• Title/Summary/Keyword: production stability

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Effects of Various Stabilizers on the Production of hGM-CSF in Transgenic Nicotiana tabacum Suspension Cell Cultures (형질전환된 담배세포배양을 이용한 hGM-CSF 생산에서 여러 가지 단백질 안정제가 미치는 영향)

  • Cho, Jong-Moon;Kim, Dong-Il
    • KSBB Journal
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    • v.22 no.4
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    • pp.185-190
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    • 2007
  • Productivity of secreted recombinant protein depends largely on its stability in the extracellular environment with protease. Most hGM-CSF produced by transgenic tobacco cell cultures and secreted to the medium was confirmed to be rapidly degraded by protease in medium. To increase the productivity, therefore, various protein stabilizers such as gelling agents such as carrageenan and alginate, polymers, polyols, and amino acids have been tested. The stability of hGM-CSF in spent medium without cells was improved by the presence of gelling agents. However, the reason for the enhanced production by the addition of gelling agents may be due to the increased expression level and permeability rather than stability. The addition of DMSO inhibited the cell growth, but improved specific yield. The others were not effective for stability as well as hGM-CSF production.

A Study of Dynamic Behavior of Production - Inventory Control System (생산(生産) - 재고관리(在庫管理) 시스템의 동적거동(動的擧動)에 관한 연구(硏究))

  • Kim, Man-Sik;Park, Yong-Seon
    • Journal of Korean Institute of Industrial Engineers
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    • v.5 no.1
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    • pp.1-6
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    • 1979
  • This paper discusses an application of discrete variable Servo Theory to the analysis of the effectiveness of production-inventory control system which uses exponential smoothing as a specific forecasting technique by establishing a new model which consists of such three departments as production planning, production, and inventory. The objective of the new production-inventory model is to keep the production to the optimal level of minimum production cost in production planning problem for obtaining, the stability of inventory subject to demand variation. On this basis, the dynamic characteristic of the system with the change of the parameters is clarified by the numerical analysis. The results of the numerical analysis show the effect that is obtained by the simultaneous stability of production and inventory as soon as possible.

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Investigation of Influence of Pulse-periodical Laser Radiation Power on Stability of Liquid-metal Contacts between Powder Particles during Selective Laser Sintering

  • Beljavin, K.E.;Minko, D.V.;Bykov, R.P.;Kuznechik, O.O.
    • Proceedings of the Korean Powder Metallurgy Institute Conference
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    • 2006.09a
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    • pp.518-519
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    • 2006
  • A connection between pulse-periodical laser radiation power and stability of liquid-metal contacts between powder particles during selective laser sintering (SLS) is determined based on analysis solving the problem of stability of liquid column in the gravity and capillary forces field. On the grounds of obtained relationships the optimization of pulse-periodical laser radiation power and SLS-process duration is realized, that allows to produce voluminous powder porous materials with pre-determined physical and mechanical properties and surface geometry. Results of metallographic investigations of powder porous materials of titanium powder produced with technological regimes calculated by means of obtained relationships are given in the work

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Quality Characteristics According to the Production Period of Products Obtained by Recycling Household Plastic Waste Materials (생활계 폐합성수지 물질 재활용 제품의 생산시기별 품질 특성)

  • Kang, Hye Ju;Shin, Sungchul;Kang, Suk Pyo
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2020.11a
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    • pp.167-168
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    • 2020
  • In order to expand the material recycling of waste plastics made of composite materials, it is necessary to develop the use of material recycling products and to secure their quality stability. In this paper, as a basic study to secure the stability of the quality of household waste plastic material recycling products, the quality characteristics of recycled materials according to the production period were compared and reviewed. In addition, the average tensile strength of the recycled products by production period for 4 months was 12.33 MPa, and the average density was 1.35 g/m3.

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Effect of Bottom Hole Pressure and Depressurization Rate on Stability and Gas Productivity of Hydrate-bearing Sediments during Gas Production by Depressurization Method (감압법을 이용한 가스 생산 시 하이드레이트 부존 퇴적층의 지반 안정성 및 가스 생산성에 대한 시추 공저압 및 감압 속도의 영향)

  • Kim, Jung-Tae;Kang, Seok-Jun;Lee, Minhyeong;Cho, Gye-Chun
    • Journal of the Korean Geotechnical Society
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    • v.37 no.3
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    • pp.19-30
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    • 2021
  • The presence of the hydrate-bearing sediments in Ulleung Basin of South Korea has been confirmed from previous studies. Researches on gas production methods from the hydrate-bearing sediments have been conducted worldwide. As production mechanism is a complex phenomenon in which thermal, hydraulic, and mechanical phenomena occur simultaneously, it is difficult to accurately conduct the productivity and stability analysis of hydrate bearing sediments through lab-scale experiments. Thus, the importance of numerical analysis in evaluating gas productivity and stability of hydrate-bearing sediments has been emphasized. In this study, the numerical parametric analysis was conducted to investigate the effects of the bottom hole pressure and the depressurization rate on the gas productivity and stability of hydrate-bearing sediments during the depressurization method. The numerical analysis results confirmed that as the bottom hole pressure decreases, the productivity increases and the stability of sediments deteriorates. Meanwhile, it was shown that the depressurization rate did not largely affect the productivity and stability of the hydrate-bearing sediments. In addition, sensitivity analysis for gas productivity and stability of the sediments were conducted according to the depressurization rate in order to establish a production strategy that prevents sand production during gas production. As a result of the analysis, it was confirmed that controlling the depressurization rate from a low value to a high value is effective in securing the stability. Moreover, during gas production, the subsidence of sediments occurred near the production well, and ground heave occurred at the bottom of the production well due to the pressure gradient. From these results, it was concluded that both the productivity and stability analyses should be conducted in order to determine the bottom hole pressure when producing gas using the depressurization method. Additionally, the stress analysis of the production well, which is induced by the vertical displacements of sediments, should be evaluated.

Phenotypic Stability of a Temperature-Controllable Expression Vector on Phenylalanine Production by Escherichia coli (대장균을 이용한 Phenylalanine 생산에 있어서 온도조절형 발현 Vector의 안정성)

  • 강상모;박인숙
    • Microbiology and Biotechnology Letters
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    • v.19 no.5
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    • pp.433-438
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    • 1991
  • The plasmid pSY130-14 for the high production of phenylalanine is a temperaturecontrollable expression vector composed of the $P_R$ and the $P_L$ promoter and a temperature sensitive repressor, $cI_{857}$ of bacteriophage lambda. Strain AT2471 harbouring plasmid pSY13O- 14 is induced the phenylalanine production by shifting up the incubation temperaure to $38.5^{\circ}C$. Plasmid stability of E. coli AT2471 harbouring pSY130-14 was very low, it was about 30% after 48 h cultivation at $38.5^{\circ}C$ without kanamycin. The plasmid disappeared immediately at $40^{\circ}C$ without kanamycin, and at $40^{\circ}C$ adding kanamycin, the plasmid stability decreased at the beginning, but rose with the extension of the culture time. For the improvement of plasmid stability, the plasmid obtaind was designated as pSY15O-1 by changing origin region (ori) pACYC 177 of pSY130-14 for ori pSC101. E. coli AT2471 harbouring pSY150-1 was stable at $38.5^{\circ}C$ without tetracycline, and the plasrnid stability was about 40% after 48 h cultivation at $40^{\circ}C$.

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A Study on the Quality Improvement of Recycled Fine Aggregates with Production Methods (생산 방식별 재생 잔골재의 품질에 대한 기초적 연구)

  • Shim, Jong-Woo;Lee, Sea-Hyun;Yu, Myoung-Youl;Lee, Mun-Hwan;Song, Tae-Hyeob
    • Proceedings of the Korea Concrete Institute Conference
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    • 2004.05a
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    • pp.368-371
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    • 2004
  • It analyzes the quality of the fine aggregate which is reproduced through a dry production process with cyclone and a wet production process. The conclusions of the study are as follows. 1. The recycled fine aggregate through the dry production process with cyclone shows the low rate of absorption and impurity content after the cyclone process. It shows that its density is 2.37, absorption rate is 4.8 and stability is $5.1\%$ and less. Therefore, it satisfies the standards of KS F 2573(recycled aggregate for concrete) as the first grade. 2. The recycled fine aggregate through the wet production process shows the low rate of absorption and foreign substance content after the process of wash and dehydration. It shows that its density is 2.40, absorption rate is 3.12 and stability is $3.2\%$ and less. Therefore, it satisfies the standards of KS F 2573(recycled aggregate for concrete) as the first grade.

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Production system influences color stability and lipid oxidation in gluteus medius muscle

  • Ana Paula Amaral de Alcantara Salim;Micheli da Silva Ferreira;Maria Lucia Guerra Monteiro;Loise Caroline Santos de Lima;Isabelle Trezze Marins Magalhaes;Carlos Adam Conte-Junior;Sergio Borges Mano
    • Animal Bioscience
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    • v.36 no.5
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    • pp.785-796
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    • 2023
  • Objective: We aimed to evaluate the color and oxidative stability of beef gluteus medius (GM) from cattle raised in organic and non-organic production systems. Methods: The GM samples (n = 10) were obtained from organic (ORG; n = 5) or nonorganic (NORG; n = 5) beef samples, sliced into 2.54-cm steaks, packaged in aerobic conditions, and stored for nine days at 4℃. ORG and NORG steaks were compared regarding myoglobin concentration, pH, instrumental color, delta E (ΔE), metmyoglobin reducing activity (MRA), and lipid oxidation on days 0, 5, and 9. Results: Feeding system did not influence (p>0.05) the myoglobin concentration. ORG steaks exhibited greater (p<0.05) meat pH, yellowness, and MRA, whereas NORG steaks exhibited greater (p<0.05) redness, chroma, R630/580, delta E, and lipid oxidation. ORG and NORG steaks exhibited similar (p>0.05) lightness and hue angle. During storage, ORG and NORG exhibited an increase in muscle pH, hue angle, and lipid oxidation; and a decrease (p<0.05) in redness, yellowness, chroma, and color stability (R630/580). Both samples exhibited a stable (p>0.05) pattern for lightness and MRA. Conclusion: Therefore, the production system can affect beef color and lipid stability during storage.

Stability and failure of symmetrically laminated plates

  • Chai, Gin Boay;Hoon, Kay Hiang;Chin, Sin Sheng;Soh, Ai Kah
    • Structural Engineering and Mechanics
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    • v.4 no.5
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    • pp.485-496
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    • 1996
  • This paper describes a numerical and experimental study on the stability and failure behaviour of rectangular symmetric laminated composite plates. The plates are simply supported along the unloaded edges and clamped along the loaded ends, and they are subjected to uniaxial in-plane compression. The finite element method was employed for the theoretical study. The study examines the effect of the plate's stacking sequence and aspect ratio on the stability and failure response of rectangular symmetric laminated carbon fibre reinforced plastics composite plates. The study also includes the effect of the unloaded edge support conditions on the postbuckling response and failure of the plates. Extensive experimental investigation were also carried out to supplement the finite element study. A comprehensive comparison between theory and experimental data are presented and discussed in this contribution.

Nexus between Production Input and Price Commodity: An Integration Analysis of Rice Barns in East Java of Indonesia

  • WULANDARI, Dwi;NARMADITYA, Bagus Shandy;PRAYITNO, Putra Hilmi;ISHAK, Suryati;SAHID, Sheerad;QODRI, Lutfi Asnan
    • The Journal of Asian Finance, Economics and Business
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    • v.7 no.10
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    • pp.451-459
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    • 2020
  • This study aims to examine the causality between production input and the price of rice in East Java, Indonesia. This study applied a quantitative method to understand in a comprehensive way the correlation between variables. The data used for this study were collected from several sources, including East Java Agriculture Office, Siskaperbapo.com, and Statistics Indonesia (BPS) of East Java. This research was carried out over five years, starting from 2014 to 2018. Furthermore, the data were analyzed using the Vector Error Correction Model (VECM) by employing E-Views (version 7). The findings of this study indicated that, in the long run, the population, rice production, and changes in people's income have a positive effect on price stability, but are inversely proportional if seen in the short term. In comparison, in the long run, farmer exchange rates variable has a negative impact on price stability, and inversely proportional in the short term, which has a positive effect. There are different implications when the people's income increases and the rice price declines; these have great potential to alleviate poverty in East Java, Indonesia. This is due to the fact that the price stability also concerns the welfare of the community.