• BMB Reports
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• v.45 no.8
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• pp.427-432
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• 2012

Primary cilia, single hair-like appendage on the surface of the most mammalian cells, were once considered to be vestigial cellular organelles for a past century because of their tiny structure and unknown function. Although they lack ancestral motility function of cilia or flagella, they share common ground with multiciliated motile cilia and flagella on internal structure such as microtubule based nine outer doublets nucleated from the base of mother centrioles called basal body. Making cilia, ciliogenesis, in cells depends on the cell cycle stage due to reuse of centrioles for cell division forming mitotic spindle pole (M phase) and assembling cilia from basal body (starting G1 phase and maintaining most of interphase). Ciliary assembly required two conflicting processes such as assembly and disassembly and balance between these two processes determines the length of cilia. Both process required highly conserved transport system to supply needed substance to grow tip of cilia and bring ciliary turnover product back to the base of cilia using motor protein, kinesin and dynein, and transport protein complex, IFT particles. Disruption of ciliary structure or function causes multiple human disorder called ciliopathies affecting disease of diverse ciliated tissues ranging from eye, kidney, respiratory tract and brain. Recent explosion of research on the primary cilia and their involvement on animal development and disease attracts scientific interest on how extensively the function of cilia related to specific cell physiology and signaling pathway. In this review, I introduce general features of primary cilia and recent progress in understanding of the ciliary length control and signaling pathways transduced through primary cilia in vertebrates.

• Korean Journal of Mathematics
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• v.22 no.2
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• pp.289-305
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• 2014

In this paper we propose a new approach to the variable selection problem for a primary resolution and wavelet basis functions in wavelet regression. Most wavelet shrinkage methods focus on thresholding the wavelet coefficients, given a primary resolution which is usually determined by the sample size. However, both a primary resolution and the basis functions are affected by the shape of an unknown function rather than the sample size. Unlike existing methods, our method does not depend on the sample size and also takes into account the shape of the unknown function.

• Journal of Society of Preventive Korean Medicine
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• v.17 no.2
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• pp.69-78
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• 2013

Objectives : Health cooperative movement is of increasing concern among medical consumers and professionals in Korea. Most health cooperative clinics provide Western Medicine and Korean Medicine(KM) to patients. This study aimed to evaluate the primary care level of health cooperative KM clinics and compare it with local KM clinics in Korea. Methods : Face to face survey was performed at the 3 health cooperative KM clinics and 5 local KM clinics with the Korean Primary Care Assessment Tool (KPCAT). The KPCAT consists of 5 domains (21 items): first contact (5), coordination function (3), comprehensiveness (4), family/community orientation (4), and personalized care (5). Subjects were patients or guardians who had visited KM clinics five times or more during the last 3 months. We compared primary care scores of each domain between health cooperative KM clinics and local KM clinics. Results : Data were collected from 200 respondents (100 patients from health cooperative KM clinics and 100 local KM clinics). Total average scores of the KPCAT for health cooperative clinics and local KM clinics were $81.1{\pm}12.0$ and $75.4{\pm}9.5$, respectively. Among primary care domains, personalized care was the highest ($89.2{\pm}12.0$, $89.6{\pm}8.4$, respectively), and comprehensiveness function was the lowest ($68.5{\pm}22.5$, $54.5{\pm}22.0$, respectively). Significant differences between two groups were noted in comprehensiveness function (68.5 vs. 54.5, P=0.000), family-community orientation (79.5 vs. 73.0, P=0.004), first contact(89.2 vs 84.0, p=0.001) and coordination function(74.0 vs 68.7, p=0.025). Conclusions : Based on the patients assessment, health cooperative KM clinics provide more primary care-oriented services than local KM clinics. This means that health cooperative clinic can be one of alternatives to strengthen the primary health care in Korea. Future researches are recommended to measure patients satisfaction and treatment effectiveness in the health cooperative clinics.

• Korean Journal of Mathematics
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• v.28 no.3
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• pp.459-481
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• 2020

In this paper we introduce relative L-order of a nonconstant entire function f with respect to another nonconstant entire function g. Also we investigate the existence of relative L-proximate order of f with respect to g.

• Journal of Korean Academy of Rural Health Nursing
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• v.14 no.2
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• pp.30-37
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• 2019

Purpose: This study was done to develop a comprehensive health promotion program based on the primary health care post, and then to examine the effectiveness of the program for rural elders. Methods: A single group pre-test post-test design was used, for 3 months and the 51 participants received the comprehensive health promotion program based on the primary health care post. Effectiveness of the intervention was measured immediately after the comprehensive health promotion program. Results: There were significant differences between pre-test and post-test on cognitive function (p=.001), depression (p=.001), systolic blood pressure (p=.001), blood sugar (p=.013), and cholesterol (p=.018). Conclusion: The comprehensive health promotion program based on the primary health care post was found to be effective for rural elders by improving cognitive function and physiological indicators and decreasing their depression.

• Journal of the Korean Academy of Clinical Electrophysiology
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• v.10 no.2
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• pp.37-42
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• 2012

Purpose : This study is to examine the effect of electrode size during transcranial direct current stimulation on hand function. Methods : By randomly assigning 26 right hand dominant subjects to two groups (I: carbon rubber electrode / II: disposable circular self-adhesive electrodes) with 13 subjects in each group depending on the electrode size, a positive electrodeof transcranial direct current stimulation was placed on the primary motor area (C4) and a negative electrode was placed on the left primary motor area (C3) and the stimulation was applied for 20 minutes.Hand function assessment before and after transcranial direct current stimulation were measured with JTT (Jebsen-Taylor hand function test). Results : According to hand function assessment by JTT, there were no interactions on both hands, and statistically significant differences according to time appeared in the main effect test. Conclusion : Regardless of the electrode size, it appears that transcranial direct current stimulation on the primary motor area activated hand function affected.

• The Journal of Fisheries Business Administration
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• v.44 no.1
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• pp.39-57
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• 2013

This study aims to examine problems of retail business operated by primary fisheries cooperatives and provide some suggestions for enhancing their retail business function. It reveals that although sales business function of fisheries cooperatives is very important for the members of Korean fisheries cooperatives, their performance and efficiency outcomes have been disappointing. The research offers six suggestions in two categories to resolve the issues. In the first category as a marketing plan for retail business of primary fisheries cooperatives, first, enhance of marine products business using local specialty goods. second, expanded of on-line shopping mall and third, joint marketings among primary cooperatives are necessary. In second category as an assistance plan of National Federation of Fisheries Cooperatives(NFFC) for primary fisheries cooperatives, First, we needed to making logistics system for fisheries. Second, conducting retail business consulting for primary fisheries cooperatives. Finally, human resource development programs are needed. Primary fisheries cooperatives have to discipline faithfully as a cooperatives for NFFC roles as a cooperatives. So making marine products sales business as a core of a economy business of primary fisheries cooperatives in Korea is very important.

• The Journal of Internal Korean Medicine
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• v.37 no.2
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• pp.182-188
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• 2016

Objective: This study was designed to assess the clinical effect of traditional Korean medicine on primary biliary cirrhosis.Method: We provided herbal medicine and acupuncture therapy to a 38-year-old male patient who complained about jaundice, itching, and fatigue. During a six-day hospital stay, we checked any changes in symptoms and conducted liver function tests (such as aspartate aminotransferase [AST], alanine aminotransferase [ALT], alkaline phosphatase [ALP], and gamma-glutamyl transferase [GGT], among others) to evaluate any improvement.Results: We observed that herbal medicine and acupuncture therapy appeared to decrease the symptoms of primary biliary cirrhosis. During each hospital stay, the symptoms and liver function test both showed improvement, especially in ALP.Conclusion: Based on the therapeutic results of the six-day hospital stay, we report improved primary biliary cirrhosis symptoms and a decreasing tendency in ALP and GGP levels following treatment with traditional Korean medicine.

• Korean Journal of Mathematics
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• v.29 no.1
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• pp.105-120
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• 2021

In this paper, we extend some results related to the growth rates of entire functions by introducing the relative logarithmic order ����g(f) of a nonconstant entire function f with respect to another nonconstant entire function g. Next we investigate some theorems related the behavior of ����g(f). We also define the relative logarithmic proximate order of f with respect to g and give some theorems on it.

• Molecules and Cells
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• v.21 no.1
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• pp.29-33
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• 2006

We have established three immortal bovine muscular epithelial (BME) cell lines, one spontaneously immortalized (BMES), the second SV40LT-mediated (BMEV) and the third hTERT-mediated (BMET). The morphology of the three immortal cell lines was similar to that of early passage primary BME cells. Each of the immortal cell lines made cytokeratin, a typical epithelial marker. BMET grew faster than the other immortal lines and the BME cells, in 10% FBS-DMEM medium, whereas neither the primary cells nor the three immortal cell lines grew in 0.5% FBS-DMEM. The primary BME cells and the immortal cell lines, with the exception of BMES, made increasing amounts of p53 protein when treated with doxorubicin, a DNA damaging agent. On the other hand, almost half of the cells in populations of the three immortal cell lines may lack $p16^{INK4a}$ regulatory function, compared to primary BME cells that were growth arrested by enforced expression of $p16^{INK4a}$. In soft-agar assays, the primary cells and immortal cell lines proved to be less transformed in phenotype than HeLa cells. The three immortal epithelial-type cell lines reported here are the first cell lines established from muscle tissue of bovine or other species.