• The Korean Journal of Applied Statistics
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• v.26 no.4
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• pp.675-686
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• 2013

The Korea Food and Drug Administration(KFDA) recommends the use of a $2{\times}2$ crossover design to assess the bioequivalence of generic drugs. However, a standard $2{\times}2$ crossover design for bioequivalence trials is often considered problematic due to ethical and economic issues as highly variable drugs are usually required by large numbers of subjects when designing the trial. To overcome this problem a $2{\times}4$ crossover design has been a recommended option as per US regulations; in addition, a $2{\times}3$ crossover design has also recently drawn special attention as an efficient alternative. The current KFDA regulation requires an ANOVA table for every bioequivalence study; however, ANOVA tables of $2{\times}4$ and $2{\times}3$ crossover designs have never been published in the literature. This study shows the derivation of tables of analysis of variance for a $2{\times}4$ cross-over design and a $2{\times}3$ cross-over design. We also suggest a sample size formulas for $2{\times}2$, $2{\times}4$ and $2{\times}3$ crossover designs to provide information on the selection of efficient designs for highly variable drugs.

• Journal of Korean Society of Steel Construction
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• v.18 no.6
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• pp.697-706
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• 2006

Tower crane's wall tie is generally used for extending of mast height according to rising of lifting height. In order to get wall tie member force this problem, this study concerning wall tie is based on load data described in manual book of 290HC model. This study made the equation of wall tie member force and computer programming for calculating wall tie member force and then get ${\theta}-P$ curves(angle-wall tie force). After considering the ${\theta}-P$ curves, optimum angle range ($48.4^{\circ}{\sim}77.2^{\circ}$) about wall ties (A), (C) members was obtained. Member force of wall tie (B) was changed from tension to compression or from compression to tension at $74^{\circ}$ in service and $54^{\circ}$ in out of service. When both horizontal force($H_A$) and torsional moment ($M_D$) were varied from (+) to (-), wall tie force(A, B, C) were changed almost symmetrically about ${\theta}$-axis. Because this study was based on wall tie analysis conditions, wall tie members in symmetric and ideal geometry shape used for analizing wall tie of tower crane, it is necessary to have more careful verification in order to apply generally the results of this study.

• The Journal of Korean Society for School & Community Health Education
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• v.1 no.2
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• pp.87-104
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• 2000

The purpose of this study was to obtain the basic data as a improvement method through the fact-revealing concerning the drinking water management of school and utilization of student. The problems of the research are as follows: First, to investigate status of management of drinking water by area and school. Second, to investigate student's utilization of drinking water by area and school. 1,400 students was selected at 45 elementary and middle-high schools located in Kang-won province, and this study was constituted of two questionnaires(for school's questionnaire and student's questionnaire). The results was analyse through the frequency analysis, $x^2$-test on the basis of the above research problem by SPSS program. The findings of this research are as follows; 1) The Management of School Drinking Water First, the source of school drinking water was mostly piped water. Inspection of water quality has been fulfilled under four times a year, in the other hands, from the result inspection, the schools which was given inadequate determination was 22.2%. Second, reservoir cleaning and hygiene inspection failed far short of the regulations. Especially, reservoir cleaning was managed by exterior consignment industry not low-level officials. Third, school water drinking was the most supplied through the type of water purifier. Water purifier has been distributed to city-located and middle-high school highly, factually the water from water purifier was served with water cup. Fourth, the selection standard of water drinking manager showed slightly differently by school, accordingly there need to develope integrated system with the respective to its effective systematic management. Fifth, water cup was mostly treated by only water clear, which is to vindicate the problems concerning hygiene management. 2) Utilization of school student on Drinking Water First, Disbelief on drinking water of school student was very high. Especially, proportion of middle-high school student's disbelief of drinking water was higher than elementary school student, also girls higher than boys. Many of student have heard to don't drink water from around people. And there were showed meaningful differences by area and school. Second, It was showed many student recognize had to utilize water purifier, boiled water. However, they have still drunken the tap water or portable water from their home. Third, Many of student showed negative response with the respective to the management conditions of drinking water in classroom, There were showed meaningful differences by area and school. From the fact-revealing of water cup management, Students mostly answered to 'only water clear' and the answer of 'None use' or 'With personal cup' was higher. Fourth, In bad experience of Drinking Water, student mostly answered to 'occasionally' and there were showed meaningful differences by school. student's disease experience with school drinking water was few and there were showed meaningful differences by area and gender.

• The Journal of the Korean Society for Microbiology
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• v.35 no.3
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• pp.203-214
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• 2000

Porphyromonas gingivalis has been implicated in periodontal diseases. Accumulating evidence suggests that cardiovascular disease is the most prevalent medical problem in patients with periodontal diseases. In order to check the possibility that P. gingivalis is involved in coronary heart disease, the present study was performed to observe P. gingivalis adherence and invasion of human coronary artery endothelial cells (HCAEC) and production of cytokines and growth factors by HCAEC upon P. gingivalis infection. $^3H$-labeled P. gingivalis 381 was incubated with HCAEC for 90 min. The radioactivity of the washed HCAEC was a measure of the absorbed (adhering and invading) P. gingivalis. The absorption radioactivity of the HCAEC infected by P. gingivalis was determined to be 59.58% of the input bacterial cells. In contrast, the absorption radioactivity of the cells infected by S. gordonii Challis which was employed as a control was negligible (0.59%). DPG3, a P. gingivalis mutant defective of fimbriae, appeared to be impaired to some extent in capability of adherence/invasion as compared to that of the parental strain 381, showing 43.04% of the absorption radioactivity. The absorption radioactivity of the HCAEC infected by P. gingivalis 381 in the presence of excessive fimbriae at the concentrations of $50\;{\mu}g$ and $100\;{\mu}g/ml$ was 57.27 and 45.44%, respectively. Invasion of HCAEC by P. gingivalis 381 was observed by an antibiotic (metronidazole) protection assay and transmission electron microscopy (TEM). In the antibiotic protection assay, invasion by the bacterium was measured to be 0.73, 1.09, and 1.51% of the input bacterial cells after incubation for 30, 60, and 90 min, respectively. Invasion by DPG3 was shown to be 0.16% after 90-min incubation. In comparison of invasion efficiency at 90 min of the incubation, the invasion efficiency of DPG3 was 0.37% while that of its parental strain 381 was 2.54%. The immunoblot analysis revealed fimbriae of P. gingivalis did not interact with the surface of HCAEC. These results suggest that fimbriae are not the major contribution to the adherence of P. gingivalis to HCAEC but may be important in the invasion of HCAEC by the bacterium. The presence of cytochalasin D ($1\;{\mu}g/ml$) and staurosporine ($1\;{\mu}M$) reduced the invasion of HCAEC by P. gingivalis 381 by 78.86 and 53.76%, respectively, indicating that cytoskeletal rearrangement and protein kinase of HCAEC are essential for the invasion. Infection of P. gingivalis induced HCAEC to increase the production of TNF-${\alpha}$. by 60.6%. At 90 min of the incubation, the HCAEC infected with P. gingivalis cells was apparently atypical in the shape, showing loss of the nuclear membrane and subcellular organelles. The overall results suggest that P. gingivalis may cause coronary heart disease by adhering to and invading endothelial cells, and subsequently damaging the cells.

• Journal of agricultural medicine and community health
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• v.35 no.2
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• pp.124-133
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• 2010

Objectives: This study is to offer basic data to understand the relationships between mental health, level of depression, and internet addiction of high school students in farming communities for developing a mental health management program for adolescents. Methods: The survey was carried out on a convenience sample of 299 high school students in farming communities during May of 2008. Data analysis procedure included $X^2$-test, t-test, Pearson correlation among Adolescent Mental Health & Problem-behavior Screening Questionnaire (AMPQ), Children's Depression Inventory (CDI), and Scales of Internet addiction (K-scales). Results: First, the level of mental health according to the AMPQ for subjects from this study showed problematic behavior was lower when compared to other researches. There were statistically significant differences according to the school type for externalization problems and overall problematic behavior. Based on gender, it was even more problematic for male students in regards to externalization problems. Secondly, the level of depression was relatively low : 5.1% for potential risk and 0.3% for high risk. Thirdly, a total of 96.9% were considered normal for Internet addition levels. 1.7% for potential risk, 1.4% for high risk; however, there was no statistically significant difference between each variable. Fourthly, there was a strong relationship between subjects AMPQ, level of depression and Internet addiction. As depression worsens, Internet addiction also becomes stronger. Conclusion: There is a need for awareness of the mental health of adolescents and precautionary measures, the development of a program for early treatment, adequate management, and decisions on the direction of treatment.

• Journal of Environmental Health Sciences
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• v.20 no.1
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• pp.62-67
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• 1994

Introduction : Recently, water and environmental pollution becomes serious social problem and high technology makes this pollution accelerate. Hydrogen sulfide, the main subject of our research, is one of the most dangerous air pollutant like SO$_x$ and NO$_x$. The major contaminant in coal gasification is H$_2$S, which is very toxic, hazardous and extremely corrosive. Therefore, control of hydrogen sulfide to a safe level is essential. Although commercial desulfurization process called liquid scrubbing is effective for removal of H$_2$S, it has drawbacks, the loss of sensible heat of the gas and costly wastewater treatment. Many investigations are carried out about high-temperature removal ol H$_2$S in hot coal-derived gas using metal oxide or mixed metal qxide sorbents. It was reported that ZnO was very effective sorbent for H2S removal, but it has big flaw to vaporize elemental zinc above 600\ulcorner \ulcorner As alternative, metal oxides such as CaO, $Fe_2O_3$, TiO$_2$ and CuO were added to ZnO. Especially, different results are reported for $Fe_2O_3$ additive. Tamhankar et al. reported SiO$_2$ with 45 wt% $Fe_2O_3$ sorbent is favorable for removal of H$_2$S and regeneration.

• Journal of Environmental Policy
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• v.13 no.4
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• pp.51-78
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• 2014

Unlike traditional environmental problems, current environmental problems occur due to by complex reasons. These complexities highlight the importance of precise spatial based analysis and expeditive use of environmental information when an environmental problem arises. However, the traditional environmental information has many problems because they are mainly numerical based and scattered in various systems. To overcome these problems, providing integrated environmental spatial information is important. Thus, a research was conducted on establishing national environment atlas system and its implications for policies. Firstly, this study selects 275 out of 2,701 materials and information from Ministry of Environment and related organizations. Secondly, total 64 thematic maps specific business support are Produced to support establishment and implementation of environmental policies. In addition, the produced thematic maps are privatized. Thirdly, the study analyzes total 17 systems and environmental thematic maps of Ministry of Environment and relevant organizations to connect the information on the business support thematic maps. As a result, 1,314 applicable spatial information and 39,331 applicable database based on spatial information based are selected, and a standardization plan is established. Fourthly, the study suggests a stepwise implementation plan for developing a national environment atlas system. The development of national environment atlas system will help establishing an environmental policy based on more relevant and accurale information.

• Journal of Korean Home Economics Education Association
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• v.26 no.3
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• pp.17-34
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• 2014

This study aimed to examine the research trends and to suggest future research directions in teaching-learning methods for Home Economics education, by analyzing articles published in three major academic journals in the field. From each of the research studies, the teaching-learning method, the related content area, and the learning effect measures were quantitatively codified. The data were analyzed using frequency analysis and cross-tabulations. According to the results, the number of teaching-learning method studies steadily increased since 1998 and peaked in 2010 and 2011. The most frequently studied content areas were combinations of more than two content areas, and the most frequently studied teaching-learning method was the Content-Based methods, followed by Practical Thinking/Problem Solving, and IT-Based methods. The most frequently used measures of learning effect were Knowledge/Understanding, Attitudes toward Home Economics subject, General Attitudes/Competencies, and the Attitudes toward the Instructional Method, in the order of frequencies. The results of this study are expected to contribute to the teaching-learning method research and also provide implications to the documentation of Home Economics curriculum for secondary education.

• Journal of Korean Home Economics Education Association
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• v.25 no.3
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• pp.105-121
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• 2013

This study aimed to investigate the validity and appropriate way of career education according to the integration of home economics subjects, as a way of revitalization of career education in technology and home economics subjects, after the implementation of free semester system. For this goal, the meaning and trend of free semester system, trend of subject-integrated career education, analysis of curriculum in technology home economics education subject, and trend of research about career education in home economics were investigated. The result was as in the following. First, in spite of the ambiguity of the meaning of free semester, the career education will be expanded as the importance of lifelong career education was more and more required. Second, the career paths separated from subjects had problem in its effectiveness, therefore, subject-integrated career education emphasizing on school subjects will become more crucial. Third, it was presented that extracting core achievement standard in subject-integrated career education in technology home economics education according to core achievement standard was critical. For these reasons, the objective and model of career education in home economics education under free semester system were illustrated.

• Journal of the Korean Institute of Gas
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• v.19 no.1
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• pp.28-37
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• 2015

This study presents the development of a well placement optimization model, combining an artificial neural network, which enables high-speed calculation, with a simulated annealing algorithm. The conventional FDM simulator takes excessive time when used to perform a field scale reservoir simulation. In order to solve this problem, an artificial neural network was applied to the model to allow the simulation to be executed within a short time. Also by using the given result, the optimization method, SA algorithm, was implemented to automatically select the optimal location without taking any subjective experiences into consideration. By comparing the result of the developed model with the eclipse simulator, it was found that the prediction performance of the developed model has become favorable, and the speed of calculation performance has also been improved. Especially, the optimum value was estimated by performing a sensitivity analysis for the cooling rate and the initial temperature, which is the control parameter of SA algorithm. From this result, it was verified that the calculation performance has been improved, as well. Lastly, an optimization for the well placement was performed using the model, and it concluded the optimized place for the well by selecting regions with great productivity.