• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1547-1551
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• 2016

Background: Acute myeloid leukemia (AML) is a clonal hematopoietic disorder resulting from genetic alterations in normal hematopoietic stem cells. The aim of this study was to evaluate prognostic factors and survival of AML patients in the Northeast of Iran. Materials and Methods: This retrospective study covered 96 patients with AML referred to Emam Reza Hospital, Mashhad city, Iran, from 2009 to 2015. Age, sex, blood group, type of AML, fever, consumption of amphotericin B, cytogenetic forms and survival were analyzed. Also, WBC, hemoglobin and platelet levels were checked. Mean follow-up was 30.5 months (60.4% mortality). Survival was plotted by GraphPad Prism 5 with Log-rank test. Results: The mean age for all AML patients at diagnosis was 40.4 years (range, 17-77 years). Some 42.7% patients were aged <35 years and 40.6% were male. In all patients, 76% had fever and 50% consumed amphotericin. T(15;17)(q22;q21) had the most prevalence (37.7%) compared to other forms. Out of 92 patients, O+(30.4%) was the most common blood group and AML-M5 (28.3%) the most common subtype. There was a significant difference in survival based on WBC and consumption of amphotericin B (P<0.05). Conclusions: WBC level, fever and consumption of amphotericin B proved to be factors for survival of AML patients. The mean age for patients in Iran is lower than other areas in the World and also survival in this study was higher than in other studies.

• The Journal of Advanced Prosthodontics
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• 제6권4호
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• pp.317-324
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• 2014

PURPOSE. This study was to evaluate the effect of grinding of the inner metal surface during the porcelain try-in stage on metal-porcelain bonding considering the maximum temperature and the vibration of samples. MATERIALS AND METHODS. Ninety-one square prism-shaped ($1{\times}1{\times}1.5mm$) nickel-chrome cast frameworks 0.3 mm thick were prepared. Porcelain was applied on two opposite outer axial surfaces of the frameworks. The grinding was performed from the opposite axial sides of the inner metal surfaces with a low-speed handpiece with two types of burs (diamond, tungsten-carbide) under three grinding forces (3.5 N, 7 N, 14 N) and at two durations (5 seconds, 10 seconds). The shear bond strength (SBS) test was performed with universal testing machine. Statistical analyzes were performed at 5% significance level. RESULTS. The samples subjected to grinding under 3.5 N showed higher SBS values than those exposed to grinding under 7 N and 14 N (P<.05). SBS values of none of the groups differed from those of the control group (P>.05). The types of bur (P=.965) and the duration (P=.679) did not affect the SBS values. On the other hand, type of bur, force applied, and duration of the grinding affected the maximum temperatures of the samples, whereas the maximum vibration was affected only by the type of bur (P<.05). CONCLUSION. Grinding the inner metal surface did not affect the metal-porcelain bond strength. Although the grinding affected the maximum temperature and the vibration values of the samples, these did not influence the bonding strength.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3085-3088
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• 2016

Background: Worldwide, colorectal cancer (CRC) is reported to be the fourth most common cancer in men and the third most common in women. KRAS is a proto-oncogene located on the short arm of chromosome 12. The aim of this study was to evaluate the KRAS oncogene and its relationship it with clinicopathologic features in 33 Kurdish patients. Materials and Methods: Metastatic CRC between 2012 and 2016 that came to Imam Reza hospital, Kermanshah province, Iran, were analysed for KRAS mutations using allele specific PCR primers and pyrosequencing. Correlations between variables was analyzed in PASW SPSS and overall survival curves were plotted in Graph Pad prism 5. Results: The mean age for them at diagnosis was $51.5{\pm}12.6$ years (range, 22-76 years). Among the 33 patients that were sequenced, 12 samples in the KRAS gene had a nucleotide change, 11 in codon 12 and 1 in codon 13.There was no significant relationship between the mutation and clinical and pathological aspects of the disease. Conclusions: Knowledge of the KRAS status can help in decision-making to treat metastatic colorectal cancer patients more efficiently and increase survival. However, many Kurdish people due to economic problems are not able to do this valuable genetic test. In addition, we need more careful research of KRAS oncogene at the molecular level in young populations with more patients.

• 한국측량학회지
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• 제28권5호
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• pp.485-491
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• 2010

붕괴된 사면의 정보는 제2차 피해의 발생우려가 있기 때문에 신속 정확하게 지형자료를 획득할 수 있어야 하고, 필요에 따라서 접근하지 않고 간접적인 측량방식으로 보다 효율적으로 표현할 수도 있어야 한다. 따라서 본 연구에서는 무인 헬리콥터 사진촬영시스템을 이용하여 붕괴된 도로 절개지 사면에 근접하여 상공에서 정지비행으로 대상지역의 영상을 촬영하였다. 그리고, 무타켓 Total Station에 의해 관측된 점과 영상해석에 의해 분석된 좌표점 10개와 비교한 결과 절대치 평균값은 X축 방향으로 평균 0.056m, Y축 방향으로 0.082m, Z축 방향으로 0.066m으로 나타났다. 또한, 검사점 10점에 대한 오차의 RMSE는 X축 방향으로 0.015636m, Y축 방향으로 0.021319m, Z축 방향으로 0.018734m로 나타났다. 따라서, 이러한 절개지 붕괴사면의 지형에 대하여 관계형 영상정합방법에 의해 접근하지 못하는 위험지역에서의 사면 범위와 각사면의 종 횡단면을 나타낼 수가 있었다.

• Archives of Plastic Surgery
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• 제49권3호
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• pp.462-470
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• 2022

Background Reactive oxygen species cause serious damage to the physiological function of tissues. Determination of total antioxidant capacity of skin tissue is one of the determinants of damaged tissue function. Mast cells (MCs) are one of the groups of cells that are invited to the site of injury. The healing process begins with the rapid release of various types of MCs' intermediate factors at the site of injury. Bone marrow mesenchymal stem cell (BMMSC) production and secretion have been shown to regenerate the skin. The aim of this research was to evaluate the wound-healing and antioxidant effects of BMMSCs per MCs. Methods Fifty-four albino Wistar male rats were divided into three groups: (1) nonsurgery, (2) surgery, and (3) surgery + BMMSCs. Groups 2 and 3 were operated with a 3 × 8 cm flap and in group 3, cell injections (7 × 10⁹ cell injection at the time of surgery) were performed. After days 4, 7, and 15, percentage of the surviving tissue, histological characteristics, superoxide dismutase (SOD) activity, and amount of malondialdehyde (MDA) were measured in the groups. For results, Graph Pad Prism 8 software was used, and data were analyzed and compared by analysis of variance and Tukey test. Results BMMSCs' application decreased the amount of MDA, increased SOD activity and survival rate of the flaps, and improved the histological characteristics. Conclusion This study revealed the protective effects BMMSCs alongside MCs against oxidative stress on the survival of the flaps. However, for clinical use, more research is needed to determine its benefits.

• Fisheries and Aquatic Sciences
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• 제26권1호
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• pp.24-34
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• 2023

Reactive oxygen species (ROS) at high concentrations induce oxidative stress, an imbalanced redox state that is a prevalent cause of neurodegenerative disorders. This study aimed to investigate the protective effect of Capsosiphon fulvescens (CF) extract on oxidative stress-induced impairment of cognitive function in models of neurodegenerative diseases. CF was extracted with subcritical water and several solvents and H₂O₂ (0.25 mM) or aluminum chloride (AlCl₃; 25 µM) as an inducer of ROS was treated in PC12 neuronal cells and zebrafish larvae. All statistical analyses were performed using one-way analysis of variance and Dunnett's test using GraphPad Prism. H₂O₂ and AlCl₃ were found to significantly induce ROS production in PC12 neuronal cells and zebrafish larvae. In addition, they strongly affected intracellular Ca²⁺ levels, antioxidant enzyme activity, brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) signaling, acetylcholinesterase (AChE) activity, and hallmarks of Alzheimer's disease. However, treatment of H₂O₂-induced PC12 cells or AlCl₃-induced zebrafish larvae with CF subcritical water extract at 90℃ and CF water extract effectively regulated excessive ROS production, intracellular Ca²⁺ levels, and mRNA expression of superoxide dismutase, glutathione peroxide, glycogen synthase kinase-3 beta, β-amyloid, tau, AChE, BDNF, and TrkB. Our study suggested that CF extracts can be a potential source of nutraceuticals that can improve the impairment of cognitive function and synaptic plasticity by regulating ROS generation in neurodegenerative diseases.

• 한국안광학회지
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• 제19권3호
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• pp.331-337
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• 2014

목적: 본 연구에서는 기존의 사위검사법인 하웰검사와 토링톤검사 및 개발된 사위검사법인 3차원편광검사를 사용하여 양안의 융합제거 시간에 따른 사위량을 측정하고 이를 비교해 보았다. 방법: 본 연구에서는 융합을 제거하는 시간을 고려하여 여러 사위검사법으로 사위량을 측정하고 비교하였다. 사위 측정에는 하웰검사, 토링톤검사, 3차원편광검사 등 세 가지 사위검사법을 사용하였다. 실험대상자가 실험 중에 사위성 눈피로가 유발되지 않도록 하기 위해 검사의 신속함을 고려하였다. 신속한 검사를 위해 세 가지 사위검사법에 호환 가능한 검사시표와 검사렌즈를 장착한 시야제한 장치를 제작하고 검사순서를 고안하였다. 순간 분리 사위량은 개발된 시야제한 장치(apparatus)를 통해 양안의 융합 분리 순간(moment separation)에 측정하고, 안정된 분리 사위량은 양안의 융합 분리 순간 후 각각의 지시상자의 움직임이 수평의 숫자배열 위에서 안정된 정지 상태를 보이는 순간(stable separation)에 측정하였다. 결과: 양안의 융합 분리 순간에 측정한 사위량(이하 "분리 순간 사위량")과 양안의 융합 분리 후 안정된 안구 정렬상태에서 측정한 사위량(이하 "분리 안정 사위량")의 비교 분석에서는 외사위(exophoria)에서 유의한 결과를 보였으며, 외사위일 때 분리 순간 사위량이 분리 안정 사위량보다 상대적으로 컸다. 세 가지 사위 검사법의 비교 분석에서는 개발된 3차원편광검사로 측정했을 때 두 가지 분리 검사 간 차이가 가장 적은 것으로 나타났다. 결론: 양안의 융합 분리 순간에 측정한 사위량과 양안의 융합 분리 후 안정된 안구 정렬 상태에서 측정한 사위량의 비교 분석에서는 외사위에서 양안의 융합 분리 순간에 측정한 사위량이 양안의 융합 분리 후 안정된 사위량보다 상대적으로 높게 측정되었다. 세 가지 사위 검사법의 비교 분석에서 두 가지 분리 방식의 검사 간 차이량은 비슷한 것으로 나타났다. 사위 검사할 때, 순간 분리 사위량과 안정된 분리 사위량을 구분없이 혼용하는 경우가 많다. 그러나 두 가지 분리 검사로 측정한 사위량 간에는 유의한 차이가 있으므로 처방전에 어떤 조건으로 사위량을 측정했는지에 대해 명확히 기입이 필요하다.

• 한국안광학회지
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• 제18권3호
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• pp.341-346
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• 2013

목적: 머리위치와 사위의 관련성, 습관적인 머리위치 평가의 유용성을 평가하고자 하였다. 방법: 무작위 참여자 중 사위가 있는 22명(남자 20명, 여자 2명, 평균나이 $23.6{\pm}2.7$세)을 대상으로 하였다. 모든 대상자는 문진, 차폐검사, 굴절검사, 사위 및 융합여력검사를 실시하였다. 습관적인 머리위치(머리기울임과 얼굴돌림)는 Impression IST에 의한 타각적 측정과 검사자에 의한 주관적 관찰로 평가하였다. 결과: 사위가 있는 대상자에서 습관적인 머리위치가 드러날 수 있다는 것을 확인할 수 있었다. 프리즘 처방이 필요한 15명의 대상자에서 원거리 사위도와 얼굴돌림에서 유의한 Spearman 상관관계를 보였다($\rho$ = 0.524, p = 0.045). 사위 이상 대상자에서 머리위치와 사위도의 상관성은 없었다. 타각적 측정과 자각적 관찰의 상관성은 없었으나 타각적 측정은 정밀하고 자각적 관찰은 판별력이 있는 방법으로 평가되었다. 결론: 사위에서 이상두위 현상이 나타났으며, 이러한 결과들은 사위에서 모든 주 주시방향에서 습관적인 머리위치를 관찰할 필요가 있음을 암시한다.

• 한방재활의학과학회지
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• 제32권1호
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• pp.51-62
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• 2022

Objectives Objective of this study is to investigate the role of paraspinal muscles by examining the correlation between slip percentage (SP) of spondylolisthesis and fatty infiltration of lumbar paraspinal muscle. Methods Retrospective analysis was performed on 45 patients diagnosed with spondylolisthesis based on medical records. Using T2-weighted axial magnetic resonance imaging, cross-sectional areas (CSAs) of psoas major (PM), multifidus (MU) and erector spinae (ES) were calculated and divided by CSA of lower level vertebral body (VB). SP was measured using sagittal T2-weighted images. Correlation of SP with muscle relative cross-sectional area (RCSA) and muscle fatty infiltration by Goutallier classification was respectively analyzed using Spearman correlation. Statistic assessment conducted by Wilcoxon signed rank test and paired t-test using program GraphPad prism 5 (GraphPad Software, Inc., San Diego, CA, USA). Results Spondylolisthesis forward slip percentage by Taillard's method was negatively associated with both side MU RCSAs. No significant correlation was found between PM RCSA, ES RCSA and SP. Forward slippage was significantly correlated with fatty infiltration of lumbar paraspinal muscle measured by Goutallier classification. Conclusions This study is to understand the role of paraspinal muscle affecting spinal instability by investigating correlation between statistical deviation of lumbar muscle characters (RCSA, fatty infiltration of lumbar muscle) and SP. We found that spondylolisthesis SP is positively related to fatty infiltration of lumbar paraspinal muscle. and is negatively associated with both side MU RCSAs.

• 한국전산구조공학회논문집
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• 제35권4호
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• pp.227-233
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• 2022

3D 프린팅은 다수의 레이어(layer)를 적층하여 물체를 제작하는 기법으로, 복잡한 형상을 가지는 물체를 비교적 쉽게 제작할 수 있다. 이를 건설 산업에 접목한 3D 콘크리트 프린팅(3D concrete printing)은 콘크리트 타설 시 거푸집을 사용하지 않으며, 비교적 적은 작업량과 인력이 요구되므로 경제적인 시공이 가능하나, 출력된 3D 프린팅 콘크리트는 일반 콘크리트 대비 다소 낮은 강도가 예상된다. 따라서, 본 연구에서는 3D 프린팅 콘크리트 시편의 물성을 분석하였다. 3D 프린팅 콘크리트 시편 출력을 위해 Ultimaker Cura 소프트웨어로 형상 및 출력 경로를 설계하고, 이를 바탕으로 3D 프린터를 제어하는 G-code를 생성하였다. 연구에서 사용된 3D 프린터의 출력 성능과 콘크리트의 적층성, 유동성 등을 고려하여 최적의 배합비를 선정하였고, 시편 출력에 활용하였다. 시편 출력 시 동일한 치수를 가지는 몰드 시편을 함께 제작하여 비교·분석에 사용하였다. 각 시편의 물성은 휨강도 시험과 압축강도 시험을 통해 각각의 강도를 측정하였고, 비교·분석하여 3D 프린팅 콘크리트 시편의 물성을 확인하였다.