• Journal of Nutrition and Health
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• 제36권9호
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• pp.924-932
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• 2003

In middle-aged men, abdominal obesity has been an important risk factor of coronary artery disease (CAD) as well as a predictor of hypertension, dyslipidemia, insulin resistance and glucose intolerance. Particularly, risks from abdominal obesity increase when adipose tissue accumulates in visceral compartment. Many studies showed that weight reduction by caloric restriction improves abdominal obesity and reduces lots of cardiovascular risk factors. Testosterone treatment also results in a significant decrease in visceral fat area and normalizes endocrine metabolism. However there is no study that compare the effect of caloric restriction with that of testosterone treatment. The purpose of this study is to investigate the effect of caloric restriction and that of testosterone treatment on body fat distribution, serum lipids and glucose metabolism in male patients with CAD. Forty five middle-aged overweight-obese men with CAD participated in 12 weeks' program. They were matched with age, body weight, body mass index (BMI) and divided into three groups : control group (n = 15) , caloric restriction group (-300 kcal/day, n = 15) and testosterone treatment group (testosterone undecanoate tablets, n = 15) . After 12 weeks, control group did not have any changes in anthropometries, lipid profile, body fat distribution, glucose metabolism and hormonal status. Expectedly, caloric restriction group showed decreases in body weight, BMI, waist to hip ratio, ％ body fat. Ten percentage of total cholesterol and 23% of triglyceride in serum were also decreased. In body fat distribution, total fat areas at both L1 and L4 levels were significantly reduced in this group without reduction in muscle of thigh and calf. However, testosterone treatment group did not have any significant changes in body weight, ％ body fat, serum lipid profile and abdominal fat distribution. In conclusion, weight reduction by caloric restriction is more beneficial in body fat distribution and serum lipid level than testosterone treatment in overweight male patients with CAD. This result suggests that modest weight reduction is possible to help decrease risk factors of CAD.

• 대한방사선기술학회지:방사선기술과학
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• 제41권5호
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• pp.463-469
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• 2018

Morphological information such as shape and margin of micro lesion is important information for diagnosis of disease in clinical imaging. In this study, we investigated the morphological changes of the micro lesions by comparing the contrast and area in grid suppressed DR images according to grid frequency. In the profile analysis of the image, the mass showed an average intensity variation of 8.6 ~ 72.4 after suppression, The higher the grid frequency, the more the contrast was increased. However, in the images obtained using 103 lp / inch, which is a grid frequency less than the sampling frequency, the contrast of the mass in the vertical direction decreased after suppression. In the binary image, the area change of the mass was also large. As a result, the shape, size, and margin of the mass changed. In the case of very small calcification, the higher the grid frequency is the larger the change in contrast, so that a clear image can be obtained in the post-suppression image. However, we could confirm that the margin of the lesion was blurred and the lesion was lost in some of the images using the 103 lp / inch grid. The higher the frequency of the grid, The change of the contrast of fiber occurred largely and clear boundary was confirmed. The decrease of the number of pixels was small and morphological change was small. In conclusion, when using a grid frequency that is not suitable for the sample frequency, morphological changes or lesion loss of micro lesions in the post- suppression image may give the possibility of misdiagnosis in diagnosis and differentiation of the image.

• Toxicological Research
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• 제22권2호
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• pp.95-102
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• 2006

Exposure to soluble nickel compound produces toxic effects on immune system, but the mechanism of action remains to be elucidated. Differential gene expression was studied to understand the potential molecular mechanism responsible for acute toxicity induced by nickel acetate in spleen cells. We exposed mouse spleen cells to nickel acetate with a nontoxic dose ($40{\mu}M$) and then extracted total RNA at 6 h and 12 h after exposure. The RNA was hybridized onto 10K mouse oligonucleotide microarrays, and data were analyzed using GeneSpring 7.1. Nickel had a modest effects on expression of many genes, in the range of 1.3-3 fold. The expression profile showed time-dependent changes in expression levels of differentially expressed genes, including some important genes related to cell cycle, apoptosis and DNA repair. In hierarchical cluster analysis of duplicate experiments, 111 genes were screened out. Out of these, 44 genes showing time- dependent up-regulation (>1.5 fold) and 38 genes showing down-regulation (>1.5 fold) at all time points were chosen for further analysis. The change in the expression of three genes (GPX1, GADD45B and FAIM) after nickel treatment was validated using RT-PCR. As a rule, a number of genes appear to be coordinately regulated between cell survival and cell death from nickel toxicity. In conclusion, changes in the gene profile in the spleen after nickel treatment are complex and genes with diverse functions are modulated. These findings will be contributed to the understanding of the complicated biological effects of nickel.

• Journal of Applied Biological Chemistry
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• 제56권4호
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• pp.219-227
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• 2013

This study was to investigate serum triglyceride (TG), phospholipid (PL), and cholesterol concentrations after feeding the combined diets of prepared traditional Cheonggukjang (TC) or Cheonggukjang made from sword bean powder (CS), the feed, and high-fat cholesterols at certain ratio for 8 weeks in rats, and then confirmed the effects of the diets based on the changes in the tissues of livers, kidneys, and spleens. The serum TG concentrations were lower in CS group compared to that of in TC group. The increase of PL concentrations was greater in CS group than that of TC group. FChCS6 group (92% feed+2% cholesterol+6% CS) showed the lowest total-cholesterol (T-C), $60.1{\pm}8.5mg/dL$, indicating that CS was effective to lower the T-C. Both TG/PL and T-C/PL ratio tended to be decreased. As CS intake was effective in the reduction of low density lipoprotein-cholesterol level as well as the increase of high density lipoprotein-cholesterol level, it would be effective in the prevention of adult diseases and circulatory diseases. It was confirmed that there were no changes in organ appearance and tissues in the rats with CS intake. Therefore, CS intake showed superior functionalities than that of TC intake.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10339-10343
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• 2015

Breast cancer is the most common cancer among females worldwide and a most prevalent malignancy in Iranian women. Chronic stress may make an important contribution to cancer, especially in the breast. Numerous studies showed roles of neurotransmitters in the occurrence and progression of cancers which are mediated by their various types of receptors. This study was conducted to evaluate alterations in the expression profile of dopamine receptor genes in peripheral blood mononuclear cells (PBMC) as stress factors in breast cancer patients and the human breast cancer cell line (MCF-7). Peripheral blood samples were obtained from 30 patients and 30 healthy individuals. Total mRNA was extracted from PBMC and MCF-7 cells and RT-PCR was performed to confirm the presence of five dopamine receptors (DRD1-DRD5). Expression changes of dopamine receptor genes were evaluated by real time PCR. We observed that DRD2-DRD4 in PBMCs of breast cancer patients were increased compared to healthy individuals. In addition, all dopamine receptor subtypes but DRD1 were expressed in MCF-7 cells. Therefore, alterations of these receptors as stress factors should be assessed for selecting appropriate drugs such as D2-like agonists for treatment of breast cancer after performing complimentary tests. Determining the expression profile of dopamine receptor genes thus seems promising.

• 지적과 국토정보
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• 제48권1호
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• pp.55-70
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• 2018

지적 및 토지행정 분야는 기술개발의 변화에 영향을 받기 쉬우며 이에 대응되는 견고한 제도가 절실하다. 몽골에서는 이러한 변화와 대응할 수 있는 미래지향적이고 견고한 지적제도가 필요하다. 따라서 본 연구에서는 국제표준화기구에서 제정한 토지행정도메인모델(Land Administration Domain Model: LADM)을 채택하여 몽골의 지적제도에 적용을 위한 분석을 하였다. LADM의 몽골 적용을 위해서 몽골 지적제도의 특성 및 LADM 적용한 국가의 사례를 바탕으로 LADM의 네 가지의 패키지 및 클래스 별로 분석하였다. 분석 결과 몽골의 LADM 국가 프로파일링을 완성하였으며, LADM 적용 가능성을 제시하였다. 향후에는 이를 바탕으로 현재 데이터모델 표준화가 구축되어 있지 않은 몽골 지적 분야에서 LADM 적용은 중요한 역할을 할 것이며 참조모델로써도 유용한 것으로 보인다.

• 대한치과교정학회지
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• 제32권3호
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• pp.155-163
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• 2002

치조성 양악 전돌 증례에서 컴퓨터 시뮬레이션을 이용한 연조직 측모의 치료 결과 예측의 객관적 정확성을 상, 하악 제 1소구치 발거를 통해 교정치료를 받은 21명의 성인 여성을 대상으로 $Quick\;Ceph\;Image\;Pro^{TM}\;&\;Quick Eeph\;2000^{TM}$ 을 이용하여 조사, 평가하였다. 치료 전 측모 두부방사선 규격사진 투사도에서 경조직 이동량을 계측하고 Quick Ceph system 상에서 경조직을 동일한 양 이동시켜 컴퓨터시뮬레이 션을 위한 기준으로 삼았다. 이후 프로그램을 통해 연조직 변화를 시뮬레이션하고, 이 자료와 실제 치료 결과로 얻어진 연조직 계측 값을 측정하여 비교해 봄으로써 치료 결과 예측에 대한 정확도를 확인하고 임상에의 적용시 고려할 사항을 알아보았다. 시뮬레이션 결과 계측 항목의 수평 성분은 실제 치료 결과보다 작게, 수직 성분은 치료 결과보다 크게 예측하는 것으로 나타났으며 치료시 의 후방 견인은 실제보다 확대되어 나타나는 경 향을 보였다. 상악에서는 항목간 예측 오차의 방향이 일정하여 예측치가 실제보다 더 후방 이동되어 나타났으나, 하악에서는 증례간 차이가 컸다 Upper Lip Length는 짧게, Upper Vermilion Length는 길게 예측하여 시뮬레이션시 상순이 말려 보이는(rolling)효과를 확인할 수 있었으며 하순에서도 유사한 성향이 나타났으나 상순에 비해서 약하게 나타났다.

• Asian-Australasian Journal of Animal Sciences
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• 제24권8호
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• pp.1112-1119
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• 2011

The study aimed to evaluate the best level of licury oil in the diet of 3/4 Boer goats, as determined by profile analysis of commercial cuts on aspects of chemical composition, sensorial quality and fatty acid content. Nineteen male goats were used, with an initial weight of 10.8 kg/live weigh. The animals were fed with hay and a concentrated mix containing different levels of licury oil, which constituted the treatments. The experiment lasted for 60 days, at which point the animals were submitted to feed fasting and slaughtered. The carcass weight, commercial yield and cuts were measured. The ham was collected for sensorial and chemical evaluation and the longissimus dorsi was collected for fatty acid profile analysis. The addition of licury oil to the diet did not promote changes in the proportions and weights of the commercial cuts, nor to the meat's sensorial attributes. The sum of medium-chain fatty acids and the atherogenicity index was increased with the addition of oil. Licury oil can be added to the diet of goats (up to 4.5%) without resulting in changes in to the proportions of the commercial cuts, or to the chemical composition or sensorial characteristics of the meat. Based on the chain length of fatty acids, the addition of 4.5% licury oil can improve the quality of meat, but no effect was noted in relation to the atherogenicity index.

• Journal of Nutrition and Health
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• 제40권4호
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• pp.327-333
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• 2007

The present study was carried out to evaluate the physiological effects of mushroom supplementation on blood glucose levels, lipid profile, and antioxidant enzyme activities in subjects with type 2 diabetes mellitus. Subjects were randomized into either a control group or mushroom supplementation group. Mushroom supplementation was provided 3 times a day for 4 weeks. We found that total dietary fiber intake was about 2.5 times higher (30.3 g vs. 12.3 g) in subjects receiving mushroom supplementation than in the control group. Two groups maintained the same food intake and amount of activity, exercise during the supplementation. We observed no difference in age, height, weight, BMI (body mass index), blood pressure between the groups. Nutrient intake did not differ appreciably between the two groups, except for fiber intake, during the supplementation. Fasting blood glucose levels and 2-hour postprandial blood glucose levels were significantly lower in those ingesting mushroom than in controls. Furthermore, the concentrations of low-density lipoprotein cholesterol were decreased significantly in the mushroom supplementation group. Small changes were observed in the concentration of total cholesterol, triglyceride, high-density lipoprotein cholesterol of those supplemented with mushroom, but these changes were not statistically significant. Activities of superoxide dismutase and catalase with mushroom supplementation were higher than in controls, but and glutathione peroxidase activity was not affected. The levels of thiobarbituric acid reactive substance of mushroom group were lower than control group, but were not significant. We conclude that addition of mushroom influences glycemic control and may be effective in lowering blood lipids and improving antioxidant enzyme activities. Accordingly, such effects may reduce risk factors for cardiovascular disease in patients with type 2 diabetes. However, to confirm these effects and to make dietary recommendations for patients with type 2 diabetes, further studies are necessary.

• Ocean and Polar Research
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• 제27권2호
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• pp.115-123
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• 2005

Recently, it has been observed in the East Sea that temperature increases below the thermocline, and dissolved oxygen increase in the intermediate layer but decrease below it. The layer of minimum dissolved oxygen deepens and the bottom homogeneous layer in oxygen becomes thinner. It emerges very probably that these changes are induced by the mode change of deep water formation associated with global warming. To further support this hypothesis, a one-dimensional model experiment is performed. First, a thermal profile is obtained by injecting a cold and high oxygen deep water into the bottom layer, say the bottom mode. Then, two thermal profiles are obtained from the bottom mode profile by assuming that either all the deep water introduce into the intermediate layer has been initiated, say the intermediate mode, or that only a part of the deep water has been initiated into the intermediate layer, say the intermediate-bottom mode. The results, from the intermediate-bottom mode experiment are closest to the observed results. They show quite well the tendency for oxygen to increase in the intermediate layer and the simultaneous thinning of the bottom homogeneous layer in oxygen. Therefore, it can be said that the recently observed slow variation of the thermal structure might be associated with changes in the deep water formation from the bottom mode to the intermediate-bottom mode.