• 약학회지
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• 제35권3호
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• pp.182-189
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• 1991

Systematic study on the extraction of ion pair by the use of picric acid (PCA) as an ion pair forming reagent to the aliphatic amines has not be done by spectrophotometric method. The extraction of ion pair by the use of PCA and 23 kinds of the aliphatic amines was examined. The procedure is as follows; Elving's buffer solution (pH 1.3~10, ionic strength 0.5) each amine solution, and PCA solution were taken into a test tube. The mixture was shaken mechanically with chlorform. The organic phase was filtered through a filter paper to remove water droplets. The absorbance was examined at $\lambda_{max}$ against a reagent blank. Primary and secondary whose carbon number were more than 7 or 6, respectively, are extractable as ion pairs with PCA, while tertiary amines and quaternary ammonium salts are also extractable without the correlation of carbon number. It was considered that the ion pair extraction of primary and secondary amines was affected by the number of carbon of amines, but its extraction of tertiary amines or quaternary ammonium salts was affected by kind of aliphatic amines rather than pKa values or carbon number of amines.

• 약학회지
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• 제18권3호
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• pp.197-202
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• 1974

The data pf dosspcoatopm cpmstamts for aliphatic amines and quaternary ammonium-methylorange salts are based on the electrosatic theory of conductance. Dissociation constants for primary amines nad quaternary ammonium-methylorange salts (1$\times$10$^{-5}$~1$\times$10$^{-3}$ M) in nitrobenzene solution or water solution was evaluated from the relation of the concentration and the electric conduction and the electric conductance at $25^{\circ}C$ Plots of ${\delta}C$ against reciprocal conductance were linear ; hence the center-to-center distance of this salt was 1.75 $\AA$ in nitrobenzene solution.

• 약학회지
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• 제35권1호
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• pp.15-21
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• 1991

Quaternary amines which are widely used as medicines are nitrogen compounds. Metanil yellow(MY) and benzalkonium chloride(BKC) were mixed and added to 10ml of the buffer solution and then the solution was shaken for 5 minutes. The maximum absorption wavelength of the reaction product was 402 nm. Dichloromethane was the best extracting solvent among the several organic solvents and the most suitable pH range was 2~8. When the BKC-MY calibration curve was made in the best experimental condition, the Lambert-Beer's law was obeyed in the range of BKC concentration of 2$\times$$10^{-6}$~9$\times$$10^{-6}$M by UV spectrophotometer. This method was possible to determine quaternary ammonium salts in the pharmaceutical preparation.

• 분석과학
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• 제20권3호
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• pp.255-260
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• 2007

A new method for the simultaneous determination of low molecular weight amines and quaternary ammonium ions based on the separation by IC with a suppressor and the detection by MS with ESI has been developed. The method has been applied to the analysis of a mixture containing tetramethylammonium ion, tetraethylammonium ion, tetrapropylammonium ion, triethanolamine, trimethylamine and triethylamine. The constituents were separated by isocratic elution using an IonPac CS17 column, a cation-exchange column, and detected by conductivity and mass spectrometry. The newly developed method for the six components demonstrated that the repeatability in terms of relative standard deviation for three measurements was in the range of 0.1-0.5 %. The detection limits were between 0.2 and $0.9{\mu}g/mL$ by the IC/ESI-MS.

• 분석과학
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• 제10권4호
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• pp.231-239
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• 1997

역상 이온쌍 고성능 액체크로마토그래피에 의해 3차 아민들과 4차 암모늄염들을 분리하고 정량하였다. 시료들은 간접분광광도법에 의해 검출하였다. 검출 시약과 이온쌍 시약으로는 염화벤질 트리메틸암모늄(BTMACl)과 도데실황산나트륨(DDSANa)을 사용하였다. 전해커패시터의 전해액 중에 포함되어 있는 이들 아민과 암모늄염의 분리 및 정량은 메탄올-물(40:60) 용액에 DDSANa를 0.010M, BTMACl을 0.004M 되게 용해시키고 염화암모늄-암모니아 완충용액(0.05M)으로 pH를 8.5되게 만든 용리액으로 Supelco LC-18이나 ${\mu}$-Bondapak phenyl 컬럼을 통하여 용리시킴으로써 가능하였다. 전해 커패시터들의 전해액을 분석하여 얻은 분석 값의 4차 암모늄염을 첨가하여 만든 커패시터는 임피던스 0.08~0.13의 성능이 우수한 커패시터가 됨도 발견함으로써 분석이 잘 이루어 졌음을 확인하였다.

• 공업화학
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• 제17권3호
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• pp.286-290
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• 2006

새로운 4급 염화 암모늄염, {alkyldimethyl-[5-(2-phenylthiazol-4-yl]-1,3,4-oxadiazol-2-ylmethyl]quaternary ammonium chlorides (ADOQACs): 6}을 화합물 5와 몇 가지 N,N-dimethylalkyl amine을 반응시켜 합성하였다. 합성한 화합물들의 구조와 물리적 특성을 조사하였고 계면활성을 측정하였다. 화합물 6의 표면장력($\gamma_{cmc}$)과 최소저해농도(MIC)는 알킬기의 영향을 받은 것으로 나타났으며, 특히 화합물 6c와 6d가 좋은 항균력과 계면활성을 보였다.

• 통합자연과학논문집
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• 제10권4호
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• pp.175-191
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• 2017

In organic chemistry amide synthesis is performed through condensation of a carboxylic acid and an amine with releasing one equivalent of water via the corresponding ammonium carboxylate salt. This method is suffering from tedious processes and poor atom-economy due to the adverse thermodynamics of the equilibrium and the high activation barrier for direct coupling of a carboxylic acid and an amine. Most of the chemical approaches to amides formations have been therefore being developed, they are mainly focused on secondary amides. Direct carbonylations of tertiary amines to amides have been an exotic field unresolved, in particular direct carbonylation of trimethylamine in lack of commercial need has been attracted much interests due to the versatile product of N,N-dimethylacetamide in chemical industries and the activation of robust N-C($sp^3$) bond in tertiary amine academically. This review is focused mainly on carbonylation of trimethylamine as one of the typical tertiary amines by transition metals of cobalt, rhodium, platinum, and palladium including the role of methyl iodide as a promoter, the intermediate formation of acyl iodide, the coordination ability of trimethylamine to transition metal catalysts, and any possibility of CO insertion into the bond of Me-N in trimethylamine. In addition reactions of acyl halides as an activated form of acetic acid with amines are reviewed in brief since acyl iodide is suggested as a critical intermediate in those carbonylations of trimethylamine.

• 약학회지
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• 제31권2호
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• pp.45-51
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• 1987

Methyl orange(MO) and cetyltrimethylammonium bromide(CTA) were mixed and added to 10ml of the buffer solution and then the solution was shaken for 5 minutes. The maximum absorption wavelength of the reaction product was 419nm. Dichloromethane was the best extracting solvent among the several organic solvents and the most suitable pH range was 2~8. When the CTA-MO calibration curve was made in the best experimental condition, the Lambert-Beer's law was obeyed in the range of CTA concentration of $1.5\times$$10^{-5}$~1.0$\times$$10^{-4}M$ by UV spectrophotometer. This method was possible to determine quaternary ammonium salts in the pharmaceutical preparations.

• 방사선산업학회지
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• 제6권1호
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• pp.49-54
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• 2012

Various anion exchange membranes were prepared by radiation graft copolymerization of vinylbenzyl chloride onto fluorinated films and subsequent quaternization with various tertiary amines such as trimethylamine, N,N-dimethylbuthylamine, N,N-dimethylaniline, and N-methylpiperidine. The quaternizations of the anion exchange membranes were confirmed by measuring of the ion exchange capacities of the membranes. The mechanical properties and the water uptakes were also measured. The elongation at break was found to be largely dependent on the fluorinated film, the quateranry ammonium, and the degree of grafting. The results indicate that the poly (ethylene-alt-tetrafluoroethylene) with quaternized trimethylamine moiety exhibits higher flexible property compared to the other prepared anion exchange membranes.

• 대한화학회지
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• 제36권6호
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• pp.933-940
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• 1992

Calix[6]arene을 포름알데히드와 이차아민과 반응시키면 물에 녹는 칼릭세린 염기가 얻어진다. 이를 메틸요오드로 처리하여 암모늄 염을 만들고 다양한 친핵성 물질과 반응시키면 칼릭세린의 파라위치에 작용기가 포함된 calix[6]arene이 얻어진다. Calix[6]arene도 포름알데히드와 이차의 아릴아민과 반응시켜 물에 녹는 칼릭세린 아민을 만들었다. 이렇게 합성된 칼릭세린중 물에 녹는 아민과 산기가 포함된 calix[6]arene과 calix[8]arene을 운반체로 이용하여 중성의 방향족 물질들을 통과시키는 연구를 U 형태의 유리관을 이용하여 수행하였다. 방향족 기질들로는 나프탈렌, 안트라센, 파이렌, 풀우란텐 등의 고체물질을 사용하였다.