• Title/Summary/Keyword: polymer pattern

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Effect of Ratio of Demineralized Bone Powder with Alginate Microcapsules on Articular Cartilage Regeneration (탈미네랄 골분이 비율별로 포접된 알지네이트 미세캡슐을 이용한 조직공학적 연골재생)

  • Kim, A Ram;Kim, Hye Min;Lee, Jung Keun;Lee, Ji Hye;Song, Jeong Eun;Yoon, Kun Ho;Lee, Dongwon;Khang, Gilson
    • Polymer(Korea)
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    • v.36 no.6
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    • pp.768-775
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    • 2012
  • Alginate, obtained from the seaweeds, is a widely used biomaterial for cell transplantation, since its positive effect on viability of capsulized cells and its easier encapsulation capability of living cells. Demineralized bone powder (DBP), derived from the natural bone tissue, is widely applied for clinical trials for its low rate of reaction and antigenicity. A chondrocyte was seeded into an alginate with DBP of different contents, and a microcapsule was produced. The adhesion and proliferation of cells was observed through the MTT analysis, and the PCR was applied to estimate the content of the glycosaminoglycan (sGAG) and collagen, and confirm the specific genetic pattern of the chondrocytes. Also, the alginate microcapsule where the chondrocyte is seeded was extracted after transplantation under the skin of a nude mouse, and was immunochemically stained. The experimental result confirmed that the alginate microcapsule containing 1% of DBP not only showed the highest proliferation of cell but had a positive effect of chondrocytes by the interaction between the alginates and the growth factor in DBP. It can be expected that the microcapsule with application of the alginates and DBP might be an appropriate scaffold for tissue engineering.

Numerical Investigation of Micro Thermal Imprint Process of Glassy Polymer near the Glass Transition Temperature (열방식 마이크로 임프린트 공정을 위한 고분자 재료의 수치적 모델링과 해석)

  • Lan, Shuhuai;Lee, Soo-Hun;Lee, Hye-Jin;Song, Jung-Han;Sung, Yeon-Wook;Kim, Moo-Jong;Lee, Moon-G.
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 2009.10a
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    • pp.45-52
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    • 2009
  • The research on miniature devices based on non-silicon materials, in particular polymeric materials has been attracting more and more attention in the research field of the micro/nano fabrication in recent years. Lost of applications and many literatures have been reported. However, the study on the micro thermal imprint process of glassy polymer is still not systematic and inadequate. The aim of this research I to obtain a numerical material model for an amorphous glassy polymer, polycarbonate (PC), which can be used in finite element analysis (FEA) of the micro thermal imprint process near the glass transition temperature (Tg). An understanding of the deformation behavior of the PC specimens was acquired by performing tensile stress relaxation tests. The viscoelastic material model based on generalized Maxwell model was introduced for the material near Tg to establish the FE model based on the commercial FEA code ABAQUS/Standard with a suitable set of parameters obtained for this material model form the test data. As a result, the feasibility of the established viscoelastic model for PC near Tg was confirmed and this material model can be used in FE analysis for the prediction and improvement of the micro thermal imprint process for pattern replication.

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Shape-Estimation of Human Hand Using Polymer Flex Sensor and Study of Its Application to Control Robot Arm (폴리머 굽힘센서를 이용한 손의 형상 추정과 로봇 팔 제어 연구)

  • Lee, Jin-Hyuk;Kim, Dae-Hyun
    • Journal of the Korean Society for Nondestructive Testing
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    • v.35 no.1
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    • pp.68-72
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    • 2015
  • Ultrasonic inspection robot systems have been widely researched and developed for the real-time monitoring of structures such as power plants. However, an inspection robot that is operated in a simple pattern has limitations in its application to various structures in a plant facility because of the diverse and complicated shapes of the inspection objects. Therefore, accurate control of the robot is required to inspect complicated objects with high-precision results. This paper presents the idea that the shape and movement information of an ultrasonic inspector's hand could be profitably utilized for the accurate control of robot. In this study, a polymer flex sensor was applied to monitor the shape of a human hand. This application was designed to intuitively control an ultrasonic inspection robot. The movement and shape of the hand were estimated by applying multiple sensors. Moreover, it was successfully shown that a test robot could be intuitively controlled based on the shape of a human hand estimated using polymer flex sensors.

Controlled Drug Delivery of Ampicillin-Poly(L-lactic acid) Films for the Treatment of Otitis Media (중이염 치료용 암피실린-폴리락트산 필름의 약물방출조건)

  • La, Sung-Bum;Jeong, Seo-Young;Park, Ki-Dong;Juhn, Sung-Kyun;Goo, Hyun-Chul;Yang, Seung-Eun;Jee, Ung-Kil
    • Journal of Pharmaceutical Investigation
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    • v.24 no.1
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    • pp.41-48
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    • 1994
  • A new local drug delivery device to treat otitis media (OM) has been developed. This device consists of a biodegradable poly(L-lactic acid) (PLLA) film containing antibiotic (ampicillin, AMP), which can be placed into the middle ear cavity and release the therapeutic concentration of AMP for prolonged period. Biodegradable films containing AMP (10 w/w%) were prepared by solution casting method using a suspension of the drug in a $PLLA/CH_{2}Cl_{2}$ solution (molecular weight of PLLA, 100,000 (100 K) and 300,000 (300 K), respectively). PLLA-AMP films were characterized by FTIR, DSC, and SEM. In vitro release of AMP from AMP-PLLA films were examined. The release pattern of AMP from AMP-PLLA films remained consistent from 1 day to 14 days, and the release rates of AMP from AMP-100K-PLLA film and AMP-300K-PLLA film were $0.7384\;{\mu}g/ml/day$, $0.4107\;{\mu}g/ml/day$, respectively.

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Fabrication of Transparent Electrode Film for Organic Photovoltaic using Ag grid and Conductive Polymer (Ag grid와 전도성 고분자를 이용한 인쇄기반 OPV용 투명전극 형성)

  • Yu, Jongsu;Kim, Jungsu;Yoon, Sungman;Kim, Dongsoo;Kim, Dojin;Jo, Jeongdai
    • 한국신재생에너지학회:학술대회논문집
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    • 2011.05a
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    • pp.116.1-116.1
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    • 2011
  • Materials with a combination of high electrical conductivity and optical transparency are important components of many electronic and optoelectronic devices such as liquid crystal displays, solar cells, and light emitting diodes. In this study, to fabricate a low-resistance and high optical transparent electrode film for organic photovoltaic, the following steps were performed: the design and manufacture of an electroforming stamp mold, the fabrication of thermal roll imprinted (TRI) poly-carbonate (PC) patterned films, the manufacture of high-conductivity and low-resistance Ag paste which was filled into patterned PC film using a doctor blade process and then coated with a thin film layer of conductive polymer by a spin coating process. As a result of these imprinting processes the PC films obtained a line width of $10{\pm}0.5{\mu}m$, a channel length of $500{\pm}2{\mu}m$, and a pattern depth of $7.34{\pm}0.5{\mu}m$. After the Ag paste was used to fill part of the patterned film with conductive polymer coating, the following parameters were obtained: a sheet resistance of $9.65{\Omega}$/sq, optical transparency values were 83.69 % at a wavelength of 550 nm.

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Preparation of Solid Dosage Form containing SMEDDS of Simvastatin by Microencapsulation (심바스타틴 자가유화약물전달시스템의 마이크로캡슐화를 통한 고형제제의 개발)

  • Kang, Bok-Ki;Yoon, Bok-Young;Seo, Kwang-Su;Jeung, Sang-Young;Kil, Hee-Joo;Khang, Gil-Son;Lee, Hai-Bang;Cho, Sun-Hang
    • Journal of Pharmaceutical Investigation
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    • v.33 no.2
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    • pp.121-127
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    • 2003
  • The objective of this study was to solidify the simvastatin self-microemulsifying drug delivery system (SMEDDS) and to improve the encapsulation efficiency of solidified alginate beads using sodium alginate. Typical simvastatin SMEDDS was composed of various oils, surfactants and cosurfactants. Also solidified-alginate beads was prepared by crosslinking liquid emulsion mixtures containing sodium alginate and other excipients (cetylpyridinum chloride (CP-Cl), hydroxypropyl methylcellulose, starch and so on). in $CaCl_2$ solution, it has been investigated that the drug release pattern and encapsulation efficiency were varied with the ratio of cationic lipid (CP-Cl). Solidified sodium alginate beads containing simvastatin SMEDDS were redispersed into media without re-aggregation. Oil droplet size of redispersed solidified-beads in media produced smaller than the initial size. The density of beads and drug loading amount were increased with increasing cationic lipid content. These systems have advantages of storage stability and predictability of drug release rate.

Design and Fabrication of Semi-cylindrical Radar Absorbing Structure using Fiber-reinforced Composites (섬유강화 복합재료를 이용한 반원통형 전자파 흡수구조의 설계 및 제작)

  • Jang, Hong-Kyu;Shin, Jae-Hwan;Kim, Chun-Gon;Shin, Sang-Hun;Kim, Jin-Bong
    • Composites Research
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    • v.23 no.2
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    • pp.17-23
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    • 2010
  • The stealth technology can increase the survivability of aircrafts or warships and enhance the capability of mission completion in hostile territory. The purpose of this paper is to present the low observable structure with curved surfaces made by fiber-reinforced composites and to show the possibility of developing omnidirectional stealth platforms for military applications. In this study, we developed a radar absorbing structures(RAS) based on a circuit analog absorber to reduce the radar cross section(RCS) of an object with curved surfaces. Firstly, the RAS with a periodic square patterned conducting polymer layer was designed and simulated using a commercial 3-D electromagnetic field analysis program. Secondly, the designed semi-cylindrical structure with low RCS was fabricated using fiber-reinforced composites and conducting polymer. To make the periodic pattern layer, acts as resistive sheet, the intrinsic conducting polymer paste containing PEDOT with a polyurethane binder was used. Finally, the radar cross section was measured to evaluate the radar absorbing performances of the fabricated RAS by the compact range facility in POSTECH.

Mechanical and Impact Properties and Heat Deflection Temperature of Wood Flour-reinforced Recycled Polyethylene Green Composites (목분강화 재활용폴리에틸렌 그린복합재료의 기계적 특성, 충격 특성 및 열변형온도)

  • Lee, Ki-Young;Cho, Dong-Hwan
    • Elastomers and Composites
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    • v.46 no.3
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    • pp.223-230
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    • 2011
  • Considering of utilizing renewable resources and recycled plastics, green composites consisted of recycled polyethylene (PE) as matrix and eco-friendly natural fibers as reinforcement were processed and characterized in the present study. First, the wood flour/recycled polyethylene pellets with different wood flour contents were prepared by twin-screw extrusion processing. Using the pellets, wood flour/recycled polyethylene green composites were fabricated and the effects of wood flour loading on their flexural, tensile, impact properties, heat deflection temperature and fracture behavior were investigated. It was concluded that the flexural strength, flexural modulus, tensile modulus and heat deflection temperature of wood flour/recycled polyethylene green composites were increased with wood flour, whereas the tensile strength and impact strength were decreased. The fracture behavior observed by means of scanning electron microscopy supported qualitatively the tendency of the impact strength with wood flour loading, compared with the ductile fracture pattern of recycled polyethylene.

Preparation and Characterization of Electrospun Nanofibers Containing Natural Antimicrobials (천연 향균물질 함유 나노섬유의 제조 및 특성분석)

  • Kim, Young-Jin;Kim, Sang-Nam;Kwon, Oh-Kyoung;Park, Mi-Ran;Kang, Inn-Kyu;Lee, Se-Geun
    • Polymer(Korea)
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    • v.33 no.4
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    • pp.307-312
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    • 2009
  • The fabrication of PHBV nanofibers containing various plant polyphenols by electrospinning has been examined. It has been found that the average diameters of fibers increased by the adding of polyphenols. The resulting fibers exhibited a uniform diameter ranging from 340 to 450 nm. As the concentration of polyphenols increased, the diameter of fibers increased due to the hydrogen bonding interaction between the ester groups of PHBV and hydroxyl groups of polyphenols. The interaction between PHBV and polyphenols, which forms a complex together in solution, was verifed by UV measurement. ATR-FTIR analysis confirmed the existence of the hydrogen bonding interaction. The semicrystalline structure of the PHBV nanofiber was observed from XRD pattern. The crystallinity of PHBV nanofibers was increased by the adding of polyphenols. PHBV nanofibers containing polyphenols showed superior antimicrobial activities.

Effect of High Water-Swelling Polymer Rate on Seedling Survival of Major Turfgrasses Grown on Soil Organic Amendment Mixtures (토양개량재 혼합구에서 고분자 중합체 비율이 주요 잔디류의 유묘 생존에 미치는 효과)

  • Kim, Kyoung-Nam;Park, So-Hyang
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.14 no.2
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    • pp.21-32
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    • 2011
  • The effects of high polymer on the seedling survival were investigated in three major turfgrasses. Twelve treatments were used in the study with different rates of sand, soil organic amendment (SOA), and water-swelling polymer (WSP). Turfgrass seedling survival rate was evaluated in creeping bentgrass (CB), Kentucky bluegrass (KB), and zoysiagrass (Zoy) grown under greenhouse conditions. Significant differences were observed among the treatments. Seedling survival rates were variable in CB, KB, and Zoy according to mixing rates of SOA and WSP, being maximum 20.2% in differences. At 6 weeks after seeding, the survival rates ranged from 0.6 to 61.9% in CB, 4.2 to 75.3% in KB and 1.7 to 82.1% in Zoy. A pattern of seedling emergence varied with time among treatments influenced by WSP rates. A proper mixing rate of WSP is considered to be 5% for CB and 5 to 10% for KB and Zoy. In general, overall effect of WSP on seedling survival was clearly observed in the mixtures of sand 80% and SOA 20% in CB. The best result, however, was found from the mixture of sand 85% and SOA 15% in both KB and Zoy. When mixing sand with WSP, a proper rate of SOA is considered to be 20% for CB and 15 to 20% for KB, while 10 to 15% for Zoy. A further research is needed to investigate the effects of WSP on the turf quality in mixtures of sand, SOA, and WSP before a field application.