• Plant Biotechnology Reports
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• v.5 no.1
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• pp.19-25
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• 2011

Tocopherols belong to the plant-derived poly phenolic compounds known for antioxidant functions in plants and animals. Activation of mitogen-activated protein kinases (MAPK) is a common reaction of plant cells in defense-related signal transduction pathways. We report a novel non-antioxidant function of ${\alpha}$-tocopherol in higher plants linking the physiological role of tocopherol with stress signalling pathways. Pre-incubation of a low concentration of $50{\mu}M$ ${\alpha}$-tocopherol negatively interferes with MAPK activation in elicitor-treated tobacco BY2 suspension culture cells and wounded tobacco leaves, whereas pre-incubated BY2 cells with ${\alpha}$-tocopherol phosphate did not show the inhibitory effect on stimuli-induced MAPK activation. The decreased MAPK activity was neither due to a direct inhibitory effect of ${\alpha}$-tocopherol nor due to the induction of an inhibitory or inactivating activity directly affecting MAPK activity. The data support that the target of ${\alpha}$-tocopherol negatively regulates an upstream component of the signaling pathways that leads to stress dependent MAPK activation.

• Food Science of Animal Resources
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• v.20 no.2
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• pp.107-113
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• 2000

This study was carried out to investigate the effects of temperature activation and agitation on lipolysis of goat milk. When goat milk was temperature activated twice at intervals of 12hours, free fatty acids were significantly increased after the first activation, but increased slightly during the re-cooling period and after the second activation. Lipolysis of the goat milk warmed at $30^{\circ}C$ was significantly facilitated during the re-cooling period. Lipolysis of the goat milk warmed at $30^{\circ}C$ was much higher than those warmed at $10^{\circ}C$ and $40^{\circ}C$ respectively. The highest lipolysis was occurred when the goat milk was warmed at $30^{\circ}C$ for 5 minutes after pre-cooling for 24 hours at $40^{\circ}C$. However, any significant difference was not found in the milk warmed at $40^{\circ}C$, regardless of the pre-cooling period. Lipolysis of the goat milk warmed and agitated at $30^{\circ}C$ was significantly facilitated during the re-cooling period. The lipolysis of that at $30^{\circ}C$ was significantly facilitated during the re-cooling period. The lipolysis of that at $30^{\circ}C$ was much enhanced with agitation. The lipolysis was much higher when agitated at $30^{\circ}C$ than when agitated at $10^{\circ}C$. The length of agitation time at $30^{\circ}C$ didn't give any effect on lipolysis.

• IMMUNE NETWORK
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• v.11 no.6
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• pp.420-423
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• 2011

Since CKD-712 has been developed as an anti-inflammatory agent, we examined the effect of CKD-712 during TLR4 signaling. Using HEK293 cells expressing TLR4, CKD-712 was pre-treated 1 hr before LPS stimulation. Activation of NF-${\kappa}B$ was assessed by promoter assay. The activation of ERK, JNK, p38, IRF3 and Akt was measured by western blotting. CKD-712 inhibited the NF-${\kappa}B$ signaling triggered by LPS. The activation of ERK, JNK, p38 or IRF3 was not inhibited by CKD-712. On the contrary the activation of these molecules was augmented slightly. The activation of Akt with stimulation of LPS was also enhanced with CKD-712 pre-treatment at lower concentration, but was inhibited at higher concentration. We suggest that during TLR4 signaling CKD-712 inhibits NF-${\kappa}B$ activation. However, CKD-712 augmented the activation of Akt as well as Map kinases. Therefore, we suggest that CKD-712 might have a role as an immunomodulator.

• Journal of Korean Physical Therapy Science
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• v.20 no.1
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• pp.37-42
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• 2013

Background : The purpose of this study is to find out the impact of kinesio-taping method for female university students, who are vulnerable to constipation, on the activation of intestine. Methods : This study has been conducted for a total of three weeks including the pre-inspection, and it explained the purpose of the study upon selecting the adequate subjects who met the criteria for constipation among the female students. And It chose the nine students, who agreed to the experiment, as the subjects. It verified the frequency and time of excretion before experiment and the constipation ejaculation measure, and compared pre-arbitration with post-arbitration as for the time and frequency of excrement, the point of constipation ejaculation measure, etc. after two weeks since the application of tape. Result : The frequency of excrement after arbitration increased compared with pre-arbitration as result of the application of kinesio-taping method, and the time, which was taken for excrement, decreased. It was also shown that the point decreased in the point comparison for constipation ejaculation measure; thus, it obtained the result that showed the improvement of the level of constipation and all were statistically significant(p<.05). Conclusion : It is believed that kinesio-taping method has a positive impact on the activation of intestine of female university students.

• Journal of the Korean Society for Heat Treatment
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• v.18 no.1
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• pp.24-28
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• 2005

New post plasma nitriding can achieve a high uniformity that have been difficult in DC nitriding and have a high productivity comparable to gas nitriding. However, it has not a enough high nitriding potential for a rapid nitriding, because surface activation or ion etching in the general plasma nitriding cannot be expected. Thus, in this study, the effects of pre-treatments with oxidation and reduction gas have been investigated to improve the nitriding kinetics of post plasma nitriding. An effective pre-treatment consisting of oxidation and reduction resulted in the increase of surface energy of STD 11. This induced the surface hardness and the effective nitriding depth of STD 11. It is thought that the increase of the surface energy and the surface area with pre-treatment promote the nucleation of nitriding layer.

• Journal of the Korean Society of Physical Medicine
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• v.1 no.1
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• pp.59-66
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• 2006

Purpose : The purpose of this study was to investigate the effects of diaphragmatic breathing on activation of lumbar paraspinal muscles of normal healthy people. Diaphragmatic breathing may affect activation of trunk muscles. The assumptions are as follows: the crural diaphragm attatches to the lumbar vertebrae from L1 to L3, the voluntary downward pressurization of the diaphragm increases intra-abdominal pressure, and this increases the stiffness of the spine. Methods : Sixty male college students ranging 19 to 34 years were screened and % maximal voluntary contraction(% MVC) of trunk muscles on the four positions of back extension exercise was compared during the pre and post of inspiration of diaphragmatic breathing. Results : 1. % MVC of right and left erector spinae had the statistically significant difference between pre and post inspiration of diaphragmatic breathing in the dynamic right arm and left leg extension position(p<0.05). 2. % MVC of right and left erector spinae had the statistically significant difference between pre and post inspiration of diaphragmatic breathing in the dynamic left arm and right leg extension position(p<0.05). 3. % MVC of right and left erector spinae had the statistically significant difference between pre and post inspiration of diaphragmatic breathing in the static lying prone extension position(p<0.05). 4. % MVC of right and left erector spinae had the statistically significant difference between pre and post inspiration of diaphragmatic breathing in the static lying on prone position(p<0.05). Conclusion : This study will be used as the purpose of data collection of lumbar paraspinal muscles on diaphragmatic breathing and be introduced as the new therapeutic intervention for management of patients with back pain.

• The Korea Journal of Herbology
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• v.31 no.1
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• pp.33-40
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• 2016

Objectives : Liver is one of the largest organs in the human, and has a function of detoxification and energy sensing to prevent severe disease. Paeoniae radix has been used to treat a variety of liver diseases such as hepatitis and chronic hepatic failure. Although P. radix has been used as an medicinal herb for a long time, the effects of P. radix on severe oxidative stress and its action mechanism on the liver was not clearly verified.Methods : This study investigated the protective effects of P. radix extract (PRE), and the underlying mechanism of its action in the liver. tert-butyl hydroperoxide (t-BHP) and carbon tetrachlroride (CCl₄) were used to induce oxidative stress in the HepG2 hepatocyte cell line and Sprague-Dawley rats, respectively.Results : t-BHP significantly induced cell death and ROS production in HepG2 cell, as indicated by MTT and FACS analysis. However, pretreatment of PRE inhibited a decrease in cell viability and H₂O₂ production in the HepG2 cells. PRE also blocked the ability of t-BHP to damage in mitochondrial membrane transition. More importantly, PRE induced Nrf2 activation and antioxidant Phase II enzyme, which may have a role in the effects of PRE. In mice, PRE inhibited the liver damage induced by CCl₄.Conclusions : PRE inhibited oxidative stress and hepatic damages as mediated with Nrf2 activation. This study unveil, in part, the effect and mechanism of old medicinal herb, P. radix.

• Applied Chemistry for Engineering
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• v.7 no.2
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• pp.356-361
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• 1996

Cure kinetics of diglycidyl ether of bisphenol A(DGEBA)/4,4'-methylene dianiline(MDA) with hydroquinone-phenyl glycidyl ether(HQ-PGE) as a reactive additive, which was preliminarily synthesized, was investigated by DSC and FT-IR analyses. Kissinger equation and Arrhenius' equation were used to calculate activation energy and pre-exponential factor. When HQ-PGE was added to DGEBA/MDA system, it reduced activation energy of system. When the 5 phr of HQ-PGE was added to DGEBA/MDA system, activation energy was 7.8 kcal/mol by FT-IR analysis and 11.3 kcal/mol by DSC, in comparison with the system without HQ-PGE, activation energy decreased about 30% and 9%, respectively. According to these results, HQ-PGE, introducing agent of this system, acted as a catalyst.

• Resources Recycling
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• v.23 no.6
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• pp.47-53
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• 2014

Effective treatment and energy conversion technologies are necessary due to the ban of the dumping of organic waste including the sewage sludge. In this study, the kinetics of pyrolysis and combustion were derived in a TGA and thermobalance reactor, which is essential for thermal conversion of sewage sludge to energy. Three steps are shown for the pyrolysis in TGA and the different pre-exponential factors and activation energies are derived depending on the temperature range. Three models of gassolid reaction were applied to the reaction kinetics analysis for the combustion of sewage sludge char and shrinking core model was an appropriated model. Apparent activation energy and pre-exponential factor were evaluated and the effect of oxygen partial pressure was examined.

• Journal of the Korean Society of Safety
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• v.31 no.1
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• pp.66-73
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• 2016

Lyocell fibers were used as a precursor in order to improve yield and strength of cellulose-based precursor while manufacturing activated carbon fiber(ACF). Lyocell fibers as a precursor for the preparation of ACF were surface-modified by reaction with 3-aminopropyltriethoxysilane(APTES) and pre-treated with KOH and H3PO4. Using aforementioned precursor, ACFs were prepared by a series of stabilization, carbonization and activation process at high temperatures. On each process, FT-IR, TGA, UTM and SEM were used to observe fibers' physical properties including structure and porous surfaces. FT-IR results proved that surface modification was achieved during stabilization, carbonization and activation process. TGA results during carbonization process found that surface modified fibers with APTES 0.02 mol(A2) showed higher thermostability, and extended pre-treatment increased yield. Especially, yield was found to have an increase of 10~20 wt% with surface modification during activation process. UTM results showed that tensile strength has the same order of concentration of APTES after surface modification, however, was found to show lower tensile strength than lyocell fibers after stabilization process. SEM results revealed that more homogeneous porosity control could be proceed after modifying the surface for the effective removal of hazardous substances.