• Bulletin of the Korean Chemical Society
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• 제34권4호
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• pp.1212-1220
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• 2013

The human coagulation factor XI (FXI) is a serine protease that plays a significant role in blocking of the blood coagulation cascade as an attractive antithrombotic target. Selective inhibition of FXIa (an activated form of factor XI) disrupts the intrinsic coagulation pathway without affecting the extrinsic pathway or other coagulation factors such as FXa, FIIa, FVIIa. Furthermore, targeting the FXIa might significantly reduce the bleeding side effects and improve the safety index. This paper reports on a docking-based three dimensional quantitative structure activity relationship (3D-QSAR) study of the potent FXIa inhibitors, the chloro-phenyl tetrazole scaffold series, using comparative molecular field analysis (CoMFA) and comparative molecular similarity analysis (CoMSIA) methods. Due to the characterization of FXIa binding site, we classified the alignment of the known FXIa inhibitors into two groups according to the docked pose: S1-S2-S4 and S1-S1'-S2'. Consequently, highly predictive 3D-QSAR models of our result will provide insight for designing new potent FXIa inhibitors.

• 기술혁신학회지
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• 제16권2호
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• pp.424-443
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• 2013

교육과학기술부와 한국연구재단은 창의적 도전적 연구를 적극 장려하고자 2012년 기초연구사업 중점 추진방향으로 '한국형 그랜트' 지원 방식을 도입하였으며, 이에 따라 연구자가 추후 과제 신청시 기존 연구수행 성과를 집중적으로 평가 받게 되었다. 이에, 선정평가에서 과제관리 및 종료평가에 이르는 전주기적 성과관리 시스템의 필요성이 크게 대두되었다. 본 연구에서는 전주기적 성과관리 시스템의 첫 단계로 분야별 연구실적의 정량적 가이드라인를 제시하여 연구역량평가의 보조적 수단으로 사용할 방안을 도출하고자 하였다. 그 결과, 상위그룹 간 비교 시에는 순위보정영향력지수(Ranked Normalized Impact Factor, rnIF), 하위그룹 간 비교 시에는 영향력지수(Impact Factor, IF) 또는 rnIF를 정량가이드라인으로 제안하였다. SCI급 논문 수는 동일 분류 내 위상비교 또는 동일 위상내 분류별 비교 등에 사용할 것을 제안하였다.

• Journal of Mechanical Science and Technology
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• 제18권9호
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• pp.1493-1499
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• 2004

This paper describes the speckle shearing interferometry, a non-destructive optical method, for quantitative estimation of void defect and monitoring separation defect inside of a pneumatic tire. Previous shearing interferometry has not supplied quantitative result of inside defect, due to effective factors. In the study, factors related to the details of an inside defect are classified and optimized with pipeline simulator. The size and the shape of defect can be estimated accurately to find a critical point and also is closely related with shearing direction. The technique is applied for quantitative estimation of defects inside of a pneumatic tire. The actual traveling tire is monitored to reveal the cause of separation and the starting points. And also unknown void defects on tread are inspected and the size and shape of defects are estimated which has good agreement with the result of visual inspection.

• 한국조경학회지
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• 제19권3호
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• pp.55-71
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• 1991

The purpose of this thesis is to suggest objective basic data for the environmental design through the quantitative analysis of the visual quality included in the physical environment of Basemsagol valley sequence landscape. For this, visual volumes of physical elements have been evaluated by using the mesh analysis, spatial images structure of physical elements have been analyzed by factor analysis algorithm, and degree of visual quality have been measured mainly by questionnaires. Also, this study aims to understand semiotics and to grope the possibility of application to the sequence landscape assessment. A semiological approach suggests a new dimension in sequence landscape assessment, which is a contrast to the existing scientific evaluation methods. Result of this thesis can be summarized as follows. Visual volumes of the immediate vegetation, rock, bridge, road and distant vegetation are found to be the main factor determining the visual quality. Factors covering the spatial image of natural park sequence landscape have been found to be the overall synthetic evaluation, potentiality, natural quality, spatial, appeal and dignity. By using the control method for the number of factors, T.V. has been obtained as 40.22%. The characteristics of the semiological approach is qualitative, open, holistic, and experiential, whereas that of the scientific approach is quantitative, closed, reductive, and experimental.

• 통합자연과학논문집
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• 제10권3호
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• pp.141-147
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• 2017

Vascular endothelial growth factor (VEGF) is an important signaling protein involved in angiogenesis, which is the formation of new blood vessels from pre-existing vessels. Consequently, blocking of the vascular endothelial growth factor receptor (VEGFR-2) by small molecule inhibitors leads to the inhibition of cancer induced angiogenesis. In this study, we performed a two dimensional quantitative structure activity relationship (2D-QSAR) study of 38 N-Phenyl-N'-{4-(4-quinolyloxy) phenyl} urea derivatives as VEGFR-2 inhibitors based on hologram quantitative structure-activity (HQSAR). The model developed showed reasonable $q^2=0.521$ and $r^2=0.932$ values indicating good predictive ability and reliability. The atomic contribution map analysis of most active compound (compound 7) indicates that hydrogen and oxygen atoms in the side chain of ring A and oxygen atom in side chain of ring C contributes positively to the activity of the compounds. The HQSAR model developed and the atomic contribution map can serve as a guideline in designing new compounds for VEGFR-2 inhibition.

• 한국안전학회지
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• 제17권4호
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• pp.110-118
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• 2002

During the last ten years, the need has been increase for reducing maintenance cost for aged equipments are ensuring safety, efficiency and profitability of petrochemical and refinery plants. American Petroleum institute(API) developed a code, API 581 for proposing standard procedures of risk based inspection. Even though the API 581 code covers general RBI procedures, there must be some limitations. In this study, a semi-quantitative assessment algorithm for RBI based on the API 581 code was reconstructed for developing an RBI software. The user-friendly realRBI software is developed with a module for evaluation semi-quantitative risk category using the potential consequence factor and the likelihood factor. Also, inspection planning module for inspection time and inspection method for equipments are included.

• Safety and Health at Work
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• 제13권4호
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• pp.500-506
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• 2022

This study evaluated the consistency between two quantitative fit test devices with different methods of ambient aerosol counting. Three types of respirators (N95, half mask, and full facepiece) were worn by 50 participants (male, n = 25; female, n = 25), PortaCount (Pro+ 8038) and MT (05U) were connected to one probe to one mask, and fit factors (FFs) were measured simultaneously with the original and modified protocols. As a result of comparing MT FFs with PortaCount FFs as references and by applying for the pass/fail criteria (FF = 100), the consistency between the two devices for half masks and full facepieces was very high. N95 was somewhat weaker than the two type of respirators in the consistency; however, the correlation between the two devices was very strong (p < 0.0001). The results showed that an FF of 100 as measured by PortaCount was likely to be measured as 75 by the MT. Therefore, when performing the fit test for N95 using the MT and pass level of FF 100, a certain level of adjustment is necessary, whether end-user or putting a scaling factor by manufacturer.

• Journal of the Korean Data and Information Science Society
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• 제15권2호
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• pp.339-345
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• 2004

This paper deals with a mixed logit model for ordered polytomous data. There are two types of factors affecting the response varable in this paper. One is a fixed factor with finite quantitative levels and the other is a random factor coming from an experimental structure such as a randomized complete block design. It is discussed how to set up the model for analyzing ordered polytomous data and illustrated how to estimate the paramers in the given model.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2004년도 추계학술대회
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• pp.208-213
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• 2004

Methods for estimation of the effective stress intensity factor range (${\Delta}K_{eff}$) are evaluated for narrow and wide band random loading crack growth test data of 2024-T351 aluminum alloy. Three methods of determining $K_{op}$, visual measurement, ASTM offset compliance method, and the neural network method proposed by Kang and Song, and three methods of estimating ${\Delta}K_{eff}$, conventional, the 2/PI0 and 2/PI methods proposed by Donald and Paris, are compared in a quantitative manner by using the results of fatigue crack growth life prediction under random loading. For all $K_{op}$ determination methods discussed, the 2/PI0 and 2/PI methods of estimating ${\Delta}K_{eff}$ provide better results than conventional method for narrow and wide band random loading data.

• 디지털산업정보학회논문지
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• 제5권2호
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• pp.133-140
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• 2009

In the paper, we proposed the systematical and quantitative software risk management methodology based on risk analysis model. A software risk management consists of the basic risk management method(BRIMM) and the detailed risk management method(DRIMM). BRIMM is applied to unimportant phases or the phase which also the risk factor does not heavily influence to project. DRIMM is used from the phase which influences highly in project success or the phase where the risk factor is many. Fulfilling risk management combined two methods, we can reduce project's budget, term and resource's usage, and prevent risk with the optimum measures obtained by the exact risk analysis.