• Journal of Engineering Education Research
• /
• v.14 no.3
• /
• pp.15-24
• /
• 2011

The purpose of this study is to develop the 'Engineering Team Mission Project Education Program and Textbook', which is improved creativity and creative problem for Juniors(middle school students) that is in the growth stage to become the leading role in future society. This can be applied the creative experience activities time of revised curriculum in 2009 being implemented to secondary education by 2011. The results of this study are as follows. The formation of Team Mission Project Education Program is the big field 2 project, lower field 8 module and 38 total lessons. This education program has secured the validity of the SME(Subject Matter Expert) expert conference. Actually, by putting the education program and textbook to the invention talent class formed by middle school students and by normally analyzing, it has been analyzed as very satisfying result. Therefore, the "Engineering Team Mission Project Education Program and Textbook" can be provided as a practical education course of new talent training and engineering talent model of the nation's knowledge property education. And it can perform as an education program using usefully in the creative experience activity education course in middle class education stage. Also, it is concluded to become the basis of engineering design education's high grade education and department of engineering's creative engineering.

• The Korean Journal of Physiology and Pharmacology
• /
• v.20 no.3
• /
• pp.287-295
• /
• 2016

Involuntary physical activity induced by the avoidance of electrical shock leads to improved endurance exercise capacity in animals. However, it remains unknown whether voluntary stand-up physical activity (SPA) without forced simulating factors improves endurance exercise capacity in animals. We examined the effects of SPA on body weight, cardiac function, and endurance exercise capacity for 12 weeks. Twelve male Sprague-Dawley rats (aged 8 weeks, n=6 per group) were randomly assigned to a control group (CON) or a voluntary SPA group. The rats were induced to perform voluntary SPA (lifting a load equal to their body weight), while the food height (18.0 cm) in cages was increased progressively by 3.5 every 4 weeks until it reached 28.5 cm for 12 weeks. The SPA group showed a lower body weight compared to the CON group, but voluntary SPA did not affect the skeletal muscle and heart weights, food intake, and echocardiography results. Although the SPA group showed higher grip strength, running time, and distance compared to the CON group, the level of irisin, corticosterone, genetic expression of mitochondrial biogenesis, and nuclei numbers were not affected. These findings show that voluntary SPA without any forced stimuli in rats can effectively reduce body weight and enhance endurance exercise capacity, suggesting that it may be an important alternative strategy to enhance endurance exercise capacity.

• Journal of Korea Society of Digital Industry and Information Management
• /
• v.13 no.4
• /
• pp.179-191
• /
• 2017

The purpose of this study is to investigate the change of comprehension degree about learning satisfaction and capstone class by applying the subject which draws idea for team project task in college to creative capstone design program. The Capstone Design Program is designed to train fieldworkers with creative problem solving skills and is widely applied as a problem-solving course in team-based projects. In this paper, based on the case study of the 'fusion capstone design' operated in the first semester of 2015 ~ 2017, the capstone design course was established in the course of designing ideas for problem solving. The results of this study are as follows: First, the questionnaire about capstone design instruction process, instruction method, and learning achievement satisfaction were analyzed. As a result, understanding of capstone design was found to be higher than that of class before class, and satisfaction of performance course, method of teaching performance and learning outcome were obtained.

• Journal of Multimedia Information System
• /
• v.4 no.4
• /
• pp.243-248
• /
• 2017

In a basic engineering design class, first year engineering department students learn about engineering design relevant theories and carry out simple projects in teams. By doing a group project in this subject, students develop basic skills such as creativity, teamwork, communication, and problem solving. Before, class proceeded in a way where teams were randomly configured in the beginning of semester and students began working on their project immediately. However, this research introduces a new method where at the beginning of the semester, students are assigned group assignments. Teammates are randomly chosen and constantly switched so that students get a chance to work with different people and experience diverse styles and characteristics. Then, they autonomously form into teams with people they work best and carry out their project. We present the behavior of a monkey robot that recognizes emotions as a case of applying the proposed method. The feedback from the students suggest that this proposed team forming method serves to be effective especially since students who were not aware of other students' characteristics can get to know one another better and form a productive team.

• Bulletin of the Korean Chemical Society
• /
• v.30 no.12
• /
• pp.2989-2992
• /
• 2009

An efficient synthetic route of novel 2′(${\alpha}$)-C-fluoro-2′(${\beta}$)-C-methyl carbocyclic nucleoside analogues is described. The key fluorinated intermediate 7 was prepared from the epoxide intermediate 5 via selective ring-opening of epoxide. Coupling of 7 with nucleosidic bases under the Mitsunobu reactions followed by deprotection afforded the target carbocyclic nucleoside analogues. The synthesized compounds were evaluated as inhibitors of the hepatitis C virus (HCV) in Huh-7 cell line in vitro.

• Proceedings of the KSRS Conference
• /
• 2003.11a
• /
• pp.343-345
• /
• 2003

This paper describes the system development for the Ground Control Point collection and management through the major coastline region in KOREA, which will collect and manage the ground control point based on high resolution satellite image database. The module of this system is following 1) GCP/Coarstline research plan module 2) GCP/Coarstline ground collection module 3) GCP/Coarstline post processing module Our team developed the core components of ‘High Resolution Satellite Image Processing Technique’ project, and this system, among applications of our project, is constructed to apply to practical use. In this application, you will also see how to apply core components of our project.

• International conference on construction engineering and project management
• /
• 2015.10a
• /
• pp.259-262
• /
• 2015

Due to the labor-intensiveness, high investment cost, long execution time, frequent change orders, and many stakeholders in a BIM project, a BIM manager is bound to face a lot of risks to make decisions in cost managing process. Since the productivity of a BIM team will affect the execution cost, this study investigates a simple method of assessing the productivity of a BIM team using the working timesheet records of the team. In this research, the productivity of a BIM team is defined as the effective working floor area (in square meters) of BIM uses per labor-time (in man-months) spent by the team. After the applicability of this method is tested by regression analysis using data from 5 real BIM projects in the construction phase, it is found that the simple productivity definition adopted in the method, although easy-to-implement, does not produce a statistically constant productivity value. More research is therefore needed in the future to devise better indicator(s) for assessing the productivity of a BIM team.

• 한국약용작물학회:학술대회논문집
• /
• 2008.11a
• /
• pp.249-250
• /
• 2008

• The Korean Journal of Physiology and Pharmacology
• /
• v.20 no.3
• /
• pp.305-314
• /
• 2016

Inflammatory and fibrotic responses are accelerated during the reperfusion period, and excessive fibrosis and inflammation contribute to cardiac malfunction. NecroX compounds have been shown to protect the liver and heart from ischemia-reperfusion injury. The aim of this study was to further define the role and mechanism of action of NecroX-5 in regulating inflammation and fibrosis responses in a model of hypoxia/reoxygenation (HR). We utilized HR-treated rat hearts and lipopolysaccharide (LPS)-treated H9C2 culture cells in the presence or absence of NecroX-5 ($10{\mu}mol/L$) treatment as experimental models. Addition of NecroX-5 significantly increased decorin (Dcn) expression levels in HR-treated hearts. In contrast, expression of transforming growth factor beta 1 ($TGF{\beta}1$) and Smad2 phosphorylation (pSmad2) was strongly attenuated in NecroX-5-treated hearts. In addition, significantly increased production of tumor necrosis factor alpha ($TNF{\alpha}$), $TGF{\beta}1$, and pSmad2, and markedly decreased Dcn expression levels, were observed in LPS-stimulated H9C2 cells. Interestingly, NecroX-5 supplementation effectively attenuated the increased expression levels of $TNF{\alpha}$, $TGF{\beta}1$, and pSmad2, as well as the decreased expression of Dcn. Thus, our data demonstrate potential antiinflammatory and anti-fibrotic effects of NecroX-5 against cardiac HR injuries via modulation of the $TNF{\alpha}/Dcn/TGF{\beta}1/Smad2$ pathway.

• The Korean Journal of Physiology and Pharmacology
• /
• v.20 no.2
• /
• pp.213-220
• /
• 2016

Mast cells are primary mediators of allergic inflammation. Beta-1,3-glucan (BG) protects against infection and shock by activating immune cells. Activation of the BG receptor induces an increase in intracellular $Ca^{2+}$, which may induce exocytosis. However, little is known about the precise mechanisms underlying BG activation of immune cells and the possible role of mitochondria in this process. The present study examined whether BG induced mast cell degranulation, and evaluated the role of calcium transients during mast cell activation. Our investigation focused on the role of the mitochondrial calcium uniporter (MCU) in BG-induced degranulation. Black mouse (C57) bone marrow-derived mast cells were stimulated with $0.5{\mu}g/ml$ BG, $100{\mu}g/ml$ peptidoglycan (PGN), or $10{\mu}M$ A23187 (calcium ionophore), and dynamic changes in cytosolic and mitochondrial calcium and membrane potential were monitored. BG-induced mast cell degranulation occurred in a time-dependent manner, and was significantly reduced under calcium-free conditions. Ruthenium red, a mitochondrial $Ca^{2+}$ uniporter blocker, significantly reduced mast cell degranulation induced by BG, PGN, and A23187. These results suggest that the mitochondrial $Ca^{2+}$ uniporter has an important regulatory role in BG-induced mast cell degranulation.