• Journal of Genetic Medicine
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• v.19 no.2
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• pp.63-75
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• 2022

Purpose: Osteoporosis is a common calcium and metabolic skeletal disease which is characterized by decreased bone mass, microarchitectural deterioration of bone tissue and impaired bone strength, thereby leading to enhanced risk of bone fragility. In this study, we aimed to identify novel genes for susceptibility to osteoporosis and/or bone density. Materials and Methods: To identify differentially expressed genes (DEGs) between control and osteoporosis-induced cells, annealing control primer-based differential display reverse-transcription polymerase chain reaction (RT-PCR) was carried out in pre-osteoblast MC3T3-E1 cells. Expression levels of the identified DEGs were evaluated by quantitative RT-PCR. Association studies for the quantitative bone density analysis and osteoporosis case-control analysis of single nucleotide polymorphism (SNPs) were performed in Korean women (3,570 subjects) from the Korean Association REsource (KARE) study cohort. Results: Comparison analysis of expression levels of the identified DEGs by quantitative RT-PCR found seven genes, Anxa6, Col5a1, Col6a2, Eno1, Myof, Nfib, and Scara5, that showed significantly different expression between the dexamethason-treated and untreated MC3T3-E1 cells and between the ovariectomized osteoporosis-induced mice and sham mice. Association studies revealed that there was a significant association between the SNPs in the five genes, ANXA6, COL5A1, ENO1, MYOF, and SCARA5, and bone density and/or osteoporosis. Conclusion: Using a whole-genome comparative expression analysis, gene expression evaluation analysis, and association analysis, we found five genes that were significantly associated with bone density and/or osteoporosis. Notably, the association P-values of the SNPs in the ANXA6 and COL5A1 genes were below the Bonferroni-corrected significance level.

• Journal of the Korean School Mathematics Society
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• v.25 no.4
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• pp.333-352
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• 2022

This study is aimed at developing the STEAM instruction materials for mathematics subject-based advanced technology and ICT teaching tools. In order to develop the STEAM materials, a PDI model in which the implementation and evaluation steps were simplified to Improvement was used. The developed STEAM materials were revised and supplemented by a group of experts. The subject of the STEAM class material developed in this study is 『Graph! The bridge that connects the past, present and future』 , 『You are the same but different!』 , 『Creating a virtual reality three-dimensional space together』 , 『And making interesting figures』 and 『Cover the roof of the turtle ship!』 . As a suggestion based on the results of this development study, various STEAM education materials should be developed and shared so that STEAM education can be performed in the elementary education field. And for the spread and settlement of STEAM education, the cultivation and expansion of STEAM education capabilities of on-site elementary school teachers or pre-service teachers will be an absolute prerequisite. And this suggests the need for a continuous and long-term approach to follow-up research on STEAM education.

• Journal of Korean Medicine Rehabilitation
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• v.33 no.1
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• pp.77-85
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• 2023

Objectives This study is designed to evaluate the safety of palmul-tang soft extract in healthy male volunteers. Methods Twelve healthy male volunteers were recruited. And this study was conducted in a single center. As a result of the laboratory test, the safety was evaluated by collecting vital signs of volunteers. Twelve subjects were assigned by serial number according to the registration order. For safety evaluation, blood samples were collected and vital signs were checked four times throughout the test period, including screening, pre-administration, post-administration (after 48 hours) and post-administration (after 7 days). The difference in variables was summarized as the mean±standard deviation. The normality was performed using Kolmogorov-Smirnov and Shapiro-Wilk test. If normality is satisfied, a paired t-test is applied. Otherwise, the Wilcoxon sign rank test, which is a nonparametric method, is applied. The significance was p<0.05. The incidence of all side effects is expressed as a percentage. Results In the case of red blood cell, hemoglobin, and hematocrit values, the result of normality test of variables for the difference value before and after administration is significant level p<0.05. However, all laboratory test values before and after administration did not deviate from the normal range. Also the deviations in the normal range could not be seen as significance related to this clinical trial. And no side effects related to clinical trial drugs were observed. Conclusions The soft extract of palmul-tang was considered safe for healthy male volunteers.

• Journal of Korean Tunnelling and Underground Space Association
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• v.25 no.3
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• pp.187-200
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• 2023

This study analyzed the seismic fragility of bored tunnels based on their surrounding conditions and suggested a representative seismic fragility model. By analyzing the existed seismic fragility models developed for bored tunnels, we developed weighted combination models for each surrounding conditions, such as ground conditions and depth of the tunnel. The seismic fragility curves use the peak ground acceleration (PGA) as a parameter. When the PGA was 0.3 g, the probability of damage exceeding minor or slight damage was 20% for depth of 50 m or less, 10% for depth between 50 m and 100 m, and 3% for depth of 100 m or more. It was also found that the probability of damage was higher for the same PGA and depth when the surrounding ground was rock rather than soil. The probability of damage decreases as the depth increase. This study is expected to be used for developing a comprehensive seismic fragility function for tunnels in the future.

• Journal of Korean society of Dental Hygiene
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• v.23 no.2
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• pp.105-113
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• 2023

Objectives: The purpose of this study is to verify the usefulness and practicality of the program in the daily life of the elderly by performing a three-dimensional tongue muscle exercise for the elderly to identify the dysphagia, swallowing ability, and tongue pressure. Methods: The subjects of the study were 29 elderly people aged 65 or older living in Busan, divided into a oral exercises group and tongue strength training program combined with oral exercises group, and operated 16 times for 8 weeks twice a week, and the pre and post-program evaluation was conducted in the 1st and 8th weeks. For variable selection, 7 general characteristics, 5 oral health-related characteristics, 5 Likert scale for swallowing disorder, repetitive swallowing ability test for swallowing power measurement, and tongue pressure measurement was used. Data analysis was conducted using SPSS window program 25.0 version (IBM), general characteristics and homogeneity tests, oral health-related characteristics and homogeneity tests were chi-square test, swallowing disorder, swallowing ability, and change in tongue pressure were paired t-test, Wilcoxon signed rank test, t-test, Mann-Whitney U test for swallowing disorder and changes in swallowing ability and tongue pressure, and Spearman's correlation for the relationship between swallowing disorder and swallowing ability and tongue pressure. Results: As a result of tongue strength training program combined with oral exercise, both relieve swallowing disorder and improve low eating and tongue pressure than oral exercise, and the difference in improvement effects of both relieve swallowing disorder, swallowing ability, and tongue pressure is higher. Conclusions: Based on the results of this study, it is believed that simple and practical oral muscle function reinforcement products and practical use are needed, and institutional devices to seek oral health promotion programs for the elderly are needed.

• Journal of Information Technology Services
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• v.22 no.4
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• pp.141-157
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• 2023

The present work aimed to present the development of 'Funt', the augmented reality-based digital app as an educational tool for foreign language learning. Our work further evaluated the learning efficacy of the tool by the assessment of the three dependent measures including learning motivation, learning satisfaction, and learning involvement. With a learning app of 'Funt', students can use AR app to access recognition-based or location-based experiences such that any objects, artifacts, or media appear to be in the app. Students are then able to interact with the digital content by manipulating it to learn more about it. Students's engagement should also increase when they create their own experience in AR to demonstrate their understanding of a particular concept or words. Learning effects were evaluated on survey data collected from a hundred respondents aging six to nine years. One-group design for pre-test and post-test was utilized to examine the differences of learning efficacy by comparing the non-'Funt' group and the Funt group scores. A pairwise t-Test was performed for pairwise comparisons between two learning groups. The results indicate that the 'Funt' group scored significantly higher than the non-'Funt' group in the measures of learning motivation, learning satisfaction, and learning involvement. Overall, our results suggest that 'Funt' attracted the students' attention, provided them with a fun context to learn English vocabulary, and develop positive motivation and satisfaction towards vocabulary learning through AR technology.

• The Journal of Advanced Prosthodontics
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• v.15 no.4
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• pp.214-226
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• 2023

PURPOSE. This study aimed to compare the bite force (BF) between complete dentures and implant overdentures (IODs) retained by two mandibular implants. Additionally, we evaluated the quality of life (QoL) and patient satisfaction among individuals using IODs. In addition, the effects of demographic parameters such as age and sex, and clinical parameters such as implant length, implant diameter, attachment height, attachment color, and interimplant distance on BF, QoL, and patient satisfaction were evaluated. MATERIALS AND METHODS. A total of 51 edentulous patients rehabilitated with the maxillary complete dentures and mandibular IODs retained by two implants were included in this study. BF was measured using a force meter pre- and post-implant in the same patients. Oral health-related quality of life (OHRQoL) was assessed with the Oral Health Impact Profile (OHIP-14) and patient satisfaction was assessed with the Visual Analog Scale (VAS) questionnaires. RESULTS. It was found that BF values were statistically higher for IODs than complete dentures (P < .001). In terms of attachment height of the OHIP scores, there was a significant difference in the psychological disability and social disability domains (P < .05). When examining the change in patient satisfaction as a function of sex, it was found that mandibular retention satisfaction differed significantly by sex (P < .05), but there was no significant difference in the other domains. CONCLUSION. Within the limitations of this study, it was observed that the BF increased after the use of IODs. Several factors, including age, interimplant distance, attachment height, and attachment color, were found to impact OHRQoL. Sex and implant diameter were identified as factors affecting patient satisfaction.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.367-367
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• 2022

토지이용의 고도화에 따라 비점오염원 부하는 증가하는 추세이며 기후변화에 따른 강우강도 증가 등으로 지표면에 축적된 고농도의 비점오염물질이 하천으로 유출, 수질오염을 가중시키고 있어 비점오염원 관리가 필요하다. LID 기법은 자연적 기작(mechanisms)과 공정(process)을 이용하여 생태계의 물질순환(물순환 포함)과 에너지 흐름이 원활하도록 조성하는 기법으로, 불투수층면에서 발생되는 강우유출수를 관리 가능하다. LID 시설에는 전처리 시설을 두어 초기 고농도의 입자상 물질을 저감시키고, 강우유출수 저류공간을 통한 유출저감, 첨두유량 등을 저감시킨다. 이러한 전처리 시설에는 유기물질 및 영양소의 생물학적 제거를 위한 미생물 서식공간의 제공 등의 역할을 수행하기 위하여 다양한 여재를 적용하고 있다. 본 연구는 비점오염물질 유입이 LID 기법 전처리 시설 내 여재층의 물리·화학적 및 생물학적 환경을 평가하였다. 3개 시설 모두 100%의 불투수층에서 발생되는 강우유출수를 처리하는 LID 시설을 연구대상으로 선정하였으며, 각각의 전처리 시설에는 자갈, 우드칩, 쇄석 등이 적용되어 있다. 퇴적물의 경우 가장 상부에 존재하는 층으로 퇴적물의 오염물질 농도는 2~10.7배 이상 매우 높게 나타났다. 우드칩의 경우 다른 여재에 비해 높은 함수량과 유기물 함량을 보였으며 이는 우드칩의 수분을 보유하는 능력과 거친 표면공극에 오염물질이 부착되기 때문으로 나타났다. 또한, 같은 무기성 여재인 쇄석과 자갈의 경우 여재 크기의 차이를 보임에도 불구하고 미생물의 군집구성과 함수량의 차이를 보이는 것으로 평가되었다. 유기물의 함량이 낮은 강우유출수의 생물학적 처리능력을 향상시키기 위해서는 유기성 여재가 필요하며, 다공성 무기 멀칭재를 적용하고 하부의 토양은 적정 유기물을 배합하여 질산화 및 탈질화 유도가 가능하도록 설계가 필요한 것으로 분석되었다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2022.05a
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• pp.129-132
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• 2022

Super-resolution is the process of converting a low-quality image into a high-quality image. This study was conducted using ESPCN. In a super-resolution deep neural network, different quality images can be output even when receiving the same input data according to the activation function that determines the weight when passing through each node. Therefore, the purpose of this study is to find the most suitable activation function for super-resolution by applying the activation functions ReLU, ELU, and Swish and compare the quality of the output image for the same input images. The CelebaA Dataset was used as the dataset. Images were cut into a square during the pre-processing process then the image quality was lowered. The degraded image was used as the input image and the original image was used for evaluation. As a result, ELU and swish took a long time to train compared to ReLU, which is mainly used for machine learning but showed better performance.

• Journal of the Korean Geotechnical Society
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• v.23 no.6
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• pp.115-126
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• 2007

The tilting-train is very attractive to the railroad users in the world because it runs with high speed in curved track using pre-existing infrastructure. The tilting-train has a unique allowable speed and mechanism expecially in curved track. Therefore, it should be evaluated in terms of the stability of the train operation and roadbed. In this study, when the tilting-train is being operated with the allowable speed, the behavior of the roadbed is evaluated by examining the settlement and bearing capacity of the roadbed. Additionally, the stability of the roadbed is estimated in the condition of soft roadbed influenced by the weather effects and cyclic train loading. The numerical results show that the roadbed settlements satisfy the allowable settlement when Young's moduli of the upper roadbed and in-situ soil are more than $2,300t/m^2\;and\;3,300t/m^2$, respectively, in the continuous welded rail (CWR) and $3,800t/m^2\;and\;4,600t/m^2$, respectively, in the rail joint.