• The Korean Journal of Physiology and Pharmacology
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• v.17 no.6
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• pp.511-516
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• 2013

Bladder cancer is the seventh most common cancer in men that smoke, and the incidence of disease increases with age. The mechanism of occurrence has not yet been established. Potassium channels have been linked with cell proliferation. Some two-pore domain $K^+$ channels (K2P), such as TASK3 and TREK1, have recently been shown to be overexpressed in cancer cells. Here we focused on the relationship between cell growth and the mechanosensitive K2P channel, TREK2, in the human bladder cancer cell line, 253J. We confirmed that TREK2 was expressed in bladder cancer cell lines by Western blot and quantitative real-time PCR. Using the patch-clamp technique, the mechanosensitive TREK2 channel was recorded in the presence of symmetrical 150 mM KCl solutions. In 253J cells, the TREK2 channel was activated by polyunsaturated fatty acids, intracellular acidosis at -60 mV and mechanical stretch at -40 mV or 40 mV. Furthermore, small interfering RNA (siRNA)-mediated TREK2 knockdown resulted in a slight depolarization from $-19.9mV{\pm}0.8$ (n=116) to $-8.5mV{\pm}1.4$ (n=74) and decreased proliferation of 253J cells, compared to negative control siRNA. 253J cells treated with TREK2 siRNA showed a significant increase in the expression of cell cycle boundary proteins p21 and p53 and also a remarkable decrease in protein expression of cyclins D1 and D3. Taken together, the TREK2 channel is present in bladder cancer cell lines and may, at least in part, contribute to cell cycle-dependent growth.

• Journal of Science Education
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• v.37 no.3
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• pp.513-524
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• 2013

The purpose of this study is to provide the proper methods of presenting question materials for generate of various question by comparing type, level, objectivity, manipulation of question in the presenting methods of question phenomena. I selected and showed actual objects, movies, and photographs as ways of presenting question materials, to each of which three question tasks were assigned. The generated questions by students were compared. The results showed that the question of conjectural, predictive, methodological, exploratory, verificational, qualitative, quantitative, simple-manipulative, pre-manipulative questions turned out to have significantly higher average frequencies in the cases of the presentation of photographs and movies than in the cases of the presentation of actual objects. However, the question of post-manipulative questions turned out to have significantly higher average frequencies in the cases of the presentation of actual objects than in the cases of the presentation of photographs and movies. and There were no significant differences between individual methods of question task presentation in average frequencies with respect to causal and methodological, subjective questions. Thus, we have learned from this that methods of presenting question phenomena had influence on the students' question. This suggests that we should consider forms of presentation of question materials in planning the teaching-learning of question.

• The Korean Journal of Food And Nutrition
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• v.19 no.1
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• pp.62-69
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• 2006

This study was performed to investigate the biocogical activity of the phospholipid separated and purified from duck egg yolk as functional brain food. A quantitative restriction of maternal diet was given to Sprague-Dawely rats during lactation. Animals were separated into three groups, such as control, duck egg phospholipid(PL) or pig-brain phospholipid additions groups. And ad libitum during lactation was given to control groups. All of the offsprings at 3 weeks of age fed a diet ad libitum for 4 weeks of rehabilitation. Body weight and brain weight and protein, phosphplipid, and cholesterol were determined on offsprings of each of group sacrificed at 0, 1, 2, 3, 5 and 7 weeks of age, sacrified body weight of duck egg phospholipid and pig brain phospholipid group were significantly higher than the control group. Body weight and brain weight after a recovery period were significantly at the control group. However, protein, phospholipid and cholesterol contents were significantly high than the control group. Response latency in the passive avoidance task was the lowest in the ${\beta}$-amyloid group and highest in the phospholipid group. It is consequently suggested that phospholipid supplement may be effective in memory improvement.

• The KIPS Transactions:PartD
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• v.10D no.5
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• pp.859-872
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• 2003

Class hierarchies often constitute the backbone of object-oriented software. Their quality is therefore quite crucial. Building class hierarchies with good qualify is a very important and common tasks on the object oriented software development, but such hierarchies are not so easy to build. Moreover, the class hierarchy structure under construction is frequently restructured and refined until it becomes suitable for the requirement on the iterative and incremental development lifecycle. Therefore, there has been renewal of interest in all methodologies and tools to assist the object oriented developers in this task. In this paper, we define a set of quantitative metrics which provide a wav of capturing features of a rough estimation of complexity of class hierarchy structure. In addition to, we suggest a set of algorithms that transform a original class hierarchy structure into reorganized one based on the proposed metrics for class hierarchy structure. Furthermore, we also prove that each algorithm is "object-preserving". That is, we prove that the set of objects are never changed before and after applying the algorithm on a class hierarchy. The technique presented in this paper can be used as a guidelines of the construction, restructuring and refinement of class hierarchies. Moreover, the proposed set of algorithms based on metrics can be helpful for developers as an useful instrument for the object-oriented software development.velopment.

• Journal of Technology Innovation
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• v.27 no.4
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• pp.21-48
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• 2019

In the basic research field, quantitative expansion is carried out with active support from the government, but there is no research and policy data suggesting systematic investment plans or data-based financial requirements yet. Therefore, this study predicted future financial requirements of basic research support programs by using time series prediction model. In order to consider various factors including the characteristics of the basic research field, we selected the ARIMAX model which can reflect the effect of multi valuable factors rather than the ARIMA model which predicts the value of single factor over time. We compared the predictions of ARIMAX and ARIMA models for model suitability and found that the ARIMAX model improves the prediction error rate. Based on the ARIMAX model, we predicted the fiscal spending of basic research support programs for five years from 2017 to 2021. This study has significance in that it considers the financial requirements of the basic research support programs as a pilot research conducted by applying a time series model, which is a statistical approach, and multi-variate rather than single-variate. In addition, considering the policy trends that emphasize the importance of basic research investment such as 'the expansion of basic research budget twice', which is the current government's national policy task, it can be used as reference data in establishing basic research investment strategy.

• Magazine of the Korean Society of Agricultural Engineers
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• v.29 no.3
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• pp.125-137
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• 1987

The purpose of this paper is to examine some difficulties in water management of agricultural reservoirs in Korea, for there are approximately more than 15,000 reservoirs which are now being utilized for the purpose of irrigation, along with the much amount of expenses and labors to be invested against droughts and floods periodically occurred. Recently, the effective use of water resources in the agricultural reservoirs with a single purpose, is becomming multiple according to the alterable environment of water use. Therefore, the task to allocate agricultural water rationally and economically must be solved for the multiple use of agricultural reservoirs. On the basis of the above statement, this study aims at suggesting the rational method of water management by introducing an optimal technique to allocate the water in an existing agricultural reservoir rationally, for the sake of maximizing the economic effect. To achieve this objective, a reservoir, called "0-Bongje" as a sample of the case study, is selected for an agricultural water development proiect of medium scale. As a model for the optimum allocation of water in the multi-purpose use of reservoirs a linear programming model is developed and analyzed. As a result, findings of the study are as follows : First, a linear programing model is developed for the optimum allocation of water in the multi-purpose use of agricultural reservoirs. By adopting the model in the case of reservoir called "O-Bongje," the optimum solution for such various objects as irrigation area, the amount of domestic water supply, the size of power generation, and the size of reservoir storage, etc., can be obtained. Second, by comparing the net benefits in each object under the changing condition of inflow into the reservoir, the factors which can most affect the yearly total net benefit can be drawn, and they are in the order of the amount of domestic water supply, irrigation area, and power generation. Third, the sensitivity analysis for the decision variable of irrigation which may have a first priority among the objects indicate that the effective method of water management can be rapidly suggested in accordance with a condition under the decreasing area of irrigation. Fourth, in the case of decision making on the water allocation policy in an existing multi-purpose reservoir, the rapid comparison of numerous alternatives can be possible by adopting the linear programming model. Besides, as the resources can be analyed in connection with various activities, it can be concluded that the linear programing model developed in this study is more quantitative than the traditional methods of analysis. Fifth, all the possible constraint equations, in using a linear programming model for adopting a water allocation problem in the agricultural reservoirs, are presented, and the method of analysis is also suggested in this study. Finally, as the linear programming model in this study is found comprehensive, the model can be adopted in any different kind of conditions of agricultural reservoirs for the purpose of analyzing optimum water allocation, if the economic and technical coefficients are known, and the decision variable is changed in accordance with the changing condition of irrigation area.

• 대한공업교육학회지
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• v.39 no.2
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• pp.122-143
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• 2014

The purpose of this research were to develop program of elementary school technology education using history of technology and to learn about its effect. In order to accomplish the purpose of the research, we developed the program by referring to various records and perform the qualitative experiment study through several questionnaire, pictures and materials, to learn about the program effect. The research took the mixed-model design, consisted of collection of quantitative data by Likert scale and collection of qualitative data including the open-ended questions. And the research results were as below. First, development of elementary school technology education program using history of technology was developed as program for 12 hours, 12 themes, for the elementary levels. Second, seeing the result of program of elementary school technology education using history of technology, the program for history of technology for the primary school students, a majority of answers showed high satisfaction about the program, giving answers such as 'I want to do it again following hands on minds on activity.' Third, according to the analysis on the qualitiative evidence of the program, students were found to take pictures with hands on minds on activity camera obscura with much interest and curiosity. Many students are seen to complete the task on their own with a great a look of self-satisfaction, understanding the principle of camera.

• The Journal of the Korea Contents Association
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• v.15 no.8
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• pp.389-396
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• 2015

The liver fibrosis is a disease we often see in clinical medicine, and the persistence and repeatition of inflammation and necrosis of liver cells continue for several years, and it is proceeded to cirrhosis. So decrease of death rate and prevalence rate by complications of cirrhosis and hepatocellular carcinoma is main task of clinical medicine by protection of chronic liver ailment patients from proceeding to cirrhosis and hepatocellular carcinoma. So this study tried to represent the ultrasonic image, blood test, the relationship with liver stiffness of diffuse liver ailment patients as numbers. This study was performed with patients from whom the image was taken by ultrasonic and 141 people who were treated by fibroscan, the basic data for blood test was obtained from the test results at the time when ultrasonic image and liver fibroscan was performed. The statistical analysis was performed by One-way analysis of variance(ANOVA) to verify difference between groups. The value of liver stiffness was increased in the order of normal, chronic liver disease and cirrhosis. As a results, ALT and Albumin have no statistical difference between object groups, and there are statistical differences in the results of ultrasonic decoding at age, AST, ALP, Bilirubin, PLT, PT, and kPa, and they are statistically meaningful(p<0.005). And the value of liver stiffness of chronic liver ailment was presented only as over 12.5kPa in other study, but it was represented as numbers for quantitative diagnosis by presenting average kPa threshold value according to disease in this study. And by presenting relationship of diagnosed results, it is considered that it could be used as first tool to diagnose chronic liver ailment patients according to their disease.

• Safety and Health at Work
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• v.10 no.4
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• pp.482-503
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• 2019

Introduction: A new third version of the Copenhagen Psychosocial Questionnaire (COPSOQ III) has been developed in response to trends in working life, theoretical concepts, and international experience. A key component of the COPSOQ III is a defined set of mandatory core items to be included in national short, middle, and long versions of the questionnaire. The aim of the present article is to present and test the reliability of the new international middle version of the COPSOQ III. Methods: The questionnaire was tested among 23,361 employees during 2016-2017 in Canada, Spain, France, Germany, Sweden, and Turkey. A total of 26 dimensions (measured through scales or single items) of the middle version and two from the long version were tested. Psychometric properties of the dimensions were assessed regarding reliability (Cronbach α), ceiling and floor effects (fractions with extreme answers), and distinctiveness (correlations with other dimensions). Results: Most international middle dimensions had satisfactory reliability in most countries, though some ceiling and floor effects were present. Dimensions with missing values were rare. Most dimensions had low to medium intercorrelations. Conclusions: The COPSOQ III offers reliable and distinct measures of a wide range of psychosocial dimensions of modern working life in different countries; although a few measures could be improved. Future testing should focus on validation of the COPSOQ items and dimensions using both qualitative and quantitative approaches. Such investigations would enhance the basis for recommendations using the COPSOQ III.

• Journal of Technology Innovation
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• v.22 no.2
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• pp.1-30
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• 2014

Offset trade has been applied in Republic of Korea's defense acquisition programs since early 1980s and used for national economic development as well as enhancement of military capabilities. The accumulated offset trade value amounts to over 10 billion dollars by 2010. However, questions in regards to the effectiveness of offset trade have been constantly raised. As it is a quite difficult task to analyze and calculate the application performance of defense technologies acquired by offsets objectively, limited level of quantitative analysis of application performance have been conducted so far. Hence, in this paper, we came to understand the overall status of application of those technologies through in-depth performance analysis and suggested some specific policies for the further development of offset trade based on the analysis results. To begin with, we developed a questionnaire based on performance indicator deducted through literature review of relevant researches, and conducted survey of major offset recipients. Also, another survey of offset experts belonged to the army, government organization, research institute and companies was conducted to evaluate the performance and effectiveness of offsets qualitatively. And we analyzed the efficiency of application performance using DEA. The results of all surveys are showing that there is positive accomplishment in the technological aspect, but in economic aspect, it shows relatively inactive outcome. Based on these results, policy direction is considered to be changed from the emphasis on the acquisition of core technology to revitalization of domestic defense industry in line with new government's policy orientation.