Parasites, Hosts and Diseases
- Volume 24 Issue 2
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- Pages.159-170
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- 1986
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- 2982-5164(pISSN)
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- 1738-0006(eISSN)
Serologic follow-up Study in neurocysticercosis patients by ELISA after praziquantel treatment
프라지콴텔 치료후 효소면역측정법에 의한 뇌 유구낭미충증 환자의 혈청학적 추적검사
- Cho, Seung-Yull (Department of Parasitology, College of Medicine, Chung-Ang University) ;
- Kim, Suk-Il (Department of Parasitology, College of Medicine, Chung-Ang University) ;
- Kang, Shin-Yong (Department of Parasitology, College of Medicine, Chung-Ang University)
- Published : 1986.12.31
Abstract
A total of 69 patients of confirmed neurocysticercosis was followed serologically by ELISA up to 22 months after praziquantel treatment. The intervals and numbers of follow-up were variable by patient. Serially collected samples of serum and CSF were examined simultaneously for their specific IgG antibody levels by ELISA, using cystic fluid, saline extracts of bladder wall and scolex as antigen. Within 4 months after praziquantel treatment, the antibody levels were elevated temporarily in both serum and CSF in most patients. In some cases antibody levels exhibited steady declining tendency after the treatment. Concomitant administration of dexamethasone appeared to suppress the elevation of antibody levels. The rate of mean absorbance of antibody changed more in serum than in CSF. The rate of elevation was greater in antibodies to parenchymal antigens than that to cystic fluid, but absolute difference of antibody levels was greater in antibody to cystic fluid. Previously negative samples for IgG antibody may become positive after the praziquantel treatment, which could be used as a complementary tool (provocation test) in serodiagnosis. One month was considered to be sufficient interval for the follow-up test for that purpose. In the follow-up of up to 22 months, only few cases of chronic neurocysticercosis showed declining tendency of IgG antibody levels below negative range. During acute encephalitic attacks in chronic patients, IgG antibody to parenchymal antigen were elevated in CSF temporarily. These results indicated that serologic follow-up of every year was recommendable to differentiate the cured patients from chronic patients with slowly calcifying lesions.
1984년 1월부터 1986년 6월까지 30개월간, 확진된 뇌 유구낭미충증 환자 69명에 대하여 혈청학적 추적검사를 실시하였다. 환자는 모두 치료전에 뇌전산화 단층 촬영을 실시하였고 효소면역측정법에 의하여 혈청 및 뇌척수액의 특이 IgG 항체가를 측정하였다. 프라지콴텔에 의한 약물 치료는
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