• Parasites, Hosts and Diseases
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• 제55권1호
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• pp.61-64
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• 2017

We described a human case of zoonotic dog tapeworm, Dipylidium caninum (Eucestoda: Dilepidiidae), rarely occurring in China. The mother of a 17 month-old boy noted the appearance of small white and active worms over a month period in her son's feces, but the boy was asymptomatic except mild diarrhea. We observed 3 tapeworm proglottids resembling cucumber seeds in his stool sample. Microscopically, each proglottid had 2 genital pores, 1 on each lateral edge, and numerous egg capsules in the uterus. The patient was successfully treated with a single oral dose of praziquantel. Adult worms were recovered in the diarrheic stool after praziquantel treatment and purgation. His family had household pet dogs for several years, and he might have acquired the infection by ingestion of infected fleas of his pet dogs. A history of dog or cat pets and flea bites may be important clues to diagnosis of D. caninum infection. The infected pets should also be treated.

• Journal of Korean Neurosurgical Society
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• 제29권10호
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• pp.1357-1359
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• 2000

Isolated brainstem invlovement of neurocysticercosis is rare. We present the clinical and radiological features of a patient with a solitary cysticercus granuloma in the brainstem confirmed by MRI and CSF ELISA test. Good response was obtained from conservative treatment, using praziquantel. We believe that patients from regions where cysticercosis is endemic, who have no systemic disease, who present with nonprogressive symptoms and signs of brainstem involvement, and display a solitary ring-enhancing mass in the brainstem measuring less than 20mm on neuroimaging may be managed conservatively.

• Parasites, Hosts and Diseases
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• 제26권1호
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• pp.61-64
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• 1988

Echinostoma cineterchis(Trematoda: Echinostomatidae)의 인체감염 1예를 praziquantel 투여후 수집된 성충으로 확인하고 국내 계 4례로 기록하였다. 환자에서 이 흡충 감염과 관련된 특별한 증상은 없었고 송사리, 올챙이, 미판리 등을 생식한 경력이 있어 이들이 감염원이 되었을 것으로 추측되었다.

• Journal of Yeungnam Medical Science
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• 제27권1호
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• pp.69-73
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• 2010

A paragonimiasis infestation is caused by the paragonimus species. Paragonimiasis mainly occurs by ingestion of raw or undercooked freshwater crabs or crayfish. In our country, the prevalence of paragonimiasis was high until late 1960s due to eating habits, but after the 1970s the prevalence of the disease has markedly decreased and now the disease is rarely seen. The diagnosis of tuberculosis by Chest X-ray is often confused with pulmonary carcinoma, bacillary and parasitic infections, and chronic mycosis. Pulmonary paragonimiasis must be considered in the differential diagnosis of lung cancer especially in the appropriate clinical setting because effective treatment with praziquantel can be rewarding. We report a case of a 58-year-old woman with pulmonary paragonimiasis that was suspicious for lung cancer, as detected by biopsy.

• Parasites, Hosts and Diseases
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• 제34권1호
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• pp.87-90
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• 1996

긴이형흡충(Heterophyopsis continua)에 의한 인체감염 1례를 보고한다. 이 사람은 53세 남자로 경상남도 진주시에 거주하였으며 수년 동안 반염수어와 민물고기를 즐겨 생식했다고 하였다. 대변 겁사에서 간흡충 요코가와흡충. 극구흡충의 충란이 검출되어 이 사람에게 praziquantel을 투여하였다. 치료 후 설사변에서 긴이형흡충 2마리, 유해이형흡충 12마리, 요코가와흡충 2,329마리와 호르텐스극구흡충 2따리를 수집하였다. 이 사람의 임상증상은 소화불량 상복부불쾌감, 식욕부진, 피로감 등이었다. 이 증상은 소수의 긴이형흡충, 유해이형흡충과 호르텐스극구흡충 감염보다는 많은 수의 요코가와흡충 감염에 의한 것으로 해석되었다. 이 증례는 문헌상 긴이형흡충 인체감염례의 국내 제3례에 해당된다.

• Parasites, Hosts and Diseases
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• 제59권6호
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• pp.635-638
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• 2021

In this study, we intended to describe a human case of lumbosacral canal sparganosis in People's Republic of China (China). A 56-year-old man was admitted to Xiangya Hospital Central South University in Changsha, Hunan province, China after having an experience of perianal pain for a week. An enhancing mass, a tumor clinically suggested, was showed at the S1-S2 level of the lumbosacral spine by the examination of magnetic resonance imaging (MRI) with gadolinium contrast. The patient was received the laminectomy from S1 to S2, and an ivory-white living worm was detected in inferior margin of L5. In ELISA-test with cerebrospinal fluid (CSF) and serum samples, anti-sparganum antibodies were detected. He had a ingesting history of undercooked frog meat in his youth. By the present study, a human case of spinal sparganosis invaded in lumbosacral canal at the S1-S2 level was diagnosed in China. Although the surgical removal of larvae is known to be the best way of treatment for sparganosis, we administered the high-dosage of praziquantel, albendazole and dexamethasone to prevent the occurrence of another remain worms in this study.

• Parasites, Hosts and Diseases
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• 제44권4호
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• pp.361-366
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• 2006

Sustained-releasing praziquantel (SRP) tablet was designed for single dose treatment regimen of clonorchiasis. A previous pre-clinical study confirmed its sustained-releasing characteristics and a better cure rate than conventional praziquantel (PZQ). In this clinical study, the pharmacokinetics of this SRP tablet were investigated in human volunteers (phase 1; 12 volunteers), and its curative efficacy was examined in clonorchiasis patients (phase 2; 20 volunteers). In the phase 1 clinical study, blood concentrations of both tablets showed wide individual variation. The $AUC_{last}$ of SRP was $497.9{\pm}519.0ng{\cdot}hr/ml\;(mean{\pm}SD)$ and PZQ of $628.6{\pm}695.5\;ng{\cdot}hr/ml$, and the $AUC_{inf}$ of SRP was $776.0{\pm}538.5\;ng{\cdot}hr/ml$ and of PZQ $658.6{\pm}709.9\;ng{\cdot}hr/ml$. $C_{max}$ values of SRP and PZQ were $90.7{\pm}82.2ng/ml\;and\;214.9{\pm}251.9\;ng/ml$, and $T_{max}$ values were $3.42{\pm}1.43\;hr\;and\;1.96{\pm}1.23\;hr$, respectively. SRP tablets showed similar AUC values, but lower $C_{max}$ and longer $T_{max}$ values than PZQ. In the phase 2 study, SRP at 30 mg/kg (single dose) achieved a 60% cure rate and a 95.5% egg reduction rate. The cure rate of a single dose SRP was unsatisfactory compared with that of the conventional PZQ dose, but much better than that achieved by a single dose PZQ.

• Parasites, Hosts and Diseases
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• 제24권2호
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• pp.159-170
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• 1986

1984년 1월부터 1986년 6월까지 30개월간, 확진된 뇌 유구낭미충증 환자 69명에 대하여 혈청학적 추적검사를 실시하였다. 환자는 모두 치료전에 뇌전산화 단층 촬영을 실시하였고 효소면역측정법에 의하여 혈청 및 뇌척수액의 특이 IgG 항체가를 측정하였다. 프라지콴텔에 의한 약물 치료는 $3{\times}25mg/kg$의 용량으로 $4{\sim}14$일간 실시하였다. 추적기간 및 회수는 환자마다 달랐으며 최대 추적기간은 22개월이었다. 추적검사용 혈청 및 뇌척수액은 $-40^{\circ}C$에 보관한 후 낭액항원, 낭벽항원 및 두절항원에 대한 IgG 항체가를 일시에 측정하였다. 프라지콴텔 투여후 $1{\sim}4$개월 사이에 환자의 대부분에서 혈청 및 뇌척수내 특이 IgG 항체가는 일시적으로 상승하였다. 치료 직후부터 항체가가 저하하는 환자가 있었으나 소수이었다. 프라지콴델 투여시의 부작용을 줄이기 위해 덱사메타손을 투여하면 항체가 상승은 억제되었다. 프라지콴텔 치료후 혈청내 항체가 평균치의 변동이 뇌척수액내 항체가 평균치의 변동보다 심하였고, 항체가의 변화율은 낭벽항원이나 두절항원에 대한 항체에서 낭액항원에 대한 항체에서 보다 컸으나 항체가 변동폭은 낭액항원에 대한 항체가 더 컸다. 대상 환자 69명중 혈청학적으로 음성이었던 6명중 1명은 치료후 뇌척수액내 낭액항원에 대한 항체가가 양성범위로 전환하였다. 프라지콴텔 투여후 항체가의 상승은 뇌 유구낭미충증의 혈청학적 진단에서 보조적으로 이용할 수 있다고 생각하였으며 추적기간으로는 투여후 1개월이 적합하다고 생각하였다. 치료후 6개월내지 22개월까지 추적검사한 환자 15명중 혈청과 뇌척수액에서 모두 음성으로 전환한 예는 1례뿐이었고 혈청이나 뇌척수액 어느 하나에서라도 음성으로 전환한 예도 3례에 불과하였다. 만성 경과를 취한 심한 뇌 유구낭미충증 환자에서의 혈청학적 음성전환은 관찰 기간중 없었다. 추적 검사증 급성 뇌염증상이 나타난 만성환자에서는 일시적으로 두절항원에 대한 항체가가 상승하고 있었다. 이상의 결과에서 뇌 유구낭미충증 환자를 프란지콴텔로 치료한 다음 면역효소측정 법으로 혈청학적 추적검사를 실시할 경우 투약후 매 1년에 한번씩 실시하면 완치된 환자를 감별할 수 있을 것으로 생각하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.857-862
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• 2016

Background: The prevalence of infection by the liver fluke, Opisthorchis viverrini (O. viverrini), has remained high in Northeast Thailand where it is a major risk factor for the eventual development of cholangiocarcinoma (CCA). The infection is acquired by the consumption of dishes containing unsafely prepared freshwater fish, a dietary tradition which has proved resistant to change. Since many people are aware that dosing with praziquantel (PZQ) is a successful treatment for an episode of the infection, there is a risk that, to avoid the long term consequences, they will engage in a cycle of infection, dosing and reinfection. Objectives: There is a dearth of studies of reinfection by O. viverrini, and the aims of this study were to assess re-infection rates in a typical province of Northeastern Thailand where O. viverrini infection is likely and to investigate factors associated with reinfection. Materials and Methods: A total of infected 607 villagers were treated with PZQ, and those found to be no longer infected were followed up at six-monthly intervals over 12 months. Results: At the end of this period data on 457 subjects were available for analysis using descriptive statistics and logistic regression, and 50 were found to have become reinfected, giving a cumulative reinfection rate of 10.9%. The results of a multiple logistic regression analysis showed that the only factor found to be associated with reinfection was past use of PZQ. Conclusions: Recommendations are made for future larger scale and better designed reinfection studies in the light of limitations of the current study. Further efforts are needed to discourage people from eating fish dishes likely to contain viable metacariae.

• 대한의생명과학회지
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• 제2권2호
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• pp.283-288
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• 1996

최근 한국에 있어서 광절열두조충 감염예가 가끔 보고되고 있다. 저자등은 1994년 10월 강원도 춘천시 거주 남녀 부부가 함께 담수산 송어회를 먹고 감염된 2예에 대하여 보고하는 바이다. 구충은 하제로서 Magnesium sulfate 15gm, 구충제 Praziquantel 15mg/kg를 투여하였다. 제1예는 인ㅇㅇ, 43세 남자, 69kg의 건강체였으며, 구충하여 얻은 충체의 길이 6.65m, 폭 8-13mm였다. 제2예는 최ㅇㅇ, 39세 여자, 56kg으로 소화불량, 복부 불쾌감을 호소하였고, 구충하여 얻은 충체는 5.50m, 폭 8-13mm이었다. 2예 모두에서 두부는 검출되지 않았다. 구충하여 얻은 충체의 외관상 형태, 자궁의 선회, 자궁분지(uterine loops)의 수, 생식공의 위치와 절단표본상 음경낭과 저정낭의 형태, 질의 위치, 자궁구의 위치등과 충란을 광학현미경으로 관찰 한 형태, 크기 및 SEM으로 관찰한 표피의 작은 점각(pits)의 유무, 분포 등 형태학적인 특징등으로 Diphyllobothrium latum으로 동정하였다. 이번의 인체 감염은 담수산 송어회가 원인이 된 것으로 믿어지는 예이다.