• Molecules and Cells
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• v.37 no.9
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• pp.691-698
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• 2014

SCYL1-BP1 is thought to function in the p53 pathway through Mdm2 and hPirh2, and mutations in SCYL1-BP1 are associated with premature aging syndromes such as Geroderma Osteodysplasticum; however, these mechanisms are unclear. Here, we report significant alterations in miRNA expression levels when SCYL1-BP1 expression was inhibited by RNA interference in HEK293T cells. We functionally characterized the effects of potential kernel miRNA-target genes by miRNA-target network and protein-protein interaction network analysis. Importantly, we showed the diminished SCYL1-BP1 dramatically reduced the expression levels of EEA1, BMPR2 and BRCA2 in HEK293T cells. Thus, we infer that SCYL1-BP1 plays a critical function in HEK293T cell development and directly regulates miRNA-target genes, including, but not limited to, EEA1, BMPR2, and BRCA2, suggesting a new strategy for investigating the molecular mechanism of SCYL1-BP1.

• Applied Chemistry for Engineering
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• v.4 no.2
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• pp.409-415
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• 1993

A potential function is applied to a hydrogen bonded system such as O-H---O and is slightly modified to provide a good understanding of a range of data. The use of this model requires a knowledge of terms describing the Van der Waals repulsion and the electrostatic interaction and the determination of these terms form the equilibrium conditions is described. Using this simple model, it will be shown that the relationship between the frequency shift and enthalpy of hydrogen bond formation is predicted to be linear and this is in reasonable agreement with experimental results in the literature.

• Journal of the korean Society of Automotive Engineers
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• v.13 no.5
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• pp.51-64
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• 1991

In this paper, an attempt is made to analyze the impulsive stress directly underneath the concentrated impact point for a supported square plate by using the three-dimensional dynamic theory of elasticity and the potential theory of displacement (stress function) on the supposition that the load, F$_{*}$0 sin .omega.t, acted on the central part of it. The results obtained from this study are as follows: 1. The impulsive stress cannot be analyzed directly underneath the acting point of concenrated impact load in privious theories, but can be analyzed by using the three-dimensional dynamic theory of elasticity and the potential theory of displacement. 2. Theorically, with increasing the pulse width of applied load, it was possible to clarify that the amount of stress in the point of concentrated impact load was increased and that of stress per unit impulse was decreased. 3. The numerical inversion of laplace transformation by the use of the F.F.T algorithm contributes the reduction of C.P.U time and the improvement of the accuracy or results. 4. In this paper recommended, it is found that the approximate equation of impact load function P (.tau.) = A.tau. exp (-B.tau.), and P (.tau.) =0.85A exp (-B.tau.) sinC.tau. could actually apply to all impact problem. In compared with the experimental results, the propriety of the analytical method is reasonable.

• YAKHAK HOEJI
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• v.60 no.3
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• pp.135-140
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• 2016

Heat shock protein 90 (Hsp90) is a ubiquitous molecular chaperone, which is associated with stabilization of many oncogenic proteins for cancer cell survival. Hsp90 is overexpressed 2-10 fold higher in cancer cells than normal cells. Due to its potential to simultaneously disable multiple signaling pathway, Hsp90 has been identified as a validated target for cancer therapy. Accordingly, we designed and synthesized 2',4'-dimethoxychalcone derivatives to inhibit Hsp90 chaperone function. Among 2',4'-dimethoxychalcone derivatives, we found that compound 1g disrupted Hsp90 chaperoning function and impaired the growth of cancer cells. These findings indicated that 1g could serve a potential lead compound to target Hsp90 in cancer chemotherapy.

• Animal cells and systems
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• v.8 no.2
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• pp.89-95
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• 2004

The bush warblers (Cettia diphone) have been recognized to possess two types of songs: a normal song that plays roles in attracting mate and territorial defense, and an anomalous song. The present study suggests that the anomalous song functions as an alarm signal as well as other unknown signals. Field observations and playback experiments on the anomalous song of bush warbler were conducted in order to investigate the contextual information that occurred between sender and receiver. In the field observation, the males frequently emitted anomalous songs to potential predators. The males responded with an anomalous song to stuffed potential predators. The distance from where the anomalous song occurs to the stimulating source varied depending upon the kinds of stimulus. The males of bush warbler possibly show different responses to the anomalous song depending on the level of danger. When the anomalous song was played back to terrestrial males and females, no distinctive behavior was observed. The anomalous song may be sung to defend the territory against predators or to distract invaders from the nest and female because the male and female behaviors were related with the anomalous song and its phonetic characteristics.

• Journal of Korean Ophthalmic Optics Society
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• v.5 no.2
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• pp.5-9
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• 2000

The visual evoked potential was electrophysiological method for the identify of the EEG response on visual cortex. This test was objective test method on the eye function. This study was used the visual evoked potential for the objective color test. The subjects was a normal color function in Korean adults. The test condition was performed on the differens distance and illumination. According to convergence condition of color vision target. On the appearance of EEG wave of visual stimulation on visual cortex. The most EEG wave style was delta wave, and the next amount wave form was beta wave and theta wave, and the least EEG wave form was alpha wave. The histogram of amplitude of EEG wave form was almost non-Gaussian shape, and the phase diagram of amplitude was almost all linear shape. On the kinds of color vision target, the frequency of EEG wave style appeared a similar results.

• Journal of the Korea Safety Management & Science
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• v.12 no.4
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• pp.207-213
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• 2010

Now days, the marketing environment is rapidly changed. Therefore, a lot of companies try to reduce production cost. Especially, Design is a important activities in new product development. While the concepts of design for manufacturable and concurrent engineering have made significant advances in integrating the design function with other areas in the firm. There are still major gaps in timely and accurate costing information available to designers. Inappropriate design could result in high redesign cost and delay in product relation. The generation of design and improvement is a time-consuming and mentally exhaustion process. It involves combining design features to generate as many potential design as possible. As not all features combinations are feasible, decision-makers have to narrow down the potential solutions and subsequently select appropriate design for further development. This new study is composed of 3 steps aiming at the Low Cost Design of the product. The three steps are consisted that setting up the target Cost, estimating the current functional cost, the design of a unit's reviewing according to the priority of the difference between the target cost and the functional cost.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.24 no.8
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• pp.94-100
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• 2010

Grounding system insures a reference potential point for electric devices and also provides a low impedance path for fault currents or transient currents in the earth. The ground impedance as function of frequency is necessary for determining its performance since fault currents could contain a wide range of frequencies. In this paper, the grounding resistance, grounding impedance and transient grounding impedance are measured by using 3-point fall-of-potential method in order to analyse grounding characteristics of the stainless-steel plate grounding electrode. An equivalent transfer function model of the grounding impedance and transient grounding impedance are identified from the measured values by using ARMA method and evaluated by comparing conventional grounding impedances.

• Journal of Ginseng Research
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• v.36 no.1
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• pp.16-26
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• 2012

Ginseng is one of the most widely used herbal medicines and is reported to have a wide range of therapeutic and pharmacological applications. Ginseng may also be potentially valuable in treating cardiovascular diseases. Research concerning cardiovascular disease is focusing on purified individual ginsenoside constituents of ginseng to reveal specific mechanisms instead of using whole ginseng extracts. The most commonly studied ginsenosides are $Rb_1$, $Rg_1$, $Rg_3$, $Rh_1$, Re, and Rd. The molecular mechanisms and medical applications of ginsenosides in the treatment of cardiovascular disease have attracted much attention and been the subject of numerous publications. Here, we review the current literature on the myriad pharmacological functions and the potential benefits of ginseng in this area. In vitro investigations using cell cultures and in vivo animal models have indicated ginseng's potential cardiovascular benefits through diverse mechanisms that include antioxidation, modifying vasomotor function, reducing platelet adhesion, influencing ion channels, altering autonomic neurotransmitters release, and improving lipid profiles. Some 40 ginsenosides have been identified. Each may have different effects in pharmacology and mechanisms due to their different chemical structures. This review also summarizes results of relevant clinical trials regarding the cardiovascular effects of ginseng, particularly in the management of hypertension and improving cardiovascular function.

• Annals of Clinical Neurophysiology
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• v.7 no.2
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• pp.80-82
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• 2005

Background: Idiopathic Parkinson's disease (IPD) is closely related to Lewy body pathology. Pathological changes in medullar oblongata and pontine tegmentum have been reported in patients with subclinical motor symptom. Vestibular evoked myogenic potential (VEMP) is mediated by vestibular nuclei in lower brainstem and reflects the function of lower brainstem. The purpose of our study is to estimate the lower brainstem function in IPD patients. Methods: Ten patients with idiopathic Parkinson's disease underwent VEMP test. The patients were divided into Hohn-Yahr (H-Y) stage I (unilateral motor involvement) group and H-Y stage II or more severe (bilateral motor involvement) group. VEMP results were compared between groups using Mann-Whitney U test. Results: Among patients, 6 patients showed abnormal VEMP (unilateral abnormality 2, bilateral abnormalities 4). Between H-Y stage I group and H-Y II,III group, there was no statistical difference in the results of VEMP. Conclusions: We concluded that the lower brainstem dysfunction reflected in VEMP could occur in IPD regardless of the progression of the disease.