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http://dx.doi.org/10.4333/KPS.2003.33.2.121

Preparation of Solid Dosage Form containing SMEDDS of Simvastatin by Microencapsulation  

Kang, Bok-Ki (Department of Polymer Science and Technology, Chonbuk National University)
Yoon, Bok-Young (Department of Polymer Science and Technology, Chonbuk National University)
Seo, Kwang-Su (Department of Polymer Science and Technology, Chonbuk National University)
Jeung, Sang-Young (Biomaterials Laboratory, Korea Research Institute of Chemical Technology)
Kil, Hee-Joo (Department of Macromolecular Science, Hannam University)
Khang, Gil-Son (Department of Polymer Science and Technology, Chonbuk National University)
Lee, Hai-Bang (Biomaterials Laboratory, Korea Research Institute of Chemical Technology)
Cho, Sun-Hang (Biomaterials Laboratory, Korea Research Institute of Chemical Technology)
Publication Information
Journal of Pharmaceutical Investigation / v.33, no.2, 2003 , pp. 121-127 More about this Journal
Abstract
The objective of this study was to solidify the simvastatin self-microemulsifying drug delivery system (SMEDDS) and to improve the encapsulation efficiency of solidified alginate beads using sodium alginate. Typical simvastatin SMEDDS was composed of various oils, surfactants and cosurfactants. Also solidified-alginate beads was prepared by crosslinking liquid emulsion mixtures containing sodium alginate and other excipients (cetylpyridinum chloride (CP-Cl), hydroxypropyl methylcellulose, starch and so on). in $CaCl_2$ solution, it has been investigated that the drug release pattern and encapsulation efficiency were varied with the ratio of cationic lipid (CP-Cl). Solidified sodium alginate beads containing simvastatin SMEDDS were redispersed into media without re-aggregation. Oil droplet size of redispersed solidified-beads in media produced smaller than the initial size. The density of beads and drug loading amount were increased with increasing cationic lipid content. These systems have advantages of storage stability and predictability of drug release rate.
Keywords
Simvastatin; SMEDDS; Sodium alginate; Dissolution behavior; Cationic lipid; Encapsulation efficiency;
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Times Cited By KSCI : 2  (Citation Analysis)
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