YAKHAK HOEJI (약학회지)
- Volume 35 Issue 1
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- Pages.15-21
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- 1991
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Spectrophotometric Determination of Ion Pair Extraction of Quaternary Amines with Metanil Yellow
Metanil Yellow에 의한 4급 Amine류의 Ino Pair 추출 흡광도 정량 (II) - Benzalkonium Chloride, Cetylpyridinium Chloride 및 Dimenhydrinate의 정량
Abstract
Quaternary amines which are widely used as medicines are nitrogen compounds. Metanil yellow(MY) and benzalkonium chloride(BKC) were mixed and added to 10ml of the buffer solution and then the solution was shaken for 5 minutes. The maximum absorption wavelength of the reaction product was 402 nm. Dichloromethane was the best extracting solvent among the several organic solvents and the most suitable pH range was 2~8. When the BKC-MY calibration curve was made in the best experimental condition, the Lambert-Beer's law was obeyed in the range of BKC concentration of 2