• Title/Summary/Keyword: problem analysis

Search Result 16,360, Processing Time 0.049 seconds

Effects of Lonicera caerulea extract on adipocyte differentiation and adipogenesis in 3T3-L1 cells and mouse adipose-derived stem cells (MADSCs) (댕댕이나무 열매 추출물이 지방전구세포와 마우스 지방유래줄기세포의 분화 및 지방 생성 억제에 미치는 영향)

  • Park, Miey;Lee, Changho;Lee, Hae-Jeung
    • Journal of Nutrition and Health
    • /
    • v.52 no.1
    • /
    • pp.17-25
    • /
    • 2019
  • Purpose: Obesity is a major health problem of global significance because it is clearly associated with an increased risk of health problems, such as nonalcoholic fatty liver disease (NAFLD), diabetes, cardiovascular diseases, and cancer. Lonicera caerulea (LC) originates from high mountains or wet areas and has been used as a traditional medicine in northern Russia, China, and Japan. LC contains a range of bioactive constituents, such as vitamins, minerals, and polyphenols. This study examined the anti-obesity effects of LC during differentiation in preadipocytes. Methods: The cell viability assay was performed after the differentiation of 3T3-L1 cells for 7 days. Oil Red O staining was used to visualize the changes in lipid droplets in 3T3-L1 cells and mouse adipose-derived stem cells (MADSCs). The mRNA expression of obesity-related genes was determined by quantitative real-time PCR. Results: According to the results of Oil Red O staining, the lipid levels and size of lipid droplets in the adipocytes were reduced and the LC extract (LCE, 0.25-1 mg/mL) markedly inhibited adipogenesis in a dose-dependent manner. The treatment of LCE also decreased the mRNA expression of peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$), CCAAT/enhancer binding protein-${\alpha}$ ($C/EBP{\alpha}$), and sterol regulatory element binding protein 1 (SREBP1) in 3T3-L1 cells. Western blot analysis showed that the $PPAR{\gamma}$, $C/EBP{\alpha}$, and SREBP1 protein levels in both 3T3-L1 and MADSC were reduced in a dose-dependent manner. Conclusion: These results suggest that LCE can inhibit adipogenic differentiation through the regulation of adipogenesis-related markers.

Design and Implementation of Blockchain Network Based on Domain Name System (블록체인 네트워크 기반의 도메인 네임 시스템 설계 및 구현)

  • Heo, Jae-Wook;Kim, Jeong-Ho;Jun, Moon-Seog
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.20 no.5
    • /
    • pp.36-46
    • /
    • 2019
  • The number of hosts connected to the Internet has increased dramatically, introducing the Domain Name System(DNS) in 1984. DNS is now an important key point for all users of the Internet by allowing them to use a convenient character address without memorizing a series of numbers of complex IP address. However, relative to the importance of DNS, there still exist many problems such as the authorization allocation issue, the disputes over public registration, security vulnerability such as DNS cache poisoning, DNS spoofing, man-in-the-middle attack, DNS amplification attack, and the need for many domain names in the age of hyper-connected networks. In this paper, to effectively improve these problems of existing DNS, we proposed a method of implementing DNS using distributed ledger technology, blockchain, and implemented using a Ethereum-based platform. In addition, the qualitative analysis performance comparative evaluation of the existing domain name registration and domain name server was conducted, and conducted security assessments on the proposed system to improve security problem of existing DNS. In conclusion, it was shown that DNS services could be provided high security and high efficiently using blockchain.

An experimental study on the influence of undular bore on the hydraulic stability at Shinwol rainwater storage and drainage system (불규칙 단파가 신월저류배수시설의 수리적 안정성에 미치는 영향에 대한 실험 연구)

  • Oh, Jun Oh
    • Journal of Korea Water Resources Association
    • /
    • v.52 no.5
    • /
    • pp.313-323
    • /
    • 2019
  • Deep Tunnel system is a large-scale urban flood control facility installed underground in order to reinforce the lack of drainage systems in developed cities. In a structure like a deep tunnel system, the undular bore generated in the downstream causes a problem in the hydraulic stability of the tunnel. In this study, to investigate the influence of the undular bore on the hydraulic stability at the "Shinwol rainwater storage and drainage system", under construction for the first time in the country, a hydraulic model experiment was conducted on various flooding inflow scenarios. As a result of the hydraulic model experiment carried out in this study, the undular bore generated downstream is trapped in the pipe while moving to upstream, pushes the compressed air. It is judged that overflow occurred by choking the vertical drop shaft in the process when this compressed air is being exhaust through the upstream vertical drop shaft and blocking flood inflow. In addition, the analysis of velocity of undular bore shows that the undular bore transfers energy, and at this time, the pressure rose in the pipe and the velocity increment occurred of the undular bore. Further studies are needed to predict the size and velocity of undular bore, which plays an important role in the hydraulic stability of the tunnel in the deep tunnel system.

A Study on Pre-service Early Childhood Teachers' Perception of Bullying (예비유아교사의 따돌림 인식에 대한 연구)

  • Bae, Jae-Hyun
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.20 no.5
    • /
    • pp.417-426
    • /
    • 2019
  • This study examined to offer practical implications for the bullying for the prevention and response in early childhood education at the scene of the bullying that occur by to confirm the perception of the bullying to pre-service early childhood teachers. The survey questionnaire was completed by 313 pre-service early childhood teachers. SPSS Win program was used to perform frequency analysis, ANOVA. (1)The perception of bullying were significantly different according to grade and experience of child care practice, classroom observation, education program for taking preventive measure. (2)Teachers' perception about the action that can be seen as bullying followed by 'apply the violence, such as kicking, or were frequent', 'shared in things that often prevents','often to another carrier or shame in front of a friend'. (3)Perception about characteristics of bullying Perpetrators was 'aggressive behavior and talk much' and perception about characteristics of bullying victims was 'shy and not much'. (4)The reason of bullying perpetrators was 'Just for fun without a special reason' and the cause of bullying victims was 'problem of parents' child-rearing attitudes and home environment'. (5)Important institutions to combat bullying prevention followed by teacher, parents and family, community and the nation, preschool educational institution. Teachers guidance content of combat and prevent bullying was 'to be isolated from the class to infants continue to monitor'. Parents guidance content of combat and prevent bullying was 'communicate a lot and attention to children'. Early childhood education institutions guidance content of combat and prevent bullying was 'operations to come up with the bullying prevention education in educational time'. This study indicated that it is necessary to make efforts for increasing perception of bullying in pre-service early childhood teachers.

A Study on Technological Forecasting for Promising Alternative Technologies Using Fisher-Pry Modification Model (Fisher-Pry 수정모형을 활용한 유망대체기술 예측에 관한 연구)

  • Hong, Sung-Il;Kim, Byung-Nam
    • The Journal of the Korea Contents Association
    • /
    • v.19 no.5
    • /
    • pp.104-114
    • /
    • 2019
  • In the global market competition, countries and businesses are actively engaged in technology prediction activities to maximize their profits by attempting to enter and preempting the core technology of the future. In this paper, we propose a growth model based on patent application trends to predict the time to replace a product with a promising new technology to dominate the market. Although the Fisher-Pry model that Bhargava generalized to predict the emergence of promising alternative technologies was relatively satisfactory compared to the original Fisher-Pry model, it was difficult to predict the replacement rate behavior properly due to a parameter problem. The application of the Fisher-Pry Modification Model in the form of a quadratic equation through the patent trend analysis of the optical storage system for the purpose of verifying the time alternative to the light storage technology has resulted in satisfactory verification results. It is expected that small and medium-sized companies and individual researchers will apply this model and use it more easily to predict the time to replace the market for promising replacement technologies.

Development of Standard Method for Quality Innovation to Strengthen Global Competitiveness and Create Management Performance of Small and Medium-sized Manufacturing Firms (중소 제조기업의 글로벌 품질경쟁력 강화 및 경영성과 창출을 위한 품질혁신 표준방법론 개발)

  • Park, Jong Kab;Kim, Youn Sung
    • Journal of Korean Society for Quality Management
    • /
    • v.46 no.4
    • /
    • pp.843-862
    • /
    • 2018
  • Purpose: The purpose of this study was to develop quality innovation techniques specialized for the small and medium-sized businesses. which account for the majority of Korean companies, were having a hard time utilizing the widely recognized quality innovation techniques due to resource constraints. Methods: First, we do review the existing Single PPM and 6 Sigma. And investigate the utilization of these methods including Toyota Production System. Second, we devised a four-step problem-solving methodology based on recent trends in quality innovation such as Simple, Speedy, and Smart. Third, we do survey on frequently used tools for quality innovation. Many opinion leaders including quality consultants and professors answered and gave us valuable comments about our selected quality tools. Finally, we do specify and map tools to each step of PASS. Results: In 2017, 167 companies participated in the quality innovation support business for small businesses according to the Korea Chamber of Commerce & Industry. We conducted performance checks on 167 companies that had completed the "PASS" projects. For the purpose of evaluating improvement performance, the survey was carried out using a structured questionnaire during the field visit of these companies mentioned above. For the reference, 165 out of 167 companies (98.8 % response rate) responded to the questionnaire and conducted performance analysis based on it. According to the survey, 97.6 percent of the respondents were very satisfied with their overall satisfaction with the quality innovation support projects for small and medium sized enterprises in 2017. Also, 93.3 % of the respondents were satisfied with the results of level of the target achievement. As a result, 160 companies (97.0 % of the participating companies) hope to partic ipate in the quality improvement project using "PASS" once again. Conclusion: In this paper, we introduce the new quality innovation methodology, which is named as 'PASS', It could support the long-range business plan of the small and medium-sized businesses to achieve total customer satisfaction resulting in increased market share and improved profit margin. The most small companies can use this "PASS" technique more easily, quickly and most efficiently than their existing known quality innovation techniques such as Six Sigma and Single PPM, etc.

Multi-modal Image Processing for Improving Recognition Accuracy of Text Data in Images (이미지 내의 텍스트 데이터 인식 정확도 향상을 위한 멀티 모달 이미지 처리 프로세스)

  • Park, Jungeun;Joo, Gyeongdon;Kim, Chulyun
    • Database Research
    • /
    • v.34 no.3
    • /
    • pp.148-158
    • /
    • 2018
  • The optical character recognition (OCR) is a technique to extract and recognize texts from images. It is an important preprocessing step in data analysis since most actual text information is embedded in images. Many OCR engines have high recognition accuracy for images where texts are clearly separable from background, such as white background and black lettering. However, they have low recognition accuracy for images where texts are not easily separable from complex background. To improve this low accuracy problem with complex images, it is necessary to transform the input image to make texts more noticeable. In this paper, we propose a method to segment an input image into text lines to enable OCR engines to recognize each line more efficiently, and to determine the final output by comparing the recognition rates of CLAHE module and Two-step module which distinguish texts from background regions based on image processing techniques. Through thorough experiments comparing with well-known OCR engines, Tesseract and Abbyy, we show that our proposed method have the best recognition accuracy with complex background images.

Instructional Development of Making Upcycle Clothing Accessories for the Middle School Home Economics Classes Applying the Design Thinking Technique (디자인씽킹 기법을 활용한 중학교 가정교과 의류 업사이클링 소품제작 수업개발)

  • Yu, Myoung Suk;Lee, Yhe Young
    • Journal of Korean Home Economics Education Association
    • /
    • v.33 no.3
    • /
    • pp.173-187
    • /
    • 2021
  • The purpose of this research was to develop instructions for making upcycled clothing accessories related to the 'clothing management and recycling' unit of middle school home economics applying the design thinking technique. Teaching and learning process plans were developed according to the ADDIE model which includes the following process: analysis, design, development, implementation, and evaluation. The design thinking process includes understanding the related knowledge, sympathizing, problem identification(sharing perspectives) and idea development, making prototypes, testing, and making the actual product. Thirteen home economics teachers served as critics. Student feedbacks were collected to evaluate whether the course objectives were attained after the implementation. As a result, teaching and learning process plans, course materials, and evaluation rubrics for ten class sessions were developed. Student feedbacks confirmed the attainment of following five course objectives: improvement of ethical responsibilities through the exploration of various clothing recycling techniques, practice of creative and eco-friendly clothing culture, acquisition of the skills to use sewing tools safely, improvement of abilities to think, sympathize, and communicate, and exploration of aesthetic activities and fashion careers.

A Study on Improvement Plans for National Archives of Korea Website's Search Service through Its Usability Evaluation (국가기록원 웹사이트 검색서비스의 사용성 평가를 통한 개선방안 연구)

  • Lee, Hyojin;Kim, Jihyun
    • Journal of Korean Society of Archives and Records Management
    • /
    • v.21 no.3
    • /
    • pp.187-215
    • /
    • 2021
  • Archives should provide a web-based archival information service with good usability based on the understanding of users' needs. Thus, this study analyzed the usability of the National Archives of Korea (NAK) website's search service through expert and usability evaluations for various users and suggested improvement plans. A literature review, heuristic evaluation, one of the usability expert evaluation methods, and usability evaluation for users were performed. As a result of expert evaluation, the severity rating for the usability problem was highest regarding a match between the system and real world and the lowest in error prevention. In the usability evaluation, it was assumed that the user's background and whether the website's help was provided is associated with usability. Usability evaluation was conducted for 22 participants, including those majoring in records management, web/application developers, and people without such backgrounds. Furthermore, a presurvey, a five-second test, and search tasks were conducted in a row. The analysis based on usability components in ISO 9241-11: 2018, i.e., effectiveness, efficiency, and satisfaction, showed that web/application developers had the highest search effectiveness, and those majoring in records management showed high effectiveness only in the search for archival content services. Background factors did not affect efficiency, and the more familiar with the finding aids, the better the efficiency. Moreover, providing the website's help was found to be positively associated with effectiveness and satisfaction. This study suggests that the NAK website will offer a user-friendly interface and search function, expand help support, and display a consistent web interface.

The Relationship Analysis of the Korean Science Curriculum with the Physical Science Domains of the 4th Grade TIMSS 2019 (TIMSS 2019의 4학년 물상과학 영역과 우리나라 과학 교육과정의 비교 분석)

  • Kim, Sun-Kyoung;Kim, Hyun-Kyung
    • Journal of Science Education
    • /
    • v.45 no.1
    • /
    • pp.1-10
    • /
    • 2021
  • In this study, we analyzed the relationship between the physical science domain of TIMSS 2019 and the Korean science curriculum. Twelve subjects are presented in the physical science domain of the TIMSS 2019 4th grade evaluation framework. Research group consisting of elementary and middle school teachers and science education experts, a total of 12, participated to analyze in which grade these subjects were included in the Korea 2009 revised and 2015 revised science curriculum. As a results of analyzing whether the achievement standards of the TIMSS 2019 evaluation framework and Korean science curriculum are consistent, the subjects pertinent to chemistry like 'chemical changes in everyday life,' 'heat transfer,' and 'electricity and simple electrical circuits' appeared not covered at all until the 4th grade curriculum in Korea. Given that the TIMSS 2019 evaluation framework is an international achievement standard, we are proposing to improve the Korean curriculum as follows: first, for the development of the next science curriculum, there is a need for science curriculum organized from the 1st grade of elementary school to connect the content and scope of chemistry in elementary, middle, and high schools as a whole including the Nuri curriculum. Second, as an alternative to the problem of suitability of learning volume and level of learning, it is possible to think of a method to readjust the grade of dealing with related concepts by lowering the difficulty or simplifying the concept. Third, it is necessary to discuss about introducing essential concepts and standard terms into Korea science curriculum according to international trends.