• 약학회지
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• 제11권3_4호
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• pp.39-40
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• 1967

The saponificated part of the ethereal extract of the fruits of Angelica gigas N$_{AKAI}$ (Umbelliferae) afforded decursinol of pyranocoumarin derivative, which was already known in the same roots.

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 춘계총회 및 학술대회
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• pp.187.1-187.1
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• 2000

• Bulletin of the Korean Chemical Society
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• 제29권8호
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• pp.1572-1574
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• 2008

• 생약학회지
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• 제3권4호
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• pp.215-216
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• 1972

Five compounds$(I{\sim}V)$ were isolated from the roots of Peucedanum terebinthacem growing in Korea. Compounds I, IV and V are ${\beta}-sitosterol$, bergapten and umbelliferone, respectively. IR and NMR spectra of compounds II (mp. $190^{\circ}$) and III(mp. $111{\sim}120^{\circ}$), both white needle crystalls, indicate that compounds II is a furocoumarin and that compound III, yielding decursinol upon saponification, is a pyranocoumarin.

• Natural Product Sciences
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• 제10권6호
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• pp.262-267
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• 2004

A reversed-phase liquid chromatographic method for decursin and decursinol angelate of Angelicae gigantis Radix, an important crude drug in Korean traditional medicine, was developed and validated. Decursin and decursinol angelate, the structure isomer (pyranocoumarin) each other, are the main organic constituents in Angelicae gigantis Radix. This method was developed using a RP-18 column, UV detector at 280 nm and 50% acetonitrile solution containing 0.01 M sodium dodecyl sulfate and 25 mM sodium dihydrogen phosphate (pH 5.0) as the mobile phase. Various validation parameters were included and evaluated satisfactorily. Linearity was established in range 2-75 mg/ml of decursin and decursinol angelate (correlation coefficient = 0.9997 and 0.9995, respectively). This analytical method showed good accuracy (98.1% and 99.5%, respectively). Precision (repeatability) revealed a relative standard deviation value of 1.71% (decursin) and 3.19% (decursinol angelate). For intermediate precision measure the considered variables were equipment and days. A robustness test showing the influence of deferent counter-ion concentration in mobile phase was also performed.

• 생약학회지
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• 제25권4호통권99호
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• pp.311-318
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• 1994

From the root of Angelica decursiva-albiflora Yook, which has been used as a folk medicine for a sedative, analgesic and expectorant, four free coumarins, e.g., decursidin(I), decursin(II), umbelliferone(III) and nodakenetin(IV), and two coumarin glycosides, e.g., nodakenin(V) and decuroside I(VI) were isolate. The cytotoxicity of nodakenin(V) against L-1210 leukemia cells was less effective than cisplatin, but in the nephrotoxicity against rabbit kidney proximal tubular cell nodakenin(V) showed remarkably less nephrotoxicant than cisplatin.

• 생약학회지
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• 제4권4호
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• pp.191-192
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• 1973

Silica gel column chromatography of the ether extract of the root of Angelica decursiva $F_{RANCHET}\;et\;S_{AVATIER}$ form. albiflora $N_{AKAI}$ (Umbelliferae) gave four kinds of crystalline products of pyranocoumarin and furocoumarin: decursidin $(mp\;60{\sim}61^{\circ},\;C_{24}H_{26}O_7)$, decursin$(mp\;110{\sim}111^{\circ},\;C_{19}H_{20}O_5)$, umbelliferone $(mp\;227{\sim}228^{\circ},\;C_{9}H_{6}O_3)$, and nodakenetin $(mp\;187{\sim}189^{\circ},\;C_{14}H_{14}O_4)$. Besides, the methanol extract of the root was found to contain sucrose.

• 약학회지
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• 제30권2호
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• pp.73-78
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• 1986

Peucedanum terebinthaceum Fischer (Umbelliferae) known as "Gi Reum Na Mool" in Korea and used for the treatment of cough, phlegm, headache and common cold etc. The substances were isolated from the fruits of Peucedanum terebinthaceum and identified by UV, GLC, IR, NMR, Mass spectra and physico-chemical tests. The steroidal compounds from the fruits were identified as $\beta$-sitosterol (tR 33.01 min.) and stigmasterol (tR 28.87 min.) by GLC. Substance I (colorless prismatic crystal, $C_{19}H_{20}O_5$, mp $110~111^{\circ}$) was identified as decursin which is one of the pyranocoumarin. Hydrolysis of substance I with 5%-potassium hydroxide produced decursinol. Acetylation of decursinot gave its monoacetate, white needles, $C_{16}H_{16}O_5$. Substance II(light yellowish white needle crystal, $C_9H_6O_3$, mp $227~228^{\circ}$) was proved to be umbelliferone. Substance I, decursin, was isolated for the first time from the fruits of Peucedanum spp. (Umbelliferae).

• Journal of Applied Biological Chemistry
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• 제52권4호
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• pp.187-194
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• 2009

참당귀 뿌리로부터 2종의 pyranocoumarin 성분을 분리하고 그들의 구조는 NMR 분석에 의해 각각 decursinol angelate(1), decursin(2)로 결정하였다. 이들 화합물에 대하여 hACAT 저해활성을 검정해본 결과, decursinol angelate(1)가 약한 저해활성을 나타낸 반면 decursin(2)은 hACAT1와 hACAT2에 대하여 $IC_{50}$ 값이 각각 137, $168\;{\mu}M$로서 우수한 저해활성을 나타내었다. 한편, 참당귀의 뿌리를 비롯한 꽃, 종자, 잎 등 여러부위에서 decursinol angelate(1), decursin(2)를 정량분석하였는데, 이때 LC/MS/MS(ESI, positive ion mode, MRM mode) 분석을 이용하였다. Decursinol angelate의 함량은 뿌리>잎>종자>꽃 순으로 높았으며, decursin의 함량은 뿌리>종자>꽃>잎 순으로 높게 측정되었다. 이상의 결과들은, 참당귀의 decursin이 동맥경화와 같은 심혈관 질환의 개선과 치료를 위해 유용하게 이용될 수 있음을 시사하였다. 또한 뿌리 이외에 그 동안 이용되지 않고 있던 참당귀 꽃, 잎과 같은 비상용부위에도 기능성물질인 decursin, decursinol angelate이 상당량 함유되어 있음이 구명되어 이러한 부위도 새로운 천연 기능성 소재로서 활용될 수 있음을 기대할 수 있었다.

• 약학회지
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• 제53권6호
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• pp.303-313
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• 2009

Traditionally, Cham dang-gui (Angelica gigas Nakai) is one of the most popular herbal medicines in Asian countries including Korea. A. gigas has been used as a functional food product for treatment anemia, women's health care, a sedative, an anodyne or a tonic agent. Decursin and decursinol angelate isolated from the roots of A. gigas are pyranocoumarin compounds. Recently, as the global herbal medication market is increasing, investigations about pharmacological effects of decursin and decursinol angelate are rapidly increasing. We summarized previous studies about pharmacological effects of decursin and decursinol angelate, and reviewed relation with pharmacological effects of decursin and decursinol angelate on human disorder, focused on the approach for new drug development. Pharmacological effects of decursin and decursinol angelate were classified as anti-tumor activity, anti-bacterial activity, improvements of the circulating system, inhibition of cytochrome P-450 activity, anti-inflammation activity, anti-oxidant activity and cognitive-enhancing activites. The activity of A. gigas with improvement of the circulating system may have wide therapeutic potential for circulatory diseases, including diabetes, hyperlipidemia and atherosclerosis. Also, anti-inflammation activity A. gigas may be beneficial for the treatment and prevention of asthma, atopic dermatitis and rheumatism arthritis. This relation could potentially lead to the development of herbal new drugs. In order to development a new drug containing decursin and decursinol angelate, it is also necessary to consider the safety profile, and the information in this review would contribute to development a new drug from herbal medicine.