• International Journal of Fluid Machinery and Systems
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• 제2권4호
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• pp.315-323
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• 2009

Pressure oscillations triggered by the unstable interaction of dynamic flow features of the hydraulic turbine with the hydraulic plant system - including the electrical design - can at times reach significant levels and could lead to damage of plant components or could reduce component lifetime significantly. Such a problem can arise for overload as well as for part load operation of the turbine. This paper discusses an approach to analyze the overload high pressure oscillation problem using computational fluid dynamic (CFD) modeling of the hydraulic machine combined with a network modeling technique of the hydraulic system. The key factor in this analysis is the determination of the overload vortex rope volume occurring within the turbine under the runner which is acting as an active element in the system. Two different modeling techniques to compute the flow field downstream of the runner will be presented in this paper. As a first approach, single phase flow simulations are used to evaluate the vortex rope volume before moving to more sophisticated modeling which incorporates two phase flow calculations employing cavitation modeling. The influence of these different modeling strategies on the simulated plant behavior will be discussed.

• Clinical and Experimental Pediatrics
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• 제50권11호
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• pp.1041-1048
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• 2007

Not a few patients in children and adolescents are suffering from right ventricular (RV) dysfunction resulting from various conditions such as chronic lung disease, left ventricular dysfunction, pulmonary hypertension, or congenital heart defect. The RV is different from the left ventricle in terms of ventricular morphology, myocardial contractile pattern and special vulnerability to the pressure overload. Right ventricular failure (RVF) can be evaluated in terms of decreased RV contractility, RV volume overload, and/or RV pressure overload. The management for RVF starts from clear understanding of the pathophysiology of RVF. In addition to correction of the underlying disease, management of RVF per se is very important. Meticulous control of volume status, inotropic agents, vasopressors, and pulmonary selective vasodilators are the main tools in the management of RVF. The relative importance of each tool depends on the individual clinical status. Medical assist device and surgery can be considered selectively in case of refractory RVF to optimal medical treatment.

• Molecules and Cells
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• 제37권1호
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• pp.81-87
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• 2014

Chronic pressure-overload cardiac hypertrophy is associated with an increased risk of morbidity/mortality, largely due to maladaptive remodeling and dilatation that progresses to dilated cardiomyopathy. Alternative splicing is an important biological mechanism that generates proteomic complexity and diversity. The recent development of next-generation RNA sequencing has improved our understanding of the qualitative signatures associated with alternative splicing in various biological conditions. However, the role of alternative splicing in cardiac hypertrophy is yet unknown. The present study employed RNA-Seq and a bioinformatic approach to detect the RNA splicing regulatory elements involved in alternative splicing during pressure-overload cardiac hypertrophy. We found GC-rich exonic motifs that regulate intron retention in 5' UTRs and AT-rich exonic motifs that are involved in exclusion of the AT-rich elements that cause mRNA instability in 3' UTRs. We also identified motifs in the intronic regions involved in exon exclusion and inclusion, which predicted splicing factors that bind to these motifs. We found, through Western blotting, that the expression levels of three splicing factors, ESRP1, PTB and SF2/ASF, were significantly altered during cardiac hypertrophy. Collectively, the present results suggest that chronic pressure-overload hypertrophy is closely associated with distinct alternative splicing due to altered expression of splicing factors.

• 대한약리학회:학술대회논문집
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• 대한약리학회 2006년도 58th Annual Meeting of The Korean Society of Pharmacology
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• pp.39-39
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• 2006

• 전력전자학회:학술대회논문집
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• 전력전자학회 1998년도 전력전자학술대회 논문집
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• pp.328-331
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• 1998

Because of the powerful tolerance of overload, dynamic response and anti-erosion, Reluctive Pressure Transducer(RPT), as a measuring element of oil pressure equipment is applied to the measuring system of vessels, air craft. The Electrical reluctance appeared in the pressed diaphragm. To process the reluctance as a electric signal, bridge circuit is used. The design using the reluctance of pressure sensor is described in this paper. For the high efficiency of the sensitive RPT, pressure sensor structure is presented and electrical signal processing is simulated.

• 대한한방내과학회지
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• 제38권6호
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• pp.877-890
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• 2017

Objectives: Lonicerae flos (LF), a dried flower part of Lonicera japonica Thunb., has been widely used in Korean medicine as anti-inflammatory and antioxidative agent. The purpose of this study was to determine the cardioprotective effects of LF, through potential antioxidant effects, on the pressure overload (PO)-induced heart failure (HF) in C57BL/6 mice after transverse aortic constriction (TAC) surgery. Methods: Resveratrol (10 mg/kg body weight) or LF (125, 250 or 500 mg/kg body weight) was orally administered, once daily for 14 days, starting 14 days after TAC surgery. Changes in the mortality, body weights, heart weights, histopathology of the heart, and antioxidant defense systems of the heart were analyzed. Results: Marked and noticeable increases of heart weights, mortalities, and hypertrophic, focal, and lytic fibrotic histological changes in the LVs were observed, with destruction of heart antioxidant defense systems after surgery. However, HF signs, induced by TAC surgery through PO, and destruction of heart antioxidant defense systems were significantly and dose-dependently inhibited by 14 days of maintained oral treatment with LF 500, 250 or 125 mg/kg. Treatment with 250 mg/kg LF was comparable to treatment with 10 mg/kg resveratrol. Conclusions: The results in this study suggest that oral administration of LF favorably relieves PO-induced HF following TAC, through increase of heart antioxidant defense systems. The overall effects of 250 mg/kg LF were similar to those of 10 mg/kg resveratrol. More detailed mechanistic studies should be conducted in the future, with screening of the biologically active compounds in LF.

• 한국안전학회지
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• 제32권2호
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• pp.117-123
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• 2017

This study was intended to find methods of fire extinguishing system designs that can improve the equipment's usability. In this study, the fire suppression experiment through fire extinguishers and the data drawn through the experiment were analyzed, and then the guideline for the improvement of designs was presented. The procedure is as follows. A fire suppression experiment with the use of fire extinguishers was done by 43 average adults. The whole process of the fire suppression was videotaped, and then captured major scenes were analyzed with the use of RULA, a human engineering measurement tool. The analyzed data were divided into 4 steps, and then the guideline for design improvement was presented. The summary of the study is as follows. Step 1, Fire extinguisher distance step. To reduce overload occurring at the process of holding fire extinguishers suddenly, wheels are attached to the body of extinguishers, or pedestals are installed. Step 2, Fire extinguisher transportation step. The length of hose is extended, or fire fighting water is sprayed far, so that overload of legs occurring at the process of travel can be reduced. In addition, the weight of fire extinguisher shouldn't be over 2 kg. Step 3, Safety pin removal stage. Safety pins should be applied with button type, so that excessive posture of lower limbs and excessive twisting of wrists won't happen during safety pin removal process. Besides, safety pins should be designed for easy identification and operation. Step 4, Fire extinguishing agent spraying step. To reduce overload occurring at sudden spraying of fire fighting water, pressure should be increased gradually until high pressure. With the above study results applied to existing fire extinguisher design, it may contribute to reducing any fire damage.

• 항공우주기술
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• 제2권2호
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• pp.11-17
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• 2003

항공기 전기체 구조시험에 과하중 방지 밸브로 사용되는 미터-아웃방식의 유량제어 방법을 본 보고서로 소개하고자 한다. 전기체 구조시험에서는 여러 요인에 의해 비상시험 중지상태(덤프상태)가 발생하며, 이 상태가 되면 서보밸브의 전원이 차단되어 하중을 가하던 실린더의 양단에 외부조건에 따른 급격한 압력변화가 발생되고, 이 변화는 시험체에 과하중으로 가해진다. 본 연구에서는 덤프로 기인한 하중으로부터 시험체를 보호하기 위해 사용되는 오리피스 면적조절 기술에 대해 소개하였고 실제 시험에서 유압작동기의 덤프특성이 효과적으로 감소되고 있음을 확인하였다.

• Safety and Health at Work
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• 제14권2호
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• pp.207-214
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• 2023

Background: Occupational safety issues related to food delivery riders emerge with evidence of an increase in associated traffic accidents and injuries along with the rapid growth of the online food delivery business. This paper focuses on food delivery riders' job stress and investigates its relationships with both antecedents and risky riding outcomes. Method: Survey data were collected from 279 Taiwanese food delivery motorcycle riders and analyzed using hierarchical regression analysis. Results: The results show that job overload and time pressure positively impact riders' job stress, while self-efficacy slightly reduces job stress. Job stress positively leads to risky driving behavior and distraction. In addition, time pressure can strengthen the impact of job overload on job stress. Riders' risky riding attitude can also strengthen the impacts of job stress on risky riding behaviors and distraction. Conclusion: This paper advances the literature on online food delivery as well as the occupational safety improvement of food delivery riders. Specifically, this study provides insights into the job stress of food delivery motorcycle riders and the effects of job characteristics and risky behavioral consequences.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 2002년도 추계학술대회 논문집
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• pp.75-79
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• 2002

A hydraulic Excavator is applied for outdoor tasks in construction, agriculture and undersea etc. When a hydraulic Excavator works crane function tasks, most of disasters happen. In this study, In order to preventing these disasters, the safety equipment algorithm for crane working is developed, and the safety equipment algorithm for crane working is being developed. The proposed control algorithm(Zero Moment Point) is designed to avoid overload. The hydraulic excavator for crane function must work within a maximum limit of load. To accurately detect a working load, pressure sensors of boom, arm cylinder, and angle sensors of boom, arm and bucket joint are used.