results are compared with the experimental data. The model results are in a good agreement with the experimental data.

• Journal of the Korean Society of Safety
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• v.20 no.2 s.70
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• pp.32-37
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• 2005

The purpose of this study is for the sensitivity study f9r a Steam Generator Tube Rupture (SGTR) of the System-integrated Modular Advanced ReacTor for a Pilot (SMART-P) plant. The thermal hydraulic analysis of a SGIR for the Limiting Conditions for Operation (LCO) is performed using TASS/SMR code. The TASS/SMR code can calculate the core power, pressure, flow, temperature and other values of the primary and secondary system for the various initiating conditions. The major concern of this sensitivity study is not the minimum Critical Heat Flux Ratio(CHFR) but the maximum leakage amount from the primary to secondary sides at the steam generator. Therefore the break area causing the maximum accumulated break flow is researched for this reason. In the case of a SGIR for the SMART-p, the total integrated break flow is 11,740kg in the worst case scenario, the minimum CHFR is maintained at Over 1.3 and the hottest fuel rod temperature is below 606"I during the transient. It means that the integrity of the fuel rod is guaranteed. The reactor coolant system and the secondary system pressures are maintained below 18.7MPa, which is system design pressure.

• Nuclear Engineering and Technology
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• v.56 no.3
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• pp.993-1001
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• 2024

The TANDEM project is a European initiative funded under the EURATOM program. The project started on September 2022 and has a duration of 36 months. TANDEM stands for Small Modular ReacTor for a European sAfe aNd Decarbonized Energy Mix. Small Modular Reactors (SMRs) can be hybridized with other energy sources, storage systems and energy conversion applications to provide electricity, heat and hydrogen. Hybrid energy systems have the potential to strongly contribute to the energy decarbonization targeting carbon-neutrality in Europe by 2050. However, the integration of nuclear reactors, particularly SMRs, in hybrid energy systems, is a new R&D topic to be investigated. In this context, the TANDEM project aims to develop assessments and tools to facilitate the safe and efficient integration of SMRs into low-carbon hybrid energy systems. An open-source "TANDEM" model library of hybrid system components will be developed in Modelica language which, by coupling, will extend the capabilities of existing tools implemented in the project. The project proposes to specifically address the safety issues of SMRs related to their integration into hybrid energy systems, involving specific interactions between SMRs and the rest of the hybrid systems; new initiating events may have to be considered in the safety approach. TANDEM will study two hybrid systems covering the main trends of the European energy policy and market evolution at 2035's horizon: a district heating network and power supply in a large urban area, and an energy hub serving energy conversion systems, including hydrogen production; the energy hub is inspired from a harbor-like infrastructure. TANDEM will provide assessments on SMR safety, hybrid system operationality and techno-economics. Societal considerations will also be encased by analyzing European citizen engagement in SMR technology safety.

• Journal of Korean Academy of Nursing
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• v.35 no.1
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• pp.47-55
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• 2005

Purpose: This study was to evaluate the validity of the Pediatric Index of Mortality Ⅱ(PIM Ⅱ). Method: The first values on PIM Ⅱ variables following ICU admission were collected from the patient's charts of 548 admissions retrospectively in three ICUs(medical, surgical, and neurosurgical) at P University Hospital and a cardiac ICU at D University Hospital in Busan from January 1, 2002 to December 31, 2003. Data was analyzed with the SPSSWIN 10.0 program for the descriptive statistics, correlation coefficient, standardized mortality ratio(SMR), validity index(sensitivity, specificity, positive predictive value, negative predictive value), and AUC of ROC curve. Result: The mortality rate was 10.9% (60 cases) and the predicted death rate was 9.5%. The correlation coefficient(r) between observed and expected death rates was .929(p<.01) and SMR was 1.15. Se, Sp, pPv, nPv, and the correct classification rate were .80, .96, .70, .98, and 94.0% respectively. In addition, areas under the curve (AUC) of the receiver operating characteristic(ROC) was 0.954 (95% CI=0.919～0.989). According to demographic characteristics, mortality was underestimated in the medical group and overestimated in the surgical group. In addition, the AUCs of ROC curve were generally high in all subgroups. Conclusion: The PIM Ⅱ showed a good, so it can be utilized for the subject hospital. better.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.14
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• pp.6081-6087
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• 2015

Purpose: This study aimed to investigate the incidence and mortality of breast cancer, and its relationship with human development index (HDI) and its components in Asia in 2012. Materials and Methods: This study was an ecologic study in Asia for assessment of the correlation between age-specific incidence rate (ASIR) and age-specific mortality rate (ASMR) with HDI and its details that include: life expectancy at birth, mean years of schooling and gross national income (GNI) per capita. Data about SIR and SMR for every Asian country for the year 2012 were obtained from the global cancer project. We used a bivariate method for assessment of the correlation between SIR and SMR and HDI and its individual components. Statistical significance was assumed if P<0.05. All reported P-values are two-sided. Statistical analyses were performed using SPSS (Version 15.0, SPSS Inc.). Results: In 2012, 639,824 cases of breast cancer were recorded in Asian countries. Countries with the highest standardized incidence rate (ASIR) (per 100,000) were Israel (80.5), Lebanon (78.7), Armenia (74.1) and the highest standard mortality rate (ASMR) was observed in Pakistan (25.2), Armenia (24.2), and Lebanon (24). There was a positive correlation between the ASIR of breast cancer and HDI (r = 0.556, p <0.001), whereas there was a negative correlation between the ASMR of breast cancer and HDI (r = -0.051). Conclusions: Breast cancer incidence in countries with higher development is greater, while mortality is greatest in countries with less development. There was a positive and significant relationship between the ASIR of breast cancer and HDI and its components. Also there was a negative but non significant relationship between the ASMR of breast cancer and HDI.