• Clinical and Experimental Pediatrics
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• 제49권9호
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• pp.991-995
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• 2006

PFAPA 증후군은 소아 시기의 주기성 발열의 원인의 하나로, 급작스럽게 시작되는 발열과 더불어 아프타 구강 궤양, 인두염과 경부 림프절염이 동반되는 것을 특징으로 하는 질환이다. PFAPA 증후군의 원인은 아직 알려져 있지 않으며, 가족력이 없이 산발적으로 발생한다. 또한 검사실 소견에서도 특징적인 소견은 없다. 진단은 임상적인 소견을 바탕으로 이루어지며, 장기적인 합병증을 남기지는 않는다. 현재까지 알려진 치료로는 경구프레드니솔론이 증상을 조절하는 데 효과적이라고 알려져 있다. 저자들은 2년간의 임상 증상의 반복을 경험하였던 6세 여아에서 다른 질환을 배제한 후 PFAPA 증후군의 진단 요건을 만족하여 경구 프레드니솔론을 사용한 후 증세의 호전을 보인 PFAPA 증후군의 한 예를 보고하고자 한다.

• 한국임상수의학회지
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• 제16권1호
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• pp.155-162
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• 1999

This study was performed to assess that clinco-therapeutic effect of natural Italian honeybee (Apis mellifera) venom in adjuvant-induced arthritic rat. Ninety Sprague- Dawley rats of male were injected with complete Freund's adjuvant (CFA). Adjuvant arthritis was produced by a single subcutaneous injection of 1 mg Mycobacterium butyricum suspended in 0.1 ml paraffin oil into the right hindpaw. Righting reflex was uniformly lost and considered to be the point of arthritis development on day 14 after CFA injection. Experimental groups were divided into three groups. When arthritis was developed in the rat hind-paw, tested groups were administrated with prednisolone (10 mg/kg, p.o) and honeybee venom (one bee, s.c) at an interval of two days. Control group was subcutaneously injected with 0.1 ml of physiological saline solution in the rat at an interval of two days. Clinical findings, hematological values and histopathological findings were observed during or after the drugs administration. In tested groups, the development of inflammatory edema and polyarthritis on day 14 after treatment was suppressed. No significant differences of hindpaw edema volume and lameness score between prednisolone and honeybee venom groups were observed during or after therapeutic drugs treatment. WBC counts of prednisolone and honeybee venom treatment groups as compared with the control group were getting remarkably decreased during or after the therapeutic drugs administration(p＜0.01). Erosions of articular cartilage and inflammatory cell infiltrations during or after the therapeutic drugs treatment was effectively suppressed in natural honey venom.

• Childhood Kidney Diseases
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• 제21권2호
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• pp.160-164
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• 2017

C3 glomerulopathy (C3G) is a recently defined pathological entity characterized by C3 accumulation with absent or scant immunoglobulin deposition, leading to variable glomerular inflammation. The clinical presentation of patients with C3G is highly variable, as they may present with symptoms ranging from microscopic or mild proteinuria to full-blown nephrotic syndrome, with or without renal impairment. However, there is no consensus recommendation for specific treatment in children with C3G. Recently, new therapies have been suggested to target complement pathways, owing to an improvement in the understanding of the pathogenesis of C3G. C3G complement blockade with eculizumab, a monoclonal antibody targeted against complement C5, inhibits activation of the alternative complement pathway. We could not use eculizumab owing to its high price; thus, we administered oral prednisolone and mycophenolate mofetil (MMF). MMF was replaced with cyclosporine because proteinuria persisted, with a consistently low serum C3 level; we tapered off the prednisolone because of a Cushingoid appearance and amenorrhea. Thereafter, proteinuria improved, and the serum C3 level returned to normal. Thus, we report the effectiveness of cyclosporine in a patient with C3G and an inadequate response to prednisolone and MMF, who was detected via school urinary screening.

• Journal of Pharmaceutical Investigation
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• 제33권2호
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• pp.99-103
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• 2003

Four different crystal forms of prednisolone, two polymorphic forms and two pseudopolymorphic forms, were obtained by the recrystallization from different organic solvents under varying conditions. The isolated crystal forms were characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and X-ray powder diffraction (XRD). Form 1 was the most stable form that had the highest melting point and melt at $250.1^{\circ}C$. Form 2 was a monohydrate and Form 3 was a methanol solvate. The endothermic peak of Form 4 was shown at $230.2^{\circ}C$. When stored at different relative humidity over the period of 3 months, all of the modifications did not undergo transformation. The dissolution patterns of these four modifications were also checked in distilled water at $37{\pm}0.5^{\circ}C$, for 120 minutes. The dissolution rate of Form 4 was highest and those of Form 3, Form 2, Form 1 followed. Form 2, Form 3 and Form 4 had higher dissolution rate than Form 1.

• 대한핵의학회지
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• 제16권1호
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• pp.15-22
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• 1982

To evaluate the diagnostic usefulness of radioisotope bone scan and clinical activity of myositis, bone scan using $^{99m}Tc-Methylene$ diphosphonate was serially done before and after treatment with prednisolone in 10 patients with well-documented dermatomyositis-polymyositis. The observed results were as follows. 1. In all 10 patients before treatment with prednisolone, the bone scans showed evidence of increased muscle uptake. Muscle uptake was markedly increased in 4 patients, moderately increased in 3 patients and minimally increased in 3 patients. 2. The site of increased muscle uptake was consistent with the site of clinically involved muscle which was weak and tender. 3. The degree of muscle uptake correlated with the severity of the muscle weakness and tenderness at the scan was done. In all 10 patients treated with high dose prednisolone, muscle uptake was decreased following therapy. Above results suggest the radioisotope bone scanning may be useful in the diagnosis and treatment of patient with dermatomyositis-polymyositis.

• Parasites, Hosts and Diseases
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• 제58권5호
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• pp.577-581
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• 2020

A 22-year-old Thai man from the Northeast region presented with acute eye swelling, itching, and discharge on his left eye. He was suspected of having gnathostomiasis and treated with albendazole and prednisolone for 3 weeks. Nine months later, he was treated with high-dose oral prednisolone for the preliminary and differential diagnoses with thyroid-associated orbitopathy and lymphoma. He had been administered prednisolone intermittently over a few years. Then he developed a painless movable mass at the left upper eyelid and recurrent pseudotumor oculi was suspected. The surgical removal of the mass was performed. A white pseudosegmented worm revealed a definite diagnosis of ocular sparganosis by a plerocercoid larva. Molecular diagnosis of the causative species was made based on the mitochondrial cytochrome c oxidase subunit 1 (cox1) gene. Proper technique of extraction and amplification of short fragments DNA from formalin-fixed paraffin-embedded tissue successfully identified parasite species. The result from the sequencing of the PCR-amplified cox1 fragments in this study showed 99.0% sequence homology to Spirometra ranarum. This is the first report of S. ranarum in Thailand.

• Journal of Oral Medicine and Pain
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• 제37권1호
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• pp.27-33
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• 2012

피부와 구강점막에서 발견되는 편평태선은 만성 염증성 질환으로 세포매개성 면역반응이 주로 언급되고 있으나 아직 정확한 원인은 밝혀지지 않았다. 따라서 완전한 치료법은 아직 없으며 증상의 완화를 치료목표로 하고 있다. 본 연구에서는 구강편평태선의 일차적인 치료법으로 사용되는 corticosteroid의 두 가지 가글용액의 효과를 비교하였다. 2002년부터 2010년까지 부산대학교 치과병원 구강내과에서 구강편평태선으로 진단받은 환자들 중 corticosteroid 가글용액을 처방받은 환자들 총 180명의 환자기록을 조사하였다. 사용된 두 종류의 가글용액은 각각 dexamethasone(dexamethasone disodium phosphate, 0.05%)과 prednisolone($solondo^{(R)}$)을 포함하는 용액이었으며 약물 사용 후 증상의 완화 및 재발의 시기를 기록하여 분석하였다. Dexamethasone gargle(dexa gargle) 처방군은 33명(여성 25명, 남성 8명), prednisolone gargle(solon gargle)처방군은 147명(여성 114명, 남성 33명)이었으며 환자군의 평균연령대는 50대였다. 약물투여 후 초기 2주이내에 증상이 호전된 경우는 dexa gargle을 사용한 환자군에서 유의성 있게 나타났으나 증상재발의 경우는 두가지 가글용액의 차이가 나타나지 않았다. 구강편평태선 환자에 대한 도포용 스테로이드 가글을 이용한 치료에서 증상의 빠른 호전을 기대하기 위해서는 solon gargle보다는 dexa gargle을 사용할 수 있으나 재발율에 있어서는 두 약물의 차이가 발견되지 않았다.

• 한국임상수의학회지
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• 제15권2호
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• pp.267-273
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• 1998

The study was carried out to investigate the changes of total WBC, neutrophil, lymphocyte, monocite, eosinophil in the horses'blood of 3 groups which randomly assigned 3 heads to each group. In group A(daily therapy), each horse was iniected, intramuscularly, 100 mg of prednisolone acetate/day for 3 days, consecutively. In group B(alternate-day therapy), each horse was injected, 100 mg of prednisolone acetate/day 4 times on alternate days, intramuscularly. In control group, each horse was injected, intramuscularly, the equivalent volumes/day of saline solution fur 3 days, consecutively. The results were summarized as fellows: 1. Total WBC counts in group A rapidly increased until day 4th, which the counts reached the $maximum(13.10{\pm}0.13{\times}10^{3}/{\mu}l$)(p<0.05), and decreased into control group range until day loth. In group B rapidly increased until day 1st, and gradually increased until day 71% which the counts reached the maximum ($12f3{\pm} 0.20$)0<0.05), and decreased into control group range until day 16th. 2. Neutrophil counts in group A rapidly increased until day 4HL which the coun% reached the maxi um($10.85{\pm} 0.08$)0<0.05), and decreased into control group range until day loth. In group B rapidly increased until day 1st and slowly increased until day 7th, which the counts reached the maximum$(9.76{\pm}0.22)0<0.05)$, and decreased into control group range until day 16th. 3. Lymphocyte counts in group A and B rapidly decreased until day 4th, which the counts reached the minimum(2.14{\pm}0.12 and 2.09{\pm}0.20$, respectively) (p<0.05), and increased into control group range until day 10th. Group A and B, however, had no significant effects each other on Iymphocyte counts during the study. 4. Monocite and eosinophil counts in group A and B remained in the range of control group during the study. Eosinophil in group A and B slightly decreased on day 4th, significantly%<0.05), but we could not generally be reliable the result because of severe standard deviations. In conclusion, we fecund that group A had more rapidly increase and decrease than group B on hematologic counts of WBC, but group B had longer period than group A on the hematologic effects of WBC, and found not differences between daily therapy and alternate-day therapy.

• Tuberculosis and Respiratory Diseases
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• 제48권6호
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• pp.922-931
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• 2000

배경 및 목적 : 기관지천식의 중요한 특징적인 병인인 기도의 만성염증 상태와 증상의 변화를 판단하는 객관적인 지표로서 여러 가지 방법이 시도되고 있는데 최근에는 비침습적이고 비교적 간단한 유도객담 검사로 침습적인 기관지 조직 검사나 기관지폐포세척술을 대신하려는 경향이 있다. 저자들은 기관지천식 환자의 유도객담에서 호산구, eosinophil cationic protein(ECP), interleukin(IL)-3, IL-5, granulocyte-macrophage colony-stimulating factor(GM-CSF), 그리고, nitric oxide(NO)의 유도체를 측정하고, 객담내 NO 및 호산구와 관계가 있다고 알려진 cytokine들의 농도가 증상 및 기도의 염증상태를 반영하는 지표로서 이용될 수 있는지를 알아보고자 하였다. 방법 : 기관지천식 환자 30명을 대상으로 2주간 경구용 프레드니솔론 30mg을 투여하고, 약제 투여 전후로 1초간 노력성 호기량($FEV_1$과 혈중 총 호산구수, 그리고 유도객담 검사를 시행하여 객담내 호산구 비율과 ECP, IL-3, IL-5, GM-CSF, 그리고, NO 유도체를 측정하였다. 결과 : 대상환자중 남자는 13a여(43.3%), 여자는 17명(56.7%)이었고 연령분포는 19세부터 64세까지였으며 평균연령은 41.8세였다. 30명중 2명은 두 번째 검사시 객담이 채취되지 않았고, 3명은 두 번째 방문을 하지 않았다. 프레드니솔론 투여후 평균 1초당 노력성 호기량(% of predicted value)은 78.1$\pm$27.2%에서 90.3$\pm$18.3%로 개선되었고(P<0.001), 유도객담내 평균 호산구비율은 56.1$\pm$27.2%에서 29.6$\pm$21.3%로 (P<0.001), 객담내 평균 ECP 농도는 $134.5\pm68.1{\mu}\;g/L$에서 $41.5\pm42.4\;{\mu}g/L$로 유의하게 감소하였고(P<0.001), 평균 혈중 총 호산구수는 425.7$\pm$265.9에서 287.7$\pm$294.7로 감소하는 경향을 보였지만 통계적으로 유의하지 않았다. 유도객담내 NO 유도체의 평균 농도는 프레드니솔론 투여 전호로 유의한 차이가 없었으며($70.4\pm44.6\;{\mu}mol/L$ vs $91.5\pm48.3\;{\mu}mol/L$) 평균 eotaxin 농도는 27.7$\pm$12.8 pg/ml에서 21.7$\pm$8.7 pg/ml로 감소하는 경향을 보였다. IL-3, IL-5, CSF는 대부분의 경우에서 측정되지 않았다. 치료전의 1초당 노력성 호기량과 객담내 ECP의 농도 사이에 의미있는 역상관관계가 있었고(r=0.369, P<0.05). 결론 : 유도객담내에서 측정 가능한 여러 인자중 eotaxin 및 ECP가 치료에 따른 기도염증 상태의 변화를 반영하는 지표로 이용될수 있을 것으로 생각된다. 그 외 유도객담내 호산구비율 측정도 치료에 따른 증상이나 염증의 변화를 손쉽게 관찰할수 있는 간단한 방법으로 생각되지만 유도객담에서 Griess reagent를 이용한 NO 유도체의 측정은 기관지천식의 증상이나 염증상태의 변화를 반영하는 지표로서 유용하지 않을 것으로 생각된다.

• 한국식품위생안전성학회지
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• 제28권3호
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• pp.247-251
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• 2013

소염 진통 의약품 성분인 beclomethasone, dexamethasone, prednisolone, ketoprofen, phenylbutazone 5종에 대한 동시분석을 위해 LC-MS/MS 분석 조건 중 MRM 방식으로 각 성분의 MS 분석 최적조건을 결정하고, 정량이온으로 beclomethasone 409.1/391.0, dexamethasone은 393.1/372.9, prednisolone은 361.0/343.1, ketoprofen은 255.0/209.0, phenylbutazone은 309.1/160.1을 분석하였다. 혼합표준용액을 기울기용매 조건으로 이동상 A(0.1% 개미산), B(0.1% 개미산을 함유한 아세토니트릴)를 이용하여 17분 동안 분석한 결과, prednisolone ($t_R$: 7.34 min), dexamethasone ($t_R$: 7.73 min), beclomethasone ($t_R$: 7.82 min), phenylbutazone($t_R$: 8.31 min), ketoprofen ($t_R$: 9.24 min) 순서로 검출되었다. 5종 성분 모두 약 2-100 ng/mL 농도 수준의 검정곡선에서 $R^2$ 값이 0.999 이상의 우수한 직선성을 나타내었고, prednisolone을 제외한 4종 성분의 검출한계는 0.4-0.9 ng/mL, 정량한계는 0.81-2.22 ng/mL 였으며, prednisolone은 그보다 다소 높은 4.60, 11.46 ng/mL 이었다. 환제품의 기타가공품 공시료에 5종 성분 혼합표준용액을 최종농도가 5, 20, 50 ng/mL이 되도록 직접 첨가하여 분석한 결과, 모든 농도에서 80% 이상의 우수한 회수율을 얻을 수 있었고, 일내 일간 반복 분석의 상대표준편차(%)를 통해 모든 성분에서 비교적 재현성 있는 결과가 나타났다. 실제 인터넷 상에서 유통중인 식품에 이 분석법을 적용한 결과 모든 제품에서 검출되진 않았으나, 소비자들의 건강상 위해를 끼칠 수 있는 이들 성분의 동시분석법을 활용한 지속적인 모니터링이 필요한 실정이다.