• Journal of Korean Medical classics
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• v.29 no.2
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• pp.177-185
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• 2016

Objectives : In pediatrics, one of the most difficult thing might be medication because infant or child cannot take medicine easily. In traditional medicine, Korean taffy or paste preparations sometimes prescribed. Xiao'eryaozhengzhijue was published by Qianyi in 1119 and is specialized for pediatrics text. So I tried to research paste preparations in Xiao'eryaozhengzhijue. Methods : I derived paste preparations from Xiao'eryaozhengzhijue ; paste preparations named on it, and used as paste preparations etc. Results : 1. There were external and internal application of paste preparations. 2. Diverse secondary materials were used for making paste preparations. 3. Several chief complains were recorded in Xiao'eryaozhengzhijue. Conclusions : Paste preparations are really useful way to disease of pediatrics because infant or child cannot take his or her medicine easily. Through the research, I could find out the facts that there are diverse shapes of paste preparations and usages of paste preparations in Xiao'eryaozhengzhijue.

• The Journal of Korean Medical History
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• v.27 no.2
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• pp.11-37
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• 2014

Objectives : The purpose of this study was to analyze and identify the problems of the changes in regulations that are relevant to approval, notification, and review of herbal medicinal preparations and crude drug preparations. Methods : I collected the regulations of approval, notification, and review of medicinal products mostly from official gazettes, analyzed enactment and amendments regarding herbal medicinal preparations and crude drug preparations, and studied it from the view point of Korean medicine field. Results : Regulations in regards to approval, notification, and review of herbal medicinal preparations and crude drug preparations were first established in 1978. Herbal drugs started to be categorized as crude drug preparations in 1981 and the regulatory outlines were completed in 1999. From 2008 to 2012, the regulatory standards that let crude drug preparations be new drugs from natural products were established. Through those procedures, the followings became crude drug preparations: 1) wholly new prescriptions that are not recorded in Korean Medical Classics, 2) prescriptions that are recorded in Korean Medical classics but prepared with new standard, composition and efficacy, 3) prescriptions that are recorded in Korean Medical classics but prepared with new formulation, and 4) herbal drugs. In case of herbal medicinal preparations, however, only regulations that are related to 1) drugs prepared with new compositions that are not recorded in Korean Medical Classics, 2) drugs with same prescription and same formulation, and 3) drugs with new formulation were arranged. Conclusions : Actual circumstances on crude drug-oriented regulations regarding approval, notification and review and future forms of prescription and drug administration in Korean Medical Institutions can be expected due to expansion in range of herbal medicinal preparations and shrink in that of on-site preparations. Reasonable improvement in efficient usage of modernized herbal medicinal preparations in Korean medical institutions and prospective cooperation from related pharmaceutical industry are needed.

• Journal of Korean Medical classics
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• v.27 no.4
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• pp.181-198
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• 2014

Objectives : This study was to analyze definitions of herbal medicinal preparations, crude drug preparations, and new drugs from natural products in the relevant laws and regulations, understand the related problems, and propose directions for improvement. Methods : I analyzed the legal definitions in respect of herbal medicinal preparations, crude drug preparations, and new drugs from natural products in relevant laws and regulations since 1945, explained the problems, and suggested the solution-considering the academic stance of Traditional Korean Medicine and the dualistic medical and pharmaceutical system. Results : Regarding the current laws and regulations that are relevant to herbal medicinal preparations, we should 1) clarify the boundaries between the duty of physicians and that of pharmacists, 2) limit the principles of Korean Medicine as well as the contents of the related textbooks, 3) find a way to protect the intellectual property rights for herbal medicinal preparations, and 4) establish a separate standard for drug classification regarding herbal medicinal preparations. In case of crude drug preparations, we should 1) clarify the meaning and limitations of the phrase, "the point of view of Western medicine," and 2) establish a classification standard for drugs that are used in Korean Medicine and clarify the boundaries between herbal drug preparations and crude drug preparations. Furthermore, laws and regulations apropos of new drugs from natural products do not actually fit the concept of "new drug," and due to subordinate laws, a supplement to a new drug submission is contradictorily misclassified as a new drug from natural products. Conclusions : The problems of legal definitions of herbal medicinal preparations, crude drug preparations, and new drugs from natural products have emerged in the process of giving approval to drugs that are made of herbs and natural products under the dualistic medical and pharmaceutical System. Laws and regulations that differentiate the process of approving herbs that are used in Korean Medicine and the others should be established.

• Journal of Korean Medical classics
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• v.24 no.2
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• pp.109-149
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• 2011

Objectives : The study contains formulas, medicinal herbs, how to make of paste preparations in "Dongeuibogam". Methods : I will try to find paste preparations in "Dongeuibogam" using a word, paste(膏). Results : Paste preparations are categorized into two types: the external and the internal medicine. Paste preparations were used not only in the dermatology disease but in the internal disease. The same formula name to have different information was written by other people. Various kinds of medicinal herbs, minerals, animals were used and type of oil or juice was used to dissolve these. Methods to process paste preparations were to grind medicines or extract from medicinal materials. Paste preparations for the external was used to put in eyes or to push into wound and apply them to the skin. Paste preparations for the internal was used to take with wine, water and herbal tea. Some paste preparations were used both external and internal. Conclusion : These results explain that Paste preparations were variously used in "Dongeuibogam".

• The Journal of Korean Medicine
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• v.36 no.1
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• pp.61-74
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• 2015

Objectives: The main purpose of this study is to find a solution for modernized classification of herbal medicinal preparations in dual medical systems. Through this study, we expect to provide a reasonable foundation of herbal medicine for public health. Methods: We studied legal or technical terms of herbal medicinal preparations from the past regulations, and through this procedure, we could suggest clear definitions of terms for herbal medicinal preparations. We also investigated documents for approval of herbal medicinal preparation from US, EU(European union), The People's Republic of China, Japan, so that we can refer to them to revise regulation for appropriate use of herbal preparations. Results: In Korea pharmaceutical affairs act, any basis of 'Crude drugs' does not exist. But in some subordinary notifications, the way that they use the 'Natural product medicine' is used as a means of limiting basic rights of doctor or pharmacist of Korean medicine compared to doctor or pharmacist. At the same time, in subordinary notifications, provisions are vague and not enough for scientific evidence of Korean medicine. Thus, we re-categorized herbal medicinal preparations into new drugs, drugs made from herbal medicinal preparations and suggested requirements for drug approval. Conclusions: Instead of using the term 'Crude drug preparations', and we should use term 'Herbal medicinal preparations' in related act and notification. And also we suggest to amend subordinary regulations and documents for approval of herbal medicinal preparations. Through this, we can make herbal medicinal preparations be more industrialized.

• Korean Journal of Pharmacognosy
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• v.17 no.4
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• pp.292-301
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• 1986

The combined preparations of the traditional Korean prescriptions, Sahyangsohap-won (A1) and Woohwangporyong-hwan (B1) were evaluated on pharmacological actions in rats and mice, in parallel with the preparations of their modified prescriptions (A2 and B2). The acute toxicities of the four preparations were very low of which $LD_{50}$ values were more than 4g/kg, p.o. and no systematic symptoms were found at the doses. All the preparations showed sedative action by prolongation of sleeping time induced with hexobarbital sodium. The action was more potent in the modified preparations than in the original ones. All the preparations had no anticonvulsant action both in chemoshock seizures induced by pentetrazole and strychnine and in electroshock seizure. In rat fundus preparation, A1 and A2 elicited strong contraction at the concentration of $1{\times}10^{-3}\;g/ml$ in bath, whereas B1 and B2 did neither contraction nor relaxation at the same concentration. The four preparations had no inhibitory effect against acetylcholine induced spasm. In rat intestinal preparation, the four preparations exhibited neither contraction nor relaxation. However, A1 and A2 had antagonistic effect against spasm at the concentration of $1{\times}10^{-3}\;g/ml$. Single administration of each preparation at the dose of 0.24g/kg, p.o. stimulated the secretion of pepsin in rat stomach without inciting the secretion of gastric juice. Their stimulating actions were more marked in B1 and B2 than in A1 and A2, and were more promptly exhibited in the modified preparations (A2 and B2). Accelerating action of bile secretion by single administration of each preparation was found at the dose of 0.24g/kg, p.o. in rats. All the preparations except A2 also stimulated the secretion of bile acid.

• Journal of the Korean Home Economics Association
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• v.42 no.7
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• pp.89-102
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• 2004

The purpose of this study is to examine the factors causing the attitudes and preparations toward retirement. Tow hundred eight employees participated in this study. The results of this study are as fellows: First, income, age, sex, self-esteem, attitudes toward job, family, and leisure affect the attitudes toward retirement. Second, income and attitudes toward leisure affect economic preparations. Third, age, attitudes toward family and leisure affect psychologic preparations. Fourth, age, self-esteem, locus of control, and attitudes toward leisure affect physical preparations.

• Advances in nano research
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• v.13 no.3
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• pp.217-231
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• 2022

This study investigates the geometrical impact on the nanomedicine drug delivery via nanodevices. A nanomotor made of the nanotube carrying the drug as the motor blade is considered in the blood flow. Physical activities change the blood flow, and sports training enhances the blood flow and plays a significant role in the stability of drug delivery devices. This paper studies the impact of geometrical parameters on the nanomotors carrying the nanomedicine. The effect of physical exercise on the dynamic response regarding the stability of drug delivery devices is discussed in detail.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.2
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• pp.45-57
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• 2016

This study examined the effect factors for the preparations for the old age on the current satisfaction of life of the middle-aged. A survey of middle aged people living in Seoul and metropolitan areas was conducted. The data from 442 subjects were collected from 450 questionnaires excluding 8 incomplete datasets and analyzed. The results were as follows. First, the emotional and economical preparations for the old age had influences on the emotional satisfaction positively. Second, the educational background, jobs for technician/working, emotional and physical preparations for old age had a positive effect on the physical satisfaction. Third, the household income, emotional and economical preparation for the old age had a positive influence on the economical satisfaction. Fourth, sex, emotional preparations for old age had a positive effect on the social relation satisfaction. The research results suggested that the preparations for the old age should be arranged from the middle-aged years because it is difficult to improve the satisfaction of life for old age in the elderly.

• Korean Journal of Pharmacognosy
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• v.16 no.4
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• pp.214-220
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• 1985

The preservatives in 32 commercial liquid preparations of crude drugs have been analyzed by using high performance liquid chromatography. Benzoic acid (BA) and p-hydroxybenzoates were separated with mobile phase of $MeOH-H_2O$ (70:30) (pH 7.0) at a flow rate of 0.9ml/min. BA, sorbic acid and dehydroacetic acid were separated with mobile phase of $MeOH-H_2O$ (40:60) (pH 4.5) at a same flow rate. In addition, the pH values of the preparations were investigated. It was found that BA was used in most of the preparations.