• 제목/요약/키워드: pseudomembranous colitis

검색결과 24건 처리시간 0.026초

Clostridium difficile 감염에 의한 위막성 대장염 1례 (A Case of Clostridium difficile Pseudomembranous Colitis)

  • 서정호;이종원;이창한;정기섭
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제3권1호
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    • pp.98-104
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    • 2000
  • Pseudomembranous colitis, thought to be uncommon in children, is a bacterial, toxin-mediated inflammatory process resulting in acute or chronic diarrhea and is characterized by colonic pseudomembranes. It is mediated by toxins produced by Clostridium difficile and is increasingly recognized in pediatric population. Diagnosis is based on positive culture of C. difficile in selective media and positive test of C. difficile toxin. Oral metronidazole or vancomycin are the main treatment options but avoidance of further antibiotics should also be encouraged where possible. We have experienced a case of pseudomembranous colitis in a 4-year-old female presented with septic shock and colitis. This case was diagnosed with positive test of C. difficile toxin B and confirmed by isolation of the organism on cultire in selective media. Symptoms have been ameliorated by discontinuation of antibiotics and administration of metronidazole and oral vancomycin, and ICU care.

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장염을 동반한 뇌졸중환자의 시령탕을 이용한 호전 2례 (Effects of Shirhyung-Tang in Two Stroke Patients with Pseudomembranous Colitis)

  • 노기환;정기현;조기호;김영석
    • 대한한의학회지
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    • 제22권3호
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    • pp.179-188
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    • 2001
  • Diarrhea is the frequent passage of loose, watery stool (frequency: ${\geq}4/day$, weight: ${\geq}250g/day$) Most antibiotics can cause inflammatory change of the colon or Pseudomembranous colitis (PMC). Typical presentations of PMC are watery diarrhea, abdominal pain, fever, leukocytosis ($12,000~20,000/\textrm{mm}^3$), hypoalbuminemia, hypovolemia and recent or concurrent use of antibiotics. Diagnostic methods of PMC are stool assay, sigmoid scopy, abdominal CT, abdominal US, etc. The age-related susceptibility noted with PMC is impressive but unexplained. Two stroke patients had diarrhea, abdominal pain, fever hypoalbuminemia and a history of recent or concurrent use of antibiotics. By use of Shirhyung- Tang, we could improve clinical symptoms (diarrhea, abdominal pain, fever hypoalbuminemia, etc.) and so report clinical course of two stroke patients with antibiotics-associated PMC.

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Ischemic colitis complicated by Clostridioides difficile infection treated with fecal microbiota transplantation

  • Seok Hyung Kang;Tae-Geun Gweon;Hyunjung Hwang;Myong Ki Baeg
    • Clinical Endoscopy
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    • 제56권5호
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    • pp.666-670
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    • 2023
  • Ischemic colitis is an inflammatory condition of the colon that results from insufficient blood supply commonly caused by enterocolitis, vessel occlusion, or shock. In contrast, pseudomembranous colitis is a clinical manifestation of Clostridioides difficile infection (CDI). Ischemic colitis caused by CDI has rarely been reported. Fecal microbiota transplantation (FMT) is an efficient treatment for refractory or fulminant CDI, and the indications for its use have recently expanded. However, performing FMT in patients with ischemic colitis is challenging because of the risk of perforation. Here, we have presented a case of ischemic colitis caused by CDI that was successfully treated with FMT via sigmoidoscopy.

위막성 대장염 1례 (A Case of Pseudomembranous Colitis)

  • 정문관;양창헌;이헌주;이영현;김종설;최원희
    • Journal of Yeungnam Medical Science
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    • 제1권1호
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    • pp.171-178
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    • 1984
  • 저자들은 최근 영남대학교 의과대학 부속병원에서 대장암으로 인한 설사를 세균성 적리로 인한 설사로 잘못 알고 계속적인 항생제 투여로 말미암아 생긴 위막성 장염 1례를 경험 치료하였기에 문헌고찰과 함께 보고하는 바이다.

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The American Cockroach Peptide Periplanetasin-2 Blocks Clostridium Difficile Toxin A-Induced Cell Damage and Inflammation in the Gut

  • Hong, Ji;Zhang, Peng;Yoon, I Na;Hwang, Jae Sam;Kang, Jin Ku;Kim, Ho
    • Journal of Microbiology and Biotechnology
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    • 제27권4호
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    • pp.694-700
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    • 2017
  • Clostridium difficile, which causes pseudomembranous colitis, releases toxin A and toxin B. These toxins are considered to be the main causative agents for the disease pathogenesis, and their expression is associated with a marked increase of apoptosis in mucosal epithelial cells. Colonic epithelial cells are believed to form a physical barrier between the lumen and the submucosa, and abnormally increased mucosal epithelial cell apoptosis is considered to be an initial step in gut inflammation responses. Therefore, one approach to treating pseudomembranous colitis would be to develop agents that block the mucosal epithelial cell apoptosis caused by toxin A, thus restoring barrier function and curing inflammatory responses in the gut. We recently isolated an antimicrobial peptide, Periplanetasin-2 (Peri-2, YPCKLNLKLGKVPFH) from the American cockroach, whose extracts have shown great potential for clinical use. Here, we assessed whether Peri-2 could inhibit the cell toxicity and inflammation caused by C. difficile toxin A. Indeed, in human colonocyte HT29 cells, Peri-2 inhibited the toxin A-induced decrease in cell proliferation and ameliorated the cell apoptosis induced by this toxin. Moreover, in the toxin A-induced mouse enteritis model, Peri-2 blocked the mucosal disruption and inflammatory response caused by toxin A. These results suggest that the American cockroach peptide Peri-2 could be a possible drug candidate for addressing the pseudomembranous colitis caused by C. difficile toxin A.

Rifampicin에 의한 위막성 대장염 1예 (A Case of Rifampicin Induced Pseudomembranous Colitis)

  • 윤종욱;황정혜;함형석;이한철;노길환;강수정;서지영;김호중;정만표;권오정;이종헌;손희정
    • Tuberculosis and Respiratory Diseases
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    • 제49권6호
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    • pp.774-779
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    • 2000
  • 저자들은 항결핵제중 rifampicin 사용 후 발생한 위막성 대장염 1예를 경험 하였기에 보고하는 바이며 전신상태가 좋지 않거나 간질환이 있는 고령의 환자에서 항결핵제 사용 중 심한 설사가 있을 때 이의 가능성을 생각해야 되며 필요한 경우 조기에 진단적 검사를 시행해야 한다고 생각된다.

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항생제로 유발된 Pseudomembranous Colitis환자의 이중탕(理中湯) 치료 1례 (A case study of the antibiotics-associated Pseudomembranous Colitis treated with Yijoong-tang (Lizhong-tang))

  • 최원우;김미영;김영지;이승엽;민인규;홍진우;나병조;정우상
    • 대한중풍순환신경학회지
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    • 제8권1호
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    • pp.58-62
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    • 2007
  • Objective : Stroke patients tend to take antibiotics due to infection resulting from complication. One of many side effects from using antibiotics is diarrhea, which infact causes anaerobic organism dysfunction resulting Pseudo-Membranous Colitis (P.M.C). To treat P.M.C, antibiotics and antibacterial agents are usually used. But they may cause other side effects, therefore extreme caution must be taken. Methods : We treated an antibiotic induced P.M.C patient who diagnosed by sigmoid scopy with only Yijoong-tang (Lizhong-tang) without antibiotics and observed patients stool aspects. Results and Conclusion : Patiensts symptom was improved after 7days, and we can see the improvement by follow-up sigmoid scopy. This case may give us a possibility of that oriental medical treatments as complementary and alternative medicine to standard antibiotic treatment.

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Refractory Clostridium difficile Infection Cured With Fecal Microbiota Transplantation in Vancomycin-Resistant Enterococcus Colonized Patient

  • Jang, Mi-Ok;An, Jun Hwan;Jung, Sook-In;Park, Kyung-Hwa
    • Intestinal research
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    • 제13권1호
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    • pp.80-84
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    • 2015
  • The rates and severity of Clostridium difficile infections, including pseudomembranous colitis, have increased markedly. However, there are few effective treatments for refractory or recurrent C. difficile infections and the outcomes are poor. Fecal microbiota transplantation is becoming increasingly accepted as an effective and safe intervention in patients with recurrent disease, likely due to the restoration of a disrupted microbiome. Cure rates of >90% are being consistently reported from multiple centers. We cured a case of severe refractory C. difficile infection with fecal microbiota transplantation in a patient colonized by vancomycin-resistant enterococcus.

Histopathological Profile of Benign Colorectal Diseases in Al-Madinah Region of Saudi Arabia

  • Albasri, Abdulkader Mohammed
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권18호
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    • pp.7673-7677
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    • 2014
  • Background: Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC). Colon cancer risk in IBD increases with longer duration and greater anatomic extent of colitis, the presence of primary sclerosing cholangitis, family history of CRC and degree of inflammation of the bowel. This study aimed to characterize the histopathological pattern of benign colorectal diseases among Saudi patients and to highlight age and gender variations of lesions as base line data for future studies to investigate the link between benign/IBD and colorectal cancers in the local population. Materials and Methods: The materials consisted of 684 biopsies, reported as benign (excluding malignancies and polyps) at the Department of Pathology, King Fahad Hospital, Madinah, Saudi Arabia from January 2006 to December 2013. Data collected and entered in MS-Excel and were analyzed using SPSS-20. Results: Of 684 colorectal tissues reviewed, 408 specimens (59.6%) were from male patients and 276 specimens (40.4%) were from females giving a male: female ratio of 1.5:1. Age of the patients ranged from 4 to 75 years with a mean of 39.6 years. The most frequent histologic diagnosis was a chronic non specific proctocolitis followed by ulcerative colitis, accounting respectively for 52.6% and 31.7% of all cases. These were followed by Crohn's disease 22 (3.2%), ischemic bowel disease 20 (2.9%), diverticular disease 14 (2%), eosinophilic colitis 12 (1.7%) and solitary rectal ulcer 12 (1.7%). A minority of 21 patients (3.1%) were cases of acute nonspecific proctocolitis, schistosomiasis, tuberculosis, volvulus and pseudomembranous colitis. Conclusions: These data show that although chronic non specific proctocolitis and ulcerative colitis were the dominant diagnoses, Crohn's disease, ischemic bowel disease and diverticular disease also existed to a lesser extent and should be considered in the differential diagnosis of benign colorectal diseases. This study provides a base line data for future studies which would be taken up to investigate the link between benign/IBD and colorectal cancers in the local population.