• Tuberculosis and Respiratory Diseases
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• v.83 no.1
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• pp.61-70
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• 2020

Background: Circulating tumor cells (CTCs) are frequently detected in patients with advanced-stage malignant tumors and could act as a predictor of poor prognosis. However, there is a paucity of data on the relationship between CTC number and primary tumor volume in patients with lung cancer. Therefore, our study aimed to evaluate the relationship between CTC number and primary tumor volume in patients with lung adenocarcinoma. Methods: We collected blood samples from 21 patients with treatment-naive lung adenocarcinoma and 73 healthy individuals. To count CTCs, we used a CTC enrichment method based on fluid-assisted separation technology. We compared CTC numbers between lung adenocarcinoma patients and healthy individuals using propensity score matching, and performed linear regression analysis to analyze the relationship between CTC number and primary tumor volume in lung adenocarcinoma patients. Results: CTC positivity was significantly more common in lung adenocarcinoma patients than in healthy individuals (p<0.001). The median primary tumor volume in CTC-negative and CTC-positive patients was 10.0 ㎤ and 64.8 ㎤, respectively. Multiple linear regression analysis showed that the number of CTCs correlated with primary tumor volume in lung adenocarcinoma patients (β=0.903, p=0.002). Further subgroup analysis showed a correlation between CTC number and primary tumor volume in patients with distant (p=0.024) and extra-thoracic (p=0.033) metastasis (not in patients with distant metastasis). Conclusion: Our study showed that CTC numbers may be associated with primary tumor volume in lung adenocarcinomas patients, especially in those with distant metastasis.

• Imaging Science in Dentistry
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• v.52 no.3
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• pp.327-332
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• 2022

Mucocele of the paranasal sinuses is a benign, slow-growing, expansile lesion. Maxillary sinus mucoceles are usually associated with painless bulging of the cheek; however, orbital expansion is rarely observed. Maxillary sinus mucoceles can be classified as primary or secondary according to their etiology. An impediment to sinus ostium ventilation is thought to be the cause of primary mucocele, while sequestering of residual mucosa after surgery in the wound and long-term retention of tissue fluid have been suggested to lead to the formation of secondary mucocele. This report presents 2 cases of primary and secondary mucoceles, with a focus on radiographic features. As primary and superiorly positioned secondary maxillary sinus mucoceles are uncommon and their close proximity to the orbit predisposes the patient to significant morbidity, the authors expect that this report will contribute to a better understanding and diagnosis of maxillary sinus mucocele involving the orbit.

• 한국신재생에너지학회:학술대회논문집
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• 2010.06a
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• pp.237.1-237.1
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• 2010

Recent developments such as concern over global warming, depletion of fossil fuels and increase in energy demands by the increasing world population has eventually lead to mass production of electricity using renewable sources. Ocean contains energy in form of thermal energy and mechanical energy: thermal energy from solar radiation and mechanical energy from the waves and tides. The current paper looks at generating power using waves. The primary objective of the present study is to maximize the primary energy conversion (first stage conversion) of the base model by making some design changes. The model entire consisted of a numerical wave tank and the turbine section. The turbine section had three components; front guide nozzle, augmentation channel and the rear chamber. The augmentation channel further consisted of a front nozzle, rear nozzle and an internal fluid region representing the turbine housing. Different front guide nozzle configuration and rear chamber design were studied. As mentioned, a numerical wave tank was utilized to generate waves of desired properties and later the turbine section was integrated. The waves in the numerical wave tank were generated by a piston type wave maker which was located at the wave tank inlet. The inlet which was modeled as a plate wall which moved sinusoidally with the general function, $x=asin{\omega}t$. In addition to primary energy conversion, observation of flow characteristics, pressure and the velocity in the augmentation channel, rear chamber as well as the front guide nozzle are presented in the paper. The analysis was performed using the commercial code of the ANSYS-CFX. The base model recorded water power of 29.9 W. After making the changes, the best model obtained water power of 37.1 W which represents an increase of approximately 24% in water power and primary energy conversion.

• The Korean Journal of Cytopathology
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• v.6 no.2
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• pp.116-124
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• 1995

Eighty cases of malignant effusion were cytologically studied to elucidate the incidence of primary tumor site and cytologic characteristics of each tumor types. Eighty fluid specimens were composed of 43 ascitic, 35 pleural, and 2 pericardial effusion and primary tumor site had been confirmed by histology. The frequent primary sites were stomach(22 cases, 28%), lung(21 cases, 26%), ovary(11 cases, 14%), liver(7 cases, 9%), and breast (4 cases, 5%). The principal malignant tumors were adenocarcinoma (56 cases, 70%), squamous cell carcinoma (7 cases, 9%), liver cell carcinoma (7 cases, 9%), small cell carcinoma (4 cases, 5%), and non-Hodgkin's lymphoma (4 cases, 5%). The distinctive cytologic findings according to primary tumor types were as follows; the gastric adenocarcinomas were mainly characterized by isolated cells and irregular clusters sometimes with signet ring cells. Papillary serous cystadenocarcinoma of ovary showed frequently papillary clusters and occasional psammoma bodies. Breast carcinoma of ductal type showed cell balls with smooth margins. Colonic adenocarcinoma showed rather irregular clusters or palisading pattern of cylindrical cells. Metastatic squamous cell carcinoma, liver cell carcinoma, small cell carcinoma, and non-Hodgkln's lymphoma showed also characteristic features. These findings Indicate that the cytological features observed in the great majority of malignant effusion are similar to those of primary tumor types, which are very helpful to indentify the primary tumor site.

• Parasites, Hosts and Diseases
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• v.23 no.2
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• pp.247-252
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• 1985

In the present study, the effect of primary infection to reinfection with Ascaris suum larvae was experimented in mouse model. Mice were challenged with 1,000 infective stage eggs of Ascaris suum. The embryonated eggs were directly introduced into stomach of mice. Reinfection was performed at 50 days after the primary infection with same method as primary infection. Mice were sacrificed 3, 5, 7, 10, 15 and 20 days after infection in both groups respectively. Larvae collected from livers and lungs with Baermann's apparatus were enumerated and measured after sacrifice. Sera of mice were also collected at same time. The results of the experiment were as follows: With antigen prepared from coelomic fluid of adult Ascaris suum and sera collected from mice before reinfection, the production of antibody in experimental mice was confirmed by the gel-diffusion technique. In the livers of reinfected mice, the larvae were recovered up to 10 days after challenge, otherwhile in the primary infected mice, the larvae were observed up to 7 days. The maximum number of larvae were observed in the lungs of primary infected mice on 10 days after inoculation. In the lungs of reinfected mice, maximum number of larvae were recovered on 7 days after, only few larvae were recovered on 10 days after reinfection. As regards the growth of the larvae, the third stage larvae, over $500{\mu\textrm{m}}$ in length, appeared in livers at 5 days after reinfection, but it couldn't be found on 7 days and 10 days after challenge. The third stage larvae continuously developed were observed in lungs of mice from 5 days after reinfection. In conclusion, it was found that development of larvae in livers of immune mice were probably repressed by the immune mechanisms being rises in livers and defence mechanism is also acting by interfering with the process of larval penetration into the lung from the liver.

• The KSFM Journal of Fluid Machinery
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• v.15 no.3
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• pp.25-31
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• 2012

A computational study on the improvement of the pressure loss of intake system, which is located at engine manifold of the combat vehicle, has been conducted using a finite-volume-based, Reynolds-Averaged Navier-Stokes (RANS) solver. The computational result of the pressure loss through the air cleaner is in good agreement with equivalent experimental data. A parametric study was done for improving of the pressure loss of intake system over the baseline case. The effects of five primary parameters such as the height of inlet, the width of interconnection pipe, the shape of drain chamber and the diameter of filter housing were considered in this study. Consequently, this computational investigation can contribute to finding an optimal guideline for the idea of improvement in the pressure loss of intake system.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.35 no.4
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• pp.428-434
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• 1999

Experimental studies on the characteristics of annular jet pump were carried out in this paper. Jet pump can be used widely for the transportation of solid materials, farm produce and fishes. The effects of high pressure chamber on the characteristics of annular jet pump were sought in this paper. Experiments were done for three shapes of high pressure chamber, and for several lengths of the high pressure chamber. Three types of the high pressure chamber's entrances($90^{\circ}$ single inflow, $45^{\circ}$single inflow, and $45^{\circ}$ double inflow) were tested. Water was used for both the primary fluid and secondary fluid. The results obtained in this study are as follows; $45^{\circ}$double inflow type is the most effective among the tested three types of the high pressure chamber's entrances. The efficiency of jet pump with 400mm of high pressure chamber length is the highest among the chamber lengths tested in this study, thus indicating appropriate chamber length is required to get an efficient.

• Transactions of the Korean Society of Mechanical Engineers
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• v.5 no.3
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• pp.159-169
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• 1981

The mixing length theory is extended to close the momentum queations for two-phase turbulent flow at a first-order closure level. It is assumed that the mass fraction of the particles is of the order of unity, that the particle size is so small that the particles are fully suspended is the primary fluid, and that the relaxation time scale of the particles is of the same order as the time scale of the energy containing eddies so that the suspended particles are responsive to the fluctuating turbulent field. The bulk motion of the particles is treated as a secondary fluid with its own coefficient of momentum transport. The proposed closure is uniformly destributed acress the pipe section. Predicted velocity profiles and the friction factors are in good agreement with avaiable experimental data.

• Journal of the korean Society of Automotive Engineers
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• v.14 no.2
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• pp.76-87
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• 1992

Flow and heat transfer characteristics in a horizontal electronic circuit board are studied numerically. The board has the arrays of heated blocks and the spaces between the plates and blocks are changed. Air in used as cooling fluid, of which prandt1 number is 0.7. The velocity distributions, temperature distributions, Nusselt numbers and dimensionless friction factors are obtained on the spaces between the plates and the blocks, for the cases of Rayleigh number, 0 and 10$^{5}$ . When Rayleigh number is so large, such as 10$^{5}$ , that the effect of bouyancy is not negligible, fluid friction and heat transfer is increased more than those of forced convection. This may be caused by the generation of secondary flow on the cross section of primary flow. The effect of bouyancy is of the most efficient, when the space of blocks is about block-width and the space of plates is about 1.7 times of block-height.

• Structural Engineering and Mechanics
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• v.23 no.4
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• pp.339-352
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• 2006

Observing the unique stress-strain curves of the superelastic shape memory alloy (SMA) in tension and compression, the primary intention of this study is to investigate the behavior of the shafts made of the same material, under torsional loading-unloading cycles for large angle of twist. Experiments have been performed for the superelastic SMA shafts with different unsupported lengths and angles of twist and the results are compared with those of stainless steel (SUS304) shafts under similar test conditions. As expected for the superelastic SMA, the residual strains are small enough after each cycle and consequently, the hysteresis under loading-reverse loading is much narrower than that for the SUS304. For large angle of twists, the torsional strength of the superelastic SMA increases nonlinearly and exceeds that of SUS304. Most interestingly, the slender solid superelastic SMA shafts are found to buckle when acted upon torsion for large angle of twist.