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Effects of Soy Isoflavones Supplementation and Exercise on Urinary Calcium, Magnecium, Copper and Zinc Excretion in Postmenopausal Women  

Yun, Mi-Eun (Department of Food and Nutrition, Sahmyook University)
Lee, Da-Hong (Department of Food and Nutrition, Wonkwang University)
Kim, Mi-Hyun (Department of Food and Nutrition, Kangwon National University)
Publication Information
Journal of Nutrition and Health / v.41, no.7, 2008 , pp. 612-620 More about this Journal
Abstract
This study assessed the effects of soy isoflavones supplementation with exercise on urinary mineral (calcium, magnesium, copper, zinc) excretion as an index of bone resorption rates in 67 postmenopausal women. A total subjects were assigned to Isoflavone (90 mg/day) or placebo groups. These groups were further divided into groups that undergone a regular exercise or a rather sedentary state performing daily activity only. We conducted study eight week period. Result showed urinary zinc excretion was more significantly decreased in the isoflavone-sedentary group ($-180.76\;{\pm}\;171.30\;ug/day$) than in the placebo-sedentary group ($-31.23\;{\pm}\;146.60\;ug/day$), placebo-exercise group ($40.93\;{\pm}\;193.44\;ug/day$) and isoflavione-exercise group ($-1.21\;{\pm}\;160.61\;ug/day$) (p < 0.05), but no significant changes in the differences between the values of the pre and post study values in urinary calcium, magnesium and copper excretion. These results suggest that Isoflavone supplementation decrease urinary zinc excretion rate in postmenopausal subjects.
Keywords
exercise; postmenopausal women; soy isoflavones; urinary calcium; copper; magnesium, zinc excretion;
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1 Gambacciani M, Cappaqli B, Cliapon M, Pepe A, Vacca F, Genazzani AR. Ultra low-dose hormone replacement therapy and bone protection in postmenopausal women. Maturitas 2008; 59 (1): 2-6   DOI   ScienceOn
2 Kim NN, Stankovic M, Armagan A, Cushman TT, Goldstein I, Traish AM. Effects of tamoxifen on vaginal blood flow and epithelial morphology in the rat. BMC Womens Health 2006; 6: 14   DOI   ScienceOn
3 North American Menopause Society. Role of progestogen in hormone therapy for postmenopausal women: position statement of The North American Menopause Society. Menopause 2003; 10(2): 113-132   DOI   ScienceOn
4 Karck U, Breckwoldt M. Low-dose oral contraception and bone density. Ther Umsch 2001; 58(9): 547-551   DOI
5 Park JH, Omi N, Nosaka T, Kitajima A, Ezawa I. Estrogen deficiency and low-calcium diet increased bone loss and urinary calcium excretion but did not altor arterial stiffness in young female rats. J Bone Miner Metab 2008; 26(3): 218-225   DOI   ScienceOn
6 Arana-Arri E, Gutierrez-Ibarluzea I, Ecenarro Muqaquren A, Asua Batarrita. Prevalence of certain osteoporosis-determing habits among postmenopausal women in the Basque Country Spain in 2003. Rev Esp Salud Publica 2007; 81(6): 647-656   DOI
7 Carvalho DC, Garlipp CR, Bottini PV, Afaz SH, Moda MA, Cliquet A Jr. Effect of treadmill gait on bone markers and bone mineral density of quadriplegic subjects. Braz J Med Biol Res 2006; 39(10): 1357-1363   DOI
8 Rico H, Roca-Botran C, Hernandez ER, SEco C, Paez E, Valencia MJ, Villa LF. The effect of supplemental copper on osteopenia induced by ovariectomy in rats. Menopause 2000; 7(6): 413-416   DOI   ScienceOn
9 Relea P, Revilla M, Ripoll E, Arribas IF, Rico H. Zinc, biochemical markers of nutrition, and type I osteoporosis. Age Ageing 1995; 24(4): 303-307   DOI   ScienceOn
10 Herzberg M, Lusky A, Blonder J, Frenkel Y. The effect of estrogen replacement on zinc in serum and urine. Obstet Gynecol 1996; 87(6): 1035-1040   DOI   ScienceOn
11 Recker RR, Saville PD, Heaney RP. Effect of estrogens and calcoum carbonate on bone loss in postmenopausal women. Ann Intern Med 1977; 87: 649-655   DOI
12 Dawson-Hughes B, Harris SS, Krall EA, Dallal GE, Falconer G, Green CL. Rate of bone loss in postmenopausal women randomized to two dosages of vitamine D. Am J Clin Nutr 1995; 61: 1140-1145   DOI
13 Cecchettin M, Bellometti S, Cremonesi G, Solimeno LP, Torri G. Metabolic and bone effects after administration of ipriflavone and salmon calcitonin in postmenopausal osteoporosis. Biomed & Pharmacother 1995; 49: 465-468   DOI   ScienceOn
14 Danz AM, Zittermann A, Schiedermaier U, Klein K, Hotzel D, Schonau E. The effect of a specific strength-development exercise on bone mineral density in perimenopausal and postmenopausal women. J Womens Health 1998; 7(6): 701-709   DOI
15 Choi MJ, Jung YJ. The Effects of Isoflavones Intake Level on Bone Markers and Bone Related Hormones in Growing Female Rats. Korean J Nutr 2008; 41(3): 199-205   과학기술학회마을
16 shizawa N, Fujimura R, Tokuyama K, Suzuki M. A bout of resistance exercise increase urinary calcium independently of osteoclast activation in man. J Appl Physio 1997; 83(4): 1159-1163   DOI
17 Estok PJ, Sedlak CA, Doheny MO, Hall R. Structural model for osteoporosis preventing behavior in postmenopausal women. Nurs Res 2007; 56(3): 148-158   DOI   ScienceOn
18 Schlemmer A, Podenphant J, Riis BJ, Christiansen C. Urinary magnesium in early postmenopausal women. influence of hormone therapy on calcium. Magnes Trace Elem 1991; 10(1): 34-39
19 Arjmandi BH, Khalil DA, Smith BJ, Lucas EA, Juma S, Payton ME, Wild RA. Soy protein has a greater effect on bone in postmenopausal women not on hormone replacement therapy, as evidenced by reducing bone resorption and urinary calcium excretion. J Clin Endocrinol Metab 2003; 88(3): 1048-1054   DOI   ScienceOn
20 Loh KY, Shonq HK. Osteoporosis: primary prevention in the community. Med J Malaysia 2007; 62(4): 355-357
21 Ohry A, Shemesh Y, Zak R, Herzberg M. Zinc and osteoporosis in patients with spinal cord inhury. Paraplegia 1980; 18(3): 174-180
22 Mcnair P, Christiansen C, Transbol I. Effect of menopause and estrogen substitutional therapy on magnesiun metabolism. Miner Electrolyte Metab 1984; 10(2): 84-87
23 Levesgue M, Martineau C, Jumarie C, Moreau R. Characterization of cadmium uptake and cytotoxicity in human osteoblast-like MG-63 cells. Toxicol Appl Pharmacol 2008; [Epub ahead of print]
24 Brodowska A. The influence of hormonal replacement therapy on bone density in postmenopausal women depending on polymorphism of vitamin D receptor (VDR) and estrogen receptor (ER) genes. Ann Acad Med Stetin 2003; 49: 111-133
25 Namiduru ES, Binnur Erbaqci A, Celik A, Yilmaz M, Tarakcioqlu M. Serum prolidase activity in postmenopausal osteoporosis. Minerva Med 2007; 98(6): 647-651
26 Bianco V, Filippi F, Tassan-simonat P, Valente I, D'Amico C, Meroni M. Diet assessment and the screening for osteoporosis: a survey in a healthy menopause population. Minerva Ginecol 2008; 60(4): 299-310
27 Prince LR, Smith M, Dick IM, Price RI, Webb PG, Henderson NK, Harris MM. Prevention of postmenopausal osteoporosis. A comparative study of exercise, calcium supplementation, and hormone-replacement therapy. New England Journal of Medicine 1991; 325: 1189   DOI   ScienceOn
28 Garnero P. Biomarkers for osteoporosis management: utility in diagnosis, fracture risk presiction and therapy monitoring. Mol Diagn Ther 2008; 12(3): 157-170   DOI
29 Kim MH, Lee DH. A Comparative Study of Bone Mineral Density and Urinary Bone Metabolic Markers according to the Nutrients Intake Levels in Postmenopausal Women. Korean J Nutr 2007; 40(8): 719-727   과학기술학회마을
30 Wong MY, Lane NE. Medication-induced osteoporosis. Curr Osteoporos Rep 2007; 5(4): 139-145   DOI   ScienceOn
31 Itoh R, Nishiyama N, Suyama Y. Dietary protein intake and urinary excretion of calcium: a cross-sectional study in a healthy Japanese population. Am J Clin Nutr 1998; 67(3): 438-444   DOI
32 Gallagher JC. Advances in bone biology and new treatments for bone loss. Maturitas 2008; 60(1): 65-69   DOI   ScienceOn
33 Shiquemoto GE, Rossi EA, Baldissera V, Gouveia CH, de Valdez Vargas GM, de Andrade Perez SE. Isoflavones-supplemented soy yoghurt associated with resistive physical exercise increase bone mineral density of ovariectomized rats. Maturitas 2007; 57 (3): 261-270   DOI   ScienceOn
34 Somekawa Y, Chiguchi M, Ishibashi T, Aso T. Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Obstet Gynecol 2001; 97 (1): 109-115   DOI   ScienceOn
35 Nordin BEC, Morris HA. The calcium deficiency model for osteoporosis. Nut Rev 1989; 47: 65-72   DOI   ScienceOn
36 Burrows M, Shepherd H, Bird S, Macleod K, Ward B. The components of the female athlete tried donot identify all physically active female at risk. J Sports Sci 2007; 25(12): 1289-1297   DOI   ScienceOn
37 Going S, Lohman T, Houtkooper L, Metcafe L, Flint-Wagner H, Blew R, Stanford V, Cussler E, Martin J, Teixeira P, Harris M, Milleken L, Figueroa-Galvez A, Weber J. Effects of exercise on bone mineral density in calcium-replete postmenopausal women with and without hormone replacement therapy. Osteoporosis Int 2003; 14(8): 637-643   DOI   ScienceOn
38 Sung CJ, Yun ME, Lee JK, Kim MH, Lee HS. Effects of soy isoflavone supplementation and exercise on bone mineral density and urinary deoxypyridinoline in postmenopausal women. Koran J Nutr 2004; 37(4): 291-301
39 Potter SM, Baum JA, Teng H, Stillman RJ, Shay NF, Erdman JR JW. Soy protein and isoflavones: their effects on blood lipids and bone density in postmenoapusal women. Am J Clin Nutr 1998; 68(s): S1375-S1379   DOI
40 Valente M, Bufalino L, Castiglione GN, D'Angelo R, Mancuso A, Galoppi P, Zichella L. Effects of 1-year treatment with ipriflavone on bone in postmenopausal women with low bone mass. Calcif Tissue Int 1994; 54(5): 377-380   DOI   ScienceOn
41 Spence LA, Lipscomb ER, Cadogan J, Martin Br, Peacock M, Wastney M, Weaver CM. Effects of soy isoflavones on calcium kinetics in postmenopausal women. J Bone Miner Res 2001; 16: S532
42 Gartner R. Osteoporosis in the elderly-diagnosis and treatment. MMW Fortschr Med 2005; 147(7): 35-36
43 Nechushton H, Peretz T, Harefuah. Tamoxifen and Breast Cancer 2002; 141(8): 718-720
44 Klavy LM. Lack of a recommended dietary allowance for copper may be hazardous to your health. J Am Coll Nutri 1998; 17 (4): 322-326   DOI
45 Schlemmer A, Podenphant J, Riis BJ, Christiansen C. Urinary magnesium in early postmenopausal women. influence of hormone therapy on calcium. Magnes Trace Elem 1991; 10(1): 34-39
46 Schwab P, Klein RF, Nonpharmacological approaches to improve bone health and reduce osteoporosis. Curr Opin Rheumatol 2008; 20(2): 213-217   DOI   ScienceOn
47 Kamel HK. Postmenopausal osteoporosis: etiology, current diagnostic strategies and nonprescription interventions. J Manaq Care Pharm 2006; 12(6s): s4-9
48 Lipscomb ER, Spence LA, Cadogan J, Martin Br, Peacock M, Weaver CM. Comparative effects of animal and legume proteins on urinary calcium, urinary sulfate, and urynary net acid excretion and kidney function in postmenopausal women. J Bone Miner Res 2001; 16: S532
49 Kotkowiak L. Behavior of selected bio-elements in women with osteoporosis. Ann Acad Med Stetin 1997; 43: 225-238
50 Munger RG, Cerhan JR, Chiu Chiu BC, Prospective study of dietary protein intake and risk of hip fracture in postmenopausal women. Am J Clin Nutr 1999; 69(1): 147-152   DOI
51 Lieberman S, Bruning N. The real vitamin & mineral book. Avery publishing group. Garden city park, New york; 1997
52 Ye YB, Tang XY, Verbruggen MA, Su YX. Soy isoflavones attenuate bone loss in early postmenopausal Chinese women: a singleblind randomized placebo-controlled trial. Eur J Nutr 2006; 45 (6): 327-334   DOI   ScienceOn
53 Sievanen H, McKay H, Heinonen A, Bailey D, Khan K. The Achilles heel of exercise. Lancet 2000; 355(9202): 469-470   DOI
54 Ogita M, Rached MT, Dworakowski E, Bilezikian JP, Kousteni S. Differentiation and proliferation of periosteal Osteoblast Progenitors are Differentially Regulated by Estrogens and Intermittent PTH Administration. Endocrinology 2008; [Epub ahead of prints]
55 Hawse JR, Subramaniam M, Monroe DG, Hemmingsen AH, Ingle JN, Khosla S, Oursler MJ, Spelsberg TC. Estrogen Receptor{beta} Isoform-specific Induction of Transforming Growth Factor{beta}-Inducible Early Gene-1 in Human osteoblast cells. Mol Endocrinol 2008; 22(7): 1579-1595   DOI   ScienceOn
56 Vatanparast H, Chilibeck PD. Dose the effect of soy phytoestrogens on bone postmenopausal women depend on the equolproducing phenotype? Nutr Rev 2007; 65(6 pt 1): 294-299   DOI   ScienceOn
57 Bureau I, Anderson RA, Arnauud J, Raysiguier Y, Favier AE, Roussel AM. Trace mineral status in post menopausal women: impact of hormonal replacement therapy. J Trace Elem Biol 2002; 16(1): 9-13   DOI   ScienceOn
58 Valente M, Bufalino L, Castiglione GN, D'Angelo R, Mancuso A, Galoppi P, Zichella L. Effects of 1-year treatment with ipriflavone on bone in postmenopausal women with low bone mass. Calcif Tissue Int 1994; 54(5): 377-380   DOI   ScienceOn
59 Park HM, Seo YS, Hur M. The distribution and transition of postmenopausal population in Korea. J Korean Menopause 1998; 4(1): 61-71
60 Spelsberg TC, Subramaniam M, Riggs BL, Khosla S. The actions and interactions of sex steroids and growth factors/cytokines on the skeleton. Mol Endocrinol 1999; 13(6): 819-828   DOI   ScienceOn
61 Lee DH, Sung CJ. Effect of soy isoflavone supplementation on bone metabolism maker and urinary mineral excretion in postmenopausal women. Koran J Nutr 2003; 35(6): 476-482
62 Kaplan B, Neri A, Kitai E, Pardo Y, Blum M, Freidman J. Low dose estrogen replacement therapy in early postmenopausal women effect on urinary magnesium and calcium: creatinine ratios. Clin Exp Obstet Gynecol 1994; 21(3): 170-172
63 Szathmari M, Steczek K, Szucs J, Hollo I. Zinc excretion in osteoporotic women. Orv Hetil 1993; 134(17): 911-914
64 Alekel DL, Germain AS, Peterson CT, Hanson KB, Stewart JW, Toda T. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr 2000; 72(3): 844-852   DOI
65 Wu J, Oka J, Ezaki J, Ohtomo T, Ueno T, Uchiyama S, Toda T, Uebra M, Ishimi Y. Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controled trial. Menopause 2007; 4(5): 866-874
66 Na HB, Kim HJ, Park J. Effect of calcium supplementation and exercise on bone mineral density in middle aged women. Korean J Nutr 2003;, 35(9): 962-969
67 Rickard DJ, Subramaniam M, Spelsberg TC. Molecular and cellular mechanisms of estrogen action on the skeleton. J Cell Biochem 1999; 32/33(Suppl): 123-132
68 Robinson JA, Waters KM, Turner RT, Spelsberg TC. Direct action of anturally occurring estrogen metabolites on human osteoblastic cells. J Bone Miner Res 2000; 15(3): 499-506   DOI   ScienceOn
69 Bailey DAm McKay HA, Mirwald R, Crocker PR, Faulkner RA. A six-year longitudinal study of the relationship of physical activity to bone mineral accrual in growing children: The university of Saskatchewan bone mineral accrual study. J Bone Miner Res 1999; 14(10): 1672-1679   DOI   ScienceOn
70 Sung CJ, Kim SY, Lee JK, Yun ME, Kim MH. Effect of soymilk and bone mineral density and bone metabolism pelated markers in under-weight college women with low bone density. Korean J Community Nutrition 2003; 5(3): 132-140
71 Bush RA. Female high-school varsity athletics: An opportunity to improve bone mineral density. J Sci Med Sport 2008; [Epub ahead of print]
72 Choi YH, Sung CJ. Effects of physiological Factors and Lifestyles on Bone Mineral Density in Postmenopausal Women. Korean J Nutr 2007; 40(6): 517-524   과학기술학회마을
73 Eriksen EF, Colvard DS, Berg NJ, Graham ML, Mann KG, Spelsberg TC, Riggs BL. Evidence of estrogen receptors in human osteoblast-like cells. Science 1988; 241(4861): 84-86   DOI