• Journal of the Korean Society of Industry Convergence
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• v.24 no.6_2
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• pp.801-808
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• 2021

In this paper, a numerical analysis was conducted on the effect of the flow control valve of a oscillation water column(OWC) type wave power generator turbine. The OWC wave power turbine operates with compressed air in the air chamber according to the change of wave height. When the wave height changes rapidly, a flow control valve is required due to overload of the turbine and reduced efficiency. Therefore, in this paper, a flow control valve with an opening angle of 60 degrees was installed in the front of the turbine, and the pressure drop, torque, and overall performance were calculated according to the change of turbine RPM and flow rate of turbine inlet. In conclusion, the flow control valve with an opening angle of 60 degrees affects when the turbine rotates at low rotation and the inlet flow rate is large. But it does not have a significant effect on overall turbine performance and it is necessary to find the optimal angle in the future works.

• Nuclear Engineering and Technology
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• v.53 no.5
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• pp.1436-1445
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• 2021

To obtain the dynamic characteristics of reactor secondary circuit under transient conditions, the system analysis program was developed in this study, where dynamic models of secondary circuit were established. The heat transfer process and the mechanical energy transfer process are modularized. Models of main equipment were built, including main turbine, condenser, steam pipe and feedwater system. The established models were verified by design value. The simulation of the secondary circuit system was conducted based on the verified models. The system response and characteristics were investigated based on the parameter transients under emergency shutdown and overload. Various operating conditions like turbine emergency shutdown and overspeed, condenser high water level, ejector failures were studied. The secondary circuit system ensures sufficient design margin to withstand the pressure and flow fluctuations. The adjustment of exhaust valve group could maintain the system pressure within a safe range, at the expense of steam quality. The condenser could rapidly take out most heat to avoid overpressure.

• Tuberculosis and Respiratory Diseases
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• v.63 no.4
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• pp.346-352
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• 2007

Background: Pulmonary hypertension is one of the cardiovascular complications of in COPD. However, a diagnosis of pulmonary hypertension requires an invasive test, such as right heart catheterization. NT-proBNP is a cardiac hormone that is elevated when a cardiac volume or pressure overload is present. It was hypothesized that NT-proBNP might play a role in detecting of pulmonary hypertension in COPD patients. Method: The 31 COPD patients, who underwent all of NT-proBNP, echocardiography, and spirometry in Seoul National University Bundang Hospital during the period from November 2003 to July 2005, were retrospectively analyzed. Result: Of the 31 COPD patients, 9 patients had pulmonary hypertension. A significant positive correlation was observed between the NT-proBNP and pulmonary arterial pressure (r=0.589, p=0.002). However, there was no significant correlation observed between the $FEV_1$ and NT-proBNP and $FEV_1$ and pulmonary arterial pressure. Conclusion: NT-proBNP might indicate the presence of pulmonary hypertension in COPD patients.

• The KIPS Transactions:PartA
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• v.16A no.6
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• pp.481-488
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• 2009

GIS is used to isolate large power electrical equipment using SF6 gas. While GIS has simple structure, it has few break down, relatively high reliability. But it is hard to check up faults for reason of pressure. Faults of GIS should have a ripple effect on community and be hard to recovery. Consequently, GIS imports a preventive diagnostic system to find internal faults in advance. It is most important that reliability on the GIS preventive diagnostic system, because it estimates abnormality of system by analysis result of collected data. But, exist system which used central data management is low efficiency, and hard to guarantee timeliness and accuracy of data. To guarantee timeliness and accuracy, the GIS preventive diagnostic system needs accordingly to use a real-time middleware. So, in this paper, to improve reliability of the GIS preventive diagnostic system, we use a middleware based on TMO for guaranteeing timeliness of real-time distributed computing. And we propose an improved GIS preventive diagnostic system applying data acquisition, monitoring and control methods based on the TMO model. The presented system uses the Communication Control Unit(CCU) for distributed data handling which is supported by TMO. CCU can improve performance of the GIS preventive diagnostic system by guaranteeing timeliness of data handling process and increasing reliability of data through the TMO middleware. And, it has designed to take full charge of overload on a data acquisition task had been processed in an exist server. So, it could reduce overload of the server and apply distribution environment from now. Therefore, the proposed system can improve performance and reliability of the GIS preventive diagnostic system and contribute to stable operation of GIS.

• Journal of Veterinary Clinics
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• v.24 no.4
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• pp.613-617
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• 2007

A 1-year-old castrated male Maltese dog(weighing 2.4 kg) was presented with primary complaints of occasional coughing, dyspnea and exercise intolerance. Based on diagnostic findings including paradoxical split S2, diastolic regurgitant murmur, marked dilation of pulmonary artery, right ventricular eccentric hypertrophy with thickening of ventricular septum, severe tricuspid and pulmonic regurgitation(5.4 m/sec and 3.4 m/sec, respectively) and the absence of any congenital intracardiac shunting, obstructive pulmonary diseases and systemic diseases associated with right ventricular pressure overload or pulmonary hyperperfusion, the case was tentatively diagnosed as primary pulmonary hypertension. The dog was treated with furosemide, aspirin and oxygen supplementation. This case report described a rare case of primary pulmonary hypertension in a Maltese dog.

• Human Ecology Research
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• v.52 no.1
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• pp.43-53
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• 2014

The purpose of this study was to 1) investigate the characteristics of burnout of Korean elementary school students and 2) develop and validate the Korean Academic Burnout Scale-Elementary School Students (KABS-ESS). Fifty-one behavioral descriptions of burnout extracted through a preliminary survey, focus group interview, and literature review were administered to a sample of 531 elementary students of the 4th to 6th grade in Gyeonggi Province. The results of an exploratory factor analysis indicated that the structure of the burnout of Korean elementary school students consists of seven factors (i.e., inefficacy, avoidance, cynicism, emotional exhaustion, physical exhaustion, antipathy and cognitive exhaustion), and this structure of final 28 items was confirmed by the confirmatory factor analysis. The KABS-ESS showed a correlation of .771 with a representative academic burnout scale, Maslach Burnout Inventory-Student Survey, and -.561 with the academic engagement scale, indicating that both convergent and discriminant validities were confirmed. Furthermore, all fit indices of the structural equation model of the Schaufeli and Bakker's job demands-resources in an academic setting were satisfactory, and the possibility of the validity generalization of the model was supported. The demand variables predicting academic burnout and engagement were academic overload and parental pressure, while self-resilience, self-regulated learning strategies, and parental and the teacher's support were identified as the resource variables. Lastly, the implications and future direction of the present study were discussed.

• Journal of Veterinary Clinics
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• v.27 no.6
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• pp.735-739
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• 2010

An 8 month old female Maltese (body weight 3.6 kg) was referred with primary complaints of dyspnea and exercise intolerance. Diagnostic imaging studies revealed marked cardiomegaly and prominent main pulmonary trunk dilation on thoracic radiography, abnormally arisen aortic roots (toward right ventricle) with left-to right shunted perimembraneous ventricular septal defect located underneath of aortic root, aortic root was located to predominantly to the right ventricle and pulmonary regurgitation (peak velocity 4.7 m/s, pressure gradient ~88 mmHg) from pulmonary over-circulation and hypertension on echocardiography, indicating double outlet right ventricle (DORV). The dog was treated with furosemide (1 mg/kg, BID) for reducing volume overload at right ventricle, spironolatcone (1 mg/kg) and enalapril (0.5 mg/kg) for minimizing deleterious cardiac remodeling, and sildenafil (1 mg/kg) for lessening pulmonary over-circulation and hypertension. The clinical condition of this dog was improved after 1 week of medical treatment. The dog is currently survived and regularly monitored.

• Journal of Chest Surgery
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• v.50 no.3
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• pp.144-152
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• 2017

Background: The ubiquitin-proteasome system (UPS) is an important pathway of proteolysis in pathologic hypertrophic cardiomyocytes. We hypothesize that MG132, a proteasome inhibitor, might prevent hypertrophic cardiomyopathy (CMP) by blocking the UPS. Nuclear factor kappa-light-chain-enhancer of activated B cells ($NF-{\kappa}B$) and androgen receptor (AR) have been reported to be mediators of CMP and heart failure. This study drew upon pathophysiologic studies and the analysis of $NF-{\kappa}B$ and AR to assess the cardioprotective effects of MG132 in a left ventricular hypertrophy (LVH) rat model. Methods: We constructed a transverse aortic constriction (TAC)-induced LVH rat model with 3 groups: sham (TAC-sham, n=10), control (TAC-cont, n=10), and MG132 administration (TAC-MG132, n=10). MG-132 (0.1 mg/kg) was injected for 4 weeks in the TAC-MG132 group. Pathophysiologic evaluations were performed and the expression of AR and $NF-{\kappa}B$ was measured in the left ventricle. Results: Fibrosis was prevalent in the pathologic examination of the TAC-cont model, and it was reduced in the TAC-MG132 group, although not significantly. Less expression of AR, but not $NF-{\kappa}B$, was found in the TAC-MG132 group than in the TAC-cont group (p<0.05). Conclusion: MG-132 was found to suppress AR in the TAC-CMP model by blocking the UPS, which reduced fibrosis. However, $NF-{\kappa}B$ expression levels were not related to UPS function.

• Biomolecules & Therapeutics
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• v.28 no.5
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• pp.482-489
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• 2020

G protein-coupled receptor kinase 5 (GRK5) has been considered as a potential target for the treatment of heart failure as it has been reported to be an important regulator of pathological cardiac hypertrophy. To discover novel scaffolds that selectively inhibit GRK5, we have identified a novel small molecule inhibitor of GRK5, KR-39038 [7-((3-((4-((3-aminopropyl)amino)butyl)amino)propyl)amino)-2-(2-chlorophenyl)-6-fluoroquinazolin-4(3H)-one]. KR-39038 exhibited potent inhibitory activity (IC₅₀ value=0.02 µM) against GRK5 and significantly inhibited angiotensin II-induced cellular hypertrophy and HDAC5 phosphorylation in neonatal cardiomyocytes. In the pressure overload-induced cardiac hypertrophy mouse model, the daily oral administration of KR-39038 (30 mg/kg) for 14 days showed a 43% reduction in the left ventricular weight. Besides, KR-39038 treatment (10 and 30 mg/kg/day, p.o.) showed significant preservation of cardiac function and attenuation of myocardial remodeling in a rat model of chronic heart failure following coronary artery ligation. These results suggest that potent GRK5 inhibitor could effectively attenuate both cardiac hypertrophy and dysfunction in experimental heart failure, and KR-39038 may be useful as an effective GRK5 inhibitor for pharmaceutical applications.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.1
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• pp.69-85
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• 2019

BeiDou navigation satellite system (BDS) is one of the four main types of global navigation satellite systems. The current system has been widely used by the military and by the aerospace, transportation, and marine fields, among others. However, challenges still remain in the BeiDou system, which requires rapid responses for delay-sensitive devices. A differential positioning algorithm called the data center-based differential positioning (DCDP) method is widely used to avoid the influence of errors. In this method, the positioning information of multiple base stations is uploaded to the data center, and the positioning errors are calculated uniformly by the data center based on the minimum variance or a weighted average algorithm. However, the DCDP method has high delay and overload risk. To solve these problems, this paper introduces edge computing to relieve pressure on the data center. Instead of transmitting the positioning information to the data center, a novel method called edge computing-based differential positioning (ECDP) chooses the nearest reference station to perform edge computing and transmits the difference value to the mobile receiver directly. Simulation results and experiments demonstrate that the performance of the ECDP outperforms that of the DCDP method. The delay of the ECDP method is about 500ms less than that of the DCDP method. Moreover, in the range of allowable burst error, the median of the positioning accuracy of the ECDP method is 0.7923m while that of the DCDP method is 0.8028m.