• Biomolecules & Therapeutics
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• v.22 no.6
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• pp.497-502
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• 2014

In the present study, we found that the natural compound arctigenin inhibited hydrogen peroxide-induced reactive oxygen species (ROS) production in rat primary astrocytes. Since hemeoxygenase-1 (HO-1) plays a critical role as an antioxidant defense factor in the brain, we examined the effect of arctigenin on HO-1 expression in rat primary astrocytes. We found that arctigenin increased HO-1 mRNA and protein levels. Arctigenin also increases the nuclear translocation and DNA binding of Nrf2/c-Jun to the antioxidant response element (ARE) on HO-1 promoter. In addition, arctigenin increased ARE-mediated transcriptional activities in rat primary astrocytes. Further mechanistic studies revealed that arctigenin increased the phosphorylation of AKT, a downstream substrate of phosphatidylinositol 3-kinase (PI3K). Treatment of cells with a PI3K-specific inhibitor, LY294002, suppressed the HO-1 expression, Nrf2 DNA binding and ARE-mediated transcriptional activities in arctigenin-treated astrocyte cells. The results collectively suggest that PI3K/AKT signaling pathway is at least partly involved in HO-1 expression by arctigenin via modulation of Nrf2/ARE axis in rat primary astrocytes.

• Journal of the Korea Institute of Military Science and Technology
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• v.9 no.1 s.24
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• pp.80-88
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• 2006

The purpose of this thesis is to research and propose a practical Information Security Technical Architecture on Primary Defense Information Infrastructure with regard to requirement of information security. The scope of this research is limited to national defense information master plan & security rule, and U.S. DoD's IATF is used to plan a detailed structure. The result of this research can be used as a guide book for providing security for Army IT infrastructure now and in the future as well as to devise a plan for research and development in information protection technology.

• Journal of the Korean Society of Tobacco Science
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• v.14 no.2
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• pp.168-195
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• 1992

Pulmonary system is a target organ and primary defense mechanism against environmental oxidants and polutants. Enzymatic and nonenzymatic antioxdant defense mechanisms undoubtedly protect the lung from oxidants even endogenous oxidative stress. In addition, new ways of augmenting pulmonary antioxidant defenses are developed, which can be used to support the intrinsic antioxidants. Therefore, improved understanding of antioxidant defense mechanisms will increase our knowledge of the cause and will suggest rational approaches for treating and preventing oxidant-induced lung injury. In this review, we discuss the formation and scavenging of free radicals, and the strategies for antioxidant defense of pulmonary system.

• Bulletin of the Korean Space Science Society
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• 2005.10a
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• pp.72-72
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• 2005

• Korean Journal of Remote Sensing
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• v.39 no.1
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• pp.111-127
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• 2023

In visual slam and 3D data modeling, the Iterative Closest Point method is a primary fundamental algorithm, and many technical fields have used this method. However, it relies on search methods that take a high search time. This paper solves this problem by applying an effective point cloud refinement method. And this paper also accelerates the point cloud registration process with an indexing scheme using the spatial decomposition method. Through some experiments, the results of this paper show that the proposed point cloud refinement method helped to produce better performance.

• Bulletin of the Korean Space Science Society
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• 2005.10a
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• pp.149-152
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• 2005

High-resolution telescope from space comprises electro-optical imagery with a ground resolution tying within the range of 1 to 5 meters. According to information documented in the literature up to now, most primary mirrors verified and flown in optical space missions have been lightweighted made from Zerodur, ULE, beryllium, SiC or aluminium. A trade off study was performed to determine as a &lightweighted& by factors like backside cell pattern, rib thickness, face thickness, mirror fixation device location and material and so on based on structural performance for primary mirror in submeter class spaceborne telescope.

• Clinical and Experimental Pediatrics
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• v.52 no.6
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• pp.649-654
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• 2009

The immune system is comprised of cells and molecules whose collective and coordinated response to the introduction of foreign substance is referred to as the immune response. Defense against microbes is mediated by the early reaction (innate immunity) and the late response (adaptive immunity). Innate immunity consists of the epithelial barrier, phagocytes, complement and natural killer cells. Adaptive immunity, a more complex defense reaction, consists of activation of later-developed lymphocytes that, when stimulated by exposure to infectious agents, increase in magnitude and defensive capabilities with each successive exposure. In this review we discuss recent advances in important primary immune deficiency disorders of innate immunity (chronic granulomatous disease, leukocyte adhesion deficiency) and adaptive immunity (severe combined immune deficiency, Wiskott- Aldrich syndrome).

• Journal of the Korea Institute of Military Science and Technology
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• v.15 no.4
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• pp.442-449
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• 2012

Cognitive Radio(CR) is the technology that allocates the frequency by using dynamic spectrum access. We proposed a model to calculate the optimal level of the cognitive radiotelegraph, where secondary users opportunistically share the spectrum with primary users through the spectrum sensing. When secondary user with cognitive radio detects the arrival of a primary user in its current channel, the secondary user moves to the idle channel or be placed in the virtual queue. We assume that the primary users have finite buffers and the population of secondary users is finite. Using a two-dimensional Makov model with preemptive priority queueing, we could derive the blocking and waiting probability as well as the optimal level of cognitive radiotelegraph under a various range of parameter circumstances.

• Journal of the Korean Society of Propulsion Engineers
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• v.19 no.5
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• pp.15-21
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• 2015

The thermal decomposition characteristics of the ZPP(Zirconium/Potassium perchlorate), widely used as a primary charge of initiators, were investigated by differential scanning calorimetry(DSC). The DSC results with different heating rates were elaborated with AKTS-Thermokinetics software for the determination of the kinetic parameters of the thermal decomposition of ZPP. There was good agreement between the experimental and the simulation curves, based on the determined kinetic parameters, which indicates the validity of the kinetic description of the thermal decomposition process of ZPP.

• The Plant Pathology Journal
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• v.35 no.6
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• pp.609-622
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• 2019

Sound vibration (SV) treatment can trigger various molecular and physiological changes in plants. Previously, we showed that pre-exposure of Arabidopsis plants to SV boosts its defense response against Botrytis cinerea fungus. The present study was aimed to investigate the changes in the proteome states in the SV-treated Arabidopsis during disease progression. Proteomics analysis identified several upregulated proteins in the SV-infected plants (i.e., SV-treated plants carrying Botrytis infection). These upregulated proteins are involved in a plethora of biological functions, e.g., primary metabolism (i.e., glycolysis, tricarboxylic acid cycle, ATP synthesis, cysteine metabolism, and photosynthesis), redox homeostasis, and defense response. Additionally, our enzyme assays confirmed the enhanced activity of antioxidant enzymes in the SV-infected plants compared to control plants. Broadly, our results suggest that SV pre-treatment evokes a more efficient defense response in the SV-infected plants by modulating the primary metabolism and reactive oxygen species scavenging activity.