• Asian Pacific Journal of Cancer Prevention
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• v.15 no.10
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• pp.4255-4259
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• 2014

Lactobacilli are probiotics shown to have antitumor activities. In addition, they can regulate gene expression through epigenetic mechanisms. In this study, we aimed to assess anti tumor activities of Lactobacillus acidophilus and Lactobacillus crispatus on the MDA-MB-231 breast cancer cell line. The effects of culture supernatants were determined by MTT [3-(4,5-dimethylthiazol-2-y-2,5-diphenyltetrazolium bromide] assay. Changes in expression of 5 cancer-testis antigens (CTAs), namely AKAP4, ODF4, PIWIL2, RHOXF2 and TSGA10, were analyzed by quantitative real time RT-PCR. The culture supernatants of the 2 lactobacilli inhibited MDA-MB-231 cell proliferation. In addition, transcriptional activity of all mentioned CTAs except AKAP4 was significantly decreased after 24 hour treatment with culture supernatants. This study shows that Lactobacillus acidophilus and Lactobacillus crispatus have antiproliferative activity against MDA-MB-231 cells. In addition, these lactobacilli could decrease transcriptional activity of 4 CTAs. Previous studies have shown that expression of CTAs is epigenetically regulated, so it is possible that lactobacilli cause this expression downregulation through epigenetic mechanisms. As expression of CTAs in cancers is usually associated with higher grades and poor prognosis, downregulation of their expression by lactobacilli may have clinical implications.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.9579-9586
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• 2014

There is growing scientific evidence linking excess body weight to breast cancer risk. However, there is no common consensus on this relation due partly to methodologies used, populations studied and the cancer subtype. We report here a summary of the present state of knowledge on the role of overweight and obesity in pathogenesis of breast cancer and possible mechanisms through which excess body weight might influence the risk, focusing on the role of oxidative stress in breast cancer etiology. The findings demonstrate duality of excess body weight action in dependence on menopausal status: a statistically significant increased risk in postmenopausal overweight/ obese women and non-significant preventive effect among premenopausal women. Due to several gaps in the literature on this topic, additional studies are needed. Future research should address factors influencing the excess body weight - breast cancer relationship, such as race/ethnicity, tumor subtype, receptor status, the most appropriate measure of adiposity, reproductive characteristics, and lifestyle components.

• Journal of the Korea Safety Management & Science
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• v.1 no.1
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• pp.171-181
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• 1999

The half of njuries by carrying-unloading machinery was injuries due to crane. The purpose of this study was to analyze present condition of injuries by the crane, to investigate hazard management model, injury prevention technique, and to suggest safety countermeasures of crane working. The hazard management model is composed of 5 rules and 10 methods. The rules are to remove, separate, protect, make up and correspond. Prior to this crane countermeasures, general protection for head, foot and hand are needed. Hazard prevention affects on industrial management economically and psychologically. The preparation of safety countermeasures are very important for the prevention of industrial injuries, The countermeasures are setting-up of safety culture, active and rationale safety education. As the industrial safety and health system should be performed for the employees' health and life, the industrial competitive power and productivity would be improved.

• Proceedings of the Safety Management and Science Conference
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• 1999.11a
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• pp.83-95
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• 1999

The half of injuries by carrying-unloading machinery was injuries due to crane. The purpose of this study was to analyze present condition of injuries by the crane, to investigate hazard management model, injury prevention technique, and to suggest safety countermeasures of crane working. The hazard management model is composed of 5 rules and 10 methods. The rules are to remove, separate, protect, make up and correspond. Prior to this crane countermeasures, general protection for head, foot and hand are needed. Hazard prevention affects on industrial management economically and psychologically. The preparation of safety countermeasures are very important for the prevention of industrial injuries. The countermeasures are setting-up of safety culture, active and rationale safety education. As the industrial safety and health system should be performed for the employees' health and life, the industrial competitive power and productivity would be improved.

• Journal of the Korean Society of Safety
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• v.37 no.2
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• pp.28-34
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• 2022

This study analyzes the impact that accidents and near misses have on clients' and contractors' awareness of safety culture. Due to the unique characteristic of employment structure in Korea, the occurrence of accidents differs by company size, which has relevant implications for the establishment of safety culture. Attention has been drawn to the importance of the management of accidents and near misses, with safety awareness acting as a core factor. A positive effect on the prevention of accidents could be achieved by noting the difference in safety awareness between clients and contractors and suggesting an associated suitable safety management system. In support of this study, a survey was distributed to workers in the automobile manufacturing industry (May-August 2020), and data from a total of 574 workers was collected and analyzed, including 399 clients' worksers and 175 contractors' workers. The questionnaire addressed participants' experiences of accidents and near misses as well as 50 items from the Nordic Occupational Safety Climate Questionnaire. Analysis of the responses was conducted using the methods of frequency analysis, Fisher's exact test, t-test, correlation analysis, and regression analysis. The results demonstrated that clients had more experiences with accidents and near misses compared to contractors. Additional differences between clients and contractors were noted in terms of the safety culture factors of learning, communication, and trust. A correlation was observed between the experience of accidents and safety justice management: for clients and contractors who experienced accidents, safety justice management was 9.4 times higher. Furthermore, clients' and contractors' awareness of employees' commitment to safety was determined to be 28.5 times higher in those who had experienced near misses This study concludes that, in order to improve accident prevention through the management of accidents and near misses, clients must focus on overseeing safety justice management and aspects of safety culture factors, while contractors must focus efforts on managing employees' commitment to safety. In further applications, this study could provide baseline data for health and safety activities in terms of the safety culture of clients and contractors. Further study on the establishment of safety culture as related to employment structure is proposed for future research.

• The Journal of the Convergence on Culture Technology
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• v.3 no.4
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• pp.145-152
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• 2017

The accident rate is higher in the small workplace than the large workplace. It is desirable to focus on the small workplace for the disaster prevention activities. The disaster prevention activities for the small workplace are achieved through the private consignment agencies' technical guidance. but it has exposed many demand of the private consignment agencies' experts and its effectiveness has been strengthened. The purpose of this study, it is to provide the system improvement plan that the problem can be solved and to present a plan to improve the effectiveness of the proposed system. It is to listen to the opinions of experts and the direction of the study was set up.

• Journal of the Korean Society of Food Culture
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• v.27 no.3
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• pp.324-330
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• 2012

This study investigated the perception, consumer pattern and satisfaction of the ginseng products of 600 people in the Seoul area surveyed from Feb. 1 to 28, 2011. The perception and satisfaction tests were performed using a 5-point scale (1=disagree (dissatisfy) very much, 5=agree (satisfy) very much. People perceived ginseng to have refreshment (3.86), immuno-modulation (3.78), anticancer (3.51), and antiaging (3.41) properties. People in their 20s (4.02) scored high on refreshment compared to people in their 60s and over (3.73). Most people (79.8%) consume ginseng products and prefer red ginseng (74.3%). More people in their 40s (54.1%) and 50s (48.2%) consume ginseng products for refreshment than people in their 20s (38.7%), 30s (41.5%) or 60s and over (40.0%). However, more people in their 50s (36.1%) and 60s and over (43.6%) consume ginseng products for disease prevention than people in their 20s (8.6%). Most people (66.4%) take ginseng all year round. People in their 20s (2.70) showed a smaller satisfaction score of the taste of ginseng products than those in their 30s (3.21), 40s (3.23), 50s (3.26) and 60s and over (3.38).

• The Journal of the Convergence on Culture Technology
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• v.2 no.2
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• pp.37-44
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• 2016

This study was performed to evaluate the safety level of consciousness of college dorm life, and to suggest the problem derivation and to improve the prevention of accidents. The survey research was performed to investigate the contents of safety training for 150 people, and the effectiveness, the demands of safety were also examined. The risk factors were identified in order to assess the level of personal security awareness. The survey was performed for the knowledge of risky behaviors, such as disaster preparedness tips. The research showed that the satisfaction and effectiveness of safety training was high by investigation. Through the research, the recognition factor of the accident, which occurs by a lack of understanding for specific responses, must be enhanced using the safety training to respond adequately when disaster occurs.

• International Journal of Advanced Culture Technology
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• v.9 no.4
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• pp.363-375
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• 2021

The purpose of this study is to analyze the safety of evacuation using the Pathfinder program for the alert at once, the priority alarm method, the priority alarm method for the four floors above, and the sequential priority alarm method, which is a modification of the priority alarm method specified in the tourist hotel building. Currently, in Korea's National Fire Safety Codes (NFSC), fire alarm methods are compulsorily applied differently depending on the number of floors and total floor area of a building. Although the growth rate is getting faster due to the diversification of building structures, it is still an obstacle to improving evacuation safety to comply with the standardized fire alarm method in NFSC. As a result of the experiment, the evacuation time was found to be faster with the priority alarm method for the four floors above than the priority alarm method applied to the specific firefighting object. Compared to the priority alarm method applied to the tourist hotel, which is a specific firefighting target with 5 or more floors and a total floor area of more than 3,000m2, the time was shortened by 3.7 seconds when measured by applying the priority alarm method for the four floors directly above. This indicates that it is necessary to take measures to select a fire alarm method suitable for the structure and environmental conditions of the building rather than applying the uniform NFSC regulations.

• Ecology and Resilient Infrastructure
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• v.7 no.3
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• pp.199-207
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• 2020

Against the backdrop of frequent weather disasters such as floods, droughts, and heat waves worldwide, urban parks should provide functions for the safety of urban residents as well as rest, culture, and ecological functions. In this study, a classification system for urban disaster prevention parks is proposed for the safety of the urbanites with the aim of securing a complex function in a green space in response to climate changes in the city. Analytical indicators were extracted through literature research, and the classification system was verified through on-site surveys of the target sites and interviews with those involved. The large class for evaluation was divided into three types: location, spatial composition, and disaster prevention complex facilities of urban parks; the direction of improvement was proposed for problems identified through empirical analysis.