• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제48권2호
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• pp.109-116
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• 1999

ZnO Varistor is an electronic ceramic device to absorb the surge voltage from low voltage to high. To investigate the puncture mechanism occurring in NnO varistor, the Voronoi simulation for formulating the relation between the applied voltage and the increase of the temperature inside grain is applied. The Voronoi network can realize the structure of the practical varistor better than the established simple network. Using the current through each grain and the voltage applied to the grain, Joule heating energy is calculated and the phenomenon that the puncture occurs can be analyzed quantitatively by simulating the electric and thermal characteristics according to the externally applied pulsed voltage.

• Journal of Korean Neurosurgical Society
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• 제51권2호
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• pp.102-104
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• 2012

Although decompressive craniectomy is an effective treatment for various situations of increased intracranial pressure, it may be accompanied by several complications. Paradoxical herniation is known as a rare complication of lumbar puncture in patients with decompressive craniectomy. A 38-year-old man underwent decompressive craniectomy for severe brain swelling. He remained neurologically stable for five weeks, but then showed mental deterioration right after a lumbar puncture which was performed to rule out meningitis. A brain computed tomographic scan revealed a marked midline shift. The patient responded to the Trendelenburg position and intravenous fluids, and he achieved full neurologic recovery after successive cranioplasty. The authors discuss the possible mechanism of this rare case with a review of the literature.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 하계학술대회 논문집 D
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• pp.1282-1284
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• 1998

ZnO Varistor is an electronic ceramic device for controlling the surge voltage from low level to high. In this study, the puncture mechanism occurring in ZnO varistor is investigated, and the simulation for restraining the puncture by formulating the relation between the applied voltage and the increase of the inside temperature of grain is applied. In order to simulate the cause of the current localization which is the primary factor causing the puncture, the localization phenomenon and the temperature distribution induced by the localized current, the Voronoi network is applied, which can realize the structure of the practical varistor better than the established simple network. Using the current through each grain and the voltage applied to the grain boundary obtained from that simulation, the Joule heating energy is calculated and the phenomenon that the puncture occurs can be analyzed quantitatively by simulating the electric and thermal characteristics according to the externally applied pulsed voltage.

• The Korean Journal of Pain
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• 제30권2호
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• pp.93-97
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• 2017

The sphenopalatine ganglion (SPG) is a parasympathetic ganglion, located in the pterygopalatine fossa. The SPG block has been used for a long time for treating headaches of varying etiologies. For anesthesiologists, treating postdural puncture headaches (PDPH) has always been challenging. The epidural block patch (EBP) was the only option until researchers explored the role of the SPG block as a relatively simple and effective way to treat PDPH. Also, since the existing evidence proving the efficacy of the SPG block in PDPH is scarce, the block cannot be offered to all patients. EBP can be still considered if an SPG block is not able to alleviate pain due to PDPH.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.229-229
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• 2002

Although hepatocellular dysfunction occurs during sepsis. the mechanism responsible for this remains unclear. Since Kupffer cells provide signals that regulate hepatic response in endotoxin and inflammation. the aim of this study was to investigate the role of Kupffer cells in the alterations in the hepatic microsomal drug metabolizing function during sepsis. Rats were subjected to polymicrobial sepsis by cecal ligation and puncture (CLP)followed by fluid resuscitation. (omitted)

• 대한의용생체공학회:의공학회지
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• 제23권4호
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• pp.323-327
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• 2002

만성 당뇨병 질환자는 일 2회 이상 모세혈액을 채취하여 혈당검사를 행함으로써 자신의 혈당 수준을 지속적으로 관리해야 한다. 모세혈액 채취를 위하여 채혈침으로 빈번하게 피부관통을 행해야 하므로 채혈시 뒤따르는 통증은 대단히 중요한 문제이다. 본 연구에서는 기존의 수동 및 자동 채혈침들이 가지는 통증 유발요인들을 모두 최소화하는 기전을 고안하였다. 경사각을 이루는 taper형 스프링, 채혈침을 일관성있는 방향으로 이동시키는 guiding tunnel, 현존하는 기술로 제조할 수 있는 가장 가는 30G 채혈침을 적용함으로써 통증을 최소화 하였다. 침의 침투 깊이를 피하 2mm로 제한하여 통증을 최소화하는 동시에 출혈량을 감소시켰다. 또한 환자 간 감염 및 이차 감염을 방지하기 위하여 사용이 용이한 재사용 방지기전을 설치하였다. 당뇨질환자. 일반인 및 간호실습생들을 대상으로 한 임상실험 결과 통증 및 사용편의성과 안전성 모두 우수한 것으로 입증되었다. 일회 채혈로 모두 성공적인 혈당검사가 가능하였으며 단순한 구조의 소형화 ·일체화된 일회용 자동채혈침의 형태로 구현하였다 본 연구결과는 혈담검사를 위한 모세혈액 채취시 최적의 방법을 제공하였으며 실용성 또한 우수한 것으로 판단되었다.

• The Korean Journal of Pain
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• 제10권1호
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• pp.104-108
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• 1997

Spontaneous intracranial hypotension, a syndrome of low CSF pressure, occurs without preceding events such as lumbar puncture, back trauma, operative procedure or medical illness. The most characteristic symptom is an occipital or frontal headache which is aggrevated in the erect position and relieved in the supine position. This syndrome usually resolves spontaneously or with strict bed rest. When the headach persists or is incapacitating, more aggressive treatment may be necessary. Autologous epidural blood patch is highly effective in the management of spontaneous intracranial hypotension. Epidural blood produces an organized clot which effectively tamponade any dural CSF leak. The rapid relief of headache immediately after the infusion of blood occur by some other mechanism, such as an increase in subarachnoid pressure that is known to occur with infusion of fluid into the lumbar epidural space. We report three cases of spontaneous intracranial hypotension successfully treated with epidural blood patch.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.301.3-302
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• 2002

Sepsis remains the leading cause of morbidity and mortality following trauma. Although hepatocellular dysfunction occurs during trauma and sepsis. the mechanism responsible for this remains unclear. We investigated the role of Kupffer cells in the alterations in microsomal drug metabolizing function during trauma and sepsis. Rats were subjected to trauma by femur fracture (FFx). After 72h, polymicrobial sepsis was induced by cecal ligation and puncture(CLP). (omitted)

• Journal of Acupuncture Research
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• 제27권4호
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• pp.9-18
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• 2010

Objectives : This study will broaden understanding of acupotomy therapy through comparison of side effects and complication which can be caused by the mechanism of treatment, surgical methods, and procedure by acupotomy therapy and epidural neuroplasty. Moreover, through an in-depth analysis of headache affected by two procedures, this research is supposed to find prospective cures for headache after acupotomy therapy. Methods : To compare acupotomy therapy with epidural neuroplasty this research was done using a comparative analysis eight theses about acupotomy therapy since 1995, as well as eleven theses about epidural neuroplasty since 2000. Other theses and data were used as references in the process of comparative analysis. Results : Acupotomy therapy and epidural neuroplasty, new treatments of damaged discs in the spine and stenosis made in 1990s, have the mechanism of treatment in common in that adhesion, a node or scar caused by the soft tissue damage is removed by putting catheter or acupuncture into the lesions. Epidural neuroplasty has additional injection into the lesions, which is different from acupotomy therapy in the process of surgical procedure. There are various reports of positive effects about curative effect in these two treatments. The two procedures may cause various complications. Headache may be a complication after surgery. The headache after acupotomy therapy is characterized as being an ache in the body, which is similar to that of post-dural puncture headache in the outbreaks and symptom. Headache after percutaneous epidural neuroplasty appears in general, which is similar to a headache as a result of the increased pressure of the brain spinal cord regardless of posture. Conclusions : Although they are alike in the mechanism of treatment, surgical methods and side effects, and complication after they are carried out as a result of analyzing theses related to acupotomy therapy and percutaneous epidural neuroplasty, there is a difference in aspects and mechanism of headaches experienced after the procedure.

• The Korean Journal of Physiology and Pharmacology
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• 제1권6호
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• pp.647-655
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• 1997

The purpose of present study is to investigate the influence of a spinal gamma-aminobutyric acid B($GABA_B$) receptor on a central regulation of blood pressure(BP) and heart rate(HR), and to define its mechanism in the spinal cord. In urethane-anesthetized, d-tubocurarine-paralyzed and artificially ventilated male Sprague-Dawley rats, intrathecal administration of drugs were carried out using injection cannula(33-gauge stainless steel) through the guide cannula(PE 10) which was inserted intrathecally at lower thoracic level through the puncture of a atlantooccipital membrane. Intrathecal injection of an $GABA_B$ receptor agonist, baclofen(30, 60, 100 nmol) decreased both BP and HR dose-dependently. Pretreatment with 8-bromo-cAMP(50 nmol), a cAMP analog, or glipizide(50 nmol), a ATP-sensitive $K^+$ channel blocker, attenuated the depressor and bradycardic effects of baclofen(100 nmol), but not with 8-bromo-cGMP(50 nmol), a cGMP analog. These results suggest that the $GABA_B$ receptor in the spinal cord plays an inhibitory role in central cardiovascular regulation and that this depressor and bradycardic actions are mediated by the decrease of cAMP via the inhibition of adenylate cyclase and the opening of $K^+$ channel.