• Nutrition Research and Practice
• /
• 제4권6호
• /
• pp.522-527
• /
• 2010

Cardiovascular disease is a leading cause of death and disability and remains so in the future. The aim of this study was to detect the impact of a 6-month diet intervention on cardiovascular risk factors in postmenopausal Iranian women. It was a randomized controlled trial that carried out in the East Health Clinic in Ahvaz-Iran. This study started on June 2007 and was completed on May 2008. A total 64 healthy postmenopausal women recruited and randomly assigned to the intervention group (35) and control (29). Over the six months follow-up, the intervention group received five educational sessions (two face to face and three lecture discussion classes with slide demonstration) at the first month. These sessions were about menopause, cardiovascular disease and healthy diet. Every participant in the intervention group received one face to face education session at the $3^{rd}$ month, and also received a telephone call at the end of each month starting with the second month to remain on the diet. Pre-intervention and post-intervention anthropometric measurements, blood pressure, blood lipids and dietary intake were assessed. Data analyzed using the SPSS version 15. Descriptive (means and SD), univariate (paired-t test, Chi-Square and Independent T-test) and multivariate (GLM Repeated Measure) statistics were used. Participants in the diet group had significantly lower weight (-0.9 kg), body mass index (-0.4 $kg/m^2$), and fasting blood sugar (-4.5 mg/dl). The diet group significantly increased their daily intake of fiber (+2.3 g, P=0.05), decreased their intake of sodium (-28 mg, P=0.04), and consumption of fruit and vegetable ${\geq}$ 5 serving a day (80%, P=0.03) compared to the control group. Post menopausal women are at a greater risk for cardiovascular disease. Healthy diet using educational intervention can be an effective means of reducing cardiovascular risk in postmenopausal women.

• 대한지역사회영양학회지
• /
• 제7권1호
• /
• pp.121-129
• /
• 2002

Osteoporosis, the typical metabolic bone disease of the elderly, is characterized by a reduction in bone mineral density (BMD) and increased fracture risk. Genetic and environmental factors are known to play a key role in bone metabolism, and diet is also considered to be one of the important factors. The purpose of the present study was to investigate the relationship among the factors affecting BMD, including stature, body weight, age, time period since onset of menopause, and biochemical markers of bone turnover in postmenopausal women. Seventy-eight postmenopausal women who visited health promotion center for health examinations volunteered to participate in this study and they were divided into two groups according to the time period since onset of menopause : women with a time period since onset of menopause of less than 5 years (Group 1) and women with a time period since onset of menopause of 5 years or more (Group 2). The demographic characteristics and dietary intake were surveyed using a questionnaire. BMDs of the lumbar spine and femoral neck of subjects were measured by dual energy X-ray absorptiometry. Serum levels of 25-hydroxy-vitamin D and parathyroid hormone (PTH), known to be indicators of bone related hormone status, were anlyzed. Serum samples were measured for calcium, phosphorus, alkaline phosphatase, and osteocalcin as bone formation indicators, and urine was analysed for deoxypyridinoline, creatinine, calcium, and sodium as bone resorption indicators. The results are as follow : The mean BMDs of the lumbar spin and femoral neck were $1.02 \pm 0.02 g/cm^2 and 0.81 \pm 0.02 g/cm^2 respectively, and the BMD level of Group 2 was significantly lower than tat of Group 1 (p<0.01, p<0.05, respectively). The mean daily intake of energy was 1838 $\pm$ 55 kcal. When nutrient intake was compared with the recommended dietary allowances (RDA) of the subjects, only calcium, vitamin A and riboflavin intake showed means lower than the RDA. The nutrient intake did not show any significant differences between Group 1 and 2 Serum and urine levels of biochemical markers of bone turnover did not show any significant differences between Group 1 and 2, and all were within the normal range. However, the PTH and deoxypyridinoline levels showed a tendency to be higher, and the osteocalcin level to be lower in Group 2 than in Group 1. Although age and years after menopause (YAM) showed negative correlations with lumbar spine bone mineral density (LBMD) (r= -0.38, p<0.001, and r= -0.26, p< 0.05, respectively), no correlation was found with femoral neck bone mineral density (NBMD). While height, body weight and body mass index (BMI) showed a positive correlation with LBMD (r= 0.32, p<0.001, r= 0.38, p<0.001, r= 0.22, p= 0.05, respectively), only body weight and BMI showed a positive correlation with NBMD (r= 0.30, p<0.01, and r= 0.27, p<0.05, respectivley). There was no significant corealtion between BMDs and the nutrient intake of subjects, except in the case of carbohydrates (r= 0.22, p<0.05). Also, serum and urine levels of bone turnover markers showed no significant correlation with nutrient intake. On the other hand, serum osteocalcin had a positive correlation with vitamin C intake (r= 0.22, p= 0.05), and urine deoxypyridinolin showed a negative correlation with niacin intake (r= -0.22, p= 0.05). Urinary na was negatively correlated with protein intake(r= -0.23, p= 0.05). The results suggested that it is difficult to prevent the decrease in bone mass among postmenopausal women eating the usual Korean diet. However, the BMDs of the lumbar spine and femoral neck were positively related to body weight ad BMI in postmenopausal women. Therefore, this study confirmed that one of the most effective ways to minimize bone loss in postmenopausal women would be to maintain an adequate body weight with balanced nutrient intake and activity in the pre-and postmenopausal periods.

• 대한한방부인과학회지
• /
• 제21권4호
• /
• pp.193-206
• /
• 2008

Purpose: In spite of many arguments on the result of WHI (Women's Health Initiative) study, no one can deny the necessity for researches on the alternative treatment to HRT (hormone replacement therapy). In this study, the author wanted to investigate the method of precedent acupuncture RCTs (randomized controlled trials) to make out the appropriate acupuncture study design on postmenopausal and perimenopausal hot flashes in Korea. Methods: Precedent studies were investigated using Pubmed search and key-words "acupuncture and hot flash", "acupuncture and menopause", "acupuncture and vasomotor", limited to RCT, from 2000 to 2008 April. Results: As a result. 10 studies were searched. In the hereafter studies, multi-center clinical trials which consist of population group of postmenopausal and perimenopausal women that would be pre-stratified and more than 50 patients per treatment arm seem adequate. Sham control study can make out the proper consequence because many people are get used to acupuncture in Korea. Flexible choice of acupoints addressed an individual's symptoms using standardized algorithm is recommended. Treatment consist of 4 weeks' observation, 11 acupuncture sessions during 7 weeks, follow-up of 3 months or more after treatment and hot flash score as a primary outcome measure seem appropriate. After all, higher level of description according to global standard must be obtained in the study report and publishing. Conclusion: The researchers should develope the methodology of acupuncture clinical trial on the postmenopausal and perimenopausal hot flashes.

• 대한방사선기술학회지:방사선기술과학
• /
• 제34권3호
• /
• pp.195-201
• /
• 2011

이 연구는 폐경 전 후 여성의 요추골밀도의 예측인자의 차이를 알아보기 위한 것이다. 총 483명의 성인 여성을 대상으로 체성분, 지질, 혈압, 골밀도를 측정하여 다음과 같은 결과를 얻었다. 폐경 전 집단의 수축기 혈압, 총콜레스테롤, 중성지방, 저밀도지단백 콜레스테롤이 폐경 후 집단에 비해 유의하게 낮은 것으로 나타났다. 골밀도와 가장 상관관계가 있는 것은 제지방인 것으로 나타났으며, 폐경 후 집단의 골밀도는 저밀도지단백콜레스테롤 수준과 유의한 음의 상관관계가 있는 것으로 나타났다. 골밀도에 영향을 미치는 예측인자를 알아본 결과 폐경 전 집단은 체중, 체지방율, 고밀도지단백 콜레스테롤이 영향을 미치는 변수였으며, 폐경 후 집단은 체중, 연령, 저밀도지단백 콜레스테롤 수준이 영향을 미치는 것으로 나타났다.

• 여성건강간호학회지
• /
• 제3권2호
• /
• pp.268-281
• /
• 1997

This study was done for the purpose of analysing the relationship between menopausal syndrome and depression in the pre and post menopausal women's group. Data were collected by a questionnaire from November, 1995 to December, 1996. The subject were 244 midlife women(94 subjects were in pre-menopausal period, 150 subject were in post-menopausal period). The instruments used for this study were the menopausal syndrome scale by Neugarton and depression scale by Zung. Data were analyzed with the SPSS/PC using frequency, t-test, and Pearson correlation coefficients. The results of this study were as follows ; 1. The most serious menopausal symptom in the midlife women was 'back pain and joint pain'. 2. The item of 'Hot flush'(t=-2.78, p<0.01), 'sweating'(t=-2.31, p<0.05) and 'nervousness'(t=-2.13, p<0.05) as menopausal syndromes were statistically significant in the two groups ; Post menopausal group were higher then premenopausal group. 3. Postmenopausal group were a little higher then premenopausal group as depression level. It was none statistically significant in the two groups. 4. The relationship between menopausal syndromes and the level of depression was statistically significant in the group of post-menopausal group(r=0.2083, p<0.01).

• 한국보건간호학회지
• /
• 제28권1호
• /
• pp.102-113
• /
• 2014

Purpose: The purpose of this study was to evaluate the effects of long term osteoporosis management education consist of exercise, drug therapy, and nutrition on bone mineral density (BMD) and medication compliance among postmenopausal women who have just been diagnosed with osteoporosis. Methods: The research design consisted of a pre-and post-test quasi-experimental design through a nonequivalent control group. The participants in this study were 60 individuals with osteoporosis, and who were classified according to two groups; the control group (n=30) who were given general clinical guidelines, and the experimental group (n=30) who received management education once for 60 minutes every three months using a standardized educational sheet. After one year, BMD was assessed using band dual energy X-ray absorptiometry (DXA) and medication possession ratio (MPR) for medication compliance. Analysis of collected data was performed using descriptive statistics t-test, chi-test, and paired t-test. Results: No significant difference in BMD (t=-1.02, p=.311) and MPR (t=-0.77, p=.440) was observed between the two groups. However, a significant increase in femur neck BMD was observed in the experimental group compared with the control group (t=-2.18, p=.033). Conclusion: Conduct of further study will be needed for examination of the effect of long-term osteoporosis management education on BMD Level and Medication Compliance in Postmenopausal Women.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권15호
• /
• pp.6053-6057
• /
• 2014

Aim: To determine utility of the frozen section (FS) in the operative management of endometrial pre-malignant lesions. Materials and Methods: We retrospectively analyzed patients who underwent abdominal hysterectomy with preoperative diagnosis of complex atypical endometrial hyperplasia (CAEH) and simple endometrial hyperplasia (SEH) between May 2007 and December 2013. Frozen and paraffin section (PS) results were compared. Sensitivity, specificity, the positive predictive value (PPV), the negative predictive value (NPV) and the accuracy in predicting EC on FS were evaluated with 95% confidence intervals (CIs) for each parameter. The correlation between FS and PS was calculated as an ${\kappa}$ coefficient. Results: Among 143 preoperatively diagnosed CAEH cases, 60 (42%) were malignant and 83 (58%) were benign in PS; and among 60 malignant cases diagnosed in PS, 43 (71%) were "malignant" in FS. Sensitivity, specificity, PPV and NPV for FS were 76%, 100%, 100% and 87.5%, respectively. Conclusions: We found that FS is reliable and applicable in the management of endometrial hyperplasias. It is important that the pathologist should be experienced because FS for endometrial pre-malignant lesions has significant inter-observer variability. The other conclusion is that patients with the diagnosis of EH, especially those who are postmenopausal, should undergo surgery where FS investigation is available.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권1호
• /
• pp.41-48
• /
• 2012

Introduction: Breast cancer is the second leading cancer in Korean women. To assess potential genetic associations between the prostate stem cell antigen (PSCA) gene in the chromosome 8q24 locus and breast cancer risk in Korean women, 13 SNPs were selected and associations with breast cancer risk were analyzed with reference to hormone receptor (HR) and menopausal status. Methods:We analyzed DNA extracted from buffy coat from 456 patients and 461 control samples, using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) based upon region-specific PCR followed by allelespecific single base primer extension reactions. Risks associated with PSCA genotypes and haplotypes were estimated with chi-square test (${\chi}^2$-test), and polytomous logistic regression models using odds ratios (OR) and 95% confidence intervals (CIs), by HR and menopausal status. Results: In case-control analysis, odds ratios (OR) of rs2294009, rs2294008, rs2978981, rs2920298, rs2976395, and rs2976396 were statistically significant only among women with estrogen receptor (ER) negative cancers, and those of rs2294008, rs2978981, rs2294010, rs2920298, rs2976394, rs10216533, and rs2976396 were statistically significant only in pre-menopausal women, and not in postmenopausal women. Risk with the TTGGCAA haplotype was significantly elevated in ER (-) status (OR= 1.48, 95% CI= 1.03~2.12, p<0.05). Especially risk of allele T of rs2294008 is significantly low in pre-menopausal breast cancer patients and AA genotype of rs2976395 in ER (-) status represents the increase of OR value. Conclusion: This report indicated for the first time that associations exist between PSCA SNPs and breast cancer susceptibility in Korean women, particularly those who are pre-menopausal with an estrogen receptor negative tumor status.

• Journal of Nutrition and Health
• /
• 제41권7호
• /
• pp.612-620
• /
• 2008

골다공증의 위험율이 높은 폐경 후 여성을 대상으로 이소플라본 보충과 운동의 단독 또는 복합적인 중재가 소변 칼슘, 마그네슘, 구리, 아연배설량에 미치는 영향을 알아보기 위하여 $45{\sim}67$세의 폐경 후 여성 67명을 연령, 체질량 지수와 Base line 골밀도에 차이가 없도록 대조군 (16명), 보충군 (19명), 운동군 (16명), 보충 + 운동군 (16명)으로 나누어 연구를 수행하였다. 보충 + 운동군과 보충군에게는 8주 동안 매일 이소플라본 90 mg을 보충하였으며 운동군과 보충+운동군에게는 함께 운동을 실시한 후 중재 전후의 소변 칼슘, 마그네슘, 구리, 아연 배설량 변화를 측정하여 다음과 같은 결과를 얻었다. 소변의 칼슘, 마그네슘, 구리의 배설량은 유의적인 변화를 보이지 않았다. 그러나 식이 아연의 섭취량이 운동과 이소플라본 보충을 실시하는 동안 변화가 없었음에도 불구하고, 이소플라본 보충군에서 소변 아연의 배설량이 유의적으로 감소하여 이소플라본의 보충이 골대사에 중요한 역할을 하는 아연 보유량을 증가시킨 것으로 나타났다. 이상의 결과를 통하여 폐경 후 여성에서 운동과 이소플라본의 동시 중재가 각각의 중재방법보다 골대사의 향상에 유의적인 상승 작용이 없음을 확인 할 수 있었다. 또한 이소플라본의 단독 보충군에서만 소변의 아연 배설량을 감소시키는 다소 미미한 연구 결과가 제시되었다. 그러나 본 연구는 연구 기간이 짧고, 이소플라본의 보충량이나 운동의 중재방법이 다양하지 못하다는 많은 제한점을 가지고 있으므로, 추후 효과적인 투여 농도와 운동중재 방법을 모색하고, 또한 운동과 기능성 식이성분의 효과적인 복합 중재 방법을 결정 할 수 있는 계속적인 연구가 필요하다고 본다.

• 융합정보논문지
• /
• 제10권5호
• /
• pp.224-231
• /
• 2020

본 연구의 목적은 피톤치드흡입이 폐경기 여성의 기분상태 및 건강 관련 삶의 질에 변화를 8주간 실험을 통하여 분석하는 것이였다. 연구대상자는 서울 소재 D, N구의 폐경 후 2년 이하 41명을 목적적 표집하였다. 실험설계는 피톤치드흡입집단과 통제집단으로 구성되는 연구대상자 요인과 사전측정(0week)·중간측정(4week)·사후측정(8week)의 3개 측정시점으로 구성되는 2×3 반복측정에 의한 요인설계를 이용하였다. 본 연구의 종속변인으로는 기분상태와 건강관련 삶의 질로 설정하였으며 사전측정·중간측정·사후측정 3회 질문지를 통하여 자료를 수집하였다. 분석방법은 one-way ANOVA와 사후검증을 실시하였다. 도출된 결과는 첫째, 폐경기 여성의 피톤치드흡입집단이 통제집단에 비하여 긴장, 우울, 피로, 혼돈 요인의 감소 효과와 활력 요인의 증가 효과가 통계적 유의하게 나타났다. 둘째, 폐경기 여성의 피톤치드흡입집단은 통제집단에 비하여 유능감, 정신적 안녕, 안정성, 활력 요인에서 통계적 유의한 증가 추이를 나타내었다.