• Applied Biological Chemistry
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• 제51권2호
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• pp.119-123
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• 2008

3-치환된 5,5'-diphenylimidazolidine-2,4-dione 유도체(1-22)들의 fatty acid amide hydrolase (FAAH) 저해활성에 관한 3차원적인 정량적 구조와 활성과의 관계(3D-QSARs)를 비교 분자장 분석(CoMFA)과 비교분자 유사성 지수분석(CoMFA) 방법으로 각각 검토하였다. CoMFA A1 모델과 CoMSIA 2F 모델 모두 상관성과 예측성이 양호하였다. 두 모델의 정보에 의한 등고도에 따라 설계된 X=I, Y=$N_2{^+}$-치환체(P1: $Pred.pI_{50}$=6.55)는 FAAH에 대하여 가장 높은 저해활성을 나타내었다.

• 대한의용생체공학회:의공학회지
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• 제38권6호
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• pp.313-320
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• 2017

Myocardial infarction is a disease caused by stenosis of the coronary arteries. The high risk of sudden cardiac death due to myocardial infarction has triggered related researches that have been actively studied so far. However, these studies focused on the clinical results, which are mainly based on observations of symptoms due to infarction through electrocardiograms. Therefore, in this study, we tried to analyze the behavior of heart according to the position and volume of infarction lesion through the computer simulation study using three dimensional ventricular models. In order to implement infarction, commercial software was used to simulate cell necrosis due to blockage of a specific coronary. In addition, the conduction block due to infarction was mimicked by reducing the electrical conduction in the infarcted area, which was 100 times less than the electrical conduction of the whole ventricular lattice implemented by the finite element analysis method. Thus, this study classified the infarcted cases into the upper, middle, lower, and apex according to lattice data of eight different infraction areas. In other words, we assumed that myocardial infarction would have inherent electro-dynamic characteristics depending on the location and extent, and analyzed the ventricular electromechanical responses for infarction lesions using a three dimensional cardiac physiome model. The results showed that the volume of infarction did not directly affect the cardiac responses, but the location of the infarction lesions could influence the ventricular pumping efficiency. These suggest that the occlusion of specific coronary arteries may have a fatal effect on the decline in ventricular performance. In conclusion, although location of myocardial infarction lesions is considered to be an important variable to be considered clinically rather than lesion size, quantitative predictions should be made more in the future considering physiological factors such as lesion location and direction of myocardial fiber at that location.

• Nutrition Research and Practice
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• 제12권5호
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• pp.443-448
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• 2018

BACKGROUND/OBJECTIVES: This study was conducted to investigate the effects of sodium-potassium ratio on insulin resistance and sensitivity in Korean adults. SUBJECTS/METHODS: Subjects were 3,722 adults (1,632 men and 2,090 women) aged 40-69 years participating in the Korean genome and epidemiology study_Ansan and Ansung study. Insulin resistance was assessed using homeostasis model assessment of insulin resistance (HoMA-IR) and fasting insulin, and insulin sensitivity was assessed by using the quantitative insulin sensitivity check index (QUICKI). The 24-h urinary sodium and potassium excretion were estimated from spot urinary samples using the Tanaka formula. The generalized linear model was applied to determine the association between urinary sodium-potassium ratio and insulin resistance. RESULTS: HoMA-IR (P-value = 0.029, P-trend = 0.008) and fasting insulin (P-value = 0.017, P-trend = 0.005) levels were positively associated with 24-h estimated urinary sodium-potassium ratio in the multivariable model. QUICKI was inversely associated with 24-h estimated urinary sodium-potassium ratio in all models (P-value = 0.0002, P-trend < 0.0001 in the multivariate model). CONCLUSION: The present study suggests that high sodium-potassium ratio is related to high insulin resistance and low insulin sensitivity. Decreasing sodium intake and increasing potassium intake are important for maintaining insulin sensitivity. Further studies are needed to confirm these findings in longitudinal studies.

• Journal of Nutrition and Health
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• 제53권4호
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• pp.356-368
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• 2020

Purpose: Histidine-containing dipeptides, which are rich in chicken, have been reported to reduce the risk of metabolic abnormalities via anticarbonylation mechanism in animal models. To determine the effect of dietary histidine-containing dipeptides on metabolic risk factors in humans, the relation between chicken consumption and insulin resistance were determined in a population consuming high carbohydrate and low protein. Methods: A total of 7,183 subjects (2,929 men and 4,254 women) aged ≥ 50 years from the Korea National Health and Nutrition Examination Survey (KNHANES) were divided into three groups according to chicken consumption (rarely, monthly, and weekly), and evaluated for the metabolic risk factors using homeostasis model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) in this cross-sectional study. The fourth and fifth (IV-1-3 & V-1) KNHANES, which had blood insulin data, were chosen for the current study. Results: The chicken consumption was significantly associated with insulin (p for trend = 0.018) and HOMA-IR (p for trend = 0.023) in men. In particular, the 'weekly' chicken consuming men in the lowest tertile (< 65.0%) of carbohydrate intake group had significantly lower HOMA-IR (p for trend = 0.033) and higher QUICKI (p for trend = 0.043) than the 'rarely' intake group. In addition, the odds ratio for abnormal HOMA-IR was 0.55 (95% confidence interval [CI], 0.31-0.99) and QUICKI was 0.47 (95% CI, 0.26-0.86) for the 'weekly' chicken consuming group. Conclusion: The 'weekly' chicken consumption had a beneficial effect on insulin resistance and it may partially be due to the major bioactive components in chicken, histidine-containing dipeptides.

• 한국항해항만학회지
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• 제27권5호
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• pp.493-498
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• 2003

선박충돌사고는 많은 원인이 서로 복잡하게 상호작용을 하여 발생하고 있으며, 특히 인적요인에 의한 충돌사고가 가장 큰 비중을 차지하고 있다. 이러한 선박충돌사고 원인분석은 선박의 안전 운항상의 측면에서 매우 중요하다고 할 수 있다. 따라서 본 연구의 목적은 시스템 다이내믹스법을 이용하여 선박충돌사고 인적요인 모델을 구축하고, 선박충돌사고를 감소시키기 위한 가장 효과적인 대책을 수립하기 위한 정책요소를 제시하고자 한다. 본 연구의 수행을 위해 FSM법에 의한 충돌사고원인의 구조분석을 인과지도상의 정량적, 정성적, 피드백 루프로 변환하였다. 그리고 시뮬레이션 기간을 20년간(1993-2012)으로 설정하여 표준시뮬레이션모델과 8가지 정책시뮬레이션모델에 대해 시뮬레이션을 수행하였다.

• Nutrition Research and Practice
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• 제5권2호
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• pp.157-162
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• 2011

The importance of dietary intake in the treatment of type 2 diabetes was emphasized. This study was performed to investigate the dietary intakes of Korean type 2 diabetes patients according to the treatment and duration of diabetes and to examine the relationships between their diet and serum lipid profiles. The subjects were 111 type 2 diabetic patients who were treated by medical nutrition therapy only, oral hypoglycemic agents (OHA), or insulin with medical nutrition therapy. Dietary intake was assessed by a registered dietitian using semi-quantitative food frequency questionnaires Comparisons according to treatment type were made using covariance analyses. General linear models identified the independent effects of the different treatments after covarying for age, duration of diabetes, and 2-way interactions. There were no significant differences in age and BMI but was in duration of diabetes according to treatment type in these subjects. Carbohydrate to energy ratio was higher in the OHA group (P < 0.05), whereas the fat to energy ratio was higher in the insulin group for males (P < 0.05). Carbohydrate ($R^2$ = 0.24, P = 0.005) and fat ($R^2$ = 0.26, P = 0.02) to energy ratios were independently associated with the duration of diabetes after covarying for age, sex, treatment, and 2-way interactions. The levels of triglyceride (TG; $R^2$ = 0.32, P = 0.02) and total cholesterol (TC) were associated independently with energy intake and the carbohydrate ($R^2$ = 0.15, P = 0.02) and fat ($R^2$ = 0.15, P = 0.01) to energy ratios, respectively. The concern that the independent association of dietary intake with either duration of diabetes or dietary factors affects blood lipid levels could suggest that specific dietary recommendations may work better for identifiable groups of diabetes patients.

• 대한교통학회지
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• 제36권1호
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• pp.1-12
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• 2018

본 연구는 교통온실가스 감축목표 설정 및 효과적 이행계획 수립에 기여하기 위한 교통온실가스 감축정책의 정량적 효과분석 방법론 정립을 목적으로 한다. 본 연구는 실제 교통 배출 자료에 근거한 교통수단별 온실가스 배출 원단위 추정모형을 포함하여, 수단효용함수와 수요추정모형 등을 활용하고 있다. 연구결과, 전기차 등 온실가스 감축정책 효과는 지역과 대상차종 등에 따라 다양하게 도출될 수 있으며, 저예산 정책인 에코드라이브 활성화 정책은 높은 온실가스 감축효과를 기대할 수 있는 것으로 확인되었다. 또한 자동차 배출개선 정책 뿐 아니라 대중교통 이용활성화 정책도 높은 온실가스 감축효과를 기대할 수 있으며, 본 연구는 이러한 사실을 정량적으로 확인하고 있다. 본 연구결과는 신기후체제 대응을 위한 국가 및 지자체의 온실가스 감축정책 평가에 유용하게 활용될 수 있을 것으로 기대된다.

• 한국정보시스템학회지:정보시스템연구
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• 제28권4호
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• pp.293-311
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• 2019

목적 본 연구는 2011년부터 8년간의 영문문헌에 대해 메타분석법을 이용하여 소셜미디어의 사용과 학습성과간의 관계를 규명하고자 하였다. 또한 소셜미디어 사용 상황과 연구분석방법론 변인의 조절효과 여부를 분석하였다. 연구방법론 주요 연구방법으로 유사한 연구 의문점이 제시된 선행의 실증연구들에 대해 메타분석기법을 사용하였으며, 문헌분석을 통해 정량적 데이터를 도출하고, 이를 실증 분석하였다. 연구결과 연구결과로 소셜미디어의 사용과 학습성과간에는 정의 상관을 보였으며, 상황변수와 연구방법론 변수가 조절효과를 보였다. 상황변수의 구성개념으로는 소셜미디어형태, 사용자 집단, 플랫폼 종류 등으로 하였고, 분석을 위한 측정방법 변수에는 측정모형, 데이터속성 등의 개념으로 구성하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2725-2729
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• 2015

Background: Transitional cell carcinoma (TCC) and prostate cancer are the most frequent cancers in the male genitourinary tract. Measurement of biological biomarkers may facilitate clinical monitoring and aid early diagnosis of TCC. The aim of the present investigation was to detect the mRNA levels of S100A12 and RAGE (receptor for advanced glycation end products) in patients suffering from bladder TCC. Materials and Methods: To explore the involvement of S100A12 and RAGE genes, total RNA was harvested from cancer tissues and samples obtained from normal non-tumorized urothelium of the same patients. Quantitative PCR (qPCR) was subsequently employed to determine the mRNA levels of S100A12 and RAGE. Results: The results showed that mRNA expression of S100A12 and RAGE was significantly up-regulated in the cancer tissue. Conclusions: According to the results presented in the current study, mRNA expression of S100A12 and RAGE might be as a useful biomarker for TCC. Therefore, this ligand-receptor axis possibly plays important roles in the development of TCC and may serve either as an early diagnostic marker or as a key factor in monitoring of response to treatment. More research is required concerning inhibition of the S100A12-RAGE axis in different cancer models.

• 디지털콘텐츠학회 논문지
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• 제19권3호
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• pp.547-559
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• 2018

본고는 개인의 혁신성이 소셜미디어 상에서 제공되는 스마트커머스 서비스의 수용에 미치는 영향을 정량적으로 실증한 연구다. 연구자들은 개인의 혁신성이 감성 및 특성의 세분화된 요소인 심미성, 쾌락성, 경제성, 주관적 규범 등에 영향을 주는 것으로 보았다. 또한 감성 및 특성 변인들이 전기 기술 수용모형(TAM)과 후기 기술 수용모형(PAM)의 구매의도와 구전 의도 등의 변인들에 영향을 주는 것으로 가설을 제시하였다. 본 연구에서 제시하고 있는 연구모형은 선행 연구에서 검증된 모형을 통합하여 제시하고 있는 것으로 연구의 이론적, 실무적 공헌점이 있을 것으로 보았다. 연구자들은 본 연구가 e-커머스 및 소셜미디어 마케팅 분야에서 새롭게 대두되는 스마트커머스 서비스의 수용을 다룬 점에서 산업과 정책에 상당한 공헌이 있을 것으로 기대한다.