• Journal of Microbiology
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• 제38권4호
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• pp.239-244
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• 2000

The cats gene encodes the major catalase in Sreptomyces coelicolor, whose production increases upon H$_2$O$_2$treatment. Besides the previously identified primary promoter (catApl), a minor promoter (catAp2) was newly assigned by S1 nuclease mapping. The catAp2 transcript was observed transiently upon entry into the stationary phase in liquid culture and upon differentiation on solid plates, whereas the level of catApl transcription did not chance significantly during this growth transition. ThecatApl promoter was transcribed by the major vegetative RNA polymerase holoenzyme containing $\sigma$$\^$HrdB/, whereas the catAp2 was transcribed in vitro by the holoenzyme containing $\sigma$$\^$R/ that is activated under oxidative conditions. The cia-element regulating the H$_2$O$_2$-inducibility of catApl was identified within the 23 bp inverted repeat sequence located between -65 and -43 of the catApl promoter. We roamed this sequence HRE (H$_2$O$_2$-responsive Element). The distal half of the inverted repeat was more crucial for H$_2$O$_2$-dependent induction of the catApl transcript than the proximal half. HRE most likely serves as a binding site for the H$_2$O$_2$-responsive repressor CatR.

• 한국재료학회지
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• 제20권3호
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• pp.142-147
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• 2010

Nano-sized $BaNd_2Ti_5O_{14}$ powders were prepared by the spray pyrolysis process. Sucrose used as the organic additive enabled the formation of nano-sized $BaNd_2Ti_5O_{14}$ powders. The powders prepared from the spray solution without sucrose had a spherical shape, dense structure and micron size before and after calcination. However, the precursor powders prepared from the spray solution with sucrose had a large size, and hollow and porous morphology. The precursor powders had an amorphous crystal structure because of the short residence time of the powders inside the hot wall reactor. The complete decomposition of sucrose did not occur inside the hot wall reactor. Therefore, the precursor powders obtained from the spray solution with sucrose of 0.5M had a carbon content of 39.2wt.%. The powders obtained from the spray solution with sucrose of 0.5M had a slightly aggregated structure of nano-sized primary powders of $BaNd_2Ti_5O_{14}$ crystalline phase after calcination at $1000^{\circ}C$. The calcined powders turned into nano-sized $BaNd_2Ti_5O_{14}$ powders after milling. The mean size of the $BaNd_2Ti_5O_{14}$ powders was 125 nm.

• 동의생리병리학회지
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• 제17권4호
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• pp.845-851
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• 2003

The objective is to establish the standard of criteria for differential diagnosis of signs and symptoms. This study selected signs and symptoms related to heart which stands for Fire(火) as a kind of five phase(五行). Eleven experts was asked to evaluate the adequateness of criteria which was developed by Korea Institute of Oriental Medicine(KIOM) and to suggest the amendment of them. To implement the study, we used the questionnaire which asks about the diagnosis criteria for an insufficiency of the heart-qi(心氣虛證), deficiency of the heart blood(心血氣證), deficiency of the heart-yin(心陰虛證), insufficiency of the heart-yang(心陽虛證), exuberant fire due to hyperactivity of the heart(心火亢盛證), stagnation of the heart blood(心血瘀阻證), heart disturbed by phlegm-fire(痰火擾心證), attack of the heart by retainedfluid(水氣凌心證). Every criteria consists of primary symptoms, secondary symptoms, tongue findings. and pulse findings. In perspectives of the classification of patterns for signs and symptoms and criteria for diagnosis, the result shows that the previous standard doesn't have so many problem. So many of experts were agree with the criteria which was suggested but the trend is that they use, in their actual practice, less than the criteria. Additionally, they pointed that every element in a criterion should have the different weight value, criteria for the overlapped pattern should be added, and, in future, criteria which are based on clinical investigation should be established.

• 한국산업융합학회 논문집
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• 제23권4_2호
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• pp.617-626
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• 2020

The drilling mud is essentially used in oil and gas development. There are several roles of using the drilling mud, such as cleaning the bottomhole, cooling and lubricating the drill bit and string, transporting the cuttings to the surface, keeping and adjusting the wellbore pressure, and preventing the collapse of the wellbore. The fragments from rocks and micro-sized bubbles generated by the high pressure are mixed in the drilling mud. The systems to separate those mixtures and to keep the uniformly maintained quality of drilling mud are required. In this study, the simulation is conducted to verify the performance of the mud tank's agitation capacity. The primary role of the mud tank is the mixing of mud at the surface with controlling the mud condition. The container type is chosen as a mud tank pursuing efficient transport and better management of equipment. The single- and two-phase simulations about the agitation in the mud tank are performed to analyze and identify the inner flow behavior. The convergence of results is obtained for the vertical- and axis-direction velocity vector fields based on the grid-dependency tests. The mixing time analysis depending on the multiphase flow conditions indicates that the utilization of a two-stepped impeller with a smaller size provides less time for mixing. This study's results are expected to be utilized as the preliminary data to develop the mixing and integrating equipment of the onshore drilling mud system.

• 대한원격탐사학회지
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• 제26권2호
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• pp.167-173
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• 2010

본 논문은 통신해양기상위성에 탑재된 해양탑재체의 관측자료를 지상에서 처리하는 영상전처리 시스템을 소개하는 것으로, 주요 기능, 개발 과정, 운영 계획으로 나누어 기술한다. 해양탑재체 영상전처리시스템은 주 시스템과 백업 시스템이 해양위성센터 (한국해양연구원)와 위성운영센터 (한국항공우주연구원)에 각각 설치되어 있으며, 현재 모든 시험을 완료하고 위성 발사 전의 최종 시험 운영 중에 있다. 해양탑재체 영상전처리시스템이 제공할 통신해양기상위성의 해양데이터는 정지궤도에서 연속적으로 한반도 주변을 관측한 것으로서, 해수 온도 변화나 해양 생태계 등의 해양환경연구에 중요한 자료로 활용 가능할 것으로 기대되고 있다.

• Clinical and Experimental Reproductive Medicine
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• 제7권1_2호
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• pp.3-10
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• 1980

뇌하수체의 성선자극 홀몬 분비 세포는 혈액내 estradiol양의 변화에 따라 LH와 FSH를 분비하므로써 주기적인 변화를 보인다. 성선 자극 홀몬의 분비는 성선 자극 홀몬을 합성하고 보유하는 두가지 형태의 능력의 크기에 의하여 조절되며 이들을 조절하는 것은 시상하부에서 분비되는 황체형성 홀몬-분비 홀몬(LH-RH)과 난소에서 분비되는 estradiol이다. LH-RH는 성선 자극 홀몬 분비세포에 작용하여 성선 자극 홀몬 합성, 저장 및 분비를 촉진시키며 estradiol은 LH-RH의 기능을 확대하고 LH-RH가 self-priming효과를 나타내도록 유도하기도 하며 LH-RH의 성선 자극 홀몬 분비 기능을 저해하기도 한다. Estradiol은 기저성 성선 자극 홀몬을 분비시키기 위하여 negative feedback작용을 하고 배란성 성선 자극 홀몬을 분비시키기 위하여는 positive feedback작용을 하며 feedback작용 부위는 시상하부 및 뇌하수체 전엽이다. 또한, estradiol이 feedback작용을 하여 성선 자극 홀몬의 분비를 조절하는 데는 LH-RH뿐만 아니라 중추신경-시상하부에서 분비되는 dopamine, norepinephrine, prostaglandin등이 참여한다.

• 대한임상독성학회지
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• 제12권2호
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• pp.39-45
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• 2014

Purpose: The purpose of this study is to review the evidence comparing the efficacy and safety between L-carnitine and extracorporeal elimination therapy in the management of acute valproic acid L-carnitine vs Extracorporeal Elimination for Acute Valproic acid Intoxication Methods: PubMed, Embase, Cochrane library, Web of Science, KoreaMed, KMbase, and KISS were searched, using the terms carnitine and valproic acid. All studies, regardless of design, reporting efficacy or safety endpoints were included. Reference citations from identified publications were reviewed. Both English and Korean languages were included. Two authors extracted primary data elements including poisoning severity, presenting features, clinical management, and outcomes. Results: Thirty two articles including 33 cases were identified. Poisoning severity was classified as 3 mild, 11 moderate, and 19 severe cases. Nine cases were treated with L-carnitine while 24 cases received extracorporeal therapy without L-carnitine. All patients except one expired patient treated with hemodialysis recovered clinically and no adverse effects were noted. A case report comparing two patients who ingested the same amount of valproic acid showed increased ICU stay (3 vs 11 days) in case of delayed extracorporeal therapy. Conclusion: Published evidence comparing L-carnitine with extracorporeal therapy is limited. Based on the available evidence, it is reasonable to consider L-carnitine for patients with acute valproic acid overdose. In case of severe poisoning, extracorporeal therapy would also be considered in the early phase of treatment.

• 한국지반공학회논문집
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• 제35권7호
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• pp.5-14
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• 2019

본 연구는 교각 안전성 평가 기법을 확립하기 위해 실대형 교각을 구축하여 충격하중을 이용해 일련의 비파괴 실험을 수행하였다. 실대형 교각에 상재 하중은 0 tonf에서 2.5 tonf씩 적재하여, 최대 25 tonf 까지 적재하였다. 타격 방향에 따른 교각의 거동을 분석하기위해 교축 방향과 교축직각 방향 그리고 교각의 외측방향으로 타격하였고, 타격 높이도 교각의 상단과 하단으로 실험을 수행하였다. 계측기는 가속도계를 사용하여 타격했을 시의 가속도 응답을 측정하였다. 일련의 실험결과를 바탕으로, 고속 푸리에 변환(FFT)를 이용해 타격 방향 및 상재 하중에 따른 고유진동수를 산정했다. 또한 위상차를 이용해 교각의 1차 모드에서 4차 모드까지 분석이 가능했으며, 세굴에 대한 영향을 수치해석을 통해 분석했다. 그 결과, 2차 모드와 3차 모드를 통해 합리적인 교각의 안정성 평가가 가능한 것으로 판단된다.

• Tuberculosis and Respiratory Diseases
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• 제82권3호
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• pp.211-216
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• 2019

Background: Docetaxel is one of the standard treatments for advanced non-small cell lung cancer. Docetaxel is usually administered in a 3-week schedule, but there is significant toxicity. In this phase II clinical study, we investigated the efficacy and safety of a 4-weekly schedule of docetaxel monotherapy, as first-line chemotherapy for advanced squamous cell carcinoma in elderly lung cancer patients. Methods: Patients with stage IIIB/ IV lung squamous-cell carcinoma age 70 or older, that had not undergone cytotoxic chemotherapy were enrolled. Patients received docetaxel $25mg/m^2$ on days 1, 8, and 15, every 4 weeks. Primary endpoint was the objective response rate (ORR). Secondary endpoints were progression-free survival (PFS), overall survival (OS), and toxicity profiles. Results: A total of 19 patients were enrolled. Among 19 patients, 17 were for evaluated efficacy and safety. In the intent-to-treat population, ORR and disease control rate (DCR) were 11.8% and 47.1%, respectively. In the response evaluable population, ORR was 16.7% and DCR was 66.7%. Median PFS and OS were 3.1 months and 3.3 months, respectively. There were three adverse grade 3/4 events. Grade 1 neutropenia was reported in one patient. Conclusion: Our data failed to demonstrate efficacy of a 4-weekly docetaxel regimen, in elderly patients with a poor performance status. However, incidence of side effects, including neutropenia, was lower than with a 3-week docetaxel regimen, as previously reported.

• 대한금속재료학회지
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• 제46권6호
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• pp.338-344
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• 2008

The crystallization kinetics of the $Cu_{43}Zr_{43}Al_7Be_7$ bulk metallic glass were studied by differential scanning calorimetry(DSC) in the continuous heating and isothermal annealing modes. Only one major peak could be detected on the DSC traces of $Cu_{43}Zr_{43}Al_7Be_7$ bulk amorphous alloy, and the activation energy for crystallization corresponding to the peak determined by the Kissinger method was resulted of 239 kJ/mol. The isothermal kinetic, analyzed by the Johnson-Mehl-Avrami equation yielded values for the Avrami exponents in the range 1.69 to 2.37, which implied a crystallization governed by a three-dimensioned growth. Primary phases were essentially the cubic structure CuZr together with the $Cu_{10}Zr_7$ phase. At higher temperature, the CuZr disappeared while the $Cu_{10}Zr_7$ became predominant. After long term annealing at 731 K, the phases were $Cu_{10}Zr_7$, $Cu_2ZrAl$ and $Al_3Zr_5$.