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Structure-Antifungel Activity Relationships of Cecropin A Hybrid Peptides against Trichoderma sp.

  • Shin, Song-Yub;Lee, Dong-Gun;Lee, Sung-Gu;Kim, Kil-Lyong;Lee, Myung-Kyu;Hahm, Kyung-Soo
    • Journal of Microbiology
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    • v.35 no.1
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    • pp.21-24
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    • 1997
  • The hybrid peptides, CA-ME, CA-MA and CA-BO, with the N-terminal sequence 1-8 of cecropin A and the N-terminal sequences 1-12 of melittin, magainin 2 and bombinin, respectively, have more improved antibacterial activities. CA-MA was found to have stronger antifungal activity against Trichoderma sp than other hybrid peptides and their parental peptides. In order to elucidate the relationships between the peptide structure and antifungal activity, several analogues of CA-MA or CA-BO were also designed and synthesized by the solid phase method. An tifungal activity was measured against T. reesei and T. viride, and hemolytic activity was measured by a solution method against human red blood cells. The residue 16 of CA-MA, Ser, was found to be important for antifungal activity. When the residue was substituted with Leu, showed powerful antifungal activity was dramatically decreased. CA-MA, P1, P4 and P5 designed in this study showed powerful antifungal activity against T. reesei and T. viride with low hemolytic activity against human red blood cells. These hybrid peptides will be potentially useful model to further design peptides with powerful antifungal activity for the effective therepy of fungal infection and understand the mechanisms of antifungal actions of hybrid peptides.

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Test for the Pareto Distribution Based on the Transformed Sample Lorenz Curve

  • Kang, Suk-Bok;Cho, Young-Suk
    • Proceedings of the Korean Statistical Society Conference
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    • 2002.05a
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    • pp.133-137
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    • 2002
  • A powerful and easily computed goodness-of-fit test for Pareto distribution which does not depend on the unknown location and scale parameters is proposed based on the transformed sample Lorenz curve. We compare the power of the proposed test statistic with the other goodness-of-fit tests for Pareto distribution against various alternatives through Monte Carlo methods.

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Origami inspired Temperature Sensor based on Stimuli-Responsive Hydrogel (종이접기 기반 자극 반응성 하이드젤 온도 센서 연구)

  • Na, Jun-Hee
    • Journal of Sensor Science and Technology
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    • v.26 no.1
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    • pp.35-38
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    • 2017
  • A thermally responsive hydrogel has reversibility with temperature during swelling. Here, we proposed origami inspired temperature sensor by using multi-layered hydrogel film. The formation of patterned stripes on microscale film drives bending to an angle that can be controlled linearly. Although temperature range was not wide, measured sensitivity of sensors has high resolution and accuracy. It providing a powerful platform for the design of sensitive sensors and that easily adapt other type of sensors in microscale.

Goodness-of-Fit Test for the Pareto Distribution Based on the Transformed Sample Lorenz curve

  • Kang, Suk-Bok;Cho, Young-Suk
    • Journal of the Korean Data and Information Science Society
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    • v.13 no.1
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    • pp.113-119
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    • 2002
  • A powerful and easily computed goodness-of-fit test for Pareto distribution which does not depend on the unknown location and scale parameters is proposed based on the transformed sample Lorenz curve. We compare the power of the proposed test statistic with the other goodness-of-fit tests for Pareto distribution against various alternatives through Monte Carlo methods.

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A Study on the Optimization of Temprature Controller Using Microprocessors (마이크로프로세서를 이용한 온도제어장치의 최적화에 관한 연구)

  • 김명규;장익수
    • Journal of the Korean Institute of Telematics and Electronics
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    • v.17 no.4
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    • pp.18-22
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    • 1980
  • Lately, the need for the use of calorimeter has been increased id Korea. Therefore, several met hods for the optimization of the microcomputer-based control system that can be used as a temperatare controller as well as a calorimeter are described in this paper. The instrument designed in this paper has been proved to be more powerful and costeffect ice than any other instrument not using microprocessor.

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수학교육에서 수학사적 고찰을 통한 기하학적.대수학적 두 접근 방법의 의의

  • 고상숙
    • Journal for History of Mathematics
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    • v.17 no.1
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    • pp.87-96
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    • 2004
  • This article dealt with two approaches, algebraic and geometric approaches in terms of Pythagoreans theorem. As mathematics evolves, many theorems had been developed beginning with geometric approaches. However, the algebraic techniques that survive these days are so powerful and generalized in school curriculum. So, if students have more chances to see mathematical properties in geometrical ways, they can experience how beautiful and meaningful they are through the process of the advent of them. Also, it was to try to develop an insight into their applications to other problems.

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A Study on Market Segmentation of Urban Park (도시공원의 시장분할에 관한 연구)

  • 홍성권
    • Journal of the Korean Institute of Landscape Architecture
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    • v.20 no.2
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    • pp.18-26
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    • 1992
  • The purpose of this study is to suggest a method for identifying target markets of potential urban park users by their sociodemographic variables. Data was classified into(ⅰ) users vs. nonusers ; (ⅱ) of chosen three urban parks ; or(ⅲ) users of each urban park then analyzed by discriminant analysis. The results showed that linear combination of selected sociodemographic variables could be used for identifying target markets in some cases. In general, season and sex were the most powerful discriminant variables. But the other cases were not satisfactory. The weak points of this study due to adapting secondary data for analysis were discussed.

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TQM′s Position as the Sources of the Competitiveness: In View of International Competitiveness of Japanese Corporations (경쟁력 원천으로서의 TQM의 위상: 일본기업의 국제경쟁력을 중심으로)

  • 정규석;김형욱
    • Journal of Korean Society for Quality Management
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    • v.27 no.4
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    • pp.67-94
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    • 1999
  • TQM(total quality management) is accepted as the powerful and holistic management innovation tools in the worldwide corporations since "Malcom Baldrige National Quality Award" model is established by US government. But nowadays, TQM′s roles and positions for the competitiveness is challenged from other many management innovations tools. This paper identifies the TQM′s roles and positions as the sources of sustainable competitive advantages through the examples of Japanese manufacturing corporations which enjoy the strongest positions since 1980′s in world market.

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Using Neural Networks to Forecast Price in Competitive Power Markets

  • Sedaghati, Alireza
    • 제어로봇시스템학회:학술대회논문집
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    • 2005.06a
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    • pp.271-274
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    • 2005
  • Under competitive power markets, various long-term and short-term contracts based on spot price are used by producers and consumers. So an accurate forecasting for spot price allow market participants to develop bidding strategies in order to maximize their benefit. Artificial Neural Network is a powerful method in forecasting problem. In this paper we used Radial Basis Function(RBF) network to forecast spot price. To learn ANN, in addition to price history, we used some other effective inputs such as load level, fuel price, generation and transmission facilities situation. Results indicate that this forecasting method is accurate and useful.

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Characterization of uranium species in molten salt : An application of synchrotron-based XAFS spectroscopy

  • Cho, Young-Hwan;Choi, In-Kyu;Kim, Won-Ho
    • Proceedings of the Korean Nuclear Society Conference
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    • 2002.10a
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    • pp.319.2-319
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    • 2002
  • Synchrotron-based X-ray absorption spectroscopy has been applied to determine the changes in bulk oxidation state of uranium oxides in molten salt. From an analysis of XANES data, one can determine the cahnges in bulk oxidation-state of U compounds in salts(LiCl/KCl). XAFS spectroscpy is a powerful tool for probing the changes in valence state and structure of uranium compounds in colten salt as well as in noncrystalline form and doped in other matrices.

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