• Title/Summary/Keyword: postmenopausal symptoms

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Verification of Estrogen Like Activities of Herbal Medicines Using an In Vitro Detection System (In vitro 검출 시스템을 이용한 한약재 추출물들의 에스트로겐 유사활성 검증)

  • Park, Seong Hwan;Jeon, Myong Je;Jang, Min Kyung;Lee, Sol Jee;Kim, Bo Kyung;Jeon, Myeong Jeong;Kim, Seo Yeon;Kim, Mihyang;Lee, Dong Geun;Lee, Tae Ho;Nam, Jae Sub;Hur, Ji Won;Lee, Sang Hyeon
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.27 no.6
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    • pp.752-758
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    • 2013
  • Estrogen like activities were evaluated using ethanol and hot water extracts of herbal medicines by using an in vitro detection system. Bokryung (Poria cocos), Sanyak (root of Dioscorea batatas) and Mokdanpi (root skin of Paeonia suffruticosa) represented statistically significant estrogen-like activities (p<0.001), while Omija (fruit of Schizandra chinensis), Taeksa (root of Alisma canaliculatum A. BR.), Jihwang (root of Rhemannia glutinosa), and Sansuyu (fruit of Cornus officinalis) did not. Estrogen-like activities of Bokryung hot water extract (500 ${\mu}g/ml$) and ethanol extract (50 ${\mu}g/ml$) were almost same as that of a C M $17{\beta}$-estradiol. Furthermore, estrogen-like activities of ethanol extracts (500 ${\mu}g/ml$) of Bokryung and Mokdanpi were stronger than that of $10^{-7}$ M $17{\beta}$-estradiol. These results suggest that Bokryung, Sanyak and Mokdanpi show estrogen-like activities. Especially, Sanyak and Mokdanpi represented promotive effect on the proliferation of MC3T3-E1 osteoblastic cells. Bokryung, Sanyak and Mokdanpi also exhibited superior inhibitory effect on the viability of RAW 264.7 cells. In conclusion, these three herbal medicines might be interpreted as candidates for the further study or development of functional foods or medicine to prevent or avoid postmenopausal symptoms of women.

A Study of Bone Mineral Density in Children (소아의 골밀도에 관한 연구)

  • Chang, Gyu-Tae;Kim, Jang-Hyun;Seo, Young-Min
    • The Journal of Pediatrics of Korean Medicine
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    • v.19 no.1
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    • pp.53-66
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    • 2005
  • Objectives : Osteoporosis is generally occurred in old age, especially postmenopausal women therefore, it is relatively overlook osteoporosis in children, but the authors have paid attention to bone density in children because maximizing peak bone mass of childhood is advocated as a way to prevent osteoporosis and environmental factor of childhood play role in the regulation of bone density. the present study was performed to measure bone density of children and to assess the influence of age, sex, body size, exercise, weak symptoms on bone density during the period of bone growth. Methods : We have measured bone density of calcaneus bone in 283 children (male 144 female 139, ranged from3 to 18) who visited in growth clinic of Pediatrics, Dongguk University Bundang Oriental Hospital, using quantitative ultra sound densitometry and they were divided into 3 groups by age(3-10, 11-15, 15-18 years). Pearson's correlation was used to assessed the influence of age, body size and Student's t-test was used to detect differences in sex, exercise, weak symptoms between the groups on bone density Results : The bone density correlated with age, height, weight, body mass index in this study. Bone density were significantly higher in males than in female. Digestive weak children's bone density were lower than normal children. Conclusion : Weight-bearing exercise and food rich in nutrition are necessary to increase maximizing peak bone mass in children.

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A Review of the Domestic Study Trends on Obstetrics & Gynecological Diseases with Pharmacopuncture Therapy (한방 여성의학 영역에서 활용된 약침요법에 대한 국내 연구 동향 분석)

  • Hwang, Su-In;Park, Kyung-Dug;Park, Jang-Kyung;Yoon, Young-Jin
    • The Journal of Korean Obstetrics and Gynecology
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    • v.32 no.3
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    • pp.192-213
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    • 2019
  • Objectives: The purpose of this study is to analyze the domestic study trends of pharmacopuncture therapy on obstetrics and gynecological diseases in Korean literature, through reviewing the clinical and experimental studies. Methods: We searched for clinical and experimental studies using pharmacopuncture therapy on obstetrics and gynecological diseases, published from January 2000 to May 2019, through 5 Korean databases. The study design, target disease, type of pharmacopuncture, method of intervention, and study results were analyzed. Results: 36 experimental studies and 15 clinical studies were finally included according to inclusion and exclusion criteria. In experimental studies, there were 12 studies about postmenopausal osteoporosis, 9 studies about obesity, 4 studies about endometriosis, 3 studies about hemostatic effects and analgesic anticoagulative effects, 2 studies about ovarian function, and analgesic antiphlogistic anticoagulative effects, and 1 study about menopausal symptoms. In clinical studies, there were 3 studies about obesity, postpartum disorders, dysmenorrhea, and women's urologic disease, and 1 study about menopausal symptoms, atypical squamous cells of undetermined significance (ASCUS) and breast cancer. Various types of pharmacopuncture have been proved to have a therapeutic effect in each of those obstetrics and gynecological diseases. Conclusions: This study indicates that pharmacopuncture therapy could be a good treatment for obstetrics and gynecological diseases. However, more well-designed and high-quality clinical researches are needed in further studies, to prove the effectiveness and safety of pharmacopuncture therapy.

A Study on the Effects of Gamisoyosan on Ovariectomized Osteoporosis in Rats (가미소요산(加味逍遙散)이 난소적출로 유발된 흰 쥐의 골다공증에 미치는 영향)

  • Park, Chan-Soo;Sohn, Young-Joo
    • The Journal of Korean Obstetrics and Gynecology
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    • v.21 no.1
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    • pp.1-15
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    • 2008
  • Purpose: Osteoporosis that occurred after menopause is one of the most common metabolic disease. and it is that bone mass significant decrease in comparison with normal people. Its symptoms are fracture, decrease of height, etc. The purpose of this study is to examine what are the effects of the Gamisoyosan on the aged ovariectomized rat model of postmenopausal osteoporosis. Methods: 24 female rats were ovariectomized and divided into normal group(normal), ovariectomized group(control), and treated with Gamisoyosan group(treated). During 8 weeks we dosed D.W to sham and control group, and dosed Gamisoyosan(105 mg/100 g) to experimental group. After 8 weeks we sacrificed rats and measured the body weight, albumin, P, Calcium, ALP, total cholesterol, triglyceride, AST, ALT, T4, estradiol, the femur weight, the tibia ash weight, trabecular bone area, trabecular thickness, osteoclast number. Results: The level of serum albumin, calcium, AST, ALT, estradiol in Gamisoyosan group showed significant increase in comparison with control group. The level of serum triglyceride in Gamisoyosan group showed significant decrease in comparison with control group. Trabecular bone area and osteoclast number in Gamisoyosan group showed significant increase in comparison with control group. Conclusions: Reviewing these experimental results, Gamisoyosan has shown to activate osteogenesis and prevent bone resorption, and it should show efficacy on prevention and improvement of osteoporosis after menopause.

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Residual Disease Following Conization of Women with Stage IA-IB1 Cervical Carcinoma in a High Incidence Region

  • Chatchotikawong, Usanee;Ruengkhachorn, Irene;Leelaphatanadit, Chairat
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.17
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    • pp.7383-7387
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    • 2014
  • Background: To determine rates of residual disease along with influencing factors in women with stage IA to IB1 cervical carcinoma after conization. Materials and Methods: A retrospective study was conducted of medical records of 198 stage IA to IB1 cervical carcinoma patients who had undergoing cervical conization followed by primary surgical treatment during 2006-2013. Independent factors correlating with residual carcinoma in subsequent surgical specimens were analyzed by stepwise regression analysis. Results: Mean age was 48.9 years. Cone specimens demonstrated free margins in 36 women (18.8%). In case of having disease at margin, high-grade cervical intraepithelial neoplasia (CIN) and carcinoma were evidenced in 58 and 97 women, respectively. Pathology of subsequent specimens revealed residual carcinoma in 78 women (39.4%), high-grade CIN or adenocarcinoma in situ (AIS) in 45 (22.7%), and no residual pathology in 75 (37.9%). Age more than 35 years, postmenopausal status, having symptoms, diseases or invasive lesions at conization margins or disease on endocervical aspect, and higher stage were significantly correlated with residual cancer in surgical treatment specimens. On regression analysis, postmenopause and stage were independent factors associated with residual carcinoma.Conclusions: Patient and tumor characteristics are predictive factors for residual cancer in the studied group of women.

Optimization of Isoflavone Extraction from Soy Germ - Research Note-

  • Bae, Sang-Moon;Jang, Chan-Ho;Kim, Jang-Hoon;Lim, Hyun-Ae;Kim, Joo-Ryong;Kim, Jeong-Hwan;Kim, Jong-Sang
    • Preventive Nutrition and Food Science
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    • v.10 no.3
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    • pp.290-293
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    • 2005
  • Soy isoflavones have drawn much attention due to their potential to prevent breast and prostate cancers, osteoporosis, heart disease, and other postmenopausal symptoms. Soy germ is one of the richest sources of isoflavones, and thus has good potential to be used as the ingredient of health foods. This study examined the extraction rate of isoflavones from soy germ at various conditions. After the effect of extraction temperature and duration on isoflavones extraction from soy germ was examined, the optimum concentration of ethanol as extraction solvent was determined. When ethanol concentration was fixed at $60\%\;(v/v)$, the maximum isoflavone extraction was achieved at 2 hrs and $30^{\circ}C$. Among various concentrations of ethanol tested, $80\%\;(v/v)$ ethanol showed the highest extraction efficiency. In conclusion, the maximum extraction of isoflavones was obtained using $80\%\;(v/v)$ ethanol as a solvent, at $30^{\circ}C$ of temperature, and 2 hrs of extraction time.

Pomegranate (Punica granatum) as Resources of Phytoestrogen and Anticancer Substances. (석류(Punica granatum)의 Phytoestrogen 및 항암 활성 성분)

  • Song, Bang-Ho;Tran, Hoang Ngoc Ai;Bae, Soo-Young
    • Microbiology and Biotechnology Letters
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    • v.35 no.2
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    • pp.81-97
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    • 2007
  • Punica granatum, L. (Pomegranate) has 613 seeds which accidentally corresponds to the 613 commandments in the Bible. Accordingly, the fruit has been worshipped by the Jewish and other religious people from the ancient. Pomegranate's seed, peel and juice contain a variety of ethnomedical components so much as the sum of three kinds of other common fruits. The number of published papers related to the pomegranate in recent 7 years flourished 7 times more than before at the bases of Medline record. Since the containments of estrogen, as $17{\alpha}-estradiol,\;17{\beta}-estradiol$, estrone, and estradiol, etc., in pomegranate have been reported, public interests and commercial values of pomegranate arose considerably. The report was disproved later, however, merits of this fruit remained yet; clinical efficacy for preventing and remediating cancers including breast and prostate cancers by oral administration of the juice, seed oil, and peel extract is still believed to be true. In this review, target components of pomegranate such as antioxidants, anticancers, antiestrogens and ethnomedical components were analyzed and discussed along with examining its pharmaceutical efficacy and prescription to postmenopausal lesion, cardiosclerosis, cosmetic beautification, viral and allergic symptoms, and diabetes mellitus, etc.

Changes of Somatostatin-Immunoreactive Cells on the Stomach of Ovariectomized Rats

  • Chang, Jeong-Hyun
    • Biomedical Science Letters
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    • v.15 no.1
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    • pp.25-29
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    • 2009
  • The changes on the regional distributions and frequencies of somatostatin-immunoreactive (IR) cells in the fundus and pylorus of the stomach of osteoporotic Sprague-Dawley rats induced by ovariectomy were studied by immunohistochemical methods. The experimental animals were divided into two groups, one for non-ovariectomized group (Sham) and the other for ovariectomized group (OVX). Samples were collected from the fundus and pylorus regions at the 10 th week after ovariectomy or sham-operation. Somatostatin-IR cells were observed in both regions of the stomach regardless of ovariectomy. Most of these IR cells in the mucosa of the fundus or pylorus were generally spherical or spindle in shape (open type cell) while cells found in the gastric gland regions were round in shape (close type cell). Significantly lower number (P<0.01) of somatostatin-IR cells were detected in OVX as compared with Sham in the fundus and pylorus. In the present study, the density of somatostatin in the stomach was markedly decreased. Therefore, these changes in density of somatostatin-IR cells detected in this study may support the speculation that the development of gastrointestinal symptoms in osteoporosis such as impairments of calcium and some lipids, frequently encountered in patients with postmenopausal osteoporosis because the changes in gastrointestinal endocrine density would reflect the change in the capacity of producing these hormones and regulating gut motility and digestion.

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An Analysis of Clinical Application of Guibi-tang for Obstetrics and Gynecological Disease (동국대학교 일산한방병원 여성의학과에서의 귀비탕(歸脾湯) 임상 적용 사례 분석 연구)

  • Park, Jang-Kyung;Kim, Dong-Il
    • The Journal of Korean Obstetrics and Gynecology
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    • v.24 no.2
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    • pp.79-96
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    • 2011
  • Objectives: This study was to investigate clinical usage of Guibi-tang based on actual application in obstetrics and gynecology. Methods: This study investigated the number of patients who were prescribed Guibi-tang-gami-bang and what herbal medicines were adjusted according to their chief complaint from January 1st, 2007 to August 31th, 2008. Results: The number of patients who were prescribed Guibi-tang for obstetrics and gynecological diseases at the Department of Obstetrics and Gynecology was 721. Guibi-tang has been used to treat menstrual irregularity, postpartum general weakness, postpartum pantalgia, perimenopausal symptoms and postmenopausal syndrome most frequently. And Guibi-tang has been widely used in obstetric and gynecologic diseases such as general weakness after abortion or gynecological surgery, pelvic pain, dysmenorrhea, uterine myoma, endometriosis, infertility, premenstrual syndrome, urinary incontinence and breast disease. Conclusions: Guibi-tang can be used in obstetric and gynecologic diseases as described in classical oriental medicine literatures, and it is necessary to research clinical usage of Guibi-tang through randomized controlled trial.

Dioscorea bulbifera tuber extract causes sterility in mice

  • Jayaswori, Sharma;Sabina, Bhandari;Sarbesh, Rijal;Ramanuj, Rauniyar;Young-Joo, Yi;Gaurishankar, Manandhar
    • Korean Journal of Agricultural Science
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    • v.49 no.3
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    • pp.451-462
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    • 2022
  • Dioscorea bulbifera tubers contain several phytochemicals of pharmaceutical value. They have been traditionally used for treating various ailments, including postmenopausal symptoms. In the present study, we analyzed the direct effects of Dioscorea tuber extract on mouse spermatozoa. Its contraceptive effect was also evaluated by an intravaginal application before copulation. Mouse spermatozoa were cultured in vitro with various concentrations of the extract. After culturing, the spermatozoa were stained with fluorescein isothiocyanate peanut agglutinin or Coomassie blue to study the acrosome reaction, stained with trypan blue to study the viability, or treated with a hypo-osmotic medium to study the membrane damage. Estrous female mice were intravaginally injected with the extract and copulated with males. The extract induced acrosome exocytosis, viability loss, and membrane damage in a concentration-dependent manner. Female mice treated with the extract showed complete loss of fertility. These observations indicate that the Dioscorea bulbifera tuber extract could be used as a topical contraceptive. Infertility could be due to the precocious acrosome exocytosis of the spermatozoa or membrane damage.