Korean Journal of Pharmacognosy (생약학회지)
- Volume 25 Issue 4 Serial No. 99
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- Pages.311-318
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- 1994
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Coumarins from the Roots of Angelica decursiva-albiflora
개바디 뿌리의 쿠마린성분
- Jung, Nam-Il (College of Pharmacy, Kyung-Hee University) ;
- Yook, Chang-Soo (College of Pharmacy, Kyung-Hee University) ;
- Lee, Hyeong-Kyu (Genetic Engineering Research Institute, KIST)
- Published : 1994.12.31
Abstract
From the root of Angelica decursiva-albiflora Yook, which has been used as a folk medicine for a sedative, analgesic and expectorant, four free coumarins, e.g., decursidin(I), decursin(II), umbelliferone(III) and nodakenetin(IV), and two coumarin glycosides, e.g., nodakenin(V) and decuroside I(VI) were isolate. The cytotoxicity of nodakenin(V) against L-1210 leukemia cells was less effective than cisplatin, but in the nephrotoxicity against rabbit kidney proximal tubular cell nodakenin(V) showed remarkably less nephrotoxicant than cisplatin.
Keywords
- Angelica decursiva-albiflora;
- coumarin;
- pyranocoumarin;
- furanocoumarin;
- decursidin;
- decursin;
- umbelliferone;
- nodakenetin;
- nodakenin;
- decuroside I;
- cytotoxicity;
- nephrotoxicity