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Synthesis and Surface Activity of New Quaternary Ammonium Salts Prepared from 2-Chloromethyl-5-(2-Phenylthiazol-4-yl)-1,3,4-Oxadiazole  

Bae, Sun Kun (School of Science and Technology, Kunsan National University)
Yeon, Young Heum (School of Science and Technology, Kunsan National University)
Publication Information
Applied Chemistry for Engineering / v.17, no.3, 2006 , pp. 286-290 More about this Journal
Abstract
New quaternary ammonium chlorides, [alkyldimethyl-[5-(2-phenylthiazol-4-yl]-1,3,4-oxadizol-2-ylmethyl]quaternary ammonium chlorides (ADOQACs): 6] were obtained with high yields by the reaction of compound 5 with N,N-dimethylalkyl amines in isopropyl alcohol. The structures and physical properties of the synthesized compounds were investigated and those surface-active properties were measured. The surface tension ($\gamma_{cmc}$) and the minimal inhibitory concentration (MIC) of compound 6 were found to be influenced by the number of alkyl chain carbon. Especially, compounds 6c and 6d exhibited high anti-bacterial activities and good surface-active properties.
Keywords
1,3,4-oxadiazole; surfactant; minimal inhibitory; anti-bacterial activity;
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